Molecular Cardiology Research Institute (MCRI)

DuPont JJ, Jaffe IZ. 30 years of the minealocortoid Receptor: The role of the mineralocorticoid receptor in the vasculature. J Endocrinol. 2017 Jul;234(1):T67-T82. doi: 10.1530/JOE-17-0009. Review. PMID: 28634267

Diaz-Otero JM, Fisher C, Downs K, Moss ME, Jaffe IZ, Jackson WF, Dorrance AM. Endothelial Mineralocorticoid Receptor Mediates Parenchymal Arteriole and Posterior Cerebral Artery Remodeling During Angiotensin II-Induced Hypertension. Hypertension. 2017 Dec;70(6):1113-1121. doi: 10.1161/HYPERTENSIONAHA.117.09598. PMID: 28974571

Good ME, Chiu YH, Poon IK, Medina CB, Butcher JT, Mendu SK, DeLalio LJ, Lohman AW, Leitinger N, Barrett EJ, Lorenz UM, Desai BN, Jaffe IZ, Bayliss D, Isakson BE, Ravichandran KS. Pannexin 1 Channels as an Unexpected New Target of the Anti-Hypertensive Drug Spironolactone. Circ Res. 2017 Dec 13. pii: CIRCRESAHA.117.312380. doi: 10.1161/CIRCRESAHA.117.312380. [Epub ahead of print] PMID: 29237722

Berger SE, Huggins GS, McCaffery JM, Lichtenstein AH. Comparison among criteria to define successful weight-loss maintainers and regainers in the Action for Health in Diabetes (Look AHEAD) and Diabetes Prevention Program trials. Am J Clin Nutr. 2017 Dec;106(6):1337-1346. doi: 10.3945/ajcn.117.157446. PMID: 29046304

Esposito M, Bader Y, Pedicini R, Breton C, Mullin A, Kapur NK. The role of acute circulatory support in ST-segment elevation myocardial infarction complicated by cardiogenic shock. Indian Heart J. 2017 Sep - Oct;69(5):668-674. doi: 10.1016/j.ihj.2017.05.011. Epub 2017 May 22. Review. PMID: 29054200 [PubMed - in process]

Kapur NK, Davila CD. Timing, timing, timing: the emerging concept of the 'door to support' time for cardiogenic shock. Eur Heart J. 2017 Dec 14;38(47):3532-3534. doi: 10.1093/eurheartj/ehx406. No abstract available. PMID: 29020366 [PubMed - in process]

Kiernan MS, Grandin EW, Brinkley M Jr, Kapur NK, Pham DT, Ruthazer R, Rame JE, Atluri P, Birati EY, Oliveira GH, Pagani FD, Kirklin JK, Naftel D, Kormos RL, Teuteberg JJ, DeNofrio D. Early Right Ventricular Assist Device Use in Patients Undergoing Continuous-Flow Left Ventricular Assist Device Implantation: Incidence and Risk Factors From the Interagency Registry for Mechanically Assisted Circulatory Support.

Lala A, Guo Y, Xu J, Esposito M, Morine K, Karas R, Katz SD, Hochman JS, Burkhoff D, Kapur NK. Right Ventricular Dysfunction in Acute Myocardial Infarction Complicated by Cardiogenic Shock: A Hemodynamic Analysis of the Should We Emergently Revascularize Occluded Coronaries for Cardiogenic Shock (SHOCK) Trial and Registry. J Card Fail. 2017 Oct 12. Pii: S1071-9164 (17) 31232-0. doi: 10.1016/j.cardfail.2017.10.009 [Epub ahead of Print] PMID: 29032225

Kuchibhotla S, Esposito ML, Breton C, Pedicini R, Mullin A, O'Kelly R, Anderson M, Morris DL, Batsides G, Ramzy D, Grise M, Pham DT, Kapur NK. Acute biventricular mechanical circulatory support for cardiogenic shock. J Am Heart Assoc. 2017 Oct 20;6 (10) pii: e006670. doi: 10.1161/JAHA.117.006670. PMID: 29054842 [PubMed - in process]

Hall SA, Uriel N, Carey SA, Edens M, Gong G, Esposito M, O’Kelly R, Annamalai S, Aghili N, Adatya S, Kapur NK, Use of percutaneous temporary circulatory support device as a bridge to decision during acute decompensation of advanced heart failure. J Heart Lung Transplant. 2017 Sep 30. pii: S1053-2498(17)32035-1. doi: 10.1016/j.healun.2017.09.020. [Epub ahead of print] PMID: 29056460

Nevers T, Salvador AM, Velasquez F, Ngwenyama N, Carrillo FJ, Aronovitz M, Blanton RM, Alcaide P. J Th1 effector T cells selectively orchestrate cardiac fibrosis in nonischemic heart failure.Exp Med. 2017 Nov 6; 214 (11): 3311-3329. doi: 10.1084/jem.20161791 Pub Med PMID: 28970239

Blanton RM. What can haemodynamic profiles teach us about heart failure in the paediatric population? Eur Heart J. 2017 Oct 17; (38): 2910-2911. doi: 10.1093/eurheartj/ehx548. Pubmed PMID: 29019618

Marzolla V, Armani A, Mammi C, Moss ME, Pagliarini V, Pontecorvo L, Antelmi A, Fabbri A, Rosano G, Jaffe IZ, Caprio M. Essential role of ICAM-1 in aldosterone-induced atherosclerosis. Int J Cardiol. 2017 Apr 1;232:233-242. doi: 10.1016/j.ijcard.2017.01.013. Epub 2017 Jan 5. PubMed PMID: 28089144.

Morine KJ, Qiao X, Paruchuri V, Aronovitz MJ, Mackey EE, Buiten L, Levine J, Ughreja K, Nepali P, Blanton RM, Karas RH, Oh SP, Kapur NK. Conditional knockout of activin like kinase-1 (ALK-1) leads to heart failure without maladaptive remodeling. Heart Vessels. 2017 Feb 17. doi: 10.1007/s00380-017-0955-x. [Epub ahead of print] PubMed PMID: 28213819.

Joseph C. McCarthy, Mark Aronovitz, Jennifer J. DuPont, Timothy D. Calamaras, Iris Z. Jaffe, Robert M. Blanton. Short-Term Administration of Serelaxin Produces Predominantly Vascular Benefits in the Angiotensin II/L-NAME Chronic Heart Failure Model. JACC: Basic to Translational Science Jun 2017, 2 (3) 285-296; DOI: 10.1016/j.jacbts.2017.03.011

Salvador AM, Moss ME, Aronovitz M, Mueller KB, Blanton RM, Jaffe IZ, Alcaide P. Endothelial mineralocorticoid receptor contributes to systolic dysfunction induced by pressure overload without modulating cardiac hypertrophy or inflammation. Physiol Rep. 2017 Jun;5(12). pii: e13313. doi: 10.14814/phy2.13313. PMID: 28637706

Annamalai SK, Buiten L, Esposito ML, Paruchuri V, Mullin A, Breton C, Pedicini R, O'Kelly R, Morine K, Wessler B, Patel AR, Kiernan MS, Karas RH, Kapur NK. Acute Hemodynamic Effects of Intra-Aortic Balloon Counterpulsation Pumps in Advanced Heart Failure. J Card Fail. 2017 May 26. pii: S1071-9164(17)30154-9. doi: 10.1016/j.cardfail.2017.05.015. 

Esposito ML, Kapur NK. Acute mechanical circulatory support for cardiogenic shock: the "door to support" time. F1000Res. 2017 May 22;6:737. doi: 10.12688/f1000research.11150.1. eCollection 2017. Review.

Jin H, Welzig CM, Aronovitz M, Blanton RM, Wang B, Rajab M, Albano A, Link MS,  Park H, Galper J. QRS/T-wave and calcium alternans in a type I diabetic mouse model for spontaneous postmyocardial infarction ventricular tachycardia: A mechanism for the antiarrhythmic effect of statins. Heart Rhythm. 2017 May 15. pii: S1547-5271(17)30622-7. doi: 10.1016/j.hrthm.2017.05.026.

Saha M, Mitsuhashi S, Jones MD, Manko K, Reddy HM, Bruels C, Cho KA, Pacak CA, Draper I, Kang PB. Consequences of MEGF10 deficiency on myoblast function and Notch1 interactions. Hum Mol Genet. 2017 May 11. doi: 10.1093/hmg/ddx189. 

Lynch TL 4th, Kuster DWD, Gonzalez B, Balasubramanian N, Nair N, Day S, Calvino JE, Tan Y, Liebetrau C, Troidl C, Hamm CW, Güçlü A, McDonough B, Marian AJ, van der Velden J, Seidman CE, Huggins GS, Sadayappan S. Cardiac Myosin Binding Protein-C Autoantibodies are Potential Early Indicators of Cardiac Dysfunction and Patient Outcome in Acute Coronary Syndrome. JACC Basic Transl Sci. 2017 Apr;2(2):122-131. doi: 10.1016/j.jacbts.2016.12.001. 

Robert M. Blanton, Pilar Alcaide.  Cardiac Myosin Binding Protein C: New Roles, New Questions, Potential Opportunities. JACC: Basic to Translational Science Apr 2017, 2 (2) 132-134; DOI: 10.1016/j.jacbts.2017.03.007

de Denus S, Rouleau JL, Mann DL, Huggins GS, Pereira NL, Shah SH, Cappola TP, Fouodjio R, Mongrain I, Dubé MP. CYP3A4 genotype is associated with sildenafil concentrations in patients with heart failure with preserved ejection fraction. Pharmacogenomics J. 2017 Apr 25. doi: 10.1038/tpj.2017.8. 

van Diepen S, Katz JN, Albert NM, Henry TD, Jacobs AK, Kapur NK, Kilic A, Menon V, Ohman EM, Sweitzer NK, Thiele H, Washam JB, Cohen MG; American Heart Association Council on Clinical Cardiology; et al. Contemporary Management of Cardiogenic Shock: A Scientific Statement From the American Heart Association. Circulation. 2017 Sep 18. pii: CIR.0000000000000525. Epub ahead of print] Review. PubMed PMID: 28923988.

Freeman LM, Rush JE, Stern JA, Huggins GS, Maron MS. Feline Hypertrophic Cardiomyopathy: A Spontaneous Large Animal Model of Human HCM. Cardiol Res. 2017 Aug;8(4):139-142. doi: 10.14740/cr578w. Epub 2017 Aug 23. Review. PubMed PMID: 28868097; PubMed Central PMCID: PMC5574284.

Penumatsa KC, Toksoz D, Warburton RR, Kharnaf M, Preston IR, Kapur NK, Khosla C, Hill NS, Fanburg BL. Transglutaminase 2 in Pulmonary and Cardiac Tissue Remodeling in Experimental Pulmonary Hypertension. Am J Physiol Lung Cell Mol Physiol. 2017 Aug 3:ajplung.00170.2017. doi: 10.1152/ajplung.00170.2017. [Epub ahead of print] PubMed PMID: 28775095.

Kapur NK, Davila CD, Jumean MF. Integrating Interventional Cardiology and Heart Failure Management for Cardiogenic Shock. Interv Cardiol Clin. 2017 Jul;6(3):481-485. doi: 10.1016/j.iccl.2017.03.014. Epub 2017 Apr 22. Review. PubMed PMID: 28600099.

Kapur NK, Esposito ML, Bader Y, Morine KJ, Kiernan MS, Pham DT, Burkhoff D. Mechanical Circulatory Support Devices for Acute Right Ventricular Failure. Circulation. 2017 Jul 18;136(3):314-326. doi: 10.1161/CIRCULATIONAHA.116.025290. Review. PubMed PMID: 28716832.

Morine KJ, Qiao X, Paruchuri V, Aronovitz MJ, Mackey EE, Buiten L, Levine J, Ughreja K, Nepali P, Blanton RM, Oh SP, Karas RH, Kapur NK. Reduced activin receptor-like kinase 1 activity promotes cardiac fibrosis in heart failure. Cardiovasc Pathol. 2017 Jul 18;31:26-33. doi: 10.1016/j.carpath.2017.07.004. [Epub ahead of print] PubMed PMID: 28820968.

Julian B, Gao K, Harwood BN, Beinborn M, Kopin AS. Mutation-Induced functional alterations of CCR6. J Pharmacol Exp Ther, 2017 Jan;360(1):106-116. 

Burke SD, Zsengellér ZK, Khankin EV,et al. . Soluble fms-like tyrosine kinase 1 promotes angiotensin II sensitivity during preeclampsia by impairing endothelial nitric oxide function. Journal of Clinical Investigation, 2016;126(7):2561-74.

Davel AP, Anwar IJ, Jaffe IZ. The endothelial mineralocorticoid receptor: mediator of the switch from vascular health to disease. Curr Opin Nephrol Hypertens, 2016 Dec 7.

DuPont JJ, McCurley A, Davel AP, et al.Vascular mineralocorticoid receptor regulates microRNA-155 to promote vasoconstriction and rising blood pressure with aging. JCI Insight. 2016;1(14

Esposito M, Kuchibhotla S, Zisa D, et al. . TCT-114 Comparing hemodynamic profiles and outcomes in Cardiogenic shock requiring VA-ECMO or Impella for circulatory support. J Am Coll Cardiol, 2016 Nov 1;68(18S)

Esposito M, O'Kelly R, Aghili N, et al. TCT-135 Increased circulating plasma-free hemoglobin levels, not lactate dehydrogenase, levels identify hemolysis among patients with cardiogenic shock treated with an Impella micro-axial flow catheter. J Am Coll Cardiol, 2016 Nov 1;68(18S)

Esposito M, Zhang Y, Schnitzler G, et al. TCT-196 From door to balloon to door to unload: A Transcriptomic analysis identifies that primary unloading globally shifts gene expression and preserves mitochondrial Integrity within the infarct zone during the acute phase of AMI. J Am Coll Cardiol, 2016 Nov 1;68(18S)

Ferrés MA, Bianchi DW, Siegel AE, Bronson RT, Huggins GS, Guedj F. Perinatal Natural History of the Ts1Cje Mouse Model of Down Syndrome: Growth restriction, early mortality, heart defects, and delayed development. PLoS One, 2016 Dec 8;11(12)

Gopal S, Miller KB, Jaffe IZ. Molecular mechanisms for vascular complications of targeted cancer therapies. Clin Sci (Lond)., 2016 Oct 1;130(20):1763-79.

Hall S, Uriel N, Carey S, et al. TCT-122 Use of the Impella 5.0 circulatory support device for bridge to decision during acute decompensation of advanced heart failure. JAm Coll Cardiol. 2016 Nov 1;68(18S)

Hwang MH, Yoo JK, Luttrell M, et al. Acute effect of mineralocorticoid receptor antagonism on vascular function in healthy older adults. Experimental Gerentology, 2016;73:86-94.

Jia G, Habibi J,  Aroor AR,   et al. Endothelial mineralocorticoid receptor mediates diet induced aortic stiffness in females. Circulation Research, 2016;118:935-943. PMID:26879229. PMC4798906.

Julian B, Gao K, Harwood BN, Beinborn M, Kopin AS. Mutation-Induced functional alterations of CCR6. J Pharmacol Exp Ther, 2017 Jan;360(1):106-116.

Kapur N, Breton C, O'Kelly R, et al. TCT-126 Simultaneous, not staged, deployment of biventricular Micro-Axial Flow Impella catheters (BiPella) is associated with improved survival for cardiogenic shock involvingBiventricular Failure. J Am Coll Cardiol, 2016 Nov 1;68(18S):B51.

Kapur NK, Esposito M. Small acute mechanical circulatory support pumps for small people. Catheter Cardiovasc Interv, 2016 Oct;88(4):590-591.

Kiernan MS, Sundareswaran KS, Pham DT, et al. Preoperative determinants of quality of life and functional capacity response to left ventricular Aassist device therapy. J Card Fail, 2016 Jan 14.

Kuchibhotla S, Esposito M, Zisa D, et al. TCT-132 Utility of the SAVE Score as a predictor of survival in cardiogenic shock requiring VA-ECMO or Impella for Acute Mechanical Circulatory Support. J Am Coll  Cardiol, 2016 Nov 1;68(18S)

Lekva T, Lyle R, Roland MCP, et al and Ueland T. Gene expression in term placentas is regulated more by spinal or epidural anesthesia than by preeclampsia or gestational diabetes mellitus. Scientific Reports, 2016 Jul 11;6:29715.

Lu Q, Schnitzler GR, Vallaster CS, et al. Unliganded estrogen receptor alpha regulates vascular cell function and gene expression. Mol Cell Endocrinol. 2016 Nov 22;442:12-23.

Mador CA, Bertocchio JP, Andre-Gregoire G, et al. Deletion of mineralocorticoid receptors in smooth muscle cells blunts renal vascular resistance following acute cyclosporine administration. Kidney International, 2016; 89(2):354-362.

Morine KJ, Kapur NK. Percutaneous Mechanical Circulatory Support for Cardiogenic Shock. Curr Treat Options Cardiovasc Med, 2016 Jan;18(1):6.

Morine KJ, Paruchuri V, Qiao X, et al. Endoglin selectively modulates transient receptor potential channel expression in left and right heart failure. Cardiovasc Pathol,  2016 Nov - Dec;25(6):478-482.

Regna K, Kurshan PT, Harwood BN, et al. A critical role for the Drosophila dopamine D1-like receptor Dop1R2 atthe onset of metamorphosis. BMC Dev Biol, 2016 May 16;16(1):15.

Salvador AM, Nevers T, Velázquez F, et al. Intercellular adhesion molecule 1 regulates left ventricular leukocyte infiltration, cardiac remodeling and function in pressure overload induced heart failure. J Am Heart Assoc, 2016 Mar 15;5(3)

Victorio JA, Clerici SP, Palacios R, et al. Spironolactone prevents endothelial nitric oxide synthase uncoupling and vascular dysfunction induced by β-adrenergic overstimulation: Role of perivascular adipose tissue. Hypertension, 2016 Sep;68(3)

Velázquez F, Grodecki-Pena A, Knapp A, Salvador AM, Nevers T, Croce KJ, Alcaide P. CD43 Functions as an E-Selectin Ligand for Th17 Cells In Vitro and Is Required for Rolling on the Vascular Endothelium and Th17 Cell Recruitment during Inflammation In Vivo. J Immunol. 2015 Dec 23. pii: 1501171. [Epub ahead of print] PubMed PMID: 26700769. Pubmed Abstract

Schnoor M, Alcaide P, Voisin MB, van Buul JD. Crossing the Vascular Wall: Common and Unique Mechanisms Exploited by Different Leukocyte Subsets during Extravasation. Mediators Inflamm. 2015;2015:946509. doi: 10.1155/2015/946509. Epub 2015 Oct 19. Review. PubMed PMID: 26568666; PubMed Central PMCID: PMC4629053.  Pubmed Abstract

Bou Ghanem EN, Clark S, Roggensack SE, McIver SR, Alcaide P, Haydon PG, Leong JM. Extracellular Adenosine Protects against Streptococcus pneumoniae Lung Infection by Regulating Pulmonary Neutrophil Recruitment. PLoS Pathog. 2015 Aug 27;11(8):e1005126. doi: 10.1371/journal.ppat.1005126. eCollection 2015 Aug. PubMed PMID: 26313746; PubMed Central PMCID: PMC4552087.   Pubmed Abstract

Heller D, Doyle JR, Raman VS, Beinborn M, Kumar K, Kopin AS. Novel Probes Establish Mas-Related G Protein-Coupled Receptor X1 Variants as Receptors with Loss or Gain of Function. J Pharmacol Exp Ther. 2016 Feb;356(2):276-83. doi: 10.1124/jpet.115.227058. Epub 2015 Nov 18. PubMed PMID: 26582731.  Pubmed Abstract

Ellis KL, Zhou Y, Rodriguez-Murillo L, Beshansky JR, Ainehsazan E, Selker HP, Huggins GS, Cupples LA, Peter I. Common variants associated with changes in levels of circulating free fatty acids after administration of glucose-insulin-potassium (GIK) therapy in the IMMEDIATE trial. Pharmacogenomics J. 2015 Dec 8. doi: 10.1038/tpj.2015.84. [Epub ahead of print] PubMed PMID: 26644202.   Pubmed Abstract

Alkofide H, Huggins GS, Beshansky JR, Ruthazer R, Peter I, Ray M, Mukherjee JT, Selker HP. C-Reactive protein reactions to glucose-insulin-potassium infusion and relations to infarct size in patients with acute coronary syndromes. BMC Cardiovasc Disord. 2015 Dec 3;15(1):163. doi: 10.1186/s12872-015-0153-7. PubMed PMID: 26631004; PubMed Central PMCID: PMC4668670.   Pubmed Abstract

Belalcazar LM, Papandonatos GD, Erar B, Peter I, Alkofide H, Balasubramanyam A, Brautbar A, Kahn SE, Knowler WC, Ballantyne CM, McCaffery JM, Huggins GS; Genetics Subgroup of the Look AHEAD Study. Lifestyle Intervention for Weight Loss and Cardiometabolic Changes in the Setting of Glucokinase Regulatory Protein (GCKR) Inhibition: GCKR-Leu446Pro Variant in Look AHEAD. Circ Cardiovasc Genet. 2015 Nov 17. pii: CIRCGENETICS.115.001192. [Epub ahead of print] PubMed PMID: 26578543.   Pubmed Abstract

Miller VM, Jenkins GD, Biernacka JM, Heit JA, Huggins GS, Hodis HN, Budoff MJ, Lobo RA, Taylor HS, Manson JE, Black DM, Naftolin F, Harman SM, de Andrade M. Pharmacogenomics of estrogens on changes in carotid artery intima-medial thickness and coronary arterial calcification: Kronos Early Estrogen Prevention Study. Physiol Genomics. 2016 Jan;48(1):33-41. doi: 10.1152/physiolgenomics.00029.2015. Epub 2015 Oct 27. PubMed PMID: 26508701.   Pubmed Abstract

Morine KJ, Paruchuri V, Qiao X, Mohammad N, Mcgraw A, Yunis A, Jaffe I, Kapur NK. Circulating multimarker profile of patients with symptomatic heart failure supports enhanced fibrotic degradation and decreased angiogenesis. Biomarkers.2015 Dec 15:1-7. [Epub ahead of print] PubMed PMID: 26667393.   Pubmed Abstract

Hwang MH, Yoo JK, Luttrell M, Kim HK, Meade TH, English M, Talcott S, Jaffe IZ, Christou DD. Acute effect of mineralocorticoid receptor antagonism on vascular function in healthy older adults. Exp Gerontol. 2016 Jan;73:86-94. doi: 10.1016/j.exger.2015.11.017. Epub 2015 Nov 27. PubMed PMID: 26639352; PubMed Central PMCID: PMC4713256.   Pubmed Abstract

van Nunen LX, Noc M, Kapur NK, Patel MR, Perera D, Pijls NH. Usefulness of Intra-aortic Balloon Pump Counterpulsation. Am J Cardiol. 2016 Feb 1;117(3):469-76. doi: 10.1016/j.amjcard.2015.10.063. Epub 2015 Nov 19. Review. PubMed PMID: 26708637. Pubmed Abstract

Doll JA, Ohman EM, Patel MR, Milano CA, Rogers JG, Wohns DH, Kapur NK, Rao SV. A team-based approach to patients in cardiogenic shock. Catheter CardiovascInterv. 2015 Nov 3. doi: 10.1002/ccd.26297. [Epub ahead of print] PubMed PMID: 26526563.  Pubmed Abstract

Kapur NK, Qiao X, Paruchuri V, Morine KJ, Syed W, Dow S, Shah N, Pandian N, Karas RH. Mechanical Pre-Conditioning With Acute Circulatory Support Before Reperfusion Limits Infarct Size in Acute Myocardial Infarction. JACC Heart Fail. 2015 Nov;3(11):873-82. doi: 10.1016/j.jchf.2015.06.010. PubMed PMID: 26541785.   Pubmed Abstract

Kapur NK, Vest AR, Cook J, Kiernan MS. Pump Thrombosis: A Limitation of Contemporary Left Ventricular Assist Devices. Curr Probl Cardiol. 2015 Dec;40(12):511-40. doi: 10.1016/j.cpcardiol.2015.03.004. Epub 2015 Mar 16. PubMed PMID: 26542611.

