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Molecular Cardiology Research Institute (MCRI)

Transgenic Core Facility

The Tufts Medical Center and Tufts University School of Medicine Transgenic Core Facility (TCF) is a fee-for-service facility providing  for the production of standard transgenic mice, blastocyst injections for the production of knockout and knock-in mice, rederivation services, and >embryo cryopreservation. The facility is operated by Janis Lem, PhD, Director. The facility provides consultation services for the design of transgenes, animal husbandry, and genotypic analysis of transgenic animals.

Protocol Requirements

Animal Protocol

It is the responsibility of each investigator to have an approved animal protocol on file at their institution. This protocol must be obtained prior to the submission of an application.

Tufts Medical Center or TUSM investigators who are submitting applications to the IACUC should note that the application does not need to include information on the production of transgenic animals, but only reference the planned usage of the Transgenic Core Facility.

If you would like a list of what should be included in your application, please e-mail a request to the Administrator.

Recombinant DNA Protocol

It is also the responsibility of each investigator to have Institutional Biosafety Committee approval for the use of rDNA either on file with the Tufts University and Tufts Medical Center IBC, or the IBC at their institution. The registration form can be downloaded at

The Transgenic Core Facility is a service center in the Molecular Cardiology Research Institute at Tufts Medical Center. 

Note: The lab providing this service is not certified by GLP Standards.