Share on facebook Share on Twitter Share on Google Plus Share This

Molecular Cardiology Research Institute (MCRI)

Center for Translational Pharmacology and Genomics

The Center for Translational Pharmacology and Genomics includes investigators whose core interest’s center on leveraging molecular pharmacology, biology and genetic approaches toward the development of novel therapeutics. Ongoing studies have clinical application in cardiovascular, inflammatory, metabolic and skeletal muscle disease. Work performed by the Center laboratories includes (i) state of the art genomic approaches (e.g. ChIP-seq, RNA-seq, RNAi), (ii) generation and analysis of invertebrate (Drosophila) and vertebrate animal models of human diseases, (iii) structure-function studies on a wide variety of pharmacological targets (receptors, channels, enzymes) and (iv) development of novel tools enabling peptide and small molecule drug discovery. The wide array of research capabilities featured by the Center laboratories naturally extends beyond the boundaries of one organ system or pathway offering the unique ability to understand many complex and/or inherited chronic diseases.

The Center Investigators hold faculty positions in the Tufts University School of Medicine graduate programs and regularly mentor Masters, PhD-level thesis students and Post-Doctoral Fellows in Pharmacology, Genetics, Clinical Translational Sciences and Cell, Molecular and Developmental Biology.

The primary goal of this laboratory is to make discoveries relevant to human diseases for the purpose of understanding the biology of human development and disease that in addition to providing greater insight into mechanisms of disease may also translate to improved diagnostics and therapies. We seek to make our primary discoveries by studying human DNA and/or tissues. Genes or pathways identified through discovery work based upon human samples then serve as the basis for traditional hypothesis-oriented research in animal and cellular model systems employed by my laboratory. In addition, I direct the NHLBI Heart Failure Network program at Tufts that includes implementing network clinical trials and co-direct the Committee on Participation of Women in Heart Failure Clinical Trials.

- Gordon Huggins, MD

Gordon S. Huggins, MD

Gordon S. Huggins, MD

Title(s): Director, Molecular Cardiology Research Institute (MCRI) Center for Translational Pharmacology and Genomics; Cardiologist; Associate Professor, Tufts University School of Medicine
Department(s): Medicine, CardioVascular Center, Cardiology, Molecular Cardiology Research Institute
Appt. Phone: 617-636-2807
Fax #: 617-636-5649

Genetic mechanisms in cardiovascular cells including analysis of human trains and disease as a discovery platform biological studies, genetic susceptibility to heart and vascular diseases and molecular regulation of gene expression in cardiomyocytes and cardiomyocyte precursor cells.

View Full Profile

Martin Beinborn, MD

Martin Beinborn, MD

Title(s): Co-Director, Molecular Pharmacology Research Center; Assistant Professor of Medicine, Tufts Medical Center
Department(s): Molecular Cardiology Research Institute, Molecular Pharmacology Research Center
Appt. Phone:
Fax #:

Molecular pharmacology

View Full Profile

Michael T. Chin, MD, PhD

Michael T. Chin, MD, PhD

Title(s): Research Director, Hypertrophic Cardiomyopathy (HCM) Center and Research Institute, Molecular Cardiology Research Institute (MCRI), CardioVascular Center (CVC), and the Division of Cardiology
Department(s): Medicine, CardioVascular Center, Cardiology
Appt. Phone: 617-636-8066
Fax #: 617-636-7175

Hypertrophic cardiomyopathy, cardiovascular disease

View Full Profile

Isabelle Draper, PhD

Isabelle Draper, PhD

Title(s): Principal Investigator, Molecular Cardiology Institute; Assistant Professor, Tufts School of Medicine
Department(s): Molecular Cardiology Research Institute, Molecular Pharmacology Research Center
Appt. Phone:
Fax #:

Biochemistry

View Full Profile

Alan S. Kopin, MD

Alan S. Kopin, MD

Title(s): Director, Molecular Pharmacology Research Center; Professor, Tufts University School of Medicine; Professor, Pharmacology and Genetics, Sackler School of Graduate Biomedical Sciences
Department(s): Molecular Cardiology Research Institute, Molecular Pharmacology Research Center
Appt. Phone:
Fax #:

Molecular pharmacology, gastroenterology, physiology

View Full Profile

Molecular Cardiology Research Institute 20th Anniversary logo

20 years of discovery

For the past 20 years, the investigators and research teams of the Molecular Cardiology Research Institute (MCRI) have continually translated basic findings into new clinical strategies for the diagnosis and treatment of cardiovascular disease.

Learn about our discoveries