Pubmed Abstract

Morine KJ, Kiernan MS, Pham DT, Paruchuri V, Denofrio D, Kapur NK. Pulmonary Artery Pulsatility Index Is Associated With Right Ventricular Failure After Left Ventricular Assist Device Surgery. J Card Fail. 2015 Nov 10. pii: S1071-9164(15)01172-0. doi: 10.1016/j.cardfail.2015.10.019. [Epub ahead of print] PubMed PMID: 26564619. Pubmed Abstract

Anderson MB, Goldstein J, Milano C, Morris LD, Kormos RL, Bhama J, Kapur NK, Bansal A, Garcia J, Baker JN, Silvestry S, Holman WL, Douglas PS, O'Neill W. Benefits of a novel percutaneous ventricular assist device for right heart failure: The prospective RECOVER RIGHT study of the Impella RP device. J Heart Lung Transplant. 2015 Dec;34(12):1549-60. doi: 10.1016/j.healun.2015.08.018. Epub 2015 Sep 8. PubMed PMID: 26681124.   Pubmed Abstract

Richardson K, Schnitzler GR, Lai CQ, Ordovas JM. Functional Genomics Analysis of Big Data Identifies Novel Peroxisome Proliferator-Activated Receptor γ Target Single Nucleotide Polymorphisms Showing Association With Cardiometabolic Outcomes. Circ Cardiovasc Genet. 2015 Dec;8(6):842-51. doi: 10.1161/CIRCGENETICS.115.001174. Epub 2015 Oct 30. PubMed PMID: 26518621.   Pubmed Abstract

Cowan CS, Abd-El-Barr M, van der Heijden M, Lo EM, Paul D, Bramblett DE, Lem J, Simons DL, Wu SM. Connexin 36 and Rod Bipolar Cell Independent Rod Pathways Drive Retinal Ganglion Cells and Optokinetic Reflexes. Vision Res. 2015 Dec 21. pii: S0042-6989(15)00367-3. doi: 10.1016/j.visres.2015.11.006. [Epub ahead of print] PubMed PMID: 26718442. Pubmed Abstract

Barrett Mueller K, Bender SB, Hong K, Yang Y, Aronovitz M, Jaisser F, Hill MA, Jaffe IZ. Endothelial Mineralocorticoid Receptors Differentially Contribute to Coronary and Mesenteric Vascular Function Without Modulating Blood Pressure. Hypertension. 2015 Nov;66(5):988-97. doi:10.1161/HYPERTENSIONAHA.115.06172. Epub 2015 Sep 8. PubMed PMID: 26351033; PubMed Central PMCID: PMC4600033. Pubmed Abstract

Alkofide H, Huggins GS, Ruthazer R, Beshansky JR, Selker HP. Serum adiponectin levels in patients with acute coronary syndromes: Serial changes and relation to infarct size. Diabetes and Vascular Disease Research. 2015 Nov;12(6):411-9. doi:10.1177/1479164115592638. Epub 2015 Jul 20. PubMed PMID: 26193887. Pubmed Abstract

Jia G, Habibi J, DeMarco VG, Martinez-Lemus LA, Ma L, Whaley-Connell AT, Aroor AR, Domeier TL, Zhu Y, Meininger GA, Mueller KB, Jaffe IZ, Sowers JR. Endothelial Mineralocorticoid Receptor Deletion Prevents Diet-Induced Cardiac Diastolic Dysfunction in Females. Hypertension. 2015 Oct 5. pii: HYPERTENSIONAHA.115.06015. [Epub ahead of print] PubMed PMID: 26441470. Pubmed Abstract

Thoonen R, Cauwels A, Decaluwe K, Geschka S, Tainsh RE, Delanghe J, Hochepied T, De Cauwer L, Rogge E, Voet S, Sips P, Karas RH, Bloch KD, Vuylsteke M, Stasch JP, Van de Voorde J, Buys ES, Brouckaert P. Cardiovascular and pharmacological implications of haem-deficient NO-unresponsive soluble guanylate cyclase knock-in mice. Nature Communications. 2015 Oct 7;6:8482. doi: 10.1038/ncomms9482. PubMed PMID:26442659. Pubmed Abstract

Thoonen R, Giovanni S, Govindan S, Lee DI, Wang GR, Calamaras TD, Takimoto E, Kass DA, Sadayappan S, Blanton RM. A Molecular Screen Identifies Cardiac Myosin Binding Protein-C as a Protein Kinase G I Alpha Substrate. Circulation: Heart Failure. 2015 Oct 18. pii: CIRCHEARTFAILURE.115.002308. [Epub ahead of print] PubMed PMID: 26477830. Pubmed Abstract

Upshaw JN, Kiernan MS, Morine KJ, Kapur NK, DeNofrio D. Incidence, Management and Outcome of Suspected Continuous-Flow Left Ventricular Assist Device Thrombosis. ASAIO J. 2015 Oct 5. [Epub ahead of print] PubMed PMID: 26479464. Pubmed Abstract

Moss ME, Jaffe IZ. Mineralocorticoid Receptors in the Pathophysiology of Vascular Inflammation and Atherosclerosis. Frontiers in Endocrinology (Lausanne). 2015 Sep 28;6:153. doi: 10.3389/fendo.2015.00153. eCollection 2015. Review. PubMed PMID:26441842; PubMed Central PMCID: PMC4585008. Pubmed Abstract

Amador CA, Bertocchio JP, Andre-Gregoire G, Placier S, Duong Van Huyen JP, El Moghrabi S, Berger S, Warnock DG, Chatziantoniou C, Jaffe IZ, Rieu P, Jaisser F. Deletion of mineralocorticoid receptors in smooth muscle cells blunts renal vascular resistance following acute cyclosporine administration. Kidney International. 2015 Sep 30. doi: 10.1038/ki.2015.312. [Epub ahead of print] PubMed PMID: 26422501. Pubmed Abstract

Kapur NK, Jumean M, Ghuloom A, Aghili N, Vassallo C, Kiernan MS, DeNofrio D, Pham DT. First Successful Use of 2 Axial Flow Catheters for Percutaneous Biventricular Circulatory Support as a Bridge to a Durable Left Ventricular Assist Device. Circulation: Heart Failure. 2015 Sep; 8(5):1006-8. doi:10.1161/CIRCHEARTFAILURE.115.002374. PubMed PMID: 26374919. Pubmed Abstract

Kapur NK, Karas RH. A new shield from the double-edged sword of reperfusion in STEMI. European Heart Journal. 2015 Sep 8. pii: ehv438. [Epub ahead of print] PubMed PMID: 26351396. Pubmed Abstract

Qin Z, Bagley J, Sukhova G, Baur WE, Park HJ, Beasley D, Libby P, Zhang Y, Galper JB. Angiotensin II-induced TLR4 mediated abdominal aortic aneurysm in apolipoprotein E knockout mice is dependent on STAT3. Journal of Molecular and Cellular Cardiology. 2015 Aug 20;87:160-170. doi: 10.1016/j.yjmcc.2015.08.014. [Epub ahead of print] PubMed PMID: 26299839. Pubmed Abstract

Papandonatos GD, Pan Q, Pajewski NM, Delahanty LM, Peter I, Erar B, Ahmad S, Harden M, Chen L, Fontanillas P; GIANT consortium, Wagenknecht LE, Kahn SE, Wing RR, Jablonski KA, Huggins GS, Knowler WC, Florez JC, McCaffery JM, Franks PW; Diabetes Prevention Program and the Look AHEAD Research Groups. Genetic predisposition to weight loss & regain with lifestyle intervention: analyses from the Diabetes Prevention Program & the Look AHEAD randomized controlled trials. Diabetes. 2015 Aug 7. pii: db150441. [Epub ahead of print] PubMed PMID: 26253612. Pubmed Abstract

Selker HP, Buse JB, Califf RM, Carter R, Cooper DM, Davis J, Ford DE, Galassetti P, Guay-Woodford L, Huggins GS, Kasper A, Kieburtz K, Kirby A, Klein AK, Kline J, O' Neill RT, Rape M, Reichgott DJ, Rojevsky S, Rosenthal GE, Rubinstein EP, Shepherd A, Stacy M, Terrin N, Wallace M, Welch L. CTSA Consortium Consensus Scientific Review Committee (SRC) Working Group Report on the SRC Processes. Clinical and Translational Science. 2015 Jul 16. doi: 10.1111/cts.12306. [Epub ahead of print] PubMed PMID: 26184433. Pubmed Abstract

Pham DT, Kapur NK, Dermody M, Halin N. Stenting of an outflow graft obstruction after implantation of a continuous-flow, axial-flow left ventricular  assist device. J Thorac Cardiovasc Surg. 2015 Jul;150(1):e11-2. doi: 10.1016/j.jtcvs.2015.04.005. Epub 2015 Apr 9. PubMed PMID: 25940413. Pubmed Abstract

Belalcazar LM, Papandonatos GD, McCaffery JM, Peter I, Pajewski NM, Erar B, Allred ND, Balasubramanyam A, Bowden DW, Brautbar A, Pi-Sunyer FX, Ballantyne CM, Huggins GS; Look AHEAD Research Group. A common variant in the CLDN7/ELP5 locus predicts adiponectin change with lifestyle intervention and improved fitness in obese individuals with diabetes. Physiological Genomics. 2015 Jun;47(6):215-24. doi: 10.1152/physiolgenomics.00109.2014. Epub 2015 Mar 10. PMID:25759378 Pubmed Abstract

Nevers T, Salvador AM, Grodecki-Pena A, Knapp A, Velázquez F, Aronovitz M, Kapur NK, Karas RH, Blanton RM, Alcaide P. Left Ventricular T-Cell Recruitment Contributes to the Pathogenesis of Heart Failure. Circulation: Heart Failure. 2015 Jul;8(4):776-87.

doi:10.1161/CIRCHEARTFAILURE.115.002225. Epub 2015 May 28. PubMed PMID: 26022677; PubMed Central PMCID: PMC4512916. Pubmed Abstract

Parikh A, Wu J, Blanton RM, Tzanakakis ES. Signaling Pathways and Gene Regulatory Networks in Cardiomyocyte Differentiation. Tissue Engineering Part B Reviews. 2015 May 11. [Epub ahead of print] PMID:25813860 Pubmed Abstract

Kapur NK, Jumean M, Halin N, Kiernan MS, DeNofrio D, Pham DT. Ventricular square-wave response: case illustrating the role of invasive hemodynamics in the management of continuous-flow left ventricular assist device dysfunction. Circulation: Heart Failure. 2015 May;8(3):652-4. doi: 10.1161/CIRCHEARTFAILURE.115.002160. PubMed PMID: 25991809. Pubmed Abstract

Bender SB, DeMarco VG, Padilla J, Jenkins NT, Habibi J, Garro M, Pulakat L, Aroor AR, Jaffe IZ, Sowers JR. Mineralocorticoid receptor antagonism treats obesity-associated cardiac diastolic dysfunction. Hypertension. 2015 May;65(5):1082-8. doi: 10.1161/HYPERTENSIONAHA.114.04912. Epub 2015 Feb 23. PMID:  25712719 Pubmed Abstract

Kapur NK, Paruchuri V, Pham DT, Reyelt L, Murphy B, Beale C, Bogins C, Wiener D, Nilson J, Esposito M, Perkins S, Perides G, Karas RH. Hemodynamic effects of left atrial or left ventricular cannulation for acute circulatory support in a bovine model of left heart injury. ASAIO J. 2015 May-Jun;61(3):301-6. doi: 10.1097/MAT.0000000000000195. PMID:    25485565 Pubmed Abstract

Jumean M, Pham DT, Kapur NK. Percutaneous bi-atrial extracorporeal membrane oxygenation for acute circulatory support in advanced heart failure. Catheterization and Cardiovascular Interventions. 2015 May;85(6):1097-9. doi: 10.1002/ccd.25791. Epub 2015 Jan 13. PMID:  25529821 Pubmed Abstract

Kapur NK, Paruchuri V, Majithia A, Esposito M, Shih H, Weintraub A, Kiernan M, Pham DT, Denofrio D, Kimmelstiel C. Hemodynamic effects of standard versus larger-capacity intraaortic balloon counterpulsation pumps. Journal of Invasive Cardiology. 2015 Apr;27(4):182-8.  PMID:  25840400 Pubmed Abstract

Pruthi D, Khankin EV, Blanton RM, Aronovitz M, Burke SD, McCurley A, Karumanchi SA, Jaffe IZ. Exposure to experimental preeclampsia in mice enhances the vascular response to future injury. Hypertension. 2015 Apr;65(4):863-70. doi: 10.1161/HYPERTENSIONAHA.114.04971. Epub 2015 Feb 23.PMID: 25712723 Pubmed Abstract

Kapur NK, Esposito M. Hemodynamic support with percutaneous devices in patients with heart failure. Heart Failure Clinics. 2015 Apr;11(2):215-30. doi: 10.1016/j.hfc.2014.12.012. Epub 2015 Feb 21. Review. PMID:  25834971 Pubmed Abstract

Kapur NK, Dimas V, Sorajja P, Borlaug BA, Fang J, Kern M, Naidu SS. The interventional heart failure initiative: A mission statement for the next generation of invasive cardiologists. Catheterization and Cardiovascular Interventions. 2015 Mar 18. doi: 10.1002/ccd.25685. [Epub ahead of print] No abstract available. PMID:25788437 Pubmed Abstract

Washam JB, Herzog CA, Beitelshees AL, Cohen MG, Henry TD, Kapur NK, Mega JL, Menon V, Page RL 2nd, Newby LK; American Heart Association Clinical Pharmacology Committee of the Council on Clinical Cardiology, Council on Cardiovascular Surgery and Anesthesia, Council on Functional Genomics and Translational Biology, Council on the Kidney in Cardiovascular Disease, and Council on Quality of Care and Outcomes Research. Pharmacotherapy in chronic kidney disease patients presenting with acute coronary syndrome: a scientific statement from the American Heart Association. Circulation. 2015 Mar 24;131(12):1123-49. doi: 10.1161/CIR.0000000000000183. Epub 2015 Feb 23. Review. No abstract available. PMID:  25712269 Pubmed Abstract

Ellis KL, Zhou Y, Beshansky JR, Ainehsazan E, Selker HP, Cupples LA, Huggins GS, Peter I. Genetic modifiers of response to glucose-insulin-potassium (GIK) infusion in acute coronary syndromes and associations with clinical outcomes in the IMMEDIATE trial. Pharmacogenomics Journal. 2015 Mar 17. doi: 10.1038/tpj.2015.10. [Epub ahead of print] PMID:   25778467 Pubmed Abstract

Kiernan MS, French AL, DeNofrio D, Parmar YJ, Pham DT, Kapur NK, Pandian NG, Patel AR.  Preoperative three-dimensional echocardiography to assess risk of right ventricular failure after left ventricular assist device surgery. Journal of Cardiac Failure. 2015 Mar;21(3):189-97. doi: 10.1016/j.cardfail.2014.12.009. Epub 2014 Dec 20. PMID: 25535957 Pubmed Abstract

Kiernan MS, French AL, DeNofrio D, Parmar YJ, Pham DT, Kapur NK, Pandian NG, Patel AR. Preoperative Three Dimensional Echocardiography to Assess Risk of Right Ventricular Failure Following Left Ventricular Assist Device Surgery. J Card Fail. 2014 Dec 20. [Epub ahead of print]. Pubmed Abstract

Jumean M, Pham DT, Kapur NK. Percutaneous Bi-atrial extracorporeal membrane oxygenation for acute circulatory support in advanced heart failure. Catheter Cardiovasc Interv. 2014 Dec 22. [Epub ahead of print]. Pubmed Abstract

Kapur NK, Paruchuri V, Thinh D, Reyelt L, Murphy B, Beale C, Bogins C, Wiener D, Nilson J, Esposito M, Perkins S, Perides G, Karas RH. Hemodynamic Effects of Left Atrial or Left Ventricular Cannulation for Acute Circulatory Support in a Bovine Model of Left Heart Injury. ASAIO J. 2014 Dec 5. [Epub ahead of print]. Pubmed Abstract

Hayden RS, Fortin JP, Harwood B, Subramanian B, Quinn KP, Georgakoudi I, Kopin AS, Kaplan DL. Cell-tethered ligands modulate bone remodeling by osteoblasts and osteoclasts. Adv Funct Mater. 2014 Jan 29;24(4):472-479. Pubmed Abstract

Lane JM, Doyle JR, Fortin JP, Kopin AS, Ordovás JM. Development of an OP9 derived cell line as a robust model to rapidly study adipocyte differentiation. PLoS One. 2014 Nov 19;9(11):e112123. Pubmed Abstract

Doyle JR, Harwood BN, Krishnaji ST, Krishnamurthy VM, Lin WE, Fortin JP, Kumar K, Kopin AS. A two-step strategy to enhance activity of low potency peptides. PLoS One. 2014 Nov 12;9(11):e110502. Pubmed Abstract

Harwood BN, Draper I, Kopin AS. Targeted inactivation of the rickets receptor in muscle compromises Drosophila viability. J Exp Biol. 2014 Nov 15;217(Pt 22):4091-8. Pubmed Abstract

Vu DM, Tai A, Tatro JB, Karas RH, Huber BT, Beasley D. γδT cells are prevalent in the proximal aorta and drive nascent atherosclerotic lesion progression and neutrophilia in hypercholesterolemic mice. PLoS One. 2014 Oct 14;9(10):e109416. Pubmed Abstract

Massaad MJ, Oyoshi MK, Kane J, Koduru S, Alcaide P, Nakamura F, Ramesh N, Luscinskas FW, Hartwig J, Geha RS. Binding of WIP to actin is essential for T cell actin cytoskeleton integrity and tissue homing. Mol Cell Biol. 2014 Sep 22; 34(23):4343-54. Pubmed Abstract

Barrett Mueller K, Lu Q, Mohammad NN, Luu V, McCurley A, Williams GH, Adler GK, Karas RH, Jaffe IZ. Estrogen Receptor Inhibits Mineralocorticoid Receptor Transcriptional Regulatory Function. Endocrinology. 2014 Jul 22:en20141270. Pubmed Abstract

Kapur NK, Qiao X, Paruchuri V, Mackey EE, Daly GH, Ughreja K, Morine KJ, Levine J, Aronovitz MJ, Hill NS, Jaffe IZ, Letarte M, Karas RH. Reducing endoglin activity limits calcineurin and TRPC-6 expression and improves survival in a mouse model of right ventricular pressure overload. J Am Heart Assoc. 2014 Jul 11;3(4). Pubmed Abstract

Bene NC, Alcaide P, Wortis HH, Jaffe IZ. Mineralocorticoid receptors in immune cells: Emerging role in cardiovascular disease. Steroids. 2014 Apr 21. Pubmed Abstract

Koenig JB, Jaffe IZ. Direct role for smooth muscle cell mineralocorticoid receptors in vascular remodeling: novel mechanisms and clinical implications. Curr Hypertens Rep. 2014 May;16(5):427. Pubmed Abstract

Jaffe IZ, Jaisser F. Endothelial cell mineralocorticoid receptors: turning cardiovascular risk factors into cardiovascular dysfunction. Hypertension. 2014 May;63(5):915-7. Pubmed Abstract

Chen CW, Jaffe IZ, Karumanchi SA. Pre-eclampsia and cardiovascular disease. Cardiovasc Res. 2014 Mar 15;101(4):579-86. Pubmed Abstract

Kapur NK, Paruchuri V. Interventions for failing vessels, valves, and now . ventricles: the parachute device. Catheter Cardiovasc Interv. 2014 Mar 1;83(4):631-2. Pubmed Abstract

Sasaki H, Nagayama T, Blanton RM, Seo K, Zhang M, Zhu G, Lee DI, Bedja D, Hsu S, Tsukamoto O, Takashima S, Kitakaze M, Mendelsohn ME, Karas RH, Kass DA, Takimoto E. PDE5 inhibitor efficacy is estrogen dependent in female heart disease. J Clin Invest. 2014 Jun 2;124(6):2464-71. Pubmed Abstract

Rock ML, Karas AZ, Rodriguez KB, Gallo MS, Pritchett-Corning K, Karas RH, Aronovitz M, Gaskill BN. The time-to-integrate-to-nest test as an indicator of wellbeing in laboratory mice. J Am Assoc Lab Anim Sci. 2014 Jan;53(1):24-8. Pubmed Abstract

Doyle JR, Krishnaji ST, Zhu G, Xu ZZ, Heller D, Ji RR, Levy BD, Kumar K, Kopin AS. Development of a membrane-anchored chemerin receptor agonist as a novel modulator of allergic airway inflammation and neuropathic pain. J Biol Chem. 2014 May 9;289(19):13385-96. doi: 10.1074/jbc.M113.522680. Pubmed Abstract

Draper I, Mahoney LJ, Mitsuhashi S, Pacak CA, Salomon RN, Kang PB. Silencing of Drpr Leads to Muscle and Brain Degeneration in Adult Drosophila. Am J Pathol. 2014 Aug 8. pii: S0002-9440(14)00374-5. Pubmed Abstract

Zhang Y, Welzig CM, Picard KL, Du C, Wang B, Pan JQ, Kyriakis JM, Aronovitz MJ, Claycomb WC, Blanton RM, Park HJ, Galper JB. Glycogen synthase kinase-3? inhibition ameliorates cardiac parasympathetic dysfunction in type 1 diabetic Akita mice. Diabetes. 2014 Jun;63(6):2097-113. Pubmed Abstract

Ellis KL, Zhou Y, Beshansky JR, Ainehsazan E, Yang Y, Selker HP, Huggins GS, Cupples LA, Peter I. Genetic variation at glucose and insulin trait loci and response to glucose-insulin-potassium (GIK) therapy: the IMMEDIATE trial.Pharmacogenomics J. 2014 Aug 19. doi: 10.1038/tpj.2014.41. Pubmed Abstract

Yutzey KE, Demer LL, Body SC, Huggins GS, Towler DA, Giachelli CM, Hofmann-Bowman MA, Mortlock DP, Rogers MB, Sadeghi MM, Aikawa E. Calcific Aortic Valve Disease: A Consensus Summary From the Alliance of Investigators on Calcific Aortic Valve Disease. Arterioscler Thromb Vasc Biol. 2014 Sep 4. pii: ATVBAHA.114.302523. Pubmed Abstract

Gordon FK, Vallaster CS, Westerling T, Iyer LK, Brown M, Schnitzler GR. Research Resource: Aorta- and Liver-Specific ER?-Binding Patterns and Gene Regulation by Estrogen. Mol Endocrinol. 2014 Aug;28(8):1337-51. Pubmed Abstract

Mangili A, Ahmad R, Wolfert RL, Kuvin J, Polak JF, Karas RH, Wanke CA. Lipoprotein-Associated Phospholipase A2, a Novel Cardiovascular Inflammatory Marker, in HIV-Infected Patients. Clin Infect Dis. 2014 Jan 2. [Epub ahead of print]. Pubmed Abstract

Yoneyama S, Guo Y, Lanktree MB, Barnes MR, Elbers CC, Karczewski KJ, ... Huggins GS, ... Taylor KC. Gene-centric meta-analyses for central adiposity traits in up to 57 412 individuals of European descent confirm known loci and reveal several novel associations. Hum Mol Genet. 2014 Jan 6. [Epub ahead of print]. Pubmed Abstract

Doyle JR, Lane JM, Beinborn M, Kopin AS. Naturally occurring HCA1 missense mutations result in loss of function: potential impact on lipid deposition. J Lipid Res. 2013 Mar;54(3):823-30. Pubmed Abstract

Bender SB, McGraw AP, Jaffe IZ, Sowers JR. Mineralocorticoid receptor-mediated vascular insulin resistance: an early contributor to diabetes-related vascular disease? Diabetes. 2013 Feb;62(2):313-9. Pubmed Abstract

Kapur NK, Imbrie GA. Cardiac allograft vasculopathy: vulnerable patients, not vulnerable plaques. Catheter Cardiovasc Interv. 2013 Feb;81(3):436-7. doi: 10.1002/ccd.24822. No abstract available.

