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Philip N. Tsichlis, MD
Executive Director, Molecular Oncology Research Institute; Professor and Jane F. Desforges Chair in Hematology and Oncology, Tufts University School of Medicine
Department + Services
Clinical Focus Areas
Signaling, hematopoiesis, inflammation, oncogenes, transcriptional regulation
Following graduation from the Medical School of the University of Athens, I trained in internal medicine at Baylor College of Medicine and in Hematology at Tufts Medical Center. During my hematology training, under the guidance of inspiring teachers such as Drs. Robert Schwartz and Jane Desforges, I became interested in the biology of hematologic neoplasms. To pursue this interest, I did a postdoctoral Research Fellowship in the laboratory of Dr. John Coffin at Tufts University School of Medicine.
My work in John's lab revealed that the major determinant of the retrovirus oncogenic potential resides in the proviral LTR and suggested an insertional mutagenesis model for retroviral oncogenesis. Subsequent studies in my own lab utilized insertional mutagenesis as a tool to identify genes involved in tumor induction and in phenotypic changes in tumor cells. Genes identified via this strategy were used as probes to explore function.
My first independent lab was at the National Cancer Institute, and after moves to the Fox Chase and Kimmel Cancer Centers, I returned to Tufts Medical Center in September 2002 to head the Molecular Oncology Research Institute. My laboratory has trained more than 50 students and postdoctoral fellows who are now pursuing independent scientific careers in the United States and Europe.
Tufts Medical Center
800 Washington St., #5609
Boston, MA 02111