Molecular Cardiology Research Institute (MCRI)
20 years of scientific discovery
For the past 20 years, the investigators and research teams of the Molecular Cardiology Research Institute (MCRI) have continually translated basic findings into new clinical strategies for the diagnosis and treatment of cardiovascular disease.
Some of our scientific accomplishments over the past 20 years include:
• (1998) Blood vessels respond directly to hormones. MCRI Investigators first discovered in the 1990s that the heart and blood vessels have molecular receptors needed to respond to the hormone estrogen. This discovery pioneered the field of estrogen action on the cardiovascular system and is leading to safer and more effective hormone therapies for women's heart health.
• (2004) Blood vessel constriction can directly cause high blood pressure. Previously high blood pressure was thought to be exclusively a kidney problem however, in the early 2000s, MCRI investigators made several ground breaking discoveries demonstrating that it can result from a primary defect in blood vessel function, leading to new targets for blood pressure control.
• (2002) MCRI investigators have made substantial advances in understanding how the blood vessel and the platelet interact to prevent blood clotting in the healthy vessel and lead to blood clotting when the vessel is diseased. These findings contributed to our current understanding of the cause of heart attacks and strokes and are being translated into new treatments.
• (2003-2018) Multiple MCRI Investigators spanning 2 decades have made substantial contributions to our understanding of the mechanisms leading to the number one cause of hospitalization – heart failure. These discoveries identified multiple new drug targets that are being developed for heart failure treatment and a discovery that white blood cells contribute to heart failure and may provide a potential new strategy to improve the heart function in the failing heart.
• (2006/2017) MCRI efforts to understand how cancer therapy causes heart and vascular disease are leading to safer treatments for cancer patients. Work in the mid 2000s explored how cancer therapy causes heart failure. Recent studies are uncovering how the new targeted cancer treatments cause blood vessel dysfunction leading to heart attacks and strokes and how to prevent those adverse outcomes in cancer survivors.
• (2008/2016) Small noncoding RNAs play key role in blood vessel function and contribute to hypertension as we age: In 2008, MCRI investigators discovered how microRNAs mature in blood vessel cells and can regulate blood vessel function. In 2016, one of these microRNAs was identified as contributing to blood vessel constriction with aging. High blood pressure affects 80 percent of people over the age of 80. MicroRNA levels in the serum of older people are now being evaluated as biomarkers to tailor high blood pressure treatment.
• (2013) MCRI Investigators recently discovered that, in the setting of a heart attack with a blocked coronary artery, reducing the work of the heart by unloading it with a pump while delaying opening the heart artery activates a heart protection program and reduces heart attack size. This paradigm-shifting approach is now being tested in a multicenter clinical trial in people having heart attacks.
• (2016) Establishment of the MCRI biobank is allowing MCRI investigators to advance our understanding of heart and blood vessel disease by working with the physicians that care for unique patient populations. For example, by studying tissue, blood samples, and DNA from the large population of patients treated at Tufts Medical Center with hypertrophic cardiomyopathy, MCRI investigators have identified new genes that modify the severity of heart disease in patients with this genetic condition.
• (2017) MCRI investigators are working with engineers and biotechnology companies to develop better devices and drugs to treat heart failure. Drugs are being tested in the MCRI animal physiology core that may improve heart-pumping function and decrease heart scarring to alleviate heart failure. MCRI inventions also recently lead to the formation of a company to develop novel heart failure devices.
• (2018) Obesity is a growing epidemic and contributes to blood vessel disease that leads to heart attacks and strokes. Investigators in the MCRI recently discovered that female and male blood vessels respond to obesity in completely different ways. The cause of the blood vessel dysfunction depended not only on the sex but also whether there was high blood sugar or high cholesterol along with obesity. This suggests that treatments to prevent the adverse effects of the obesity epidemic may need to be personalized based on sex as well as other risk factors in each individual patient.
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