Kapur NK. Invasive thoughts: circulatory support devices in the catheterization laboratory: evolution or revolution? J Invasive Cardiol. 2013 Feb;25(2):62-3. No abstract available.

Kapur NK, Jumean MF. Defining the Role for Percutaneous Mechanical Circulatory Support Devices for Medically Refractory Heart Failure. Curr Heart Fail Rep. 2013 Feb 7. [Epub ahead of print]. Pubmed Abstract

Wooten EC, Hebl VB, Wolf MJ, Greytak SR, Orr NM, Draper I, Calvino JE, Kapur NK, Maron MS, Kullo IJ, Ommen SR, Bos JM, Ackerman MJ, Huggins GS. Formin homology 2 domain containing 3 variants associated with hypertrophic cardiomyopathy. Circ Cardiovasc Genet. 2013 Feb 1;6(1):10-8. Pubmed Abstract

Lavigne PM, Karas RH. The current state of niacin in cardiovascular disease prevention: a systematic review and meta-regression. J Am Coll Cardiol. 2013 Jan 29;61(4):440-6. Pubmed Abstract

Miller VM, Petterson TM, Jeavons EN, Lnu AS, Rider DN, Heit JA, Cunningham JM, Huggins GS, Hodis HN, Budoff MJ, Santoro N, Hopkins PN, Lobo RA, Manson JE, Naftolin F, Taylor HS, Harman SM, de Andrade M. Genetic polymorphisms associated with carotid artery intima-media thickness and coronary artery calcification in women of the Kronos Early Estrogen Prevention Study. Physiol Genomics. 2013 Jan 22;45(2):79-88. Pubmed Abstract

Harwood BN, Fortin JP, Gao K, Chen C, Beinborn M, Kopin AS. Membrane tethered bursicon constructs as heterodimeric modulators of the Drosophila GPCR rickets. Mol Pharmacol. 2013 Jan 22. [Epub ahead of print]. Pubmed Abstract

Ueda K, Karas RH. Emerging evidence of the importance of rapid, non-nuclear estrogen receptor signaling in the cardiovascular system. Steroids. 2012 Dec 29. [Epub ahead of print].  Pubmed Abstract

Zhao J, Imbrie GA, Baur WE, Iyer LK, Aronovitz MJ, Kershaw TB, Haselmann GM, Lu Q, Karas RH. Estrogen Receptor-Mediated Regulation of MicroRNA Inhibits Proliferation of Vascular Smooth Muscle Cells. Arterioscler Thromb Vasc Biol. 2013 Feb;33(2):257-65. Epub 2012 Nov 21. Pubmed Abstract

Blanton RM, Takimoto E, Lane A, Piotrowski R, Aronovitz M, Karas RH, Kass DA, Mendelsohn M. Protein kinase Gl Ialpha inhibits pressure overload-induced cardiac remodeling and is required for the cardioprotective effect of sildenafil in vivo.  J Am Hrt Assoc. 2012 Oct;1(5):e003731. Pubmed Abstract

Mangili A, Ahmad R, Wolfert RL, Kuvin J, Polak J, Karas RH, Wanke CA. Lipoprotein-associated phospholipase A2 (Lp-PLA2), a novel cardiovascular inflammatory marker, in HIV-infected patients. JAIDS 2012 (In Press)

Kato M, Blanton R, Wang GR, Judson TJ, Abe Y, Myoishi M, Karas RH, Mendelsohn ME. Direct Binding and Regulation of RhoA by cyclic GMP-dependent protein kinase I & α. J Biol Chem. 2012 [Epub ahead of print] Pubmed Abstract

Ehsan A, McGraw AP, Aronovitz MJ, Galayda C, Conte MS, Karas RH, Jaffe IZ. Mineralocorticoid receptor antagonism inhibits vein graft remodeling in mice. J Thorac Cardiovasc Surg. 2012 Sep 13. pii: S0022-5223(12)00955-5. doi: 10.1016/j.jtcvs.2012.08.007. [Epub ahead of print]. Pubmed Abstract

Benelot Moens SJ, Schnitzler GR, Nickerson M, Guo H, Ueda K, Lu Q, Aronovitz M,  Nickerson H, Baur W, Hansen U, Iyer LK, Karas RH.    Rapid estrogen receptor signaling is essential for the protective effects of estrogen against vascular injury. Circulation. 2012; 126:1993-2004 Pubmed Abstract

McCurley A, Pires PW, Bender SB, Aronovitz M, Zhao MJ, Metzger D, Chambon P, Hill MA, Dorrance AM, Mendelsohn ME, Jaffe IZ. Direct regulation of blood pressure by smooth muscle cell mineralocorticoid receptors. Nat Med. 2012 Aug 26. doi: 10.1038/nm.2891. Pubmed Abstract

Al-Quthami AH, Jumean M, Kociol R, Pham DT, Kiernan M, Denofrio D, Kapur NK. Eptifibatide for the Treatment of HeartMate II Left Ventricular Assist Device Thrombosis. Circ Heart Fail. 2012 Jul 1;5(4):e68-70. No abstract available.

Thinh Pham D, Al-Quthami A, Kapur NK. Percutaneous left ventricular support in cardiogenic shock and severe aortic regurgitation. Catheter Cardiovasc Interv. 2012 May 28. doi: 10.1002/ccd.24501. [Epub ahead of print]. Pubmed Abstract

Kapur NK, Wilson S, Yunis AA, Qiao X, Mackey E, Paruchuri V, Baker C, Aronovitz MJ, Karumanchi SA, Letarte M, Kass DA, Mendelsohn ME, Karas RH. Reduced endoglin activity limits cardiac fibrosis and improves survival in heart failure. Circulation. 2012 Jun 5;125(22):2728-38. Epub 2012 May 16. Pubmed Abstract

Barbati C, Pierdominici M, Gambardella L, Malchiodi Albedi F, Karas RH, Rosano G, Malorni W, Ortona E. Cell Surface Estrogen Receptor Alpha Is Upregulated during Subchronic Metabolic Stress and Inhibits Neuronal Cell Degeneration. PLoS One. 2012;7(7):e42339. Epub 2012 Jul 31. Pubmed Abstract

Doyle JR, Fortin JP, Beinborn M, Kopin AS. Selected melanocortin 1 receptor single-nucleotide polymorphisms differentially alter multiple signaling pathways. J Pharmacol Exp Ther. 2012 Aug;342(2):318-26. Epub 2012 Apr 30. Pubmed Abstract

Peter I, McCaffery JM, Kelley-Hedgepeth A, Hakonarson H, Reis S, Wagenknecht LE, Kopin AS, Huggins GS. Association of Type 2 Diabetes Susceptibility Loci With One-Year Weight Loss in the Look AHEAD Clinical Trial. Obesity (Silver Spring). 2012 Aug;20(8):1675-82. doi: 10.1038/oby.2012.11. Epub 2012 Feb 6. Pubmed Abstract

Myers RB, Rwayitare K, Richey L, Lem J, Castellot JJ Jr. CCN5 Expression in mammals. III. Early embryonic mouse development. J Cell Commun Signal. 2012 Aug 28. [Epub ahead of print]. Pubmed Abstract

Makino CL, Wen XH, Michaud NA, Covington HI, DiBenedetto E, Hamm HE, Lem J, Caruso G. Rhodopsin expression level affects rod outer segment morphology and photoresponse kinetics. PLoS One. 2012;7(5):e37832. Epub 2012 May 25. Pubmed Abstract

Kyriakis JM, Avruch J. Mammalian MAPK signal transduction pathways activated by stress and inflammation: a 10-year update.  Physiol Rev. 2012 Apr;92(2):689-737. Article

Kapur NK, Shenoy C, Yunis AA, Mohammad NN, Wilson S, Paruchuri V, Mackey EE, Qiao X, Shah A, Esposito ML, Karas RH, Jaffe IZ.  Distinct Effects of Unfractionated Heparin versus Bivalirudin on Circulating Angiogenic Peptides. PLoS One. 2012;7(4):e34344. Epub 2012 Apr 11. Pubmed Abstract

Alcaide P, Maganto-Garcia E, Newton G, Travers R, Croce KJ, Bu DX, Luscinskas FW, Lichtman AH. Difference in Th1 and th17 lymphocyte adhesion to endothelium. J Immunol. 2012 Feb;188(3):1421-30. Pubmed Abstract

Albano AJ, Thompson PD, Kapur NK. Acute coronary thrombosis in Boston marathon runners. N Engl J Med. 2012 Jan;366(2):184-5. Pubmed Abstract

Sims HI, Pham CD, Schnitzler GR. Mapping assembly favored and remodeled nucleosome positions on polynucleosomal templates. Methods Mol Biol. 2012;833:311-36. Pubmed Abstract

Heffernan KS, Kuvin JT, Patel AR, Karas RH, Kapur NK. Endothelial function and soluble endoglin in smokers with heart failure.  Clin Cardiol. 2011 Dec;34(12):729-33. Epub 2011 Nov 28. Pubmed Abstract

Kapur NK, Paruchuri V, Korabathina R, Al-Mohammdi R, Mudd JO, Prutkin J, Esposito M, Shah A, Kiernan MS, Sech C, Pham DT, Konstam MA, Denofrio D. Effects of a percutaneous mechanical circulatory support device for medically refractory right ventricular failure. J Heart Lung Transplant. 2011 Dec;30(12):1360-7. Epub 2011 Aug 24. Pubmed Abstract

Heffernan KS, Patvardhan EA, Kapur NK, Karas RH, Kuvin JT. Peripheral augmentation index as a biomarker of vascular aging: an invasive hemodynamics approach. Eur J Appl Physiol. 2011 Dec 3. [Epub ahead of print] Pubmed Abstract

Davis-Dusenbery BN, Wu C, Hata A. Micromanaging vascular smooth muscle cell differentiation and phenotypic modulation. Arterioscler Thromb Vasc Biol. 2011 Nov; 31(11):2370-7. Pubmed Abstract

Wu C, So J, Davis-Dusenbery BN, Qi HH, Bloch DB, Shi Y, Lagna G, Hata A. Hypoxia Potentiates MicroRNA-Mediated Gene Silencing through Posttranslational Modification of Argonaute2. Mol Cell Biol. 2011 Dec; 31(23):4760-74. Pubmed Abstract

Georgescu SP, Aronovitz MJ, Iovanna JL, Patten RD, Kyriakis JM, Goruppi S. Decreased Metalloprotease 9 Induction, Cardiac Fibrosis and Higher Autophagy after Pressure Overload in Mice Lacking the Transcriptional Regulator p8. Am J Physiol Cell Physiol. 2011 Nov;301(5):C1046-56. Epub 2011 Jul 20. Pubmed Abstract

Kapur NK, Kociol RD.  Rise of the machines… and their mechanics. Catheter Cardiovasc Interv. 2011 Nov 15;78(6):962-3. (Commentary)

Gordon J, Hwang J, Carrier KJ, Jones CA, Kern QL, Moreno CS, Karas RH, Pallas DC. Protein Phosphatase 2A (PP2A) Binds Within the Oligomerization Domain of Striatin and Regulates the Phosphorylation and Activation of the Mammalian Ste20-Like Kinase Mst3. BMC Biochem. 2011 Oct 10;12(1):54. [Epub ahead of print]. Pubmed Abstract

Kiernan MS, Pham DT, Denofrio D, Kapur NK. Management of HeartWare left ventricular assist device thrombosis using intracavitary thrombolytics. J Thorac Cardiovasc Surg. 2011 Sep; 142(3):712-4. Pubmed Abstract

Peter I, Huggins GS, Ordovas JM, Haan M, Seddon JM. Evaluation of New and Established Age-Related Macular Degeneration Susceptibility Genes in the Women's Health Initiative Sight Exam (WHI-SE) Study. Am J Ophthalmol. 2011 Sep 8. [Epub ahead of print] Pubmed Abstract

Shapiro MD , Bagley J, Latz J, Godwin JG, Ge X, Tullius SG, Iacomini J. MicroRNA expression data reveals a signature of kidney damage following ischemia reperfusion injury. PLoS One. 2011 Aug 15; 6(8):e23011. [Epub ahead of print]. Pubmed Abstract

Newfell BG, Iyer LK, Mohammad NN, McGraw AP, Ehsan A, Rosano G, Huang PL, Mendelsohn ME, Jaffe IZ. Aldosterone Regulates Vascular Gene Transcription via Oxidative Stress-Dependent and -Independent Pathways. Arterioscler Thromb Vasc Biol. 2011 Aug; 31(8):1871-80. Pubmed Abstract

Pugliese-Pires PN, Fortin JP, Arthur T, Latronico AC, Mendonca BB, Villares SM, Arnhold IJ, Kopin AS, Jorge AA. Novel inactivating mutations in the GH secretagogue receptor gene in patients with constitutional delay of growth and puberty. Eur J Endocrinol. 2011 Aug; 165(2):233-41. Pubmed Abstract

Davis-Dusenbery BN, Chan MC, Reno KE, Weisman AS, Layne MD, Lagna G, Hata A. Down-regulation of Kruppel-like Factor-4 (KLF4) by MicroRNA-143/145 Is Critical for Modulation of Vascular Smooth Muscle Cell Phenotype by Transforming Growth Factor-{beta} and Bone Morphogenetic Protein 4. J Biol Chem. 2011 Aug 12; 286(32):28097-110. Pubmed Abstract

Kapur NK. A Clinical Commentary on the Articles "Strategies for Tissue Engineering Cardiac Constructs to Affect Functional Repair Following Myocardial Infarction" and "Stem Cell-Based Cardiac Tissue Engineering" : Repairing, Reprogramming, and Renewing: The Promise of Myocardial Cytotherapeutics. J Cardiovasc Transl Res. 2011 Aug 11. Pubmed Abstract

Pham CD, Sims HI, Archer TK, Schnitzler GR. Multiple Distinct Stimuli Increase Measured Nucleosome Occupancy around Human Promoters. PLoS One. 2011; 6(8):e23490. Pubmed Abstract

Kapur NK, Bian C, Lin E, Deming CB, Sperry JL, Hansen BS, Kakouros N, Rade JJ. Inhibition of transforming growth factor-β restores endothelial thromboresistance in vein grafts. J Vasc Surg. 2011 Jul 29. Pubmed Abstract

Patvardhan E, Heffernan KS, Ruan J, Hession M, Warner P, Karas RH, Kuvin JT. Augmentation index derived from peripheral arterial tonometry correlates with cardiovascular risk factors. Cardiol Res Pract. 2011; 253758. Pubmed Abstract

Bafford R, Sui XX, Park M, Miyahara T, Newfell BG, Jaffe IZ, Romero JR, Adler GK, Williams GH, Khalil RA, Conte MS. Mineralocorticoid receptor expression in human venous smooth muscle cells: a potential role for aldosterone signaling in vein graft arterialization. Am J Physiol Heart Circ Physiol. 2011 Jul; 301(1):H41-7. Pubmed Abstract

Smart-Halajko MC, Kelley-Hedgepeth A, Montefusco MC, Cooper JA, Kopin A, McCaffrey JM, Balasubramanyam A, Pownall HJ, Nathan DM, Peter I, Talmud PJ, Huggins GS; the Look AHEAD Study. ANGPTL4 variants E40K and T266M are associated with lower fasting triglyceride levels in Non-Hispanic White Americans from the Look AHEAD Clinical Trial. BMC Med Genet. 2011 Jun 29; 12(1):89. Pubmed Abstract

McCurley A, Jaffe IZ. Mineralocorticoid receptors in vascular function and disease. Mol Cell Endocrinol. 2011 Jun 24. Pubmed Abstract

Korabathina R, Pham DT, Kapur NK. Subacute left ventricular rupture supported with a percutaneous left ventricular assist device. J Invasive Cardiol. 2011 Jun; 23(6):246-7. Pubmed Abstract

Tangri N, Alam A, Wooten EC, Huggins GS. Lack of association of Klotho gene variants with valvular and vascular calcification in Caucasians: a candidate gene study of the Framingham Offspring Cohort. Nephrol Dial Transplant. 2011 May 12. Pubmed Abstract

Wooten EC, Huggins GS. Mind the dbGAP: the application of data mining to identify biological mechanisms. Mol Interv. 2011 Apr; 11(2):95-102. Pubmed Abstract

Malhowski AJ, Hira H, Bashiruddin S, Warburton R, Goto J, Blanton, R, Kwiatkowski DJ, Finlay GA. Smooth muscle protein-22-mediated deletion of Tsc1 results in cardiac hypertrophy that is mTORC1-mediated and reversed by rapamycin. Hum Mol Genet. 2011 Apr 1;20(7):1290-305. Epub 2011 Jan 6. Pubmed Abstract

Kimmelstiel C, Zhang P, Kapur NK, Weintraub A, Krishnamurthy B, Castaneda V, Covic L, Kuliopulos A. Bivalirudin is a dual inhibitor of thrombin and collagen-dependent platelet activation in patients undergoing percutaneous coronary intervention. Circ Cardiovasc Interv. 2011 Apr 1; 4(2):171-9. Pubmed Abstract

Heffernan KS, Kuvin JT, Sarnak MJ, Perrone RD, Miskulin DC, Rudym D, Chandra P, Karas RH, Menon V. Peripheral augmentation index and vascular inflammation in autosomal dominant polycystic kidney disease. Nephrol Dial Transplant. 2011 Feb 3. Pubmed Abstract

Heffernan KS, Maron MS, Patvardhan EA, Karas RH, Kuvin JT; Vascular Function Study Group. Relation of pulse pressure to blood pressure response to exercise in patients with hypertrophic cardiomyopathy. Am J Cardiol. 2011 Feb 15;107(4):600-3. Pubmed Abstract

Kitsios GD, Dahabreh IJ, Trikalinos TA, Schmid CH, Huggins GS, Kent DM. Heterogeneity of the phenotypic definition of coronary artery disease and its impact on genetic association studies. Circ Cardiovasc Genet. 2011 Feb 1;4(1):58-67. Pubmed Abstract

Chan MC, Weisman AS, Kang H, Nguyen PH, Hickman T, Mecker SV, Hill NS, Lagna G, Hata A. The amiloride derivative phenamil attenuates pulmonary vascular remodeling by activating NFAT and the bone morphogenetic protein signaling pathway. Mol Cell Biol. 2011 Feb;31(3):517-30. Pubmed Abstract

Kapur NK. Transforming growth factor-β: governing the transition from inflammation to fibrosis in heart failure with preserved left ventricular function. Circ Heart Fail. 2011 Jan 1; 4(1):5-7. Pubmed Abstract

Heffernan KS, Suryadevara R, Patvardhan EA, Mooney P, Karas RH, Kuvin JT. Effect of atenolol vs metoprolol succinate on vascular function in patients with hypertension. Clin Cardiol. 2011 Jan; 34(1):39-44. Pubmed Abstract

Davis-Dusenbery BN, Hata A. Smad-mediated miRNA processing: A critical role for a conserved RNA sequence. RNA Biol. 2011 Jan 1;8(1). Pubmed Abstract

Blanton RM, Nappi A, Kimmelstiel CD. Conversion of infarction-associated atrial fibrillation by restoration of atrial perfusion. Clin Cardiol. 2010 Dec; 33(12):E79-81. Pubmed Abstract

Jafri H, Alsheikh-Ali AA, Karas RH. Meta-analysis: statin therapy does not alter the association between low levels of high-density lipoprotein cholesterol and increased cardiovascular risk. Ann Intern Med. 2010 Dec 21;153(12):800-8. Pubmed Abstract

Kapur NK, Heffernan KS, Yunis AA, Parpos P, Kiernan MS, Sahasrabudhe NA, Kimmelstiel CD, Kass DA, Karas RH, Mendelsohn ME. Usefulness of soluble endoglin as a noninvasive measure of left ventricular filling pressure in heart failure. Am J Cardiol. 2010 Dec 15;106(12):1770-6. Pubmed Abstract

Saltzman AJ, Choi SW, Dabreo A, Baur WE, Weiss E, Nguyen K, Ishibashi F, Celestin FF, Karia DH, Pandian NG, Karas RH, Waxman S. Endothelial progenitor cells delivered into the pericardial space incorporate into areas of ischemic myocardium. Cardiovasc Revasc Med. 2010 Oct-Dec;11(4):241-8. Pubmed Abstract

Kapur NK, Heffernan KS, Yunis AA, Nguyen TA, Aronovitz MJ, Parpos P, Wilson S, Baker CK, Esposito ML, Shah A, Kimmelstiel CD, Weintraub A, Karas RH, Mendelsohn ME.  Elevated Soluble fms-Like Tyrosine Kinase-1 Levels in Acute Coronary Occlusion.  Arteriosclerosis Thrombosis, and Vascular Biology 2010; Nov. Pubmed Abstract

Higashimori M, Tatro JB, Moore KJ, Mendelsohn ME, Galper JB, Beasley D.  Role of toll-like receptor 4 in Intimal foam cell accumulation in apolipoprotein E-deficient mice.  Arteriosclerosis Thrombosis, and Vascular Biology 2010; Oct.  PubMed Abstract

Watson PA, Birdsey N, Huggins GS, Svensson EC, Heppe DB, Knaub LA.  Cardiac-specific overexpression of dominant-negative CREB leads to increased mortality and mitochondrial dysfunction in female mice.  American Journal of Physiology - Heart and Circulatory Physiology 2010; Oct.  PubMed Abstract

Felix-Getzik EM, Kuvin JT, Karas RH. Nonoptimal high-density lipoprotein cholesterol levels are highly prevalent in patients presenting with acute coronary syndromes and well-controlled low-density lipoprotein cholesterol
levels. J Clin Lipidol. 2010 Jul-Aug;4(4):265-71. Pubmed Abstract

Jaffe IZ, Newfell BG, Aronovitz M, Mohammad NN, McGraw AP, Perreault RE, Carmeliet P, Ehsan A, Mendelsohn ME.  Placental growth factor mediates aldosterone-dependent vascular injury in mice.  The Journal of Clinical Investigation 2010; 120(11):3891-3900.   PubMed Abstract

Goldstein C, Schroeder JC, Fortin JP, Goss JM, Schaus SE, Beinborn M, Kopin AS.  Two Naturally Occurring Mutations in the Type 1 Melanin Concentrating Hormone Receptor Abolish Agonist-Induced Signaling.  Journal of Pharmacology and Experimental Therapeutics 2010; 335(3):799-806.  PubMed Abstract

Gurley SB, Griffiths RC, Mendelsohn ME, Karas RH, Coffman TM.  Renal actions of RGS2 control blood pressure.  Journal of the American Society of Nephrology 2010; 21(11):1847-1851.  PubMed Abstract

Davis BN, Hata A.  Mechanisms of control of microRNA biogenesis.  The Journal of Biochemistry 2010; 148(4):381-392.  PubMed Abstract

Chadee DN, Kyriakis JM.  Activation of SAPK/JNKs In Vitro.  Methods in Molecular Biology 2010; 661:59-73.  PubMed Abstract

Davis BN, Hilyard AC, Nguyen PH, Lagna G, Hata A.  Smad Proteins Bind a Conserved RNA Sequence to Promote MicroRNA Maturation by Drosha.  Molecular Cell 2010; 39(3):373-384.  PubMed Abstract

