Errol Norwitz, MD, PhD is the Louis Phaneuf Professor and Chair of Obstetrics and Gynecology at Tufts University School of Medicine and Tufts Medical Center. Dr. Norwitz is a specialist in maternal-fetal medicine. His research interests include the genetics of adverse pregnancy outcome and the molecular regulation of labor and delivery, both term and preterm.
Dr. Norwitz is a former Rhodes Scholar. His research has been funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development and the March of Dimes.
The Objective of Norwitz Lab Research
The Norwitz laboratory has a number of complementary research initiatives all focused on a single overall objective: to improve the ability of obstetric care providers to predict and prevent preterm birth. Preterm birth (defined as delivery prior to 37 weeks of gestation) accounts for over 85% of all perinatal morbidity and mortality.
Preterm birth is the leading cause of perinatal death in non-anomalous newborns in the United States. Despite intense efforts, approximately 12.3% (1 in 8) of all deliveries in the United States are preterm, which translates into 500,000 premature infants each year in the United States alone.
The long-term goal of our research is to understand in detail the cellular and molecular mechanisms responsible for spontaneous preterm labor and birth with a view towards effectively delaying delivery until term thereby improving perinatal outcome. Individual research project include:
- Understanding the role of progesterone-progesterone receptor signaling in spontaneous preterm labor and birth
- Identification, characterization, and validation of biomarkers of preeclampsia
- GnRH-GnRHR signaling at the maternal-fetal interface