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The Center for Translational Pharmacology and Genomics includes investigators whose core interest’s center on leveraging molecular pharmacology, biology and genetic approaches toward the development of novel therapeutics. Ongoing studies have clinical application in cardiovascular, inflammatory, metabolic and skeletal muscle disease. Work performed by the Center laboratories includes (i) state of the art genomic approaches (e.g. ChIP-seq, RNA-seq, RNAi), (ii) generation and analysis of invertebrate (Drosophila) and vertebrate animal models of human diseases, (iii) structure-function studies on a wide variety of pharmacological targets (receptors, channels, enzymes) and (iv) development of novel tools enabling peptide and small molecule drug discovery. The wide array of research capabilities featured by the Center laboratories naturally extends beyond the boundaries of one organ system or pathway offering the unique ability to understand many complex and/or inherited chronic diseases.
The Center Investigators hold faculty positions in the Tufts University School of Medicine graduate programs and regularly mentor Masters, PhD-level thesis students and Post-Doctoral Fellows in Pharmacology, Genetics, Clinical Translational Sciences and Cell, Molecular and Developmental Biology.
The primary goal of this laboratory is to make discoveries relevant to human diseases for the purpose of understanding the biology of human development and disease that in addition to providing greater insight into mechanisms of disease may also translate to improved diagnostics and therapies. We seek to make our primary discoveries by studying human DNA and/or tissues. Genes or pathways identified through discovery work based upon human samples then serve as the basis for traditional hypothesis-oriented research in animal and cellular model systems employed by my laboratory. In addition, I direct the NHLBI Heart Failure Network program at Tufts that includes implementing network clinical trials and co-direct the Committee on Participation of Women in Heart Failure Clinical Trials.
- Gordon Huggins, MD
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Title(s): Director, Molecular Cardiology Research Institute (MCRI) Center for Translational Pharmacology and Genomics; Cardiologist; Associate Professor, Tufts University School of Medicine
Department(s): Medicine, CardioVascular Center, Cardiology, Molecular Cardiology Research Institute
Appt. Phone: 617-636-8991
Fax #: 617-636-5999
Genetic mechanisms in cardiovascular cells including analysis of human trains and disease as a discovery platform biological studies, genetic susceptibility to heart and vascular diseases and molecular regulation of gene expression in cardiomyocytes and cardiomyocyte precursor cells.
Title(s): Research Director, Hypertrophic Cardiomyopathy (HCM) Center and Research Institute, Molecular Cardiology Research Institute (MCRI), CardioVascular Center (CVC), and the Division of Cardiology; Professor, TUSM
Department(s): Medicine, CardioVascular Center, Cardiology
Appt. Phone: 617-636-8066
Fax #: 617-636-7175
Hypertrophic cardiomyopathy, cardiovascular disease
Title(s): Principal Investigator, Molecular Cardiology Institute; Assistant Professor, Tufts School of Medicine
Department(s): Molecular Cardiology Research Institute, Molecular Pharmacology Research Center