Fortin JP, Ci L, Schroeder JC, Goldstein C, Montefusco MC, Peter I, Reis SE, Huggins GS, Beinborn M, Kopin AS.  The Mu-Opioid Receptor Variant N190K is Unresponsive to Peptide Agonists Yet Can be Rescued by Small Molecule Drugs.  Molecular Pharmacology 2010; 78(5):837-845.  PubMed Abstract

Alsheikh-Ali AA, Karas RH.  Balancing the intended and unintended effects of statins.  British Medical Journal 2010; 340:c2240.  PubMed Abstract

Brooks EL, Kuvin JT, Karas RH.  Niacin's role in the statin era.  Expert Opin Pharmacother 2010; 11(14):2291-2300.  PubMed Abstract

Mendelsohn ME, Karas RH.  Rapid progress for non-nuclear estrogen receptor signaling.  Journal of Clinical Investigation 2010; 120(7):2277-2279.  PubMed Abstract

Jafri H, Alsheikh-Ali AA, Karas RH.  Baseline and on-treatment high-density lipoprotein cholesterol and the risk of cancer in randomized controlled trials of lipid-altering therapy.  Journal of the American College of Cardiology 2010; 55(25):2846:2854.  PubMed Abstract

Santen RJ, Allred DC, Ardoin SP, Archer DF, Boyd N, Braunstein GD, Burger HG, Colditz GA, Davis SR, Gambacciani M, Gower BA, Henderson VW, Jarjour WN, Karas RH, Kleerekoper M, Lobo RA, Manson JE, Marsden J, Martin KA, Martin L, Pinkerton JV, Rubinow DR, Teede H, Thiboutot DM, Utian WH.  Postmenopausal Hormone Therapy: An Endocrine Society Scientific Statement.  Journal of Clinical Endocrinology & Metabolism 2010; 97 (7 Suppl 1):s1-s66.  PubMed Abstract

Heffernan KS, Patvardhan EA, Hession M, Ruan J, Karas RH, Kuvin JT.  Elevated augmentation index derived from peripheral arterial tonometry is associated with abnormal ventricular-vascular coupling.  Clinical Physiology and Functional Imaging 2010; 30(5):313-317.  PubMed Abstract

Kong DK, Georgescu SP, Kyriakis JM, Goruppi S.  Deficiency of transcriptional regulator p8 induces autophagy and causes impaired cardiac function.  Autophagy 2010;6(5).  PubMed Abstract

Denis GV, Nikolajczyk BS, Schnitzler GR.  An emerging role for bromodomain-containing proteins in chromatin regulation and transcriptional control of adipogenesis.  FEBS Letters 2010; 584(15):3260-3268.  PubMed Abstract

Heffernan KS, Fahs CA, Ranadive SM, Patvardhan EA.  L-arginine as a nutritional prophylaxis against vascular endothelial dysfunction with aging.  Journal of Cardiovascular Pharmacology and Therapeutics 2010; 15(1):17-23.  PubMed Abstract

Maeda A, Okano K, Park PS, Lem J, Crouch RK, Maeda T, Palczewski K.  Palmitoylation stabilizes unliganded rod opsin.  Proceedings of the National Academy of Sciences, USA 2010; 107(18):8428-8433.  PubMed Abstract

Montefusco MC, Merlo K, Bryan CD, Surks HK, Reis SE, Mendelsohn ME, Huggins GS.  Little ROCK is a ROCK1 pseudogene expressed in human smooth muscle cells.  BMC Genet 2010; 11:22.  PubMed Abstract

Welzig CM, Park H-J, Karas RH, Naggar J, Estes M, Galper JB.  Differential effects of statins (Pravastatin or Simvastatin) on ventricular ectopic complexes: G∝¡2, A Possible molecular marker for ventricular irritability.  American Journal of Cardiology 2010; 105(8):1112-1117.  PubMed Abstract

Heffernan KS, Karas RH, Patvardhan EA, Kuvin JT.  Endothelium-dependent vasodilation is associated with exercise capacity in smokers and non-smokers.  Vascular Medicine 2009; 15(2):119-125.  PubMed Abstract

Miao L, Shi J, Wang CY, Zhu Y, Du X, Jiao H, Mo Z, Klocker H, Lee C, Zhang J.  Estrogen receptor-related receptor {alpha} mediates up-regulation of aromatase expression by prostaglandin E2 in prostate stromal cells.  Molecular Endocrinology 2010; 24(6):1175-1186.  PubMed Abstract

Kilili GK, Kyriakis JM.  Mammalian Ste20-like kinase (Mst2) indirectly supports Raf-1/ERK pathway activity Via maintenance of protein phosphatase-2A catalytic subunit levels and consequent suppression of inhibitory Raf-1 phosphorylation.  The Journal of Biological Chemistry 2010; 285(20):15076-15087.   PubMed Abstract

Kong DK, Georgescu SP, Cano C, Aronovitz MJ, Iovanna JL, Patten RD, Kyriakis JM, Goruppi S.  Deficiency of the transcriptional regulator p8 results in increased autophagy and apoptosis, and causes impaired heart function.  Molecular Biology of the Cell 2010; 21(8):1335-1349.  PubMed Abstract

Heffernan KS, Karas RH, Patvardhan EA, Jafri H, Kuvin JT.  Peripheral arterial tonometry for risk stratification in men with coronary artery disease.  Clinical Cardiology 2010; 33(2):94-98.  PubMed Abstract

Beinborn M, Blum A, Hang L, Setiawan T, Schroeder JC, Stoyanoff K, Leung J, Weinstock JV.  TGF-{beta} regulates T-cell neurokinin-1 receptor internalization and function.  Proceedings of the National Academy of Sciences, USA 2010; 107(9):4293-4298.  PubMed Abstract

Lavine JA, Raess PW, Davis DB, Rabaglia ME, Presley BK, Keller MP, Beinfeld MC, Kopin AS, Newgard CB, Attie AD.  Contamination with E1A-positive wild-type adenovirus accounts for species-specific stimulation of islet cell proliferation by CCK: A cautionary note.  Molecular Endocrinology 2010; 24(2):464-467.  PubMed Abstract

Patvardhan EA, Heffernan KS, Ruan JM, Soffler MI, Karas RH, Kuvin JT.  Assessment of vascular endothelial function with peripheral arterial tonometry: Information at your fingertips?  Cardiol in Rev 2010; 18(1):20-28.  PubMed Abstract

Wooten EC, Iyer LK, Montefusco MC, Hedgepeth AK, Payne DD, Kapur NK, Housman DE, Mendelsohn ME, Huggins GS.  Application of gene network analysis techniques identifies AXIN1/PDIA2 and endoglin haplotypes associated with bicuspid aortic valve.  PLoS One 2010; 5(1):e8830.  PubMed Abstract

Heffernan KS, Napolitano CA, Maron MS, Patvardhan EA, Patel AR, Pandian NG, Karas RH, Kuvin JT.  Peripheral vascular endothelial function in patients with hypertrophic cardiomyopathy.  American Journal of Cardiology 2010; 105(1):112-115.  PubMed Abstract

Heffernan KS, Karas RH, Mooney P, Patel A, Kuvin JT.  Pulse wave amplitude is associated with brachial artery diameter: Implications for gender differences in microvascular function.  Vascular Medicine 2009; 15(1):39-45.   PubMed Abstract

Pang JJ, Gao F, Lem J, Bramblett DE, Paul DL, Wu SM.  Direct rod input to cone BCs and direct cone input to rod BCs challenge the traditional view of mammalian BC circuitry.  Proceedings of the National Academy of Sciences, USA 2009; 107(1):395-400.   PubMed Abstract

Chan MC, Hilyard AC, Wu C, Davis BN, Hill NS, Lal A, Lieberman J, Lagna G, Hata A.  Molecular basis for antagonism between PDGF and the TGFbeta family of signalling pathways by control of miR-24 expression.  European Molecular Biology Organization Journal 2009; 29(3):559-573   PubMed Abstract

Pham CD, He X, Schnitzler GR.  Divergent human remodeling complexes remove nucleosomes from strong positioning sequences.  Nucleic Acids Research 2009; 38(2):400-413.  PubMed Abstract

Hata A, Davis BN.  Control of microRNA biogenesis by TGFbeta signaling pathway-A novel role of Smads in the nucleus.  Cytokine & Growth Factor Reviews 2009; 20(5-6):517-521.  PubMed Abstract

Fortin JP, Schroeder JC, Zhu Y, Beinborn M, Kopin AS.  Pharmacological characterization of human incretin receptor missense variants.  Journal of Pharmacology and Experimental Therapeutics 2009 332(1):274-280  PubMed Abstract

Draper I, Tabaka ME, Jackson FR, Salomon RN, Kopin AS.  The evolutionarily conserved RNA binding protein SMOOTH is essential for maintaining normal muscle function.  Fly 2009; 3(4):1-11.  PubMed Abstract

Danilova OV, Tai AK, Mele DA, Beinborn M, Leiter AB, Greenberg AS, Perfield JW 2nd, Defuria J, Singru PS, Lechan RM, Huber BT.  Neurogenin 3-dpecific dipeptidyl peptidase-2 deficiency causes impaired glucose tolerance, insulin resistance, and visceral obesity.  Endocrinology 2009; 150(12):5240-5248.  PubMed Abstract

Mendelsohn ME.  Estrogen actions in the cardiovascular system.  Climacteric 2009; 12 Suppl 1:18-21.  PubMed Abstract

Zhou J, Zhu Y, Cheng M, Dinesh D, Thorne T, Poh KK, Liu D, Botros C, Tang YL, Reisdorph N, Kishore R, Losordo DW, Qin G.  Regulation of vascular contractility and blood pressure by the E2F2 transcription factor.  Circulation 2009; 120(13):1213-1221.  PubMed Abstract

Zhang Y, Naggar JC, Welzig CM, Beasley D, Moulton KS, Park HJ, Galper JB.  Simvastatin inhibits angiotensin II-Induced abdominal aortic aneurysm formation in apolipoprotein E-knockout mice. possible role of ERK.  Arteriosclerosis Thrombosis, and Vascular Biology 2009; 29(11):1764-1771.   PubMed Abstract

Davis BD, Hata A.  Regulation of MicroRNA Biogenesis: A miRiad of mechanisms.  Cell Communication and Signaling 2009; 7:18.  PubMed Abstract

Mohaupt MG, Karas RH, Babiychuk EB, Sanchez-Freire V, Monastyrskaya K, Iyer L, Hoppeler H, Breil F, Draeger A.  Association between statin-associated myopathy and skeletal muscle damage.  Canadian Medical Association Journal 2009; 181(1-2):E-11-E18.  PubMed Abstract

Choi C, Fortin JP, McCarthy EV, Oksman L, Kopin AS, Nitabach MN.  Cellular dissection of circadian peptide signals with genetically encoded membrane-tethered ligands.  Current Biology 2009; 19(14):1167-1175.  PubMed Abstract

Abd-El-Barr MM, Pennesi ME, Saszik SM, Barrow AJ, Lem J, Bramblett DE, Paul DL, Frishman LJ, Wu SM.  Genetic dissection of rod and cone pathways in the dark-adapted mouse retina.  Journal of Neurophysiology 2009; 102(3):1945-1955.   PubMed Abstract

Vitale C, Mendelsohn ME, Rosano GM.  Gender differences in the cardiovascular effect of sex hormones.  Nature Reviews Cardiology 2009; 6(8):532-542.   PubMed Abstract

Han SY, Beinborn M, Ahn JM.  Facile synthesis of glucagon-like peptide-1 (GLP-1) mimetics. In: Advances in Experimental Medicine and Biology; Peptides for Youth; Susan Del Valle, Emanuel Escher and William D. Lubell (eds.), Springer New York 2009; 611:119-120.  PubMed Abstract

Ahn JM, Han SY, Murage E, Beinborn M.  Rational design of peptidomimetics for class B GPCRs: potent non-peptide GLP-1 receptor agonists. In: Advances in Experimental Medicine and Biology; Peptides for Youth; Susan Del Valle, Emanuel Escher and William D. Lubell (eds.), Springer New York 2009; 611:125-126.  PubMed Abstract

Murage E, Beinborn M, Ahn JM.  Seeking for alpha-helical propensity in a receptor-bound conformation of glucagon-like peptide-1. In: Advances in Experimental Medicine and Biology; Peptides for Youth; Susan Del Valle, Emanuel Escher and William D. Lubell (eds.), Springer New York 2009; 611:289-290.  PubMed Abstract

Dean J, Plante J, Huggins GS, Snyder RO, Aikawa R.  Role of CREB in recombinant adeno-associated virus-mediated transduction of heart muscle cells.  Human Gene Therapy 2009; 20(9):1005-1012.   PubMed Abstract

Patel AR, Hui H, Kuvin JT, Pandian NG, Karas RH.  Modestly overweight women have vascular endothelial dysfunction.  Clinical Cardiology 2009; 32(5):269-273.  PubMed Abstract

Park HJ, Zhang Y, Du C, Welzig CM, Madias C, Aronovitz MJ, Georgescu SP, Naggar I, Wang B, Kim YB, Blaustein RO, Karas RH, Liao R, Mathews CE, Galper JB.  Role of SREBP-1 in the Development of Parasympathetic Dysfunction in the Hearts of Type 1 Diabetic Akita Mice.  Circulation Research 2009; 105(3):278-294.  PubMed Abstract

Fortin JP, Zhu Y, Choi C, Beinborn M, Nitabach MN, Kopin AS.  Membrane-tethered ligands are effective probes for exploring class B1 G protein-coupled receptor function.  Proceedings of the National Academy of Sciences, USA 2009; 106(19):8049-8054  PubMed Abstract

Abraham J, Mudd JO, Kapur N, Klein K, Champion HC, Wittstein IS.  Stress cardiomyopathy after intravenous administration of catecholamines and beta-receptor agonists.  Journal of the American College of Cardiology 2009; 53(15):1320-1325.  PubMed Abstract

Park PS, Sapra KT, Jastrzebska B, Maeda T, Maeda A, Pulawski W, Kono M, Lem J, Crouch RK, Filipek S, Müller DJ, Palczewski K.  Modulation of molecular interactions and function by rhodopsin palmitylation.  Biochemistry 2009; 48(20):4294-4304.   PubMed Abstract

Gupta A, Hou R, Liu L, Hiroyasu S, Hadix JA, Huggins GS, Sibinga NE.  Daxx inhibits muscle differentiation by repressing E2A-mediated transcription.  Journal of Cellular Biochemistry 2009; 107(3):438-447.   PubMed Abstract

Aicher A, Heeschen C, Feil S, Hofmann F, Mendelsohn ME, Feil R, Dimmeler S.  cGMP-dependent protein kinase I is crucial for angiogenesis and postnatal vasculogenesis.  PLoS One 2009; 4(3):e4879.   PubMed Abstract

Schultz K, Murthy V, Tatro JB, Beasley D.  Prolyl hydroxylase 2 deficiency limits proliferation of vascular smooth muscle cells by HIF-1{alpha}-dependent mechanisms.  American Journal of Physiology - Lung Cellular and Molecular Physiology 2009; 296(6):L921-L927.  PubMed Abstract

Neuman NA, Ma S, Schnitzler GR, Zhu Y, Lagna G, Hata A.  The four-and-a-half lim domain protein 2 regulates vascular smooth muscle phenotype and vascular tone.  Journal of Biological Chemistry 2009; 284(19):13202-13212.   PubMed Abstract

Patten RD, Hall-Porter MR.  Small animal models of heart failure: Development of novel therapies, past and present.  Circulation: Heart Failure 2009; 2(2):138-144.  PubMed Abstract

Alsheikh-AA, Karas RH.  The relationship of statins to rhabdomyolysis, malignancy, and hepatic toxicity: evidence from clinical trials.  Current Atherosclerosis Report 2009;11(2):100-104.  PubMed Abstract

Heffernan KS, Karas RH, Kuvin JT, Jae SY, Vieira VJ, Fernhall B.  Carotid artery stiffness, high-density lipoprotein cholesterol and inflammation in men with pre-hypertension.  Journal of Human Hypertension 2009; 23(9):590-596.   PubMed Abstract

Peter I, Hedgepeth AK, Huggins GS, Housman DE, Mendelsohn ME, Vita JA, Vasan RS, Levy D, Benjamin EJ, Mitchell GM.  Association between arterial stiffness and variations in estrogen-related genes.  Journal of Human Hypertension 2009; 23(10):636-644  PubMed Abstract

Wen XH, Shen L, Brush RS, Michaud N, Al-Ubaidi MR, Gurevich VV, Hamm HE, Lem J, Dibenedetto E, Anderson RE, Makino CL.  Overexpression of rhodopsin alters the structure and photoresponse of rod photoreceptors.  Biophysical Journal 2009;96(3):939-950.  PubMed Abstract

Patlolla V, Patten RD, Denofrio D, Konstam MA, Krishnamani R.  The effect of ventricular assist devices on post-transplant mortality an analysis of the United network for organ sharing thoracic registry.  Journal of American College of Cardiology 2009;53(3):264-271.  PubMed Abstract

Sweet TB, Cox DH.  Measuring the influence of the BKca β1 subunit on Ca²+ binding to the BKca channel.  Journal of General Physiology 2009;133(2):139-150.  PubMed Abstract

Wang Y, Zheng XR, Riddick N, Bryden M, Baur W, Zhang X, Surks HK.  ROCK isoform regulation of myosin phosphatase and contractility in vascular smooth muscle cell.  Circulation Research 2009;104(4):531-540.  PubMed Abstract

Takimoto E, Koitabashi N, Hsu S, Ketner EA, Zhang M, Nagayama T, Bedja D, Gabrielson KL, Blanton R, Siderovski DP, Mendelsohn ME, Kass DA.  Regulator of G protein signaling 2 mediates cardiac compensation to pressure overload and antihypertrophic effects of PDE5 inhibition in mice.  Journal of Clinical Investigation 2009;119(2):408-420.  PubMed Abstract

Kelley-Hedgepeth A, Peter I, Montefusco MC, Levy D, Benjamin EJ, Vasan RS, Mendelsohn ME, Housman D, Huggins GS, Mitchell GF.  The KCNMB1 E65K variant is associated with reduced central pulse pressure in the community-based Framingham Offspring Cohort.  Journal of Hypertension 2009;27(1):55-60.  PubMed Abstract

Caprio M, Mammi C, Jaffe IZ, Zennaro MC, Aversa A, Mendelsohn ME, Fabbri A, Rosano G.  The mineralocorticoid receptor in endothelial physiology and disease: Novel concepts in the understanding of erectile dysfuction.  Current Pharmaceutica Design 2008;14(35):3749-3757.  PubMed Abstract

Kyriakis JM.  Thinking outside the box about Ras.  Journal of Biological Chemistry 2008; 284(17):10993-10994.   PubMed Abstract

Davis BN, Hilyard AC, Nguyen PN, Lagna G, Hata A.  Induction of microrna-221 by platelet-derived growth factor signaling is critical for modulation of vascular smooth muscle phenotype.  Journal of Biological Chemistry 2008;284(6):3728-3738. PubMed Abstract

Donaldson C, Eder S, Baker C, Aronovitz MJ, Weiss AD, Hall-Porter M, Wang F, Ackerman A, Karas RH, Molkentin JD, Patten RD.  Estrogen attenuates left ventricular and cardiomyocyte hypertrophy by an estrogen receptor-dependent pathway that increases calcineurin degradation.  Circulation Research 2008;104(2):265-275.  PubMed Abstract

Brieke A, Krishnamani R, Rocha MJ, Li W, Patten RD, Konstam MA, Patel AR, Udelson JE, Denofrio D.  Influence of donor cocaine use on outcome after cardiac transplantation: Analysis of the united network for organ sharing thoracic registry.  Journal of Heart and Lung Transplantation 2008;27(12):1350-1352.  PubMed Abstract

Meng H, Krishnaji ST, Beinborn M, Kumar K.  Influence of Selective Fluorination on the Biological Activity and Proteolytic Stability of Glucagon-like Peptide-1.  Journal of Medicinal Chemistry 2008;51(22):7303-7307.  PubMed Abstract

Murage EN, Beinborn M, Ahn JM.  Search for alpha-helical propensity in the receptor-bound conformation of glucagon-like peptide-1.  Bioorganic & Medicinal Chemistry 2008;16(23):10106-10112.  PubMed Abstract

Lavine JA, Raess PW, Davis DB, Rabaglia ME, Presley BK, Keller MP, Beinfeld MC, Kopin AS, Newgard CB, Attie AD.  Overexpression of pre-pro-cholecystokinin stimulates β-cell proliferation in mouse and human islets with retention of islet function.  Molecular Endocrinology 2008;22(12):2716-2728.  PubMed Abstract

Sweet TB, Cox DH.  Measurements of the BKCa channel's high-affinity Ca2+ binding constants: effects of membrane voltage.  The Journal of General Physiology 2008;132(5):491-505.  PubMed Abstract

Tsutsumi S, Zhang X, Takata K, Takahashi K, Karas RH, Kurachi H, Mendelsohn ME.  Differential regulation of the inducible nitric oxide synthase gene by estrogen receptors 1 and 2.  Journal of Endocrinology 2008;199(2):267-273.  PubMed Abstract

Kerkela R, Kockeritz L, Macaulay K, Zhou J, Doble BW, Beahm C, Greytak S, Woulfe K, Trivedi CM, Woodgett JR, Epstein JA, Force T, Huggins GS.  Deletion of GSK-3β in Mice Leads to Hypertrophic Cardiomyopathy Secondary to Cardiomyoblast Hyperproliferation.  Journal of Clinical Investigation 2008;118(11):3609-3618.  PubMed Abstract

Sharma AK, Zhou GP, Kupferman J, Surks HK, Christensen EN, Chou JJ, Mendelsohn ME, Rigby AC.  Probing the interaction between the coiled-coil leucine zipper of cGMP-dependent protein kinase Ialpha and the C-terminus of the myosin binding subunit of the myosin light chain phosphatase.  Journal of Biological Chemistry 2008;283(47):32860-32869.  PubMed Abstract

Schnoes KK, Jaffe IZ, Iyer L, Dabreo A, Aronovitz M, Newfell B, Hansen U, Rosano G, Mendelsohn ME.  Rapid recruitment of temporally distinct vascular gene sets by estrogen.  Molecular Endocrinol 2008;22(11):2544-2556.  PubMed Abstract

Anderson DS, Blaustein RO.  Preventing voltage-dependent gating of anthrax toxin channels using engineered disulfides.  The Journal General Physiology 2008;132(3):351-360.  PubMed Abstract

Utian WH, Archer DF, Bachmann GA, Gallagher C, Grodstein F, Heiman JR, Henderson VW, Hodis HN, Karas RH, Lobo RA, Manson JE, Reid RL, Schmidt PJ, Stuenkel CA.  Estrogen and progestogen use in postmenopausal women: July 2008 position statement of The North American Menopause Society.  Menopause 2008;15(4 Pt 1):584-602.  PubMed Abstract

Alsheikh-AA, Trikalinos T, Kent DM,  Karas RH.  Statins, low-density lipoprotein cholesterol and risk of cancer.  Journal of the American College of Cardiology 2008;52(14):1141-1147. PubMed Abstract   Abstract 

Fernández AB, Karas RH, Alsheikh-Ali AA, Thompson PD.  Statins and interstitial lung disease: A systematic review of the literature and of FDA adverse event reports.  Chest 2008;134(4):824-830.  PubMed Abstract

Rouf R, Greytak S, Wooten EC, Wu J, Boltax J, Picard M, Svensson EC, Dillmann WH, Patten RD, Huggins GS.  Increased FOG-2 in failing myocardium disrupts thyroid hormone-dependent SERCA2 gene transcription.  Circulation Research 2008;103(5):493-501.  PubMed Abstract

Nogueira E, Fidalgo M, Molnar A, Kyriakis J, Force T, Zalvide J, Pombo CM.  SOK1 translocates from the Golgi to the nucleus upon chemical anoxia and induces apoptotic cell death.  The Journal of Biological Chemistry 2008;283(23):16248-16258.  PubMed Abstract 

Davis BN, Hilyard AC, Lagna G, Hata A.  SMAD proteins control DROSHA-mediated microRNA maturation.  Nature 2008;454(7200):56-61.  PubMed Abstract

Ballantyne CM, Davidson MH, McKenney JM, Keller LH, Bajorunas DR, Karas RH.  Comparison of the safety and efficacy of a combination tablet of niacin extended release and simvastatin vs simvastatin monotherapy in patients with increased non-HDL Cholesterol (from the SEACOAST I Study).  American Journal of Cardiology 2008;101(10):1426-1436.  PubMed Abstract

Caprio M, Newfell BG, la Sala A, Baur W, Fabbri A, Rosano G, Mendelsohn ME, Jaffe IZ.  Functional mineralocorticoid receptors in human vascular endothelial cells regulate intercellular adhesion molecule-1 expression and promote leukocyte adhesion.  Circulation Research 2008;102(11):1359-1367.  PubMed Abstract

Peter I, Kelley-Hedgepeth A, Fox CS, Cupples LA, Huggins GS, Housman DE, Karas RH, Mendelsohn ME, Levy D, Murabito JM.  Variation in estrogen-related genes associated with cardiovascular phenotypes and circulating estradiol, testosterone, and dehydroepiandrosterone sulfate levels.  The Journal of Clinical Endocrinology & Metabolism 2008;93(7):2779-2785.  PubMed Abstract

Michael S, Surks HK, Wang Y, Zhu Y, Blanton R, Jamnongit M, Aronovitz M, Baur W, Ohtani K, Wilkerson MK, Bonev AD, Nelson MT, Karas RH, Mendelsohn ME.  High blood pressure arising from a defect in vascular function.  Proceedings of the National Academy of Sciences, USA 2008;105(18):6702-6707.  PubMed Abstract

Alsheikh-AA, Karas RH.  The safety of niacin in the US Food and Drug Administration adverse event reporting database.  American Journal of Cardiology 2008;101(8):S9-S13.

