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Mother Infant Research Institute (MIRI)

Publications + Awards

Honors and Awards 

Our principal investigators and trainees have received a number of honors and awards for their leadership and accomplishments in research that advances the understanding of preterm birth and its complications, maternal obesity and fetal and neonatal genomic medicine. We are grateful for the recognition from our peers and the honors bestowed by international and national associations and institutions for our contributions.

Investigator Honors, Awards and Accomplishments

Andrea Edlow, MD, MSc

2014

  • CREOG & APGo National Faculty Award for Outstanding Resident Teacher

2013

  • Reproductive Scientist Development Program Award from NICHD/Washington University (only three awarded nationally annually)
  • Received the 2013-2014 American College of Obstetricians and Gynecologists/Abbott Nutrition Award in Nutrition in Pregnancy, only one of which is awarded nationally
  • Received the New England Perinatal Society’s award for the best presentation in maternal-fetal medicine

2012

  • Received the Dru Carlson Memorial Award from the Society for Maternal-Fetal Medicine for Best Research in Ultrasound and Genetics for her abstract "Decreased apoptosis in fetuses of obese women: implications for neurodevelopment"

Michael D. House, MD

2016

  • "Top Doctor", Boston Magazine

2012

  • Elected Vice-President New England Perinatal Research Society
  • Received the Award for the Best Poster at the 32nd annual meeting of the Society for Maternal Fetal Medicine, Dallas, TX 

Jill L. Maron, MD, MPH

2016

  • Appointed Vice Chair of Pediatric Research, Floating Hospital for Children at Tufts Medical Center
  • Named Interim Executive Director, Mother Infant Research Institute, Tufts Medical Center

2015

  • Received Mentor Award from the New England Perinatal Society

2014

  • Founded and Inaugurated the North American Saliva Symposium (NASS), an Interdisciplinary Meeting of over 80 Participants and World Leaders in Salivary Research covering the fields of  Dentistry, Medicine, and Industry

2013

  • Received the Young Physician-Scientist Award from the American Society for Clinical Investigation

2012

  • Selected as one of four early career speakers and named Abbott Nutrition Young Investigator at the annual Perinatal Research Society Meeting
  • Received a Gerber Foundation award for the grant application for "The NOurRISH Platform: Neonatal Oral-Feeding Readiness In Salivary High-Throughput Diagnostics"

2011

  • Received a Charlton award from Tufts University School of Medicine for the grant application “Understanding developmental transcriptional regulation in premature neonates learning to feed”
  • Participated in the NICHD workshop “Bringing the Vision Together,” a series of cross-disciplinary workshops and white papers on research, synergies, and opportunities

Errol R. Norwitz, MD, PhD

2016

  • "Top Doctor", Boston Magazine
  • Appointed Interim Chief Scientific Officer, Tufts Medical Center

2015

  • "Top Doctor", Boston Magazine

2014

  • "Top Doctor", Boston Magazine

2013 

  • Appointed Member, March of Dimes Transdisciplinary Centers (TDC) Advisory Committee
  • Appointed Member, Pregnancy and Neonatology (PN) Study Section, Center for Scientific Review, NIH/NICHD
  • "Top Doctor", Boston Magazine

2012  

  • Appointed to Editorial Board, British Journal of Obstetrics and Gynaecology
  • Appointed Member, Board of Directors, Tufts Medical Center Indemnity Company (TMCIC) 
  • Appointed Member, Board of Directors, Frontiers in Reproduction™
  • Named to Top Doctors in Boston

2011

  • Named in July 2011 US News & World Report Top Doctors (in MFM)
  • Named 2011 Boston Magazine Top Doctors (in MFM)
  • Received the March of Dimes Award for the Best Research in Prematurity, “Progesterone inhibits basal apoptosis in fetal membranes by altering expression of both pro- and anti-apoptotic proteins,” at the Society for Maternal Fetal Medicine annual meeting, San Francisco, CA 
  • Received the Award for Best Oral Presentation at the annual meeting of the Society for Maternal Fetal Medicine, San Francisco, CA

Tomo Tarui, MD

2014  

  • Sydney S. Gellis, MD, Young Physician Award for seeking to improve treatments, outcomes, and the quality of life of sick children
  • Appointed Program Director of Child Neurology Fellowship Program, Floating Hospital for Children, Tufts Medical Center

