|Programs + Specialties
||impact of insulin resistance and glucose metabolism on pregnancy
maternal nutrition and its associated impact on offspring growth, metabolism and adiposity
|Training + Education
University of Vermont College of Medicine, San Francisco General Hospital, San Francisco, California
2014, Appointed Inaugural Dierker-Biscotti Professor of Women’s Health and Wellness
2012, Macy Nigh-Whitener Professorship, Children’s Hospital Foundation, University of Oklahoma
2012, University of Toronto Charles H Best Lecture, for outstanding contributions to research in diabetes Toronto Canada
2012, University of Toronto, Henderson lecture, Dept. of Obstetrics and Gynecology
2011, Jorgen Pederson Lecturer, Diabetes in Pregnancy Study Group of the European Association for the Study of Diabetes
2011, March of Dimes Agnes Higgins Award, in Recognition of Service to the Cause of Improved Maternal Nutrition
2010, Elected by peers for inclusion in the “Best Doctors in America” from 2001-2012
Co-Chair of the NICHD Vision Workshop: pregnancy
2010, Group leader of the NICHD Vision Workshop; Developmental Origins of Health and Disease
2005, Distinguished Academic Achievement Award from the Medical Alumni Association of the University of Vermont College of Medicine in Burlington, VT
2004-2006, Chair, American Diabetes Association, Pregnancy and Women’s Health Council
2001-2012, Elected by peers for inclusion in the “Best Doctors in America”
2000, Norbert Freinkel Lecture Outstanding Research in the Field of Diabetes in Pregnancy
1997, President, Perinatal Research Society
1994, National Faculty Award for Excellence in Resident Education, Council on Resident Education in Obstetrics and Gynecology
1993, Department of Obstetrics and Gynecology, MetroHealth Medical Center, Teacher of the Year Award
Catalano P, Shankar K. Obesity and pregnancy: mechanisms of short term and long term adverse consequences for mother and child. BMJ (Clinical Research Ed.) 2017;356:j1. doi: 10.1136/bmj.j1.
Berggren E, O'Tierney-Ginn P, Lewis S, Presley L, De-Mouzon S, Catalano P. Variations in resting energy expenditure: impact on gestational weight gain. Am J Obstet Gynecol 2017; 217:445.e1-445.e6. doi: 10.1016/j.ajog.2017.05.054.
Ma RC, Schmidt MI, Tam WH, McIntyre HD, Catalano PM. Clinical management of pregnancy in the obese mother: before conception, during pregnancy, and post partum. Lancet Diabetes Endocrinol 2016; pii: S2213-8587:30278-9.
Berggren EK, Groh-Wargo S, Presley L, Hauguel-de Mouzon S, Catalano PM. Maternal fat, but not lean, mass is increased among overweight/obese women with excess gestational weight gain. Am J Obstet Gynecol 2016: 214:745.e1-5. doi: 10.1016/j.ajob.2015.12.026.
Catalano PM, Mele L, Landon MB, Ramin SM, Reddy UM, Casey B, Wapner RJ, Varner MW, Rouse DJ, Thorp, Jr. JM, Saade G, Sorokin Y, Peaceman AM, Jorge E. Tolosa JE, M.S.C.E. for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. Inadequate weight gain in overweight and obese pregnant women: What is the effect on fetal growth? Am J Obstet Gynecol 2014 137:e1-7. doi: 10.1016/j.ajog.2014.02.004.
Catalano PM, McIntyre HD, Cruickshank JK, McCance DR, Dyer AR, Metzger BE, Lowe LP, Trimble ER, Coustan DR, Hadden DR, Persson B, Hod M, Oats JJN for the HAPO Study Cooperative Research Group. The hyperglycemia and adverse pregnancy outcome (HAPO) study: Associations of GDM and obesity with pregnancy outcomes. Diabetes Care 2012;35:780-6.