Wong JY, Huggins GS, Debidda M, Munshi NC, De Vivo I.  Dichloroacetate induces apoptosis in endometrial cancer cells.  Gynecologic Oncology 2008;109(3):394-402.  PubMed Abstract

Karas RH, Kashyap M, Knopp R, Keller L, Bajorunas DR, Davidson M.  Long-term safety and efficacy of a combination of niacin extended release and simvastatin in patients with dyslipidemia: The OCEANS Study.  American Journal of Cardiovascular Drugs 2008;8(2):69-81.  PubMed Abstract

Kelley-Hedgepeth A, Peter I, Kip KE, Montefusco MC, Kogan S, Cox D, Ordovas JM, Levy D, Reis SE, Mendelsohn ME, Housman D, Huggins GS.  The protective effect of KCNMB1 E65K against hypertension is restricted to blood pressure treatment with β-blockade.  Journal of Human Hypertension 2008;22(7):512-515.  PubMed Abstract

Patten RD, Pourati I, Aronovitz MJ, Alsheikh-Ali A, Eder S, Force T, Mendelsohn ME, Karas RH.  17 β-estradiol differentially affects left ventricular and cardiomyocyte hypertrophy following myocardial infarction and pressure overload.  Journal of Cardiac Failure 2008;14(3):245-253.  PubMed Abstract

Ballantyne CM, Davidson MH, McKenney JM, Keller LH, Bajorunas DR, Karas RH.  Comparison of the efficacy and safety of a combination tablet of niacin extended-release and simvastatin with simvastatin 80 mg monotherapy: The SEACOAST II (high-dose) study.  Journal of Clinical Lipidology 2008;2(2):79-80.

Stanic D, Paratcha G, Ledda F, Herzog H, Kopin AS, Hökfelt T.  Peptidergic influences on proliferation, migration, and placement of neural progenitors in the adult mouse forebrain.  Proceedings of the National Academy of Sciences 2008;105(9):3610-3615.  PubMed Abstract

Suryadevara RS, Karas RH, Kuvin JT.  Use of extended-release niacin in clinical practice.  Future Lipidology 2008;3(1):9-16.  Abstract

Lem J, Rwayitare K.  Transgenic strategies for the analysis of photoreceptor function. In: Signal Transduction in the Retina.   S. Fliesler and O. Kisselev, 2008;Chapter 7:145-161.

Al-Fulaij MA, Ren Y, Beinborn M, Kopin AS.  Pharmacological Analysis of Human D1 and D2 Dopamine Receptor Missense Variants.  Journal of Molecular Neuroscience 2008;34(3):211-223.  PubMed Abstract

Alsheikh-Ali AA, Karas RH.  Reply.  Journal of the American College of Cardiology 2008;51(1):92.

Park HJ, Georgescu SP, Du C, Madias C, Aronovitz MJ, Welzig CM, Wang B, Begley U, Zhang Y, Blaustein RO, Patten RD, Karas RH, Van Tol HH, Osborne TF, Shimano H, Liao R, Link MS, Galper JB.  Parasympathetic response in chick myocytes and mouse heart is controlled by SREBP.  Journal of Clinical Investigation 2008;118(1):259-271.  PubMed Abstract 

Brill E, Malanson KM, Radu RA, Boukharov, NV, Wang Z, Chung H-Y, Lloyd MB, Bok D, Travis GH, Obin M, Lem J.  A novel form of transducin-dependent retinal degeneration: Accelerated retinal degeneration in the absence of rod transducin.  Investigative Ophthalmology & Visual Science 2007;48(12):5445-5453.  PubMed Abstract 

Patten RD.  Models of gender differences in cardiovascular disease.  Drug Discovery Today: Disease Models 2007;4(4):227-232.

Holoshitz N, Alsheikh-Ali AA, Karas RH.  Relative safety of gemfibrozil and fenofibrate in the absence of concomitant cerivastatin use.  American Journal of Cardiology 2007;101(1):95-97.  PubMed Abstract

Surks HK.  cGMP-dependent protein Kinase I and smooth muscle relaxation: A tale of two isoforms.  Circulation Research 2007;101(11):1078-1080.  PubMed Abstract

Alsheikh-Ali AA, Lin JL, Abourjaily P, Ahearn D, Kuvin JT, Karas RH.  Prevalence of low high-density lipoprotein cholesterol in patients with documented coronary heart disease or risk equivalent and controlled low-density lipoprotein cholesterol.  American Journal of Cardiology 2007;100(10):1499-1501.  PubMed Abstract

Lagna G, Ku MM, Nguyen PH, Neuman NA, Davis BN, Hata A.  Control of phenotypic plasticity of smooth muscle cells by BMP signaling through the myocardin-related transcription factors.  The Journal of Biological Chemistry 2007;282(51):37244-37255.  PubMed Abstract

Clarkson TB, Karas RH.  Do the cardiovascular disease risks and benefits of oral versus transdermal estrogen therapy differ between perimenopausal and postmenopausal women?  Menopause 2007;14(6):963-967.  PubMed Abstract

Kim HJ, Lim HH, Rho SH, Bao L, Lee JH, Cox DH, Kim DH, Park CS.  Modulation of the Conductance-Voltage Relationship of the BKCa Channel by Mutations at the Putative Flexible Interface Between Two RCK Domains.  Biophysical Journal 2007;94(2):446-456.  PubMed Abstract

Blaustein RO.  On the Impossibility of Nonzero Reversal Potentials of Passive Pores Separating Symmetric Solutions: Comment on Haemophilus influenzae Outer Membrane Protein P5 Is Associated with Inorganic Polyphosphate and Polyhydroxybutyrate.  Biophysical Journal 2007;93(8):2978.  PubMed Abstract

Sanyal S, Karas RH, Kuvin JT.  Present-day uses of niacin: effects on lipid and non-lipid parameters.  Expert Opinion on Pharmacotherapy 2007;8(11):1711-1717.  PubMed Abstract

Riddick N, Ohtani K, Surks HK.  Targeting by myosin phosphatase-RhoA interacting protein mediates RhoA/ROCK regulation of myosin phosphatase.  Journal of Cellular Biochemistry 2007;103(4):1158-1170.  PubMed Abstract

Alsheikh-Ali AA, Maddukuri PV, Han H, Karas RH.  Effect of the magnitude of lipid lowering on risk of elevated liver enzymes, rhabdomyolysis, and cancer: insights from large randomized statin trials.  Journal of the American College of Cardiology 2007;50(5):409-418.  PubMed Abstract

Huggins GS, Lepore JJ, Greytak S, Patten RD, McNamee R, Aronovitz MJ, Wang P, Reed GL.  The CREB leucine zipper regulates CREB phosphorylation, cardiomyopathy, and lethality in a transgenic model of heart failure.  American Journal of Physiology - Heart and Circulatory Physiology 2007;293(3):H1877-H1882.  PubMed Abstract

Liu G, Fortin JP, Beinborn M, Kopin AS.  Four Missense Mutations in the Ghrelin Receptor Result in Distinct Pharmacological Abnormalities.  Journal Pharmacology Experimental Therapeutics 2007;322(3):1036-1043.  PubMed Abstract

Zhong J, Kyriakis JM.  Dissection of a signaling pathway by which pathogen-associated molecular patterns (PAMPs) recruit the JNK and p38 MAPKs and trigger cytokine release.  Journal of Biological Chemistry 2007;282(33):24246-24254.  PubMed Abstract

Chan MC, Nguyen PH, Davis BN, Ohoka N, Hayashi H, Du K, Lagna G, Hata A.  A novel regulatory mechanism of the Bone Morphogenetic Protein (BMP) signaling pathway involving the carboxyl-terminal tail domain of BMP type II receptor.  Molecular and Cellular Biology 2007;27(16):5776-5789.  PubMed Abstract

Kutcher ME, Kolyada AY, Surks HK, Herman IM.  Pericyte Rho GTPase mediates both pericyte contractile phenotype and capillary endothelial growth state.  American Journal of Pathology 2007;171(2):693-701.  PubMed Abstract

Mendelsohn ME, Karas RH.  HRT and the Young at Heart.  New England Journal of Medicine 2007;356(25):2639-2641.

Pullat RC, Gadarla MR, Karas RH, Thompson PD.  Tendon rupture associated with simvastatin/ezetimibe therapy.  American Journal of Cardiology 2007;100(1):152-153.  PubMed Abstract

Rosenzweig DH, Nair KS, Wei J, Wang Q, Garwin G, Saari JC, Chen CK, Smrcka AV, Swaroop A, Lem J, Hurley JB, Slepak VZ.  Subunit Dissociation and Diffusion Determine the Subcellular Localization of Rod and Cone Transducins.  The Journal of Neuroscience 2007;27(20):5484-5494.  PubMed Abstract

Peter I, Huggins GS, Shearman AM, Pollak A, Schmid CH, Cupples, Demissie S, Patten RD, Karas RH, Housman DE, Mendelsohn ME, Vasan RS, Benjamin EJ.  Age-related changes in echocardiographic measurements: association with variation in the estrogen receptor-α gene. Hypertension 2007;49(5):1000-1006.   PubMed Abstract

Bi S, Chen J, Behles RR, Hyun J, Kopin A, Moran TH.  Differential body weight and feeding responses to high fat diet in rats and mice lacking cholecystokinin 1 receptors.  AJP-Regulatory, Integrative and Comparative Physiology 2007;293(1):R55-R63.  PubMed Abstract

Utian WH, Archer DF, Bachmann GA, Gallagher JC, Grodstein F, Heiman, JR, Henderson VW, Hodis HN, Karas RH, Lobo RA, Manson JE, Reid RL, Schmidt PJ, Stuenkel CA.  Estrogen and progestogen use in peri- and postmenopausal women:  March 2007 position statement of the North American Menopause Society.  Menopause: Journal of the North American Menopause Society 2007;14(2):168-182.

Matthan NR, Jalbert SM, Ausman LM, Kuvin JT, Karas RH, Lichtenstein AH.  Effect of soy protein from differently processed products on cardiovascular disease risk factors and vascular endothelial function in hypercholesterolemic subjects.  The American Journal of Clinical Nutrition 2007;85(4):960-966.  PubMed Abstract

Li HJ, Haque ZK, Chen A, Mendelsohn ME. RIF-1, a novel nuclear receptor corepressor that associates with the nuclear matrix. Journal of Cellular Biochemistry 2007;102(4):1021-1035.   PubMed Abstract

Al-Fulaij MA, Ren Y, Beinborn M, Kopin A.  Identification of Amino Acid Determinants of Dopamine 2 Receptor Synthetic Agonist Function.  The Journal of pharmacology and experimental therapeutics, 2007;321(1):298-307.  PubMed Abstract

Jaffe IZ, Tintut Y, Newfell BG, Demer LL, Mendelsohn ME.  Mineralcorticoid Receptor Activation Promotes Vascular Cell Calcification.  Ateriosclerosis, Thrombosis and Vascular Biology 2007;27(4):799-805.  PubMed Abstract

O’Lone R, Knorr K, Jaffe IZ, Schaffer M, Martini P, Karas RH, Bienkowska J, Mendelsohn ME, Hansen U.  Estrogen Receptors ∝ and β Mediate Distinct Pathways of Vascular Gene Expression, Including Genes Involved in Mitochondrial Electron Transport and Generation of Reactive Oxygen Species.  Molecular Endocrinol 2007;21(6):1281-1296.  PubMed Abstract

Rajala A, Anderson RE, Ma JX, Lem J, Al-Ubaidi MR, Rajala RV.  G protein-coupled receptor rhodopsin regulates the phosphorylation of retinal insulin receptor.  Journal of Biological Chemistry 2007;282(13):9865-9873.  PubMed Abstract

Li J, Haque Z, Lu Q, Li L, Karas RH, Mendelsohn ME.  Steroid receptor coactivator-3 is a coactivator for myocardin, the regulator of smooth muscle transcription and differentiation.  Proceedings of the National Academy of Sciences, USA 2007;104(10):4065-4070.  PubMed Abstract

Schultz K, Murthy V, Tatro JB, Beasley D.  Endogenous Interleukin -1∝ promotes a proliferative and proinflammatory phenotype in human vascular smooth muscle cells.    American Journal of Physiology - Heart and Circulatory Physiology, 2007;292(6):H2927-H2934.  PubMed Abstract

Patten RD.  Cellular, molecular, and structural changes during cardiac remodeling: In.  Hosenpud JD and Greenberg BH, Editors Congestive Heart Failure, 3rd Edition, 2007;Chapter 8:128-146.

Alsheikh-Ali AA, Karas RH.  Safety of lovastatin/extended release niacin compared with lovastatin alone, atorvastatin alone, pravastatin alone, and simvastatin alone (from the United States Food and Drug Administration Adverse Event Reporting System).  American Journal of Cardiology 2006;99(3):379-381.  PubMed Abstract

Draper I, Kurshan P, McBride EW, Jackson FR, Kopin AS.  Locomotor activity is regulated by D2-like receptors in Drosophila: An anatomic and functional analysis.  Developmental Neurobiology 2007;67(3):378-393.  PubMed Abstract

Kuvin JT, Mammen A, Mooney P, Alsheikh-Ali AA, Karas RH. Assessment of peripheral vascular endothelial function in the ambulatory setting. 2007;Vascular Medicine 12(1):13-16.  PubMed Abstract

Pombo CM, Force T, Kyriakis J, Nogueira E, Fidalgo M, Zalvide J.  The GCK II and III subfamilies of the STE20 group kinases.  Frontiers in Bioscience 2007;12:850-859.  PubMed Abstract

Kyriakis JM.  The integration of signaling by multiprotein complexes containing Raf kinases.  Biochemica et Biophysica Acta 2007;1773(8):1238-1247.  PubMed Abstract

Bemelmans AP, Kostic C, Hornfeld D, Jaquet M, Crippa SV, Hauswirth WW, Lem J, Wang Z, Schorderet DE, Munier FL, Wenzel A, Arsenijevic Y.  Lentiviral vectors containing a retinal pigment epithelium specific promoter for leber congenital amaurosis gene therapy. Lentiviral gene therapy for LCA.  Advances in Experimental Medicine and Biology 2006;572:247-253.  PubMed Abstract

Isacson CK, Lu Q, Karas RH, Cox DH. RACK1 is a BKCa-Channel Binding Protein.   American Journal of Physiology - Cell Physiology, 2006;292(4):C1459-C1466.  PubMed Abstract

Cox DH.  BKCa-Channel Structure and Function. in: Biological Membrane Ion Channels, 2006;Chung, Shin-Ho; Andersen, Olaf S.; Krishnamurthy, Vikram (Eds.). Chapter 5:171-219.

Ambrose MS, Denofrio D, Kuvin JT, Pandian NG, Karas RH, Patel AR.  Low levels of high-density lipoprotein cholesterol are associated with vascular remodeling in cardiac transplant recipients.  Transplantation Proceedings 2006;38(9):3016-3020.  PubMed Abstract

Srinivasan VJ, Ko TH, Wojtkowski M, Carvalho M, Clermont A, Bursell SE, Song QH, Lem J, Duker JS, Schuman JS, Fujimoto JG.  Noninvasive volumetric imaging and morphometry of the rodent retina with high-speed, ultrahigh-resolution optical coherence tomography.  Investigative Ophthalmology & Visual Science 2006;47(12):5522-5528.  PubMed Abstract

Darman RB, Ivy AA, Ketty V, Blaustein RO.  Constraints on voltage sensor movement in the Shaker K+ channel.  Journal of General Physiology 2006;128(6):687-699.  PubMed Abstract

Soman P, Dave DM, Udelson JE, Han H, Ouda HZ, Patel AR, Karas RH, Kuvin JT.  Vascular endothelial dysfunction is associated with reversible myocardial perfusion defects in the absence of obstructive coronary artery disease.  Journal of Nuclear Cardiology 2006;13(6):756-760.  PubMed Abstract

Goruppi S, Patten RD, Force T, Kyriakis JM.  Helix-loop-helix  protein p8: a transcriptional regulator required for cardiomyocyte hypertrophy and cardiac fibroblast MMP induction.  Molecular and Cellular Biology, 2006;27(3):993-1006.  PubMed Abstract

Park HJ, Zhang Y, Georgescu SP, Johnson KL, Kong D, Galper JB.  Human umbilical vein endothelial cells and human dermal microvascular endothelial cells offer new insights into the relationship between lipid metabolism and angiogenesis.   Stem Cell Reviews 2006;2(2):93-102.   PubMed Abstract

Lagna G, Nguyen PH, Ni W, Hata A.  BMP-dependent activation of caspase-9 and caspase-8 mediates apoptosis in pulmonary artery smooth muscle cells.  American Journal Physiol - Lung Cellular and Molecular Physiology 2006;291(5):L1059-L1067.  PubMed Abstract

Alsheikh-Ali AA, Lin JL, Abourjaily P, Ahearn D, Kuvin JT, Karas RH.  Extent to which accepted serum lipid goals are achieved in a contemporary general medical population with coronary heart disease risk equivalents.  American Journal of Cardiology 2006;98(9):1231-1233.  PubMed Abstract

Shevtsov SP, Haq S, Force T.  Activation of β-catenin signaling pathways by classical G-protein-coupled receptors: Mechanisms and consequences in cycling and non-cycling cells.  Cell Cycle 2006;5(20):2295-2300.  PubMed Abstract

Bemelmans AP, Kostic C, Crippa SV, Hauswirth WW, Lem J, Munier FL, Seeliger MW, Wenzel A, Arsenijevic Y.  Lentiviral gene transfer of Rpe65 rescues survival and function of cones in a mouse model of leber congenital amaurosis.  PLoS Pathogens 2006;3(10):1892-1903.  PubMed Abstract

Alsheikh-Ali A, Husam OZ, Padian N, Karas RH, Kuvin JT.  Evaluation of peripheral vascular endothelial fuction with a portable ultrasound device.  Echocardiology 2006;23(8):623-626.  PubMed Abstract

Kuvin JT, Dave DM, Sliney KA, Mooney P, Patel AR, Kimmelstiel CD, Karas RH.  Effects of extended-release niacin on lipoprotein particle size, distribution, and inflammatory markers in patients with coronary artery disease.  American Journal of Cardiology 2006;98(6):743-745.  PubMed Abstract

Kerkela R, Force T.  p38 mitogen-activated protein kinase: a future target for heart failure therapy?  Journal of the American College of Cardiology 2006;48(3):556-558.  PubMed Abstract

Turgeon JL, Carr MC, Maki PM, Mendelsohn ME, Wise PM.  Complex actions of sex steroids in adipose tissue, the cardiovascular system, and brain: Insights from basic science and clinical studies.  Endocrine Reviews 2006;27(6):575-605. PubMed Abstract

Kerkela R, Grazette L, Yacobi R, Iliescu C, Patten R, Beahm C, Walters B, Shevtsov S, Pesant S, Clubb FJ, Rosenzweig A, Salomon RN, Van Etten RA, Alroy J, Durand JB, Force T.  Cardiotoxicity of the cancer therapeutic agent imatinib mesylate.  Nature Medicine 2006;12(8):908-916.  PubMed Abstract

Park HJ, Ward SM, Desgrosellier JS, Georgescu SP, Papageorge AG, Zhuang X, Barnett JV, Galper JB.  Transforming growth factor β regulates the expression of the M2 muscarinic receptor in atrial myocytes via an effect on RhoA and p190RhoGAP.  Journal of Biological Chemistry 2006;281(29):19995-20002. PubMed Abstract

Whited KL, Thao D, Lloyd KC, Kopin AS, Raybould HE.  Targeted disruption of the murine CCK1 receptor gene reduces intestinal lipid-induced feedback inhibition of gastric function.  American Journal Physiol Gastrointes Liver Physiol 2006;291(1):G156-G162.   PubMed Abstract

Beinborn M.  Class B GPCRs: A hidden agonist within?  Molecular Pharmacology 2006;70(1):1-4. PubMed Abstract

Mukherjee RS, McBride EW, Beinborn M, Dunlap K, Kopin AS.  Point mutations in either subunit of the GABAB receptor confer constitutive activity to the heterodimer.  Molecular Pharmacology, 2006;70(4):1406-1413. PubMed Abstract

Xu D, Patten RD, Force T, Kyriakis JM.  Gene 33/RALT is induced by hypoxia in cardiomyocytes, where it promotes cell death by suppressing phosphatidylinositol 3-kinase and extracellular signal-regulated kinase survival signaling.  Molecular and Cellular Biology 2006;26(13):5043-5054. PubMed Abstract

Yang X, Murthy V, Schultz K, Tatro JB, Fitzgerald KA, Beasley D.  Toll-like receptor 3 signaling evokes a proinflammatory and proliferative phenotype in human vascular smooth muscle cells.  Am J Physiol Heart Circ Physiol, 2006;291(5):H2334-H2343. PubMed Abstract

Moussaif M, Rubin WW, Kerov V, Reh R, Chen D, Lem J, Chen CK, Hurley JB, Burns ME, Artemyev NO.  Phototransduction in a transgenic mouse model of Nougaret night blindness.  The Journal of Neuroscience 2006;26(25):6863-6872. PubMed Abstract

Chen X, Shevtsov SP, Hsich E, Cui L, Haq S, Aronovitz M, Kerkela R, Molkentin JD, Liao R, Salomon RN, Patten R, Force T.  The β-catenin/T-cell factor/lymphocyte enhancer factor signaling pathway is required for normal and stress-induced cardiac hypertrophy.  Molecular and Cellular Biology 2006;26(12):4462-4473. PubMed Abstract