2013

  •  Susan Saltonsall Award, Floating Hospital for Children at Tufts Medical Center

2012   

  • Young Scientist Award, International Society for Prenatal Diagnosis     
  • Susan Saltonstall Award, Floating Hospital for Children at Tufts Medical Center
2011  
  • Clinical Research Training Fellowship Award,  American Academy of Neurology   
2010   
  • Baby Alex Foundation Grant, The Baby Alex Foundation
2009  
  • William Randolph Hearst Fund Fellowship, William Randolph Hearst Fund   

Trainee Awards and Accomplishments

Lisa Hui, MD (Research Fellow)

2012

  • Was one of 25 trainees to receive a Pfizer award to present her research results at the annual Society for Gynecological Investigation meeting

2011

  • Received an International Congress of Human Genetics Young Investigator Award to present her results at the International Congress of Human Genetics meeting in Montreal, CA

Stephanie Pritchard (MD, PhD student)

2011

  • Was one of four graduate students to receive a Sackler Dean’s Fellow Award. This pays for her stipend for academic year 2011-2012

Scientific Publications Authored by MIRI Principal Investigators

Mother Infant Research Institute Investigators hold the following Editorial Positions:

Jill L. Maron, MD, MPH
Section Editor, Youth and Children, Clinical Therapeutics

Errol R. Norwitz, MD, PhD
Editorial board, British Journal of Obstetrics and Gynaecology
Advisory board, American Journal of Obstetrics and Gynecology
Associate Editor & Editorial Board, Reproductive Sciences
Editorial board, Obstetrics and Gynecology International 
Peer Review Board, UpToDate, Wellesley, MA

The publications below feature scientific and clinical research being performed by investigators at MIRI.

2016 Publications

Benn P, Norwitz ER, Pergament E. Cell-free DNA vs sequential screening for the detection of fetal chromosomal abnormalities. Am J Obstet Gynecol 2016;215: 252-3.

Bianchi DW. Should we 'open the kimono' to release the results of rare autosomal aneuploidies following noninvasive prenatal whole genome sequencing? Prenat Diagn 2016;doi: 10.1002/pd.4993.

Brown JE, Partlow BP, Berman AM, House MD, Kaplan DL. Injectable silk-based biomaterials for cervical tissue augmentation: an in vitro study. Am J Obstet Gynecol 2016;214: 118.e1-9.

Chudova DI, Sehnert AJ, Bianchi DW. Copy-number variation and false positive prenatal screening results. N Engl J Med 2016;375: 97-8.

de Wert G, Dondorp W, Bianchi DW. Fetal therapy for Down syndrome: an ethical exploration. Prenat Diagn 2016;doi: 10.1002/pd.4995.

Deprest J, Ghidini A, Van Mieghem T, Bianchi DW, Faas B, Chitty LS. In case you missed it: the Prenatal Diagnosis editors bring you the most significant advances of 2015. Prenat Diagn 2016;36 :3-9.

Edlow AG. Maternal Obesity and neurodevelopmental and psychiatric disorders in Offspring Prenat Diagn 2016;doi: 10.1002/pd.4932.

Edlow AG, Edlow BL, Edlow JA. Diagnosis of acute neurologic emergencies in pregnant and postpartum women. Emerg Med Clin North Am 2016;34: 943-965.

Edlow AG, Guedj F, Pennings JL, Sverdlov D, Neri C, Bianchi DW. Males are from Mars, and females are from Venus: sex-specific fetal brain gene expression signatures in a mouse model of maternal diet-induced obesity. Am J ObstetGynecol 2016 Mar 3. pii: S0002-9378(16)00396-3. doi: 10.1016/j.ajog.2016.02.054.

Edlow AG, Hui L, Wick HC, Fried I, Bianchi DW. Assessing the fetal effects of maternal obesity via transcriptomic analysis of cord blood: a prospective case-control study. BJOG 2016;123: 180-9.

Ezzedine D, Norwitz ER. Are women with uterine fibroids at increased risk for adverse pregnancy outcome? Clin Obstet Gynecol 2016;59: 119-27.

Ferrés MA, Bianchi DW, Siegel AE, Bronson RT, Huggins GS, Guedj F. Perinatal natural history of the Ts1Cje mouse model of Down syndrome: growth restriction, early mortality, heart defects, and delayed development. PLoS One 2016;11:e0168009.