Landon MB, Spong CY, Thom E, Carpenter MW, Ramin SM, Casey B, Wapner RJ, Varner MW, Rouse DJ, Thorp JM, Sciscione A, Catalano P, Harper M, Saade G, Lain KY, Sorokin Y, Peaceman AM, Tolosa JE, Anderson GB. Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. A multicenter randomized trial of treatment for mild gestational diabetes. NEJM 2009;361:1339-48.
Catalano PM, Farrell K, Thomas A, Huston-Presley L, Mencin P, Hauguel-de Mouzon S, Amini SB. Perinatal risk factors for childhood obesity and metabolic dysregulation. Am J Clin Nutr 2009; 90:1303-13.
Catalano P, Presley L, Minium J, Hauguel-de Mouzon S. Fetuses of obese mothers develop insulin resistance in utero. Diabetes Care 2009;32:1076-80.
Catalano PM, Hoegh M, Minium J, Huston-Presley L, Bernard S, Kalhan S, Hauguel-de Mouzon S. Adiponectin in human pregnancy: Implications for regulation of glucose and lipid metabolism. Diabetologia 2006;49:1677-85.
Kirwan JP, Varastehpour A, Jing M, Presley L, Shao J, Friedman JE, Catalano PM. Reversal of insulin resistance postpartum is linked to enhanced skeletal muscle insulin signaling. J Clin Endo & Metab 2004;89:4678-84.
Catalano PM, Thomas A, Huston-Presley L, Amini SB. Increased fetal adiposity: A very sensitive marker of abnormal in-utero development. Am J Obstet & Gynecol 2003;189:1698-704.
Friedman JE, Ishizuka T, Huston LP, Highman T, Jianhua S, Catalano PM. Impaired glucose transport and insulin receptor tyrosine kinase phosphorylation in skeletal muscle from obese women with gestational diabetes mellitus. Diabetes 1999;48:1807-14.
Levine RJ, Hauth JC, Curet B, Sibai BM, Catalano PM, Morris CD, DerSimonian R, Esterlitz JR, Raymond EG, Bild DE, Clemens JD, Cutler JA. Trial of calcium to prevent preeclampsia. NEJM 1997;337:69-76.
Catalano PM, Thomas AJ, Avallone DA, Amini SB. Anthropometric estimation of neonatal body composition. Am J Obstet Gynecol 1995;173:1176-1181.
Catalano PM, Tyzbir ED, Wolfe RR, Calles JE, Roman NM, Amini SB, Sims EAH: Carbohydrate metabolism during pregnancy in control subjects and women with gestational diabetes. Am J Physiol 1993;e60-67. DOI: 10.1152/ajpendo.1993.264.1.E60.
Catalano PM, Tyzbir ED, Allen SR, McBean JH, McAuliffe TL: Evaluation of fetal growth by estimation of neonatal body composition. Obstet Gynecol 1992;79:46-50.
“Maternal Obesity: Short and Long-term Implications for the Mother and Her Offspring.” SUNY Downstate Medical Center, New York, NY, November 14, 2016.
“Maternal Pre-pregnancy Obesity/Excessive Gestational Weight Gain: Effect on Metabolic Health of the Offspring.” Canadian Diabetes Association, Current Issues in Pregnancy Professional Conference and Annual Meetings, Ottawa, Ontario, October 26-29, 2016.
“Obesity – Underlying Mechanisms for Pathophysiology.” DPSG Audit Meeting, Dublin, Ireland, September 30-October 1, 2016.
“Gestational Diabetes: Past, Present, and Future.” Dierker-Biscotti Endowed Professorship Lecture, Cleveland, OH, June 22, 2016.
“Obesity in Pregnancy: What are the Big Questions?” Rocky Mountain Reproductive Sciences Symposium, Fort Collins, CO, April 22, 2016.
“Maternal Pre-pregnancy Obesity and Excessive Gestational Weight Gain: Effect on Metabolic Health of the Offspring.” Scientific Meeting of the International Association of Diabetes and Pregnancy Study Groups, IADPSG 2016, Universidad Catolica Argentina, Buenos Aires, Argentina. March 21-23, 2016.
“Obese Pregnancy and the Impact on Offspring” 14th Annual Perinatal Conference Obesity-A Worldwide Epidemic, UWI, Mona, Jamaica, February 27-28, 2016.