Ouyang P, Michos ED, Karas RH.  Hormone replacement therapy and the cardiovascular system lessons learned and unanswered questions.  Journal of the American College of Cardiology 2006;47(9):1741-1753. PubMed Abstract

Nikonov SS, Kholodenko R, Lem J, Pugh EN Jr.  Physiological features of the S- and M-cone photoreceptors of wild-type mice from single-cell recordings.  Journal of General Physiology 2006;127(4):359-374. PubMed Abstract

Kerkela R, Force T.  Recent insights into cardiac hypertrophy and left ventricular remodeling.  Current Heart Failure Reports 2006;3(1):14-18.  PubMed Abstract

Tang D, Park HJ, Georgescu SP, Sebti SM, Hamilton AD, Galper JB.  Simvastatin potentiates tumor necrosis factor α-mediated apoptosis of human vascular endothelial cells via the inhibition of the geranylgeranylation of RhoA.  Life Science 2006;79(15):1484-1492. PubMed Abstract

Patten RD, Karas RH.  Estrogen replacement and cardiomyocyte Protection.  Trends in Cardiovascular Medicine 2006;16(3):69-75. PubMed Abstract

Shearman AM, Cooper JA, Kotwinski PJ, Miller GJ, Humphries SE, Ardlie KG, Jordan B, Irenze K, Lunetta KL, Schuit SCE, Uitterlinden AG, Pols HAP, Demissie S, Cupples LA, Mendelsohn ME, Levy D, Housman DE.  Estrogen receptor α ?gene variation is associated with risk of myocardial infarction in more than seven thousand men from five cohorts.  Circulation Research 2006;98(5):590-592. PubMed Abstract

Chadee DN, Xu D, Hung G, Andalibi A, Lim DJ, Luo Z, Gutmann DH, Kyriakis JM.  Mixed-lineage kinase 3 regulates B-Raf through maintenance of the B-Raf/Raf-1 complex and inhibition by the NF2 tumor suppressor protein.  Proceedings of the National Academy of Sciences, 2006;USA 103(12):4463-4468. PubMed Abstract

Massie BM, Force T.  The year in heart failure 2005.  Journal of Cardiac Failure 2006;12(1):1-9.  PubMed Abstract

Kuvin JT, Alsheikh-Ali AA, Karas RH.  High-density lipoprotein cholesterol-raising strategies.  Journal of Cardiovasc Pharmacol 2006;47(2):196-204. PubMed Abstract

Huggins GS, Wang JY, Hankinson SE, De Vivo I.  GATA5 activation of the progesterone receptor gene promoter in breast cancer cells is influenced by the +331G/A polymorphism.  Cancer Research 2006;66(3):1384-1390. PubMed Abstract

Schultz K, Fanburg, BL and Beasley D.  Hypoxia and hypoxia-inducible factor-1α promote growth factor-induced proliferation in human vascular smooth muscle cells.  American Journal of Physiology - Heart and Circulatory Physiology 2006;290(6):H2528-H2534. PubMed Abstract

Christensen EN, Mendelsohn ME.  Cyclic GMP-dependent protein kinase Iª inhibits thrombin receptor-mediated calcium mobilization in vascular smooth muscle cells.  Journal of Biological Chemistry 2006;281(13):8409-8416. PubMed Abstract

Liu E, Sinha S, Williams C, Cyrille M, Heller E, Snapper SB, Georgopoulos K, St-Arnaud R, Force T, Dedhar S, Gerszten RE.  Targeted deletion of integrin-linked kinase reveals a role in T-cell chemotaxis and survival.  Molecular and Cellular Biology 2005;25(24):11145-11155.  PubMed Abstract

Ku MC, Howard S, Ni W, Lagna G, Hata A.  OAZ regulates bone morphogenetic protein signaling through Smad6 activation.  Journal of Biological Chemistry 2005;281(8):5277-5287. PubMed Abstract

Peter I, Shearman AM, Zucker DR, Schmid CH, Demissie S, Cupples LA, Larson MG, Vasan RS, D'Agostino RB, Karas RH, Mendelsohn ME, Housman DE, Levy D.  Variation in estrogen-related genes and cross-sectional and longitudinal blood pressure in the Framingham Heart Study.  Journal of hypertension 2005;23(12):2193-2200. PubMed Abstract

Qui P, Ritchie R, Fu Z, Cao D, Cumming J, Miano JM, Wang DZ, Li HJ, Li L.  Myocardin enhances Smad3-medicated transforming growth factors β¹, signaling in a CArG Box independent manner.  Circulation Research 2005;97(10):983-991.  PubMed Abstract

Patten RD, Konstam MA.  Treatment of Remodeling: Inhibition of the Renin-Angiotensin-Aldosterone System. 2006;In Greenberg BH; Cardiac Remodeling; Taylor and Francis Group (Eds.). Chapter 18:325-348.

Masur K, Tibaduiza EC, Chen C, Ligon B, Beinborn M.  Basal receptor activation by locally produced glucagon-like peptide-1 contributes to maintaining β-cell function.  Molecular Endocrinology 2005;19(5):1373-1382. PubMed Abstract

Kuvin JT, Patel AR, Sliney KA, Pandian NG, Karas RH.  Comparison of flow-mediated dilatation of the brachial artery in coronary patients with low-density lipoprotein cholesterol levels <80 mg/dl versus patients with levels 80 to 100 mg/dl.  The American Journal of Cardiology 2005;95(1):93-95. PubMed Abstract

Mendelsohn ME.  In hypertension, the kidneys are not always the heart of the matter.  The Journal of Clinical Investigation 2005;115(4):840-844. PubMed Abstract

Kuvin JT, Sidhu M, Patel AR, Sliney KA, Pandian NG, Karas RH.  Pulse pressure and peripheral arterial vasoreactivity.  Journal of Human Hypertension 2005;19(6):501-502. PubMed Abstract

Bridgman P, Aronovitz MA, Kakkar R, Oliverio M, Coffman T, Rand W, Konstam MA, Mendelsohn ME, Patten RD.  Gender-specific patterns of left ventricular and myocyte remodeling following myocardial infarction in mice deficient in the angiotensin II type 1ª receptor.  American Journal of Physiology - Heart and Circulatory Physiology 2005;289(2):H586-H592. PubMed Abstract

Cox DH.  The BKCa channel's Ca2+-binding sites, multiple sites, multiple ions.  The Journal of General Physiology 2005;125(3):253-255. PubMed Abstract

Watanabe K, Beinborn M, Nagamatsu S, Ishida H, Takahashi S.  Menetrier’s disease in a patient with helicobacter pylori infection is linked to elevated glucagons-like peptide-2 activity.  Scandinavian Journal of Gastroenterology 2005;40(4):477-481. PubMed Abstract

Sharkey SW, Lesser JR, Zenovich AG, Maron MS, Lindberg J, Longe TF, Maron BJ.  Acute and reversible cardiomyopathy provoked by stress in women from the United States.  Circulation 2005;111(4):472-479. PubMed Abstract 

Dorn GW, Force T.  Protein kinase cascades in the regulation of cardiac hypertrophy.  The Journal of Clinical Investigation 2005;115(3):527-537. PubMed Abstract

Yang X, Coriolan D, Murthy V, Schultz K, Golenbock DT, Beasley D.  Proinflammatory phenotype of vascular smooth muscle cells: Role of efficient toll-like receptor 4 signaling.  American Journal of Physiology - Heart and Circulatory Physiology 2005;289(3):H1068-H1076. PubMed Abstract

Alsheikh-Ali AA, Karas RH.  Adverse events with concomitant amiodarone and statin therapy.  Preventive Cardiology 2005;8(2):95-97. PubMed Abstract

Wang Z, Wen XH, Ablonczy Z, Crouch RK, Makino CL, Lem J.  Enhanced shutoff of phototransduction in transgenic mice expressing palmitoylation- deficient rhodopsin.  The Journal of Biological Chemistry 2005;280(26):24293-24300. PubMed Abstract

Patten RD, Denofrio D, El-Zaru M, Kakkar R, Saunders J, Celestin F, Warner K, Rastegar H, Khabbaz KR, Udelson JE, Konstam MA, Karas RH.  Ventricular assist device therapy normalizes inducible nitric oxide synthase expression and reduces cardiomyocyte apoptosis in the failing human heart.  Journal of the American College of Cardiology 2005;45(9):1419-1424. PubMed Abstract

Beinborn M, Worrall CI, McBride EM, Kopin AS.  A human glucagon-like peptide-1 receptor polymorphism results in reduced agonist responsiveness.  Regulatory Peptides 2005;130(1-2):1-6. PubMed Abstract

Mendelsohn ME, Karas RH.  Molecular and cellular basis of cardiovascular gender differences.  Science 2005;308(5728):1583-1587. PubMed Abstract

Georgescu SP, Li JH, Karas RH, Brown M, Mendelsohn ME.  Modulator recognition factor 1 (MRF1), an AT-rich interaction domain family member, is a novel co-repressor for estrogen receptor α.  Molecular Endocrinol 2005;19(10):2491-2501. PubMed Abstract

Alsheikh-Ali AA, Ambrose MS, Kuvin JT, Karas RH.  The safety of rosuvastatin as used in common clinical practice: A postmarketing analysis.  Circulation 2005;111(23):3051-3057.  PubMed Abstract

Alsheikh-Ali AA, Kuvin JT, Karas, RH.  High-density lipoprotein cholesterol in the cardiovascular equation: Does the “good” still count?  Atherosclerosis 2005;180(2):217-223.  PubMed Abstract

Huggins GS, O'Gara PT.  Clinical presentation and diagnostic evaluation of ST-segment elevation myocardial infarction. In:.  Atherothrombosis and Coronary Artery Disease, 2005;Fuster V, Topol EJ, Nabel,Chapter 50:849-866.

Hedrich O, Patten RD, DeNofrio D.  Current treatment options for CHF Management: Focus on the renin-angiotensin-aldosterone system.  Current Treatment Options in Cardiovascular Medicine 2005;7(1):3-13, 2005. PubMed Abstract 

Shearman AM, Demissie S, Cupples LA, Peter I, Schmid CH, Mendelsohn ME, Ordovas J, Housman DE.  Tobacco smoking, estrogen receptor α gene variation, and small low-density lipoprotein level.  Human Molecular Genetics 2005;14(16):2405-2413.  PubMed Abstract

Demissie S, Cupples LA, Shearman AM, Gruenthal KM, Peter I, Schmid CH, Karas RH Housman DE, Mendelsohn ME, Ordovas JM.  Estrogen receptor-α variants are associated with lipoprotein size distribution and particle levels in women: The Framingham Heart Study.  Atherosclerosis, 2005;185(1):210-218.  PubMed Abstract

Ku M, Sokol SY, Wu J, Tussie-Luna MI, Roy AL, Hata A.  Positive and negative regulation of the transforming growth factor β/activin target gene goosecoid by the TFII-I family of transcription factors.  Molecular and Cellular Biology 2005;25(16):7144-7157.  PubMed Abstract

Bao L, Cox DH.  Gating and ionic currents reveal how the BKCa channel's Ca2+ sensitivity Is enhanced by its β1 subunit.  The Journal General Physiology 2005;126(4):393-412.  PubMed Abstract

Yang X, Coriolan D, Schultz K, Golenbock DT, Beasley D.  Toll-like receptor 2 mediates persistent chemokine release by chlamydia pneumoniae-infected vascular smooth muscle cells.  Arteriosclerosis, Thrombosis, and Vascular Biology 2005;25(11):2308-2314.  PubMed Abstract

Shearman AM, Cooper JA, Kotwinski PJ, Humphries SE, Mendelsohn ME, Housman DE, Miller GJ.  Estrogen receptor ª gene variation and the risk of stroke.  Stroke 2005;36(10):2281-2282.  PubMed Abstract

Fox CS, Yang Q, Cupples LA, Guo CY, Atwood LD, Murabito JM, Levy D, Mendelsohn ME, Housman DE, Shearman AM.  Sex-Specific Association Between Estrogen Receptor ª Gene Variation and Measures of Adiposity: the Framingham Heart Study.  The Journal of Clinical Endocrinology and Metabolism 2005;90(11):6257-6262.  PubMed Abstract

Kyriakis JM.  Map kinase and growth factor pathways. In:.  Endocrinology, 2005;LJ. DeGroot, JL Jameson (eds.), Elsevier, Philadelphia,Volum 1, Fifth Edition:237-275.

Maeda T, Lem J, Palczewski K, Haeseleer F.  A critical role of CaBP4 in the cone synapse.  Investigative Ophthalmology & Visual Science 2005;46(11):4320-4327.  PubMed Abstract

Peter I, Shearman AM, Vasan RS, Zucker DR, Schmid CH, Demissie S, Cupples LA, Kuvin JT, Karas RH, Mendelsohn ME, Housman DE, Benjamin EJ.  Association of estrogen receptor β gene polymorphisms with left ventricular mass and wall thickness in women.  American Journal of Hypertension 2005;18(11):1388-1395.  PubMed Abstract

Shearman AM, Demissie S, Cupples LA, Peter I, Schmid CH, Ordovas JM, Mendelsohn ME, Housman DE.  Tobacco smoking, estrogen receptor α gene variation and small low-density lipoprotein level.  Human Molecular Genetics 2005;14(16):2405-2413.  PubMed Abstract

Patten RD, Karas RH.  Cardiomyocyte apoptosis in the ischemic and failing hearts.  Drug Discovery Today: Disease Mechanisms 2005;2(1):47-53.

Surks HK, Riddick N, Ohtani K.  M-RIP targets myosin phosphatase to stress fibers to regulate myosin light chain phosphorylation in vascular smooth muscle cells.  Journal of Biological Chemistry 2005;280(52):42543-4251. PubMed Abstract

D’eon TM, Souza SC, Aronovitz MA, Obin MS, Fried SK, Greenburg AS.  Estrogen regulation of adiposity and fuel partitioning: Evidence of genomic and non-genomic regulation of lipogenic and oxidative pathways.  Journal of Biological Chemistry 2005;280(43):35983-35991.

Huggins GS, Gewirte H.  Chronic stable angina: Clinical presentation and diagnostic techniques. In:  Atherothrombosis and Coronary Artery Disease, 2005;Fuster V, Topol EJ, Nabel,Chapter 88:1301-1312.

Xu D, Makkinje A, Kyriakis JM.  Gene 33 is an endogenous inhibitor of Epidermal Growth Factor (EGF) receptor signaling and mediates dexamethasone-induced suppression of EGF function.  Journal of Biological Chemistry 2005;280(4):2924-2933.  PubMed Abstract

Liu P, Konstam MA, Force T.  Highlights of the 2004 scientific sessions of the Heart Failure Society of America, Toronto, ON, Canada Sept 12-15, 2004.  Journal of the American College of Cardiology 2005;45 (4):617-625.   PubMed Abstract

Jaffe IZ, Mendelsohn ME.  Angiotensin II and aldosterone regulate gene transcription via functional mineralocortocoid receptors in human coronary artery smooth muscle cells.  Circulation Research 2005;96(6):643-650.  PubMed Abstract

Skurk C, Maatz H, Rocnik E, Bialik A, Force T, Walsh K.  Glycogen-synthase kinase3β/β-catenin axis promotes angiogenesis through activation of vascular endothelial growth factor signaling in endothelial cells.  Circulation Research 2005;96(3):308-318.  PubMed Abstract

Patel AR, Kuvin JT, Sliney KA, Rand WM, Pandian NG, Karas RH.  Peripheral vascular endothelial function correlates with exercise capacity in women.  Clinical Cardiology 2005;28(9):433-436.  PubMed Abstract

Patel AR, Kuvin JT, Sliney KA, Rand WM, Chiang JC, Udelson JE, Pandian NG, Karas RH.  Gender-based differences in brachial artery flow-mediated vasodilation as an indicator of significant coronary artery disease.  American Journal of Cardiology 2005;96(9):1223-1226.  PubMed Abstract

Blow NS, Salomon RN, Garrity K, Reveillaud I, Kopin A, Jackson FR, Watnick PI.  Vibrio cholerae infection of drosophilamelanogaster mimics the human disease cholera.  PLoS Pathogens 2005;1(1):92-98.  PubMed Abstract

Liu E, Sinha S, Williams C, Cyrille M, Heller E, Snapper SB, Georgopoulos K, St-Arnaud R, Force T, Dedhar S, Gerszten RE.  Targeted deletion of integrin-linked kinase reveals a role in T cell chemotaxis and survival.  Molecular and Cellular Biology 2005;25(24):11145-11155.  PubMed Abstract

Shao Z, Bhattacharya K, Bhattacharya S, Hsich E, Park L, Walters B, Germann U, Wang YM, Mohanlal R, Kuida K, Namchuk M, Salituro F, Yao YM, Hou WM, Chen X, Aronowitz M, Tsichlis P, Force T, Kilter H.  c-Jun N-terminal kinases mediate reactivation of Akt and cardiomyocyte survival after hypoxic injury In vitro and in vivo.  Circulation Research 2005;98(1):111-118.  PubMed Abstract

Mendelsohn ME.  Viagra: Now mending hearts.  Nature Medicine 2005;11(2):115-116. PubMed Abstract

Maron MS, Zenovich AG, Casey SA, Link MS, Udelson JE, Aeppli DM, Maron BJ.  Significance and relationship between magnitude of left ventricular hypertrophy and heart failure symptoms in hypertrophic cardiomyopathy.  American Journal of Cardiology 2005;95(11):1329-1333.   PubMed Abstract

Seki K, Hata A.  Indian hedgehog gene is a target of the bone morphogenetic protein signaling pathway.  The Journal of Biological Chemistry 2004;279(18):18544-18549. PubMed Abstract

Wang DQ, Schmitz F, Kopin AS, Carey MC.  Targeted disruption of the murine cholecystokinin-1 receptor promotes intestinal cholesterol absorption and susceptibility to cholesterol cholelithiasis.  The Journal of Clinical Investigation 2004;114(4):521-528. PubMed Abstract

Finlay GA, York B, Karas RH, Fanburg BL, Zhang H, Kwiatkowski DJ, Noonan DJ.  Estrogen-induced smooth muscle cell growth is regulated by tuberin and associated with altered activation of PDGFR-β and ERK-1/2.  The Journal of Biological Chemistry 2004;279(22):23114-23122. PubMed Abstract

Young CE, Karas RH, Kuvin JT.  High-density lipoprotein cholesterol and coronary heart disease.  Cardiology in Review 2004;12(2):107-119. PubMed Abstract

Bond HM, Mesuraca M, Carbone E, Bonelli P, Agosti V, Amodio N, De Rosa G, Di Nicola M, Gianni AM, Moore MA, Hata A, Grieco M, Morrone G, Venuta S.  Early hematopoietic zinc finger protein (EHZF), the human homologue to mouse Evi3, is highly expressed in primitive human hematopoietic cells.  Blood 2004;103(6):2062-2070. PubMed Abstract

Lem J, Fain GL.  Constitutive opsin signaling:  Night blindness or retinal degeneration?  Trends in Molecular Medicine 2004;10(4):150-157. PubMed Abstract

Michael A, Haq S, Chen X, Hsich E, Cui L, Walters B, Shao Z, Bhattacharya K, Kilter H, Huggins G, Andreucci M, Periasamy M, Solomon RN, Liao R, Patten R, Molkentin JD, Force T.  Glycogen synthase kinase-3β regulates normal post-natal cardiac growth, calcium homeostasis and diastolic function of the heart.  The Journal of Biological Chemistry 2004;279(20):21383-21393. PubMed Abstract

Wang Y, El-Zaru MR, Surks HK, Mendelsohn ME.  Formin homology domain protein FHOD1 is a cyclic GMP-dependent protein kinase 1α binding protein and substrate in vascular smooth muscle cells.  The Journal of Biological Chemistry 2004;279(23):24420-24426. PubMed Abstract

Goruppi S, Kyriakis JM.  The pro-hypertrophic bHLH protein p8 is degraded by the ubiquitin proteasome system in a protein kinase-B/Akt and glycogen synthase kinase-3-dependent manner, while endothelin induction of p8 mRNA and renal mesangial cell hypertrophy require NFAT4.  The Journal of Biological Chemistry 2004;279(20):20950-20958. PubMed Abstract

Bao L, Kaldany C, Holmstrand EC, Cox DH.  Mapping the BKCa channels "Ca2+ bowl": Side-chains essential for Ca2+ sensing.  Journal of General Physiology 2004;123(5):475-489. PubMed Abstract

Bi S, Scott KA, Kopin AS, Moran TH.  Differential roles for cholecystokinin-A receptors in energy balance in rats and mice.  Endocrinology 2004;145(8):3873-3880. PubMed Abstract

Takabayashi T, Shimizu S, Clark BD, Beinborn M, Burke JF, Gelfand JA.  Interleukin-1 upregulates anaphylatoxin receptors on mononuclear cells.  Surgery 2004;135(5):544-554. PubMed Abstract

Danciger M, Lyon J, Worrill D, Hoffman S, Lem J, Reme CE, Wenzel A, Grimm C.  New retinal light damage QTL in mice with the light-sensitive RPE65 LEU variant.  Mammalian Genome 2004;15(4):277-283. PubMed Abstract

Alsheikh-Ali AA, Karas RH.  Adverse events with concomitant use of simvastatin or atorvastatin and thiazolidinediones.  American Journal of Cardiology 2004;93(11):1417-1418. PubMed Abstract

Giacobini P, Kopin AS, Beart PM, Mercer LD, Fasolo A, Wray S.  Cholecystokinin modulates migration of gonadotropin-releasing hormone-1 neurons.  Journal of Neuroscience 2004;24(20):4734-4748. PubMed Abstract

Grazette LP, Boecker W, Matsui T, Semigran M, Force TL, Hajjar RJ, Rosenzweig A.  Inhibition of ErbB2 causes mitochondrial dysfunction in cardiomyocytes: Implications for herceptin-induced cardiomyopathy.  Journal of the American College of Cardiology 2004;44(11):2231-2238. PubMed Abstract

Rindi G, Leiter AB, Kopin AS, Bordi C, Solcia E.  The "normal" endocrine cell of the gut: Changing concepts and new evidences.  Annals of the New York Academy of Sciences 2004;1014:1-12. PubMed Abstract

Karas RH.  Current controversies regarding the cardiovascular effects of hormone therapy.  Clinical Obstetrics & Gynecologyl 2004;47(2):489-499. PubMed Abstract

Chadee DN, Kyriakis JM.  MLK3 is required for mitogen activation of B-Raf, ERK and cell proliferation.  Nature Cell Biology 2004;6(8):770-776. PubMed Abstract

Patten RD, Soman P.  Prevention and reversal of LV remodeling with neurohormonal inhibitors.  Current Treatment Options in Cardiovascular Medicine 2004;6(4):313-325. PubMed Abstract

Endo A, Surks HK, Mochizuki S, Mochizuki N, Mendelsohn ME.  Identification and characterization of zipper-interacting protein kinase as the unique vascular smooth muscle myosin phosphatase-associated kinase.  The Journal of Biological Chemistry 2004;279(40):42055-42061. PubMed Abstract

Naftolin F, Taylor HS, Karas RH, Brinton E, Newman I, Clarkson TB, Mendelsohn M, Lobo RA, Udelson J, Nachtigall LE, Heward CB, Hecht H, Jaff MR, Harman SM.  The Women’s Health Initiative (WHI) could not have detected cardioprotective effects of starting hormone therapy during the menopausal transition.  Fertility and Sterility 2004;81(6):1498-1501. PubMed Abstract

Naash MI, Wu TH, Chakraborty D, Fliesler SJ, Ding XQ, Nour M, Peachey NS, Lem J, Qtaishat N, Al-Ubaidi MR, Ripps H.  Retinal abnormalities associated with the G90D mutation in opsin.  The Journal of Comparative Neurology 2004;478(2):149-163. PubMed Abstract

