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Olga Kashpur, PhD


Overview

Gender Female

Publications + National Presentations

Journal Papers



1. Kashpur O, Smith A, Gerami-Naini B, Maione AG, Calabrese R, Tellechea A, Theocharidis G, Liang L, Pastar I, Tomic-Canic M, Mooney D, Veves A, Garlick JA. Differentiation of diabetic foot ulcer-derived induced pluripotent stem cells reveals distinct cellular and tissue phenotypes. FASEB J. 2018 Aug 8:fj201801059.

2. Gerami-Naini B, Smith A, Maione AG, Kashpur O, Carpinito G, Veves A, Mooney DJ, Garlick JA. Generation of Induced Pluripotent Stem Cells from Diabetic Foot Ulcer Fibroblasts Using a Nonintegrative Sendai Virus. Cell Reprogram. 2016 Aug;18(4):214-23.

3. Maione AG, Smith A, Kashpur O, Yanez V, Knight E, Mooney DJ, Veves A, Tomic-Canic M, Garlick JA. Altered ECM deposition by diabetic foot ulcer-derived fibroblasts implicates fibronectin in chronic wound repair. Wound Repair Regen. 2016 Jul;24(4):630-43.

4. Jez M, Ambady S, Kashpur O, Grella A, Malcuit C, Vilner L, Rozman P, Dominko T. Expression and differentiation between OCT4A and its Pseudogenes in human ESCs and differentiated adult somatic cells. PLoS One. 2014 Feb 24;9(2):e89546.

5. Kashpur O, LaPointe D, Ambady S, Ryder EF, Dominko T. FGF2-induced effects on transcriptome associated with regeneration competence in adult human fibroblasts. BMC Genomics. 2013 Sep 26;14:656.

6. Ambady S, Malcuit C, Kashpur O, Kole D, Holmes WF, Hedblom E, Page RL, Dominko T. Expression of NANOG and NANOGP8 in a variety of undifferentiated and differentiated human cells. Int J Dev Biol. 2010; 54(11-12):1743-54.

7. Rao RP, Hunter A, Kashpur O, Normanly J. Aberrant synthesis of indole-3-acetic acid in Saccharomyces cerevisiae triggers morphogenic transition, a virulence trait of pathogenic fungi. Genetics. 2010 May; 185(1):211-20. Epub 2010 Mar 16.

8. Page RL, Ambady S, Holmes WF, Vilner L, Kole D, Kashpur O, Huntress V, Vojtic I, Whitton H, Dominko T. Induction of stem cell gene expression in adult human fibroblasts without transgenes. Cloning Stem Cells. 2009 Sept; 11(3):417-26.

Book Chapters



1. Kashpur O, Smith A, Mukhamedshina N, Baskin J, Shamis Y, Hewitt K, Gerami-Naini B, Garlick JA. 2017 Induced pluripotent stem cells potential to generate skin tissue models. In: Marques A , Reis R, Pirraco R, Cerqueira M. Skin Tissue Models for Regenerative Medicine Cambridge, MA: Academic Press.

2. Kashpur O, Smith A, Imbriaco R, Greaves B, Gerami-Naini B, Garlick JA. Cell therapies: new frontier for the management of diabetic foot ulceration. In: Veves A, Giurini JM, Guzman RJ. The Diabetic Foot - Medical and Surgical Management, 4th edition. New York, NY: Springer (in press).

Biography

Dr. Olga Kashpur, PhD is currently a Postdoctoral Research Fellow in the Wallingford Lab. Dr. Kashpur graduated from the Kiev Polytechnic Institute and the Worcester Polytechnic Institute. Dr. Kashpur was trained in the Dominko Lab at WPI Biology and Biotechnology and the Garlick Lab at Tufts University School of Dental Medicine. As a trained molecular and cellular biologist with research expertise in 2D assays and 3D tissue models, next-generation sequencing, and bioinformatics data analysis, Dr. Kashpur’s current research focus is bioengineering new tools and methodologies that can be used to advance reproductive medicine. Specifically, Dr. Kashpur is interested in applying 3D cell and tissue engineering approaches to model development of human placenta as well as elucidating signaling pathways that regulate vascular development of human placenta.

Professional Memberships

American Heart Association/American Stroke Association
Council on Basic Cardiovascular Sciences
Council on Arteriosclerosis, Thrombosis and Vascular Biology
North American Vascular Biology Organization

Research Focus

There is a lack of biomedical knowledge about development of placenta that stems in part from the inaccessibility of developing human placenta and from the variability seen in comparative placenta anatomy across species. I am designing a suite of 3D cell culture systems to model specific aspects of human placental vascular development and investigate the contribution of trophoblast cells to the development of vascular mimicry in placenta. My work in the Wallingford Lab aims to identify signaling pathways that regulate these processes in vivo by testing how gradients of angiogenic growth factors, such as VEGF and FGF2, regulate placental vascular patterning and vascular mimicry in vitro. Designing these 3D cell culture systems will allow us to model human placental vascular development and better understand and treat placental disorders such as preeclampsia.