“Introduction: What are the Big Questions?” Obesity and Pregnancy, World Obesity Federation, London, UK, October 29-30, 2015.
“Maternal Obesity and Metabolic Health in the Offspring.” Nordic Congress on Obesity in Gynecology and Obstetrics, Middelfart, Denmark, August 27-29, 2015.
“Obesity as a New Pregnancy Disease in Wealthy Countries.” Nutrition Related Pregnancy Outcomes Around the World, Milano, Italy Jun 8-9, 2015.
For a complete list of Dr. Catalano’s publications see:
Patrick Catalano MD is a Professor and Vice Chair of Obstetrics and Gynecology at Tufts University School of Medicine and a Maternal -Fetal Medicine specialist at Tufts University Medical Center. His research is focused on maternal metabolism in women whose pregnancies are complicated by diabetes and obesity. Further he is studying the short and long-term effects on mothers and their children. He has had continuous funding from the Eunice Kennedy Shriver National Institutes of Child Health and Human Development for the past 30 year
Our research program is focused on a Lifestyle Intervention in Preparation for Pregnancy (LIPP). This is a RCT that is being conducted at Tufts Medical Center, the Pennington Biologic Research Center and Case Western Reserve University. The intervention is a lifestyle intervention of healthy eating (Mediterranean diet) and exercise to have overweight/obese subjects in the intervention group decrease their weight 5-7% based on pre-pregnancy weight from their prior pregnancy as compared to a control or usual care group. The Program in Boston will be conducted at Tufts Medical Center and the Human Nutrition Research Center on Aging (HNRCA). The study is funded by NICHD.
NIH/NICHD R01 HD091054
Placental Lipid Metabolism Impacts Fetal Adiposity and is Programmed by the Maternal Metabolic Milieu in Early Pregnancy.
Goals: To determine how maternal fat metabolism in early pregnancy programs placental lipid metabolism and neonatal fat deposition.
Level and Timing of Diabetic Hyperglycemia in utero: The Transgenerational Effect on Adult Morbidity (TEAM Study).
The objective of this proposal is to combine data from research conducted on a cohort of women with pregestational diabetes and follow-up of their offspring to elucidate the effect of exposure to hyperglycemia in utero on a spectrum of metabolic diseases and cardiovascular dysfunction.
NIH/NICHD R01 HD091735
Placental miRNA Profiles Associated with Maternal Insulin Resistance and Fetal Adiposity: Maternal-Placental Crosstalk.
Goals: To determine the association between miRNA originating in the placenta with maternal insulin resistance and fetal adiposity.
NIH/NICHD NIH HD 088061-01A1
Lifestyle Intervention in Preparation for Pregnancy. hyperlink to https://www.clinicaltrials.gov/ct2/show/NCT03146156?term=LIPP&recrs=a&rank=1
The objective of this project is to break the vicious cycle of obesity/metabolic dysfunction during pregnancy to decrease the risk of maternal and neonatal perinatal morbidity. The primary aim is to decrease adiposity at birth in infants of overweight/obese women through lifestyle intervention of behavioral modification, healthy eating and exercise before a planned pregnancy using a RCT in women after their first pregnancy.
Role: Principal Investigator
NIH/NICHD NIH HD 079647
Comparison of Two Screening Strategies for Gestational Diabetes.
The study will examine the current ACOG and IADPSG screening strategies for the diagnosis of gestational diabetes based on clinical outcomes. Outcomes include if either screening and treatment strategy results in healthier infants and mothers.
NIH/NIDDK NIH R8S119091
Hyperglycemia and Adverse Pregnancy Outcome-Follow up Study (HAPO-FUS).
The HAPO-FUS will evaluate the mothers who participated in the original HAPO study and their offspring at 8-12 years of age.
The purpose of the study is to evaluate maternal obesity and glucose tolerance during pregnancy as risk factors for metabolic dysfunction in the mother and her offspring.
Role: PI at the MetroHealth site/Vice Chair Executive Committee