Guedj F, Pennings JL, Massingham LJ, Wick HC, Siegel AE, Tantravahi U, Bianchi DW. An integrated human/murine transcriptome and pathway approach to identify prenatal treatments for Down syndrome. Sci Rep 2016;6 :32353.

Hui L, Bianchi DW. Noninvasive Prenatal DNA Testing: The vanguard of genomic medicine. Annu Rev Med 2016;http://www.annualreviews.org/action/showCitFormats?doi=10.1146%2Fannurev-med-072115-033220.

Kim SM, Cho BK, Kang MJ, Norwitz ER, Lee SM, Lee J, Park CW, Kim BJ, Jun JK,Yi EC, Park JS. Expression changes of proteins associated with the development of preeclampsia in maternal plasma: A case-control study. Proteomics 2016; Mar 22. doi: 10.1002/pmic.201500381.

Ghidini A, Bianchi DW, Levy B, Deprest J, van Mieghem T, Chitty LS, McLean-Inglis A. The 2015 Malcolm Ferguson-Smith Young Investigator Award. Prenat Diag 2016;36 :599-600.

Lee SM, Park JS, Norwitz ER, Panyavatthanasinh S, Kim SM, Lee J, Park CW, Kim BJ, Jun JK. Levels of adipokines in amniotic fluid and cord blood collected from dichorionic-diamniotic twins discordant for fetal growth. PLoS One 2016;11:e0154537.

Lekva T, Lyle R, Roland MC, Friis C, Bianchi DW, Jaffe IZ, Norwitz ER, Bollerslev J, Henriksen T, Ueland T. Gene expression in term placentas is regulated more by spinal or epidural anesthesia than by late-onset preeclampsia or gestational diabetes mellitus. Sci Rep 2016;6:29715.

Lekva T, Michelsen AE, Bollerslev J, Norwitz ER, Aukrust P, Henriksen T, Ueland T. Low circulating pentraxin 3 levels in pregnancy is associated with gestational diabetes and increased apoB/apoA ratio: a 5-year follow-up study. Cardiovasc Diabetol 2016;15: 23.

Lekva T, Norwitz ER, Aukrust P, Ueland T. Impact of systemic inflammation on the progression of gestational diabetes mellitus. Curr Diab Rep 2016;16: 26.

Maron JL. From bottles to diapers: how manipulating and exploring the microbiome is defining newborn care. Clin Ther 2016;38: 704-5.

Onoyama S, Qiu L, Low HP, Chang CI, Strohsnitter WC, Norwitz ER, Lopresti M, Edmiston K, Lee IM, Trichopoulos D, Lagiou P, Hsieh CC. Prenatal maternal physical activity and stem cells in umbilical cord blood. Med Sci Sports Exerc 2016;48 :82-9.

Snyder HL, Curnow KJ, Bhatt S, Bianchi DW. Follow-up of multiple aneuploidies and single monosomies detected by noninvasive prenatal testing: implications for management and counseling. Prenat Diag 2016;36: 203-9.

Tadesse S, Norwitz NG, Guller S, Arcuri F, Toti P, Norwitz ER, Kidane D. Dynamics of base excision repair at the maternal-fetal interface in pregnancies complicated by preeclampsia. Reprod Sci 2016;pii: 1933719116670519.

Tanamai VW, Seagle BL, Yeh JY, Brady B, Miller CB, Sena S, Dodge J, Shahabi S, Samuelson R, Norwitz ER, Luo G. Urine protein/creatinine ratios during labor: a prospective observational study. PLoS One 2016;11:e0160453.

Vaughan DA, Ruthazer R, Penzias AS, Norwitz ER, Sakkas D. Clustering of monozygotic twinning in IVF. J Assist Reprod Genet 2016;33: 19-26.

Zwemer LM, Nolin SL, Okamoto PM, Eisenberg M, Wick HC, Bianchi DW. Global transcriptome dysregulation in second trimester fetuses with FMR1 expansions. Prenat Diagn 2016;doi: 10.1002/pd.4928. 

2015 Publications

Bianchi DW, Chudova D, Sehnert AJ, Bhatt S, Murray K, Prosen TL, Garber JE, Wilkins-Haug L, Vora NL, Warsof S, Goldberg J, Ziainia T, Halks-Miller M. Noninvasive Prenatal Testing and Incidental Detection of Occult Maternal Malignancies. JAMA 2015;314:162-169.

