CVCRI Achievements + Innovations | Tufts Medical Center

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Achievements + Innovation

HFSA Lifetime Achievement Award

Congratulations to CardioVascular Center Chief Physician Executive Marvin Konstam, MD on receiving the highly prestigious 2018 Lifetime Achievement Award from the Heart Failure Society of America - HFSA. Dr. Konstam will be presented with the award at the HFSA's 22nd Annual Scientific Meeting being held in Nashville, TN this September 15-18.

500th Heart transplant

Marvin Konstam, MD and Deeb Salem, MD at the first heart transplant at Tufts MC

On June 6, Tufts Medical Center reached a landmark milestone in cardiac transplantation when the Advanced Heart Failure + Cardiac Transplant Program, under the direction of David DeNofrio, MD, performed its 500th heart transplant at Tufts MC. The patient, Frank Lalli, 61, from Portsmouth, RI, is recovering well from the procedure. Since 2000, Tufts MC has performed more heart transplants in New England than any other hospital in the region. In 2016, Tufts MC completed 56 heart transplants, a New England record that ranked among the top-10 heart transplant programs in the country for volume. Learn more about this milestone >

35th Anniversary- Cardiac Arrhythmia Center

The 2018 Criscitiello Lecture featured speaker Thomas Deering, MD, MBA.

Leonard Tow Humanism in Medicine Award

Sponsored and administered by The Gold Foundation. In recognition of graduating students and faculty members who demonstrate both clinical excellence and outstanding compassion in the delivery of care and who show respect for patients, their families, and healthcare colleagues.

Dr. Munther Homoud

Natalie Zucker Prize Winners

From the The Natalie V. Zucker Research Center for Women Scholars, devoted to furthering the research careers of female basic and clinical scientists at Tufts University School of Medicine and the Graduate School of Biomedical Sciences at Tufts University.

Lija Swain, PhD - Basic Science
Mehak Dhande, MD - CardioVascular Fellow

New Facilities

Learn more about our newly renovated Cardiac Catherization lab, Hypertrophic Cardiomyopathy Center and ElectroPhysiology Lab >

Investigator	Funding Source	Title of Project
Robert Blanton, MD	NIH	Novel Protein Kinase GI Substrates in Cardiac Remodeling and Blood Pressure Control
	NIH (sub from Tufts University)	Cardiac Cell Entry-Inhibition and Protection Therapy for Chronic Chagas Disease
	Industry	Pre-clinical Study
	Industry	Pre-clinical Study
Michael Chin, MD, PhD	NIH	Intracellular mitochondrial enzyme replacement therapy for heart and skeletal myopathy in Barth Syndrome
Gordon Huggins, MD	NIH (sub from UCONN)	Salivary Amylase Gene (AMY 1) as Predictor of Weight and Diet in LookAhead & DPP
Gordon Huggins, MD	Tufts University Russo Award	Diagnosis of Heart Failure Status using Metabolomics
Iris Jaffe, MD, PhD	American Heart Association	Extra-Renal Mineralocorticoid Receptors in Hypertension
	NIH	The Role of Vascular MR-Regulated Genes in Vascular Function and Disease
	NIH	Smooth Muscle Mineralocorticoid Receptors in Vascular Aging and Hypertension
	NIH (sub from Michigan State University)	Cerebral parenchymal arteriole dysfunction and cognitive decline in a life-long high fat feeding model
	NIH (sub from University of Missouri)	Mineralocorticoid receptor-dependent coronary vascular dysfunction in obesity
	NIH (sub from University of Missouri)	Mechanisms for Sex Differences in CVD Pathology and Development of a Targeted Therapeutic
Iris Jaffe, MD, PhD/Robert Blanton, MD	Industry	Pre-clinical Study
Navin Kapur	Industry	Pre-clinical study
	NIH	Endoglin: A New Target of Therapy for Heart Failure
	NIH	Mechanical Unloading and Delayed Reperfusion Promotes Myocardial Recovery after Acute Myocardial Infarction
	Industry	Pre-clinical Study