He W, Yasumatsu K, Varadarajan V, Yamada A, Lem J, Ninomyia Y, Margolskee RF, Damak S.  Umami taste responses are mediated by α-transducin and α-gustducin.  Journal of Neuroscience 2004;24(35):7674-7680. PubMed Abstract

Patten RD, Pourati I, Aronovitz MJ, Baur J, Celestin F, Chen X, Michael A, Haq S, Neudling S, Grohe C, Force T, Mendelsohn ME, Karas RH.  17β-estradiol reduces cardiomyocyte apoptosis in vivo and in vitro via activation of phospho-inositide-3 kinase/Akt signaling. (SCOR) Circulation Research 2004;95(7):692-699. PubMed Abstract

Friedrich EB, Liu E, Sinha S, Cook S, Milstone DS, MacRae CA, Mariotti M, Kuhlencordt PJ, Force T, Rosenzweig A, St-Arnaud R, Dedhar S, Gerszten RE.  Integrin-linked kinase regulates endothelial cell survival and vascular development.  Molecular and Cellular Biology 2004;24(18):8134-8144. PubMed Abstract

Liu P, Konstam MA, Force T.  Highlights of the 2003 scientific sessions of the Heart Failure Society of America.  Journal of the American College of Cardiology 2004;43(6):1103-1109. PubMed Abstract

Zhong J, Kyriakis JM.  Germinal center kinase is required for optimal JNK activation by TLR agonists and is regulated by the ubiquitin proteasome system and agonist-induced, TRAF6-dependent stabilization.  Molecular and Cellular Biology 2004;24(20):9165-9175. PubMed Abstract

Alsheikh-Ali AA, Kuvin JT, Karas RH.  Risk of adverse events with fibrates.  American Journal of Cardiology 2004;94(7):935-938. PubMed Abstract

Chadee DN, Kyriakis JM.  A novel role for mixed lineage kinase 3 (MLK3) in B-Raf activation and cell proliferation.  Cell Cycle 2004;3(10):1225-1226. PubMed Abstract

Noguchi T, Hunlich M, Camp PC, Begin KJ, El-Zaru M, Patten R, Leavitt BJ, Ittleman FP, Alpert NR, LeWinter MM, VanBuren P.  Thin filament-based modulation of contractile performance in human heart failure.  Circulation 2004;110(8):982-987. PubMed Abstract

Woodruff ML, Lem J, Fain GL.  Early receptor current of wild-type and transducin knockout mice:  Photosensitivity and light-induced Ca2+ release.  The Journal of Physiology 2004;557(3):821-828. PubMed Abstract

Balk EM, Karas RH, Jordan HS, Kupelnick B, Chew P, Lau J.  Effects of statins on vascular structure and function: A systematic review.  American Journal of Medicine 2004;117(10):775-790. PubMed Abstract

Lu Q, Pallas DC, Surks HK, Baur WE, Mendelsohn ME, Karas RH.  Striatin assembles a membrane signaling complex necessary for rapid, nongenomic activation of endothelial no synthase by estrogen receptor α.  Proceedings of the National Academy of Sciences, 2004;USA 101(49):17126-17131. PubMed Abstract

Beinborn M, Ren Y, Bläker M, Chen C, Kopin AS.  Ligand function at constitutively active receptor mutants is affected by two distinct yet interacting mechanisms.  Molecular Pharmacology 2004;65(3):753-760. PubMed Abstract

Blaustein BO, Miller C.  Ion channels: Shake, rattle or roll?  Nature 2004;427:499-500. PubMed Abstract

Mosca L, Appel LJ, Benjamin EJ, Berra K, Chandra-Strobos N, Fabunmi RP, Grady D, Haan CK, Hayes SN, Udelson J, Keenan NL, McBride P, Oparil S, Ouyang P, Oz MC, Mendelsohn ME, Pasternak RC, Pinn VW, Robertson RM, Schenck-Gustafsson K, Sila CA, Smith SC Jr, Sopko G, Taylor AL, Walsh BW, Wenger NK, Williams CL.  Evidence-based guidelines for cardiovascular disease prevention in women.  Circulation 2004;109:672-693; Arterioscler Thromb Vascular Biology 2004;24(3):e29-e50; Journal of the American College of Cardiology 2004;43(5):900-921. PubMed Abstract

Kyriakis JM, Liu H, Chadee DN.  Activation of SAPKs/JNKs and p38s In vitro.  Methods in Molecular Biology 2004;250:61-88. PubMed Abstract

Force T, Kuida K, Namchuk M, Parang K, Kyriakis JM.  Inhibitors of protein kinase signaling pathways: Emerging therapies for cardiovascular disease.  Circulation 2004;109(10):1196-1205. PubMed Abstract

Karas RH.  Non-genomic Actions of Hormones. In.  Principles of Sex-based Differences in Physiology, 2004;Virginia M. Miller, Meredith Hay,34:49-57.

Maron BJ, Dearani JA, Ommen SR, Maron MS, Schaff HV, Gersh BJ, Nishimura RA.  The case for surgery in obstructive hypertrophic cardiomyopathy.  Journal of the American College of Cardiology 2004;44(10):2044-2053. PubMed Abstract

Harman SM, Brinton EA, Clarkson T, Heward CB, Hecht HS, Karas RH, Judleson DR, Naftolin F.  Is the WHI relevant to HRT started in the perimenopause?  Endocrine 2004;24(3):195-202. PubMed Abstract

Macklis R, Mendelsohn ME, Mudge G.  Manual of Introductory Clinical Medicine. In.  Boston: Little, 2004;Brown & Co., Fourth Edition.

Lu Q, Surks HK, Ebling H, Baur WE, Brown D, Pallas DC, Karas, RH.  Regulation of estrogen receptor α-mediated transcription by a directinteraction with protein phosphatase 2A.  Journal of Biological Chemistry 2003;278(7):4639-4645. PubMed Abstract

Patel AR, Kuvin JT, DeNofrio D, Kinan D, Sliney KA, Eranki KP, Pandian NG, Udelson JE, Konstam MA, Karas RH.  Peripheral vascular endothelial function correlates with exercise capacity in cardiac transplant recipients.  The American Journal of Cardiology 2003;91(7):897-899. PubMed Abstract

Abourjaily HM, Alsheikh-Ali AA, Karas RH.  Comparison of the frequency of adverse events in patients treated with atorvastatin or simvastatin.  The American Journal of Cardiology 2003;91(8):999-1002. PubMed Abstract

Ren Y, Blaker M, Seshadri L, McBride EW, Beinborn M, Kopin AS.  Conserved cholecystokinin receptor transmembrane domain IV amino acids confer peptide affinity.  Journal of Molecular Neuroscience 2003;20:115-123. PubMed Abstract

Lee H-Y, Srinivas H, Xia D, Lu Y, Superty R, LaPushin R, Gomez-Manzano C, Gal AM, Walsh GL, Force T, Ueki K, Mills GB, Kurie JM.  Evidence that phosphatidylinositol 3-kinase- and mitogen-activated protein kinase kinase-4/c-Jun NH2-terminal kinase-dependent pathways cooperate to maintain lung cancer cell survival.  Journal of Biological Chemistry 2003;278(26):23630-23638. PubMed Abstract

Ramet ME, Ramet M, Lu Q, Nickerson M, Savolainen MJ, Malzone A, Karas RH.  High-density lipoprotein increases the abundance of eNOS protein in human vascular endothelial cells by increasing its half-life.  Journal of the American College of Cardiology 2003;41(12):2288-2297. PubMed Abstract

Patten RD, Aronovitz MJ, Einstein M, Lambert M, Pandian NG, Mendelsohn ME, Konstam MA.  Effects of angiotensin II receptor blockade versus angiotensin-converting-enzyme inhibition on ventricular remodelling following myocardial infarction in the mouse.  Clinical Science (Lond) 2003;104(2):109-118. PubMed Abstract

Haq S, Kilter H, Michael A, Tao J, O'Leary E, Sun XM, Walters B, Bhattacharya K, Chen X, Cui L, Andreucci M, Rosenzweig A, Guerrero JL, Patten R, Liao R, Molkentin J, Picard M, Bonventre JV, Force T.  Deletion of Cytosolic phospholipase A(2) promotes striated muscle growth.  Nature Medicine 2003;9(7):944-951. PubMed Abstract

Kuvin JT, Karas RH.  Clinical utility of endothelial function testing: Ready for prime time?  Circulation 2003;107(25):3243-3247. PubMed Abstract

Hattar S, Lucas RJ, Mrosovsky N, Thompson S, Douglas RH, Hankins MW, Lem J, Biel M, Hofmann F, Foster RG, Yau K-W.  Melanopsin and rod-cone photoreceptive systems account for all major accessory visual functions in mice.  Nature 2003;424:76-81. PubMed Abstract

Takahashi S, Mendelsohn ME.  Calmodulin-dependent and -independent activation of endothelial nitric-oxide synthase by heat shock protein 90. (SCOR) Journal of Biological Chemistry 2003;278(11):9339-9344. PubMed Abstract

Kopin AS, McBride EW, Chen C, Freidinger RM, Chen D, Zhao C-M, Beinborn M.  Identification of a series of CCK-2 receptor nonpeptide agonists: Sensitivity to stereochemistry and a receptor point mutation.  Proceedings of the National Academy of Sciences, USA 2003;100(9):5525-5530. PubMed Abstract

Mendez A, Lem J, Simon M, Chen J.  Light-dependent translocation of arrestin in the absense of rhodopsin phosphorylation and transducin signaling.  Journal Neurosci 2003;23(8):3124-3129. PubMed Abstract

Li L, Ouyang B, Choukroun G, Matyal R, Mascarenhas M, Jafari B, Bonventre JV, Force T, Quinn DA.  Stretch-induced IL-8 depends on C-Jun NH2-Terminal and nuclear factor-κB-inducing kinases.  American Journal Physiol - Lung Cellular and Molecular Physiology 2003;285(2):L464-L475. PubMed Abstract

Doran AC, Wan Y-P, Kopin AS, Beinborn M.  Established theory of radiation-induced decay is not generalizable to bolton-hunter labeled peptides.  Biochemical Pharmacology 2003;65:1515-1520. PubMed Abstract

Kuvin JT, Patel AR, Sliney KA, Pandian NG, Sheffy J, Schnall RP, Karas RH, Udelson JE.  Assessment of peripheral vascular endothelial function with finger arterial pulse wave amplitude.  American Heart Journal 2003;146(1):168-174. PubMed Abstract

Kuvin JT, Karas RH.  The effects of LDL reduction and HDL augmentation on physiologic and inflammatory markers.  Current Opinion in Cardiology 2003;18(4):295-300. PubMed Abstract

Brill E, Patnala S, Lem J, Obin M.  Bright light induces retinal degeneration by a transducin-independent mechanism. In.  Advances in Experimental Medicine and Biology 2003;Vol. 533, Retinal Degenerations: Mechanisms and Experimental Therapy, LaVail MM, Hollyfield JG, Anderson RE (eds.), Plenum Publishers.533:213-219. PubMed Abstract

Karas RH, Clarkson TB.  Considerations in interpreting the cardiovascular effects of hormone replacement therapy observed in the WHI: Timing is everything.  Menopausal Medicine 2003;10:8-12.

Takahashi S, Mendelsohn ME.  Synergistic activation of endothelial Nitric-oxide synthase (eNOS) by HSP90 and Akt: Calcium-independent eNOS activation involves formation of an HSP90-Akt-CaM-BOUND eNOS complex. (SCOR) Journal of Biological Chemistry 2003;278(33):30821-30827. PubMed Abstract

Makino CL, Wen X-H, Lem J.  Piecing together the timetable for visual transduction with transgenic animals.  Current Opinion in Neurobiology 2003;13(4):404-412. PubMed Abstract

Woodruff ML, Wang Z, Chung H, Redmond M, Fain G, Lem J.  Spontaneous activity of opsin apoprotein is a cause of Leber congenital amaurosis.  Nature Genetics 2003;35(2):158-164. PubMed Abstract

Xu D, Kyriakis JM.  Phosphatidyl inositol-3’OH kinase-dependent activation of renal mesangial cell ki-ras and ERK by advanced glycation end products.  Journal of Biological Chemistry 2003;278(41):39349-39355. PubMed Abstract

Kuvin JT, Patel AR, Sidhu M, Rand WM, Sliney KA, Pandian NG, Karas RH.  Relation between high-density lipoprotein cholesterol and peripheral vasomotor function.  American Journal of Cardiology 2003;92:275-279. PubMed Abstract

Andreucci M, Michael A, Kramers C, Park KM, Chen A, Matthaeus T, Alessandrini A, Haq S, Force T, Bonventre JV.  Renal ischemia/reperfusion and ATP depletion/repletion in LLC-PK(1) cells result in phosphorylation of FKHR and FKHRL1.  Kidney International 2003;64(4):1189-1198. PubMed Abstract

Balk EM, Lau J, Goudas LC, Jordan HS, Kupelnick BA, Kim LU, Karas RH.  Effects of statins on nonlipid serum markers associated with cardiovascular disease: A systematic review.  The Annals of Internal Medicine 2003;139(8):670-682. PubMed Abstract

Seki K, Fujimori T, Savagner P, Hata A, Aikawa T, Ogata N, Nabeshima Y, Lee K.  Mouse Snail family transcription repressors regulate chondrocyte, extracellular matrix, type II collagen, and aggrecan.  Journal of Biological Chemistry 2003;278(43):41862-41870. PubMed Abstract

Kienker PK, Jakes KS, Blaustein RO, Miller C, Finkelstein A.  Sizing the protein translocation pathway of colicin Ia channels.  The Journal of General Physiology 2003;22:161-176. PubMed Abstract

Bruna A, Nicolas M, Munoz A, Kyriakis JM, Caelles C.  Glucocorticoid receptor-JKN interaction mediates inhibition of the JNK pathway by glucocorticoids.  The EMBO Journal 2003;22(22):6035-6044. PubMed Abstract

Kyriakis JM.  At the crossroads: AMP-activated kinase and the LKBI tumor suppressor link cell proliferation to metabolic regulation.  Journal of Biology 2003;2(4):Article 26. PubMed Abstract

Roelen BA, Cohen OS, Raychowdhury MK, Chadee DN, Zhang Y, Kyriakis JM, Alessandrini AA, Lin HY.  Phosphorylation of threonine 276 in Smad4 is involved in transforming growth factor-β-induced nuclear accumulation.  American Journal Physiology - Cell Physiology 2003;285(4):C823-C830. PubMed Abstract

Kuliopulos A, Covic L.  Blocking receptors from the inside: Peducin-based intervention of PAR signaling and thrombosis.  Life Sciences 2003;74:255-262. PubMed Abstract

Shearman AM, Cupples LA, Demissie S, Peter I, Schmid CH, Karas RH, Mendelsohn ME, Housman DE, Levy D.  Association between estrogen receptor α gene variation and cardiovascular disease. (SCOR) The Journal of the American Medical Association 2003;290(17):2263-2270. PubMed Abstract

Ku M, Stewart S, Hata A.  Poly(ADP-ribose) polymerase 1 interacts with OAZ and regulates BMP-target genes.  Biochemical and Biophysical Research Communications 2003;311(3):702-707. PubMed Abstract

Mendelsohn ME, Rosano GMC.  Hormonal regulation of normal vascular tone in males. (SCOR) Circulation Research 2003;93(12):1142-1145. PubMed Abstract

Pourati I, Kimmelstiel C, Rand W, Karas RH.  Statin use is associated with enhanced collteralization of severely diseased coronary arteries.  American Heart Journal 2003;146(5):876-881. PubMed Abstract

Welzig CM, Shin D-G, Park H-J, Kim Y-J, Saul JP, Galper JB.  Lipid lowering by pravastatin increases parasympathetic modulation of heart rate: Gαι2, a possible molecular marker for parasympathetic responsiveness.  Circulation 2003;108(22):2743-2746. PubMed Abstract

Udelson JE, Patten RD, Konstam MA.  New concepts in post-infarction ventricular remodeling.  Reviews in Cardiovascular Medicine 2003;4(3):S3-S12. PubMed Abstract

Martemyanov KA, Lishko PV, Calero N, Keresztes G, Sokolov M, Strissel KJ, Leskov IB, Hopp JA, Kolesnikov AK, Chen CK, Lem J, Heller S, Burns ME, Arshavsky VY.  The DEP domain determines subcellular targeting of the GTPase activating protein RGS9 in vivo.  Journal Neurosci 2003;23(32):10175-10181. PubMed Abstract

Jacques SL, Kuliopulos A.  Protease-activated receptor-4 uses dual prolines and an anionic retention motif for thrombin recognition and cleavage.  Biochem Journal 2003;376:733-740. PubMed Abstract

Covic L, Jacques SL, Kuliopulos A.  Inhibition of platelet thromboxane receptor function by a thrombin receptor-targeted pepducin.  Nature Medicine 2003;9(12):1447-1448.

Seeley S, Covic L, Jacques SL, Sudmeier J, Baleja JD, Kuliopulos A.  Structural basis for thrombin activation of a protease-activated receptor: Inhibition of intramolecular liganding.  Chemistry and Biology 2003;10(11):1033-104. PubMed Abstract

Surks HK, Richards CT, Mendelsohn ME.  Myosin phosphatase-RhoA interacting protein: A new member of the myosin phosphatase complex that directly binds RhoA. (SCOR) The Journal of Biological Chemistry 2003;278(51):51484-51493. PubMed Abstract

Mendelsohn ME.  WHI Publishes additional data analysis regarding CHD effects with EPT (Commentary). (SCOR) North American Menopause Society First-to-Know Series, 2003.

Morin DP, Konstam MA, Mendelsohn ME, Udelson JE.  Heart failure in women: Epidemiology, gender differences in pathophysiology, and implecations for therapy. In. (SCOR) Women and Coronary Disease, 2003;Shaw LJ, Redberg RF (eds.), Humana Press.Chapter 6:65-91.

Tang M, Wang G, Lu P, Karas RH, Aronovitz M, Heximer SP, Kaltenbronn KM, Blumer KJ, Siderovski DP, Zhu Y, Mendelsohn ME.  Regulator of G-protein signaling 2 mediator vascular smooth muscle relaxation and blood pressure. (SCOR) Nature Medicine 2003;9(12):1506-1512. PubMed Abstract

Konstam MA, Patten RD.  Inhibition of the renin-angiotensin system. In.  Heart Failure Management: A Companion to Braunwald’s Heart Disease, 2003;W.B. Saunders, New York.Chapter 38:603-618.

Van Eickels M, Patten RD, Aronovitz MJ, Alsheikh-Ali A, Gostyla K, Celestin F, Grohe C, Mendelsohn ME, Karas RH.  17-β-estradiol increases cardiac remodeling and mortality in mice with myocardial infarction.  See correction at volume 42(1). (SCOR) Journal of the American College of Cardiology 2003;41(11):2084-2092. PubMed Abstract

Thompson PD, Clarkson P, Karas RH.  Statin-associated myopathy.  The Journal of the American Medical Association 2003;289(13):1681-1690. PubMed Abstract

Surks HK, Mendelsohn ME.  Dimerization of cGMP-dependent protein kinase 1β and the myosin binding subunit of myosin phosphatase: Role of leucine zipper domains. (SCOR) Cellular Signalling 2003;15(10):937-944. PubMed Abstract

Kuvin JT, Gokce N, Holbrook M, Hunter LM, Patel AR, Sliney KA, Craven DE, Grayston JT, Keaney JF, Karas RH, Vita JA.  Effect of short-term antibiotic treatment on chlamydia pneumoniae and peripheral endothelial function.  The American Journal of Cardiology 2003;91(6):732-735. PubMed Abstract

Haq S, Michael A, Andreucci M, Bhattacharya K, Dotto P, Walters B, Woodgett J, Kilter H, Force T.  Stabilization of β-catenin by a wnt-independent mechanism regulates cardiomyocyte growth.  Proceedings of the National Academy of Sciences, USA 2003;100(8):4610-4615. PubMed Abstract

Karas RH, Gauer EA, Bieber HE, Baur WE, Mendelsohn ME.  Growth factor activation of the estrogen receptor in vascular cells occurs via a mitogen-activated protein kinase-independent pathway.  Journal of Clinical Investigation 1998;101(12):2851-2861. PubMed Abstract

Beinborn M, Quinn SM, Kopin AS.  Minor modifications of a cholecystokinin-B/gastrin receptor non-peptide antagonist confer a broad spectrum of functional properties.  Journal of Biological Chemistry 1998;273(23):14146-14151. PubMed Abstract

Lindner V, Kim SK, Karas RH, Kuiper GJM, Gustafsson J, Mendelsohn ME.  Increased expression of estrogen-receptor-β mRNA in male blood vessels after vascular injury.  Circulation Research 1998;83:224-229. PubMed Abstract

Schaffer K, McBride EW, Beinborn M, Kopin AS.  Interspecies polymorphisms confer consitutive activity to the Mastomys cholecystokinin-B/gastrin receptor.  Journal of Biological Chemistry 1998;273(44):28779-28784. PubMed Abstract

Berul CI, Christe ME, Aronovitz MJ, Maguire CT, Seidman CE, Seidman JG, Mendelsohn ME.  Familial hypertrophic cardiomyopathy mice display gender differences in electrophysiological abnormalities.  Journal Interv Cardiovasc Electrophys 1998;2:7-14. PubMed Abstract

Bläker M, Ren Y, Gordon MC, Hsu JE, Beinborn M, Kopin AS.  Mutations within the cholecystokinin-B/gastrin receptor ligand ‘pocket’ interconvert the functions of nonpeptide agonists and antagonists.  Molecular Pharmacology 1998;54:857-863. PubMed Abstract

Wang G-R, Zhu Y, Halushka P, Lincoln T, Mendelsohn ME.  Mechanism of platelet inhibition by nitric oxide: In vivo phosphorylation of thromboxane receptor by cyclic GMP-dependent protein kinase.  Proceedings of the National Academy of Sciences, 1998;USA 95:4888-4893. PubMed Abstract

Karas RH, Mendelsohn ME.  Rapid vasomotor effects of estrogen: Men are part of the club.  Chest (Editorial) 1998;114(6):1508-1509. PubMed Abstract

Estes NAM, Mendelsohn ME.  Molecular biology of human arrhythmias: Implications for the clinical electrophysiologist.  Journal Interv Cardiovasc Electrophys 1998;2(4):321-324. PubMed Abstract

Patten RD, Aronovitz MJ, Deras-Mejia L, Pandian N, Hanak GG, Smith JJ, Mendelsohn ME, Konstam MA.  Ventricular remodeling in a mouse model of myocardial infarction.  American Journal Physiol 1998;274:H1812-H1820. PubMed Abstract

Thomas SA, Schuessler RB, Berul CI, Beardslee MA, Beyer EC, Mendelsohn ME, Saffitz JE.  Disparate effects of deficient expression of connexin43 on atrial and ventricular conduction: Evidence for chamber-specific molecular determinants of conduction.  Circulation 1998;97(7):686-691. PubMed Abstract

Rindi G, Langhans N, Rehfeld JF, Beinborn M, Kopin AS.  Abnormal gastric morphology and function in CCK-B/gastrin receptor-deficient mice.  Yale Journal of Biology and Medicine 1998;71:347-354. PubMed Abstract

Beinborn M, Chen C, DeMeo L, McBride EW, Kopin AS.  Small synthetic ligands of the cholecystokinin-B/gastrin receptor can mimic the function of endogenous peptide hormones.  Yale Journal of Biology and Medicine 1998;71:337-346. PubMed Abstract

Taylor K, Patten RD, Smith JJ, Aronovitz M, Wight J, Salomon RN, Konstam MA.  Divergent effects of angiotensin converting enzyme inhibition and angiotensin II – receptor Anatagonism on myocardial cellular proliferation and collagen deposition after myocardial infarction in rats.  Journal of Cardiovascular Pharmacology 1998;31(5):654-660. PubMed Abstract

Kilgallen CM, Jackson E, Bankoff M, Salomon RN, Surks HK.  A case of giant cell myocarditis and malignant thymoma: A postmortem diagnosis by needle biopsy.  Clinical Cardiology 1998;21(1):48-51. PubMed Abstract

Patten RD, Udelson JE, Konstam MA.  Ventricular remodeling and its prevention in the treatment of heart failure.  Current Opinion in Cardiology 1998;13:162-167.  PubMed Abstract

Kopin AS, Mathes WF, McBride EW, Nguyen M, Al-Haider W, Schmitz F, Bonner-Weir S, Kanarek R, Beinborn M.  The cholecystokinin-A receptor mediates inhibition of food intake yet is not essential for the maintenance of body weight.  Journal of Clinical Investigation 1999;103(3):383-391. PubMed Abstract

Lem J, Krasnoperova NV, Calvert PD, Kosaras B, Cameron DA, Nicolo M, Makino CL, Sidman R.  Morphological, physiological and biochemical changes in rhodopsin knockout mice.  Proceedings of the National Academy of Sciences, USA 1999;96:736-741. PubMed Abstract

Pace MC, Chambliss KL, German Z, Yuhanna IS, Mendelsohn ME, Shaul PW.  Establishment of an immortablized fetal intrapulmonary artery endothelial cell line.  American Journal Physiol 1999;277(21):L106-L112. PubMed Abstract

Michael SK, Brennan J, Robertson EJ.  Efficient gene-specific expression of cre recombinase in the mouse embryo by targeted insertion of a novel IRES-Cre cassette into endogenous loci.  Mechanisms of Development 1999;85:35-47. PubMed Abstract

Frederick J, Krasnoperova N, Hoffmann K, Baehr W, Lem J, Klaus R.  Retinal degeneration is accelerated when a mutant rhodopsin transgene is expressed on a haploid or null rhodopsin background. In.  Retinal Degenerative Diseases and Experimental Therapy, 1999;Hollyfield JG (ed.), Plenum Publishers.Chapter 10:105-115.