Bianchi DW, Parsa S, Bhatt S, Halks-Miller M, Kurtzman K, Sehnert AJ, Swanson A. Fetal sex chromosome testing by maternal plasma DNA sequencing: clinical laboratory experience and biology. Obstet Gynecol 2015;125:375-82.

Bianchi DW. Pregnancy: Prepare for unexpected prenatal test results. Nature.2015;522:29-30. doi: 10.1038/522029a

Edlow AG, Slonim DK, Wick HC, Hui L, Bianchi DW. The pathway not taken: understanding 'omics data in the perinatal context. Am J Obstet Gynecol 2015;213:59.e1-59.e172.

Edlow AG, Slonim DK, Wick HC, Hui L, Bianchi DW. The pathway not taken: understanding 'omics data in the perinatal context. Am J Obstet Gynecol. 2015;213:59.e1-59.e172.

Fernandez M, House M, Jambawalikar S, Zork N, Vink J, Wapner R, Myers K. Investigating the mechanical function of the cervix during pregnancy using finite element models derived from high-resolution 3D MRI. Comput Methods Biomech Biomed Engin 2015;13:1-14.

Guedj F, Pennings JL, Ferres MA, Graham LC, Wick HC, Miczek KA, Slonim DK, Bianchi DW. The fetal brain transcriptome and neonatal behavioral phenotype in the Ts1Cje mouse model of Down syndrome. Am J Med Genet A 2015. doi:10.1002/ajmg.a.37156.

Guedj F, Pennings JL, Wick HC, Bianchi DW. Analysis of adult cerebral cortex and hippocampus transcriptomes reveals unique molecular changes in the Ts1Cje mouse model of down syndrome. Brain Pathol 2015;25:11-23.

 Iyengar A, Maron JL. Detecting infection in neonates: promises and challenges of a salivary approach. Clin Ther 2015 Mar 1;37(3):523-8.

Lee SM, Park JS, Norwitz ER, Oh S, Kim EJ, Kim SM, Lee J, Kim BJ, Park CW, JunJK. Mid-trimester amniotic fluid pro-inflammatory biomarkers predict the risk of spontaneous preterm delivery in twins: a retrospective cohort study. J Perinatol 2015;doi: 10.1038/jp.2015.29.

Maron JL, Hwang JS, Pathak S, Ruthazer R, Russell RL, Alterovitz G. Computational gene expression modeling identifies salivary biomarker analysis that predict oral feeding readiness in the newborn. J Pediatr 2015 Feb;166:282-8.e5.

Maron JL. Bringing salivary diagnostics into the 21st century. Clin Ther. 2015;37(3):496-7.

Med 2015;65:140-3.

Myers KM, Feltovich H, Mazza E, Vink J, Bajka M, Wapner RJ, Hall TJ, House M. The mechanical role of the cervix in pregnancy. J Biomech 2015;48:1511-23.

Norwitz ER, Bonney EA, Snegovskikh VV, Williams MA, Phillippe M, Park JS, Abrahams VM. Molecular Regulation of Parturition: The Role of the Decidual Clock. Cold Spring Harb Perspect Med 2015 pii: a023143.doi: 10.1101/cshperspect.a023143. 

Norwitz ER. Clarifying when to recommend progesterone to prevent preterm birth: clear as mud. BJOG 2015;122:92. doi: 10.1111/1471-0528.13108.

Noto K, Majidi S, Edlow AG, Wick HC, Bianchi DW, Slonim DK. CSAX: Characterizing Systematic Anomalies in eXpression Data. J Comput Biol. 2015;22:402-13.

PubMed PMID: 25772209; PubMed Central PMCID: PMC4485545.

Rosen T, Schulkin J, Power M, Tadesse S, Norwitz ER, Wen Z, Wang B. Comparative immunohistochemistry of placental corticotropin-releasing hormone and the transcription factor RelB-NFκB2 between humans and nonhuman primates. Comp

Young OM, Tang Z, Niven-Fairchild T, Tadesse S, Krikun G, Norwitz ER, Mor G, Abrahams VM, Guller S Toll-like receptor-mediated responses by placental Hofbauer cells (HBCs): a potential pro-inflammatory role for fetal M2 macrophages. Am J Reprod Immunol 2015;73:22-35.doi: 10.1111/aji.12336.