Investigator	Funding Source	Title of Project
David DeNofrio, MD	NIH	CTOT-11 Long-term Safety Follow-up
N.A. Mark Estes, MD	NIH	Genetics, Mechanisms and Clinical Phenotypes of Arrhythmogenic Cardiomyopathy
N.A. Mark Estes, MD	NIH	Late Sodium current blockade in high-risk ICD patients
Gordon Huggins, MD	NIH	Heart Failure Network: New England, New York and Quebec Regional Clinical Center
	NIH	Precision Medicine for Dilated Cardiomyopathy in European and African Ancestry
	NIH (Heart Failure Network)	Characterizing HIV-related Diastolic Dysfunction
	NIH (Heart Failure Network)	Subcutaneous Furosemide in Acute Decompensated Heart Failure –SUBQ-HF
Navin Kapur, MD	Abbott	Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients with Functional Mitral Regurgitation (The COAPT Trial)
	Abiomed	Door To Unloading with IMPELLA CP® System in Acute Myocardial Infarction to Reduce Infarct Size (DTU): A Prospective Feasibility Study
	Abiomed	CVAD Registry
	Abiomed	RECOVER RIGHT: The Use of Impella RP Support System in Patients with Right Heart Failure: Post Approval Study
	Henry Ford Health System	National Cardiogenic Shock Initiative (NCSI)
	Thoratec	Coronary InterventionS in HIgh-Risk PatiEnts Using a Novel Percutaneous Left Ventricular Support Device (SHIELD II)
Michael Kiernan, MD	NIH (sub from Northwestern)	Mechanical circulatory support: Measures of adjustment and quality of life
	NIH	Heart Failure Clinical Research Network: Entresto^TM (LCZ696) In Advanced Heart Failure (LIFE Study)
	Heartware	A Prospective, Single Arm, Multi-Center Clinical Study in Collaboration with the InterAgency Registry for Mechanically Assisted Circulatory Support (INTERMACS®) to Evaluate the Thoracotomy Implant Technique of the HeartWare HVAD® System in Patients with Advanced Heart Failure
	Heartware	A Prospective, Randomized, Controlled, Un-blinded, Multi-Center Clinical Trial to Evaluate the HeartWare® Ventricular Assist System for Destination Therapy of Advanced Heart Failure
	Heartware	A Multi Center, Post Approval Study Providing Continued Evaluation and Follow-up on Patients Who Received a HeartWare® Ventricular Assist System During IDE Trials for the Treatment of Advanced Heart Failure
Carey Kimmelstiel, MD	Boston Scientific	EVOLVE II: A Prospective Multicenter Trial to Assess the Safety and Effectiveness of the SYNERGYTM Everolimus-Eluting Platinum Chromium Coronary Stent System (SYNERGYTM Stent System) for the Treatment of Atherosclerotic Lesion(s)
	Boston Scientific	A Prospective, Multicenter, Single-arm Study Designed to Assess the Safety of 3-month Dual Antiplatelet Therapy (DAPT) in Subjects at High Risk for Bleeding Undergoing Percutaneous Coronary Intervention (PCI) With the SYNERGY Everolimus-Eluting Platinum Chromium Coronary Stent System
	Cardiovascular Systems, Inc.	Multi-center Prospective Study to Evaluate Outcomes of Moderate to Severely Calcified Coronary Lesions (MACE)
	Eisai Pharmaceuticals	A Randomized, Double-blind, Placebo-controlled, Parallel-group Study to Evaluate the Effect of Long-term Treatment with BELVIQ (lorcaserin HCl) on the Incidence of Major Adverse Cardiovascular Events and Conversion to Type 2 Diabetes Mellitus in Obese and Overweight Subjects with Cardiovascular Disease or Multiple Cardiovascular Risk Factors
	Lilly	The effect of prasugrel therapy as compared to clopidogrel on platelet function immediately following the termination of intravenous bivalirudin therapy in patients undergoing percutaneous coronary and structural cardiac intervention
	MD Start	First in man proof of concept clinical ctudy for heart failure
	Sanofi Pharmaceuticals	A Randomized, Double-Blind, Placebo-Controlled, Parallel- Group Study to Evaluate the Effect of SAR236553/REGN727 on the Occurrence of Cardiovascular Events in Patients who have Recently Experienced an Acute Coronary Syndrome (Odyssey).
Ayan Patel, MD	Alnylam Pharmaceuticals	Examining the Prevalence of TTR Mutations in Subjects Suspected of Having Cardiac Amyloidosis
Ayan Patel, MD	Alnylam Pharmaceuticals	A Phase 3 Multicenter, Multinational, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of ALN-TTRSC in Patients with Transthyretin (TTR) Mediated Familial Amyloidotic Cardiomyopathy (FAC)
Payem Salehi, MD	Bolton Medical	A Prospective, Multicenter, Non-blinded, Non-randomized Study of the Relay PRO Thoracic Stent-Graft in Subjects with Thoracic Aortic Aneurysms and Penetrating Atherosclerotic Ulcers
Jenica Upshaw, MD	Merck	A Randomized Parallel-Group, Placebo-Controlled, Double-Blind, Event-Driven, Multi-Center Pivotal Phase III Clinical Outcome Trial of Efficacy and Safety of the Oral sGC Stimulator Vericiguat in Subjects With Heart Failure With Reduced Ejection Fraction (HFrEF) - VerICiguaT Global Study in Subjects With Heart Failure With Reduced Ejection Fraction (VICTORIA)
Amanda Vest, MBBS, MPH	American Heart Association	Scientist Development Grant
	Actelion	A prospective, multicenter, double-blind, randomized, placebo-controlled parallel – group study to assess the efficacy and safety of macitentan in patients with pulmonary hypertension after left ventricular assist device implantation
	Boehringer-Ingelheim	A phase III randomised, double-blind trial to evaluate efficacy and safety of once daily empagliflozin 10 mg compared to placebo, in patients with chronic Heart Failure with preserved Ejection Fraction (HFpEF)
	Boehringer-Ingelheim	A phase III randomised, double-blind trial to evaluate efficacy and safety of once daily empagliflozin 10 mg compared to placebo, in patients with chronic Heart Failure with reduced Ejection Fraction (HFrEF)
	Corvia Medical, Inc.	REDUCE LAP-HF RANDOMIZED TRIAL II: A study to evaluate the Corvia Medical, Inc. IASD® System II to REDUCE Elevated Left Atrial Pressure in Patients with Heart Failure
	Tufts University Charlton Award	The Metabolomic Profile of Advanced Systolic Heart Failure and Changes with Metabolic Recovery after Ventricular Assist Device Implantation
Jonathan Weinstock, MD	UCSF	Vest Prevention of Early Sudden Death Trial (VEST) and VEST Registry
	St Jude Medical	CRT Implant Strategy Using the Longest Electrical Delay for Non-left Bundle Branch Block Patients (ENHANCE CRT)
	St Jude Medical	Safety and Effectiveness Trial for the Nanostim Leadless Pacemaker
Andrew Weintraub, MD	Cardiovascular Research Foundation	TAVR UNLOAD

CardioVascular Center for Research and Innovation (CVCRI)