Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI)


Kidney disease is a worldwide  public health problem, disproportionately affecting older people and lower and middle income countries, with major outcomes including kidney failure and cardiovascular disease. The CKD Epidemiology Collaboration (CKD-EPI) is a research group  with interests in measurement  and estimation of GFR (CKD-EPI GFR) and evaluation of surrogate endpoints for clinical trials in CKD (CKD-EPI CT). CKD-EPI was founded by Dr. Andrew S. Levey who served as Director from  2004 to 2018 and continues to serve as co-director. Dr. Lesley A. Inker has been the Director of the Data Coordinating Center (DCC) from 2004 and Co-Director  since 2018.


GFR estimation (CKD-EPI GFR)

The Steering Committee (SC) guides the overall direction and policies and is co-chaired by Drs. Lesley A. Inker, and Andrew S. Levey. Drs. Josef Coresh and Tom Greene  are members of the SC. The Data Coordination enter is at Tufts Medical Center under the direction of Dr. Inker and the Central Laboratory is at the University of Minnesota. Dr. John Eckfeldt was the Director of the Central Laboratory until 2015, after which Dr. Amy Karger has been serving as the Director.

Surrogate endpoints for clinical trials (CKD-EP CT)

The steering committee (SC) guides the overall direction and policies, and is chaired by Dr. Lesley A. Inker.  The SC will consistent of permanent  members, one representative of CKD-Prognosis Consortium, and 3-4 rotating members. Permanent  members are Drs. Inker, Tom Greene, Hiddo  L. Heerspink and Andrew  S. Levey. CKD-PC representative will be decided upon  by CKD-PC. Josef Coresh will be the initial representative. Rotating members will rotate every two  years and will consist of 2 collaborators and 1-2 stakeholders. The Data Coordinating Center is at Tufts Medical Center, under the direction of Dr. Inker. The statistical center is at University of Utah under the direction of Dr. Greene. Randomized Clinical Trials Identification and Acquisition Center is at Groningen University under the direction of Dr. Heerspink.

Organization and policy documents

Click here to download the CKD-EPI GFR organization and policy document.
Click here for CKD-EPI CT.