Zwemer LM, Bianchi DW. The amniotic fluid transcriptome as a guide to understanding fetal disease. Cold Spring Harb Perspect Med 2015;5. pii: a023101. doi: 10.1101/cshperspect.a023101.

2014 Publications

Bianchi DW, Oepkes D, Ghidini A. Current controversies in prenatal diagnosis 1: should noninvasive DNA testing be the standard screening test for Down syndrome in all pregnant women? Prenat Diagn 2014 ;34:6-11.

Bianchi DW, Parker RL, Wentworth J, Madankumar R, Saffer C, Das AF, Craig JA, Chudova DI, Devers PL, Jones KW, Oliver K, Rava RP, Sehnert AJ; CARE Study Group. DNA sequencing versus standard prenatal aneuploidy screening. NEJM 2014 370:799-808.

Bianchi DW, Van Mieghem T, Shaffer LG, Faas BH, Chitty LS, Ghidini A, Deprest J. In case you missed it: the Prenatal Diagnosis section editors bring you the most significant advances of 2013. Prenat Diagn 2014 34:1-5.

Edlow AG, Vora NL, Hui L, Wick HC, Cowan JM, Bianchi DW. Maternal obesity affects fetal neurodevelopmental and metabolic gene expression: a pilot study. PLoS One 2014 18;9:e88661.

Correa PJ, Vargas F, Sen S, Illanes SE. Prediction of gestational diabetes early in pregnancy: targeting the long term complications. Gynecol Obstetric Invest Epub ahead of print.

Ferres MA, Hui L, Bianchi DW. Antenatal noninvasive DNA testing: clinical experience and impact. Am J Perinatol 2014 [Epub ahead of print]

Guedj F, Bianchi DW, Delabar JM. Prenatal treatment of Down syndrome: a reality? Curr Opin Obstet Gynecol 2014;26:92-103.

Romano-Keeler J, Wynn JL, Maron JL. Great expectorations: the potential of salivary 'omic' approaches in neonatal intensive care. J Perinatol 2014;34:169-73.

Taglauer ES, Wilkins-Haug L, Bianchi DW. Review: cell-free fetal DNA in the maternal circulation as an indication of placental health and disease. Placenta. 2014 ;35 Suppl:S64-8.

van der Hoorn ML, van Egmond A, Swings GM, van Beelen E, van der Keur C,Tirado-González I, Blois SM, Karumanchi SA, Bianchi DW, Claas FH, Scherjon SA. Differential immunoregulation in successful oocyte donation pregnancies compared with naturally conceived pregnancies. J Reprod Immunol 2014;101-102:96-103.

Wick HC, Drabkin H, Ngu H, Sackman M, Fournier C, Haggett J, Blake JA, Bianchi DW, Slonim DK.
DFLAT: functional annotation for human development. 2014/15:45.

Bianchi DW, Wilkins-Haug L. Integration of noninvasive DNA testing for aneuploidy into prenatal care: what has happened since the rubber met the road? Clin Chem 2014 Jan;60:78-87.

Critchfield AS, McCabe R, Klebanov N, Richey L, Socrate S, Norwitz ER, Kaplan DL, House M. Biocompatibility of a sonicated silk gel for cervical injection during Pregnancy: in vivo and in vitro study. Reprod Sci 2014 Feb 11. [Epub ahead of print] 

Hoang M, Potter JA, Gysler SM, Han CS, Guller S, Norwitz ER, Abrahams VM. Human fetal membranes generate distinct cytokine profiles in response to bacterial toll-like receptor and nod-like receptor agonists. Biol Reprod 2014 Jan 15. [Epub ahead of print] 

House M, Tadesse-Telila S, Norwitz ER, Socrate S, Kaplan DL. Inhibitory effect of progesterone on cervical tissue formation in a three-dimensional culture system with human cervical fibroblasts. Biol Reprod 2014 Jan 30;90(1):18. doi:10.1095/biolreprod.113.112540. 

Kim YH, Park JS, Norwitz ER, Park JW, Kim SM, Lee SM, Park CW, Kim BJ, Koo JN,
Oh IH, Song YS. Genotypic prevalence of human papillomavirus infection during
normal pregnancy: a cross-sectional study. J Obstet Gynaecol Res 2014
Jan;40(1):200-7. doi: 10.1111/jog.12155. 