Saba S, VanderBrink B, Luciano B, Aronovitz MJ, Berul CI, Reddy S, Housman D, Mendelsohn ME, Estes NA, Wang PJ.  Localization of the sites of conduction abnormalities in a mouse model of myotonic dystrophy.  Journal Clin Electrophys 1999;10(9):1214-1220. PubMed Abstract

Surks HK, Mochizuki N, Kasai Y, Georgescu S, Tang M, Ito M, Lincoln TM, Mendelsohn ME.  Regulation of myosin phosphatase by a specific interaction with cGMP-dependent protein kinase 1α.  Science 1999;286:1583-1587. PubMed Abstract

Karas RH, Hodgins JB, Kwoun M, Krege JH, Aronovitz M, Mackey W, Gustafsson JA, Korach KS, Smithies O, Mendelsohn ME.  Estrogen inhibits the vascular injury response in estrogen receptor β-deficient female mice.  Proceedings of the National Academy of Sciences, USA 1999;96(26):15133-15136. PubMed Abstract

VanderBrink BA, Link MS, Aronovitz MJ, Saba S, Sloan SB, Homoud MK, Estes III NAM, Wang PJ.  Assesment of antrioventricular nodal physiology in the mouse.  Journal Interv Cardiovasc Electrophys 1999;3(3):207-212. PubMed Abstract

Mendelsohn ME, Karas RH.  Mechanisms of Disease: The protective effects of estrogen on the cardiovascular system.  New England Journal of Medicine 1999;340(23):1801-1811. PubMed Abstract

Chen Z, Yuhanna IS, Galcheva-Gargova Z, Karas RH, Mendelsohn ME, Shaul PW.  Estrogen receptor α mediates nongenomic activation of endothelial nitric oxide synthase by estrogen.  Journal of Clinical Investigation 1999;103(3):401-406. PubMed Abstract

Berul CI, Maguire CT, Aronovitz MJ, Greenwood J, Miller C,Gehrmann J, Housman D, Mendelsohn ME, Reddy S.  DMPK dosage alterations result in atrioventricular conduction abnormalities in a mouse myotonic dystrophy Model.  Journal of Clinical Investigation 1999;103(4):R1-R7. PubMed Abstract

Kuliopulos A, Covic L, Seeley SK, Sheridan PJ, Helin J, Costello CE.  Plasmin desensitization of the PAR1 thrombin receptor: Kinetics, sites of truncation and implications for thrombolytic therapy.  Biochemistry 1999;38(14):4572-4585. PubMed Abstract

Blomberg PJ, Surks HK, Long A, Rebeiz E, Mochizuki Y, Pandian N.  Transient myocardial dysfunction associated with angiotensin-converting enzyme inhibitor-induced angioedema: Recognition by serial echocardiographic studies.  Journal of the American Society of Echocardiography 1999;12(12):1107-1109. PubMed Abstract

Foran SE, Carr DB, Lipkowski AW, Maszczynska I, Marchand JE, Misicka A, Beinborn M, Kopin AS, Kream RM.  A substance P-opoid chimeric peptide as a unique nontolerance-forming analgesic.  Proceedings of the National Academy of Sciences, USA 2000;97(13):7621-7626. PubMed Abstract

Ji B, Kopin AS, Logsdon CD.  Species differences between rat and mouse CCK-A receptors determine the divergent acinar cell response to the cholecystokinin analog JMV-180.  Journal of Biological Chemistry 2000;275(25):19115-19120. PubMed Abstract

Covic L, Gresser AL, Kuliopulos A.  Biphasic kinetics of activation and signaling for PAR1 and PAR4 thrombin receptors in platelets.  Biochemistry 2000;39(18):5458-5467. PubMed Abstract

Santos BF, Serrano SMT, Kuliopulos A, Niewiarowski S.  Interaction of viper venom serine peptidases with thrombin receptors on human platelets.  Federation of European Biochemical Societies Letters 2000;477:199-202. PubMed Abstract

Cox DH, Aldrich RW.  Role of the β1 subunit in large-conductance Ca2+-activated K+ channel gating energetics: Mechanisms of enhanced Ca2+ sensitivity.  Journal of General Physiology 2000;116:411-432. PubMed Abstract

Jacques SL, LeMasurier M, Sheridan PJ, Seeley S, Kuliopulos A.  Substrate-assisted catalysis of the PAR1 thrombin receptor: Enhancement of macromolecular association and cleavage.  Journal of Biological Chemistry 2000;275(52):40671-40678. PubMed Abstract

Konstam MA, Patten RD, Thomas I, Ramahi T, La Bresh K, Goldman S, Lewis W, Gradman A, Self  KS, Bittner V, Rand W, Kinan D, Smith JJ, Ford T, Segal R, Udelson JE.  Effects of losartan and captopril on left ventricular volumes in elderly patients with heart failure:  Results of the ELITE ventricular function substudy.  American Heart Journal 2000;139(6):1081-1087. PubMed Abstract

Patten RD, Udelson JE, Konstam MA.  Left Ventricular dysfunction and heart failure following myocardial infarction: Early intervention in high-risk patients. In.  Heart Failure Management, 2000;Sharpe N. (ed.), Martin Dunitz, LTD, London.Chapter 14:183-198.

Foran SE, Carr DB, Lipkowski AW, Maszczynska I, Marchand JE, Misicka A, Beinborn M, Kopin AS, Kream RM.  Inhibition of morphine tolerance development by a substance P-opiod peptide chimera.  Journal of Pharmacology and Experimental Therapeutics 2000;295(3):1142-1148. PubMed Abstract

Mendelsohn ME.  Mechanisms of estrogen action in the cardiovascular system.  Journal of Steroid Biochemistry and Molecular Biology 2000;74(5):337-343. PubMed Abstract

Mendelsohn ME.  Nongenomic, estrogen receptor-mediated activation of endothelial nitric oxide synthase: How does it work? What does it mean? (SCOR) Circulation Research 2000;87:956-960. PubMed Abstract

Chambliss KL, Yuhanna IS, Mineo C, Liu P, German Z, Sherman TS, Mendelsohn ME, Anderson RGW, Shaul PW.  Estrogen receptor α and endothelial nitric oxide synthase are organized into a functional signaling module in caveolae. (SCOR) Circulation Research 2000;87:e44-e52. PubMed Abstract

Mendez A, Burns M, Roca A, Lem J, Wu LW, Simon MI, Baylor DA, Chen J.  Rapid and reproducible deactivation of rhodopsin requires multiple phosphorylation sites.  Neuron 2000;28:153-164. PubMed Abstract

Calvert PD, Krasnoperova NV, Lyubarsky AL, Isayama T, Nicolo M, Kosaras B, Wong G, Gannon KS, Margolskee RF, Sidman RL, Pugh EN Jr, Makino CL, Lem J.  Phototransduction in transgenic mice after targeted deletion of the rod transducin α-subunit.  Proceedings of the National Academy of Sciences, USA 2000;97(25):13913-13918. PubMed Abstract

Nagy L, Morales RE, Beinborn M, Vattay P, Szabo S.  Investigation of gastroprotective compounds at subcellular level in isolated gastric mucosal cells.  American Journal Physiol Gastrointes Liver Physiol 2000;279:G1201-G1208. PubMed Abstract

Swift S, Sheridan PJ, Covic L, Kuliopulos A.  PAR1 thrombin receptor-G protein interactions: Separation of binding and coupling determinants in the Gα subunit.  Journal of Biological Chemistry 2000;275(4):2627-2635. PubMed Abstract

Poelzel G, Kasai Y, Mochizuki N, Shaul PW, Brown M, Mendelsohn ME.  Specific association of estrogen receptor β with a cell cycle spindle assembly checkpoint protein, MAD2.  Proceedings of the National Academy of Sciences, USA 2000;97(6):2836-2839. PubMed Abstract

Mendez A, Krasnoperova NV, Lem J, Chen J.  Functional study of rhodopsin phosphorylation in vivo.  Methods in Enzymology 2000;316:167-185. PubMed Abstract

Vanderbrink BA, Gilbride C, Aronovitz MJ, Lenihan T, Schorn G, Taylor K, Guetersloh M, Carr K, Schoen FJ, Homoud MK, Estes NAM, Wang PJ.  Safety and efficacy of a steerable temporature monitoring microwave catheter system for ventricular myocardial ablation.  Journal of Cardiovascular Electrophysiology 2000;11(3):305-310. PubMed Abstract

Bläker M, Ren Y, Seshadri L, McBride EW, Beinborn M, Kopin AS.  CCK-B/gastrin receptor transmembrane domain mutations selectively alter synthetic agonist efficacy without affecting the activity of endogenous peptides.  Molecular Pharmacology 2000;58:399-406. PubMed Abstract

Kopin AS, McBride EW, Schaffer K, Beinborn M.  CCK receptor polymorphisms: An illustration of emerging themes in pharmacogenomics.  Trends in Pharmacol Sciences 2000;21(9):346-353. PubMed Abstract

Patten RD, Konstam MA.  Ventricular remodeling and the renin angiotensin aldosterone system.  Congestive Heart Failure 2000;6(4):187-192.  PubMed Abstract

Karas RH, Schulte H, Pare G, Aronovitz MJ, Ohlsson C, Gustafsson J-A, Mendelsohn, ME.  Effects of estrogen on the vascular injury response in estrogen receptor α,β (double) knockout mice. (SCOR) Circulation Research 2001;89(6):534-539. PubMed Abstract

Yuhanna IS, Zhu Y, Cox BE, Hahner LD, Osborne-Lawrence S, Lu P, Marcel YL,  Anderson RGW, Mendelsohn ME, Hobbs HH, Shaul PW.  High-density lipoprotein binding to scavenger receptor-BI activates endothelial nitric oxide synthase. (SCOR) Nature Medicine 2001;7(7):853-857. PubMed Abstract

Karas RH, Eickels MV, Lydon JP, Roddy S, Kwoun M, Aronovitz M, Baur WE, Conneely O, O’Malley BW, Mendelsohn ME.  A Complex role for the progesterone receptor in the response to vascular injury. (SCOR) Journal of Clinical Investigation 2001;108(4):611-618. PubMed Abstract

Frederick JM, Krasnoperova NV, Hoffman K, Church-Kopish J, Ruther K, Howes K, Lem J, Baehr W.  Mutant rhodopsin transgene expressed on a null background.  Investigative Ophthalmology & Visual Science 2001;42(3):826-833. PubMed Abstract

Tan E, Wang Q, Quiambao AB, Xu X, Qtaishat NM, Peachey NS, Lem J, Fliesler SJ, Pepperberg DR, Naash MI, Al-Ubaidi MR.  The relationship between opsin overexpression and photoreceptor degeneration.  Investigative Ophthalmology & Visual Science 2001;42(3):589-600. PubMed Abstract

Calvert PD, Govardovskii VI, Krasnoperova N, Anderson RE, Lem J, Makino CL.  Membrane protein diffusion sets the speed of rod phototransduction.  Nature 2001;411:90-94. PubMed Abstract

Liang F, Dejneka N, Cohen D, Krasnoperova NV, Lem J, Maguire AM, Dudus L, Fisher KJ, Bennett J.  AAV-Mediated delivery of ciliary neurotrophic factor prolongs photoreceptor survival in the rhodopsin knockout mouse.  Molecular Therapy 2001;3(2):241-248. PubMed Abstract

Tibaduiza EC, Chen C, Beinborn M.  A small molecule ligand of the glucagon-like peptide 1 receptor targets its amino-terminal hormone binding domain.  Journal of Biological Chemistry 2001;276(41):37787-37793. PubMed Abstract

Mendelsohn ME, Karas RH.  The time has come to stop letting the HERS tale wag the Dogma (Editorial). (SCOR) Circulation 2001;104:2256-2259. PubMed Abstract

Azam M, Andrabi SS, Sahr KE, Kamath L, Kuliopulos A, Chishti AH.  Disruption of the mouse µ-calpain gene reveals an essential role in platelet function.  Molecular and Cellular Biology 2001;21(6):2213-2220. PubMed Abstract

Kuvin JT, Patel AR, Sliney KA, Pandian NG, Rand WM, Udelson JE, Karas RH.  Peripheral vascular endothelial function testing as a noninvasive indicator of coronary artery disease.  Journal of the American College of Cardiology 2001;38(7):1843-1849. PubMed Abstract

Patel AR, Kuvin JT, Pandian NG, Smith JJ, Udelson JE, Mendelsohn ME, Konstam MA, Karas RH.  Heart failure etiology affects peripheral vascular endothelial function after cardiac transplantation.  Journal of the American College of Cardiology 2001;37(1):195-200. PubMed Abstract

Mendelsohn ME.  Sex steroids in the cardiovascular system: Molecular mechanisms in action. In.  Cardio and HRT, 2001;Parthenon Publishing Group.Chapter 11:87-93.

Kuvin JT, Patel AR, Karas RH.  Need for standardization of noninvasive assessment of vascular endothelial function.  American Heart Journal 2001;141(3):327-328. PubMed Abstract

Hata A.  TGF β Signaling and Cancer.  Experimental Cell Research 2001;264(1):111-116. PubMed Abstract

Kamath L, Meydani A, Foss F, Kuliopulos A.  Signaling from protease-activated receptor-1 inhibits migration and invasion of breast cancer cells.  Cancer Research 2001;61:5933-5940. PubMed Abstract

Wyckoff  MH, Chambliss KL, Mineo C, Yuhanna IS, Mendelsohn ME, Mumby SM, Shaul PW.  Plasma membrane estrogen receptors are coupled to endothelial nitric-oxide synthase through Gαι. (SCOR) Journal of Biological Chemistry 2001;276(29):27071-27076. PubMed Abstract

Karas AZ, Aronovitz M, Wolfe EM, Karas RH.  Diminished body weight and activity patterns in mice following surgery: Implications for post procedural pain/distress inlaboratory animals.  Comtemp Top Lab Animal Sciences 2001;40(4):83-83.

Mosca L, Collins P, Herrington DM, Mendelsohn ME, Pasternak RC, Robertson RM, Schenck-Gustafsson K, Smith SC, Taubert KA, Wenger NK.  Hormone replacement therapy and cardiovascular disease: A statement for healthcare pofessionals from the American Heart Association. (SCOR) Circulation 2001;104:499-503. PubMed Abstract

Nuedling S, Karas RH, Mendelsohn ME, Katzenellenbogen JA, Katzenellenbogen BS, Meyer R, Vetter H, Grohe C.  Activation of estrogen receptor β is a prerequisite for estrogen-dependent upregulation of nitric oxide synthases in neonatal rat cardiac myocytes. (SCOR) Federation of European Biochemical Societies Letters 2001;25085:1-6. PubMed Abstract

Aikawa R, Huggins GS, Snyder RO.  Cardiomyocyte-specific gene expression following recombinant adeno-associated viral vector transduction.  Journal of Biological Chemistry 2002;277(21):18979-18985. PubMed Abstract

Hao W, Wenzel A, Obin MS, Chen C-K, Brill E, Krasnoperova NV, Eversole-Cire P, Kleyner Y, Taylor A, Simon MI, Grimm C, Remé CE, Lem J.  Evidence for two apoptotic pathways in light-induced retinal degenerations.  Nature 2002;Genetics 32(2):254-260. PubMed Abstract

Woodruff ML, Sampath AP, Matthews HR, Krasnoperova NV, Lem J, Fain GL.  Measurement of cytoplasmic calcium concentration in the rods of wild-type and transducin knock-out mice.  Journal of Physiology 2002;542(3):843-854. PubMed Abstract

Covic L, Gresser AL, Talavera J, Swift S, Kuliopulos A.  Activation and inhibition of G protein-coupled receptors by cell-penetrating membrane-tethered peptides.  Proceedings of the National Academy of Sciences, 2002;USA 99(2):643-648. PubMed Abstract

Covic L, Misra M, Badar J, Singh C, Kuliopulos A.  Pepducin-based intervention of thrombin-receptor signaling and systemic platelet activation.  Nature Medicine 2002;8(10):1161-1165. PubMed Abstract

Pare G, Krust A, Karas RH, Dupont S, Aronovitz M, Chambon P, Mendelsohn ME.  Estrogen Receptor-α mediates the protective effects of estrogen against vascular injury. (SCOR) Circulation Research 2002;90:1087-1092. PubMed Abstract

Kuvin J, Ramet M, Patel A, Pandian N, Mendelsohn M, Karas R.  A novel mechanism for the beneficial vascular effects of high-density lipoprotein cholesterol: Enhanced vasorelaxation and increased endothelial nitric oxide synthase expression. (SCOR) American Heart Journal 2002;144:165-172. PubMed Abstract

Hearn MG, Ren Y, McBride EW, Reveillaud I, Beinborn M, Kopin AS.  A drosophila dopamine 2-like receptor: Molecular characterization and identification of multiple alternatively spliced variants.  Proceedings of the National Academy of Sciences, USA 2002;99(22):14554-14559. PubMed Abstract

Chen D, Zhao C-M, Al-Haider W, Hakanson R, Rehfeld JF, Kopin AS.  Differentiation of gastric ECL cells is altered in CCK(2) receptor-deficient mice.  Gastroenterology 2002;123(2):577-585. PubMed Abstract

Joost O, Wilk JB, Cupples LA, Harmon M, Shearman AM, Baldwin CT, O'Connor GT, Myers RH, Gottlieb DJ.  Genetic loci influencing lung function: A genomewide scan in the framingham study. (SCOR) American Journal of Respiratory and Critical Care Medicine 2002;165:795-799. PubMed Abstract

Jordan B, Charest A, Dowd JF, Blumenstiel JP, Yeh R-F, Osman A, Housman DE, Landers JE.  Genome complexity reduction for SNP genotyping analysis. (SCOR) Proceedings of the National Academy of Sciences, 2002;USA 99(5):2942-2947. PubMed Abstract

Mishell DR, Mendelsohn ME.  Introduction: The role of hormone replacement therapy in prevention and treatment of cardiovascular disease in postmenopausal women. (SCOR) The American Journal of Cardiology 2002;89(12A):1E-4E. PubMed Abstract

Zhu Y, Bian Z, Lu P, Karas RH, Bao L, Cox D, Hodgin J, Shaul PW, Thoren P, Smithies O, Gustafsson J-A, Mendelsohn ME.  Abnormal vascular function and hypertension in mice deficient in estrogen receptor β. (SCOR) Science 2002;295:505-508. PubMed Abstract

Patten RD, Aronovitz MJ, Bridgeman P, Pandian NG.  Use of pulse wave and color flow doppler echocardiography in mouse models of human disease.  Journal of the American Society of Echocardiography 2002;15:708-714. PubMed Abstract

Force T, Haq S, Kilter H, Michael A.  Apoptosis signal-regulating kinase/nuclear factor-κB: A novel signaling pathway regulates cardiomyocyte hypertrophy (Editorial).  Circulation 2002;105:402-404. PubMed Abstract

Lyubarsky AL, Lem J, Chen J, Falsini B, Iannaccone A, Pugh Jr EN.  Functionally rodless mice: Transgenic models for the investigation of cone function in retinal disease and therapy.  Vision Research 2002;42:401-415. PubMed Abstract

Sherman TS, Chambliss KL, Gibson LL, Pace MC, Mendelsohn ME, Pfister SL, Shaul PW.  Estrogen acutely activates prostacyclin synthesis in ovine fetal pulmonary artery endothelium. (SCOR) American Journal of Respiratory Cell and Molecular Biology 2002;26(5):610-616. PubMed Abstract

Bao L, Rapin AM, Holmstrand EC, Cox DH.  Elimination of the BK(Ca) channel's high-affinity Ca(2+) sensitivity.  The Journal of General Physiology 2002;120:173-189. PubMed Abstract

Mendelsohn ME.  Genomic and nongenomic effects of estrogen in the vasculture. (SCOR) The American Journal of Cardiology 2002;90(suppl):3F-6F. PubMed Abstract

Karas RH.  Animal models of the cardiovascular effects of exognous hormones. (SCOR) The American Journal of Cardiology 2002;90(suppl):22F-25f. PubMed Abstract

Ihionkhan CE, Chambliss KL, Gibson LL, Hahner LD, Mendelsohn ME, Shaul PW.  Estrogen causes dynamic alterations in endothelial estrogen receptor expression.  Circulation Research 2002;91(9):814-820. PubMed Abstract

Saba S, Zhu W, Aronovitz MJ, Estes NAM, Wang PJ, Mendelsohn ME, Karas RH.  Effects of estrogen on cardiac electrophysiology in female mice. (SCOR) Journal of Cardiovascular Electrophysiology 2002;13:276-280. PubMed Abstract

Blaustein RO.  Kinetics of tethering quaternary ammonium compounds to K+ channels.  The Journal of General Physiology 2002;120:203-216. PubMed Abstract

Covic L, Singh C, Smith H, Kuliopulos A.  Role of the PAR4 thrombin receptor in stabilizing platelet-platelet aggregates as revealed by a patient with Hermansky-Pudlak Syndrome.  Thrombosis and Haemostasis 2002;87:722-727. PubMed Abstract

Holubkov R, Karas RH, Pepine CJ, Rickens CR, Reicheck N, Rogers WJ, Sharaf BL, Sopko G, Merz NB, Kelsey SF, McGorray SP, Reis SE.  Large brachial artery diameter is associated with angiographic coronary artery disease in women.  American Heart Journal 2002;143(5):802-807. PubMed Abstract

Lu Q, Ebling H, Mittler J, Baur WE, Karas RH.  MAP kinase mediates growth factor-induced nuclear translocation of estrogen receptor α.  Federation of European Biochemical Societies Letters 2002;516:1-8. PubMed Abstract