Rava RP, Srinivasan A, Sehnert AJ, Bianchi DW.Circulating fetal cell-free DNA fractions differ in autosomal aneuploidies and monosomy x. Clin Chem 2014 ;60:243-50.

Tadesse S, Kidane D, Guller S, Luo T, Norwitz NG, Arcuri F, Toti P, Norwitz ER. In vivo and in vitro evidence for placental DNA damage in preeclampsia. PLoS One 2014 Jan 22;9(1):e86791. doi:10.1371/journal.pone.0086791. eCollection 2014 Jan 22.

Tarui T, Limperopoulos C, Sullivan NR, Robertson RL, du Plessis AJ.Long-term developmental outcome of children with a fetal diagnosis of isolated inferior vermian hypoplasia.Arch Dis Child Fetal Neonatal Ed. 2014 Jan;99:F54-8. doi: 10.1136/archdischild-2013-304054.

Timmons BC, Reese J, Socrate S, Ehinger N, Paria BC, Milne GL, Akins ML, Auchus RJ, McIntire D, House M, Mahendroo M.Prostaglandins Are Essential for Cervical Ripening in LPS-Mediated Preterm Birth But Not Term or Antiprogestin-Driven Preterm Ripening.Endocrinology 2014;155:287-98

2013 Publications

Arkilo D, Nabizadeh S, Malek A, Tang J, Padulsky K, Khazanie U, Helm P, Wills K, Tarui, T. Pediatric internal carotid aneurysm as a complication of sphenoid sinusitis. J Pediatr Neurol 2012;10:297-300.

Bianchi DW, Prosen T, Platt LD, Goldberg JD, Abuhamad AZ, Rava RP, Sehnert AJ;
MatErnal BLood IS Source to Accurately diagnose fetal aneuploidy (MELISSA) Study
Group. Massively parallel sequencing of maternal plasma DNA in 113 cases of fetal
nuchal cystic hygroma. Obstet Gynecol. 2013;121:1057-1062.

Critchfield AS, Yao G, Jaishankar A, Friedlander RS, Lieleg O, Doyle PS,
McKinley G, House M, Ribbeck K. Cervical mucus properties stratify risk for
preterm birth. PLoS One. 2013;8:e69528. doi:10.1371/journal.pone.0069528.

Dao MC, Sen S, Iyer C, Klebenov D, Meydani SN.Obesity during pregnancy and fetal iron status: is Hepcidin the link? J Perinatol. 2013;33:177-81.

Durfee SM, Benson CB, Adams SR, Ecker J, House M, Jennings R, Katz D,Pettigrew C, Wolfberg A. Postnatal outcome of fetuses with the prenatal diagnosis of gastroschisis. J Ultrasound Med. 2013;32:407-12.

Guedj F, Bianchi DW. Noninvasive prenatal testing creates an opportunity for antenatal treatment of Down syndrome. Prenat Diagn. 2013;33:614-618.

Heard AJ, Socrate S, Burke KA, Norwitz ER, Kaplan DL, House MD. Silk-based
injectable biomaterial as an alternative to cervical cerclage: an in vitro study.
Reprod Sci. 2013;20:929-36.

House M, McCabe R, Socrate S. Using imaging-based, three-dimensional models of
the cervix and uterus for studies of cervical changes during pregnancy. Clin
Anat. 2013;26:97-104.

Hui L, Wick HC, Edlow AG, Cowan JM, Bianchi DW. Global gene expression
analysis of term amniotic fluid cell-free fetal RNA. Obstet Gynecol. 2013;121:1248-1254.

Hui L, Bianchi DW. Recent advances in the prenatal interrogation of the human
fetal genome. Trends Genet. 2013;29:84-91.

Kim SM, Park JS, Norwitz ER, Hwang EJ, Kang HS, Park CW, Jun JK. Acceleration
Time-to-Ejection Time Ratio in Fetal Pulmonary Artery Predicts the Development of Neonatal Respiratory Distress Syndrome: A Prospective Cohort Study. Am J
Perinatol. 2013. [Epub ahead of print]

Lee SM, Park JS, Norwitz ER, Koo JN, Oh IH, Park JW, Kim SM, Kim YH, Park CW,
Song YS. Risk of vertical transmission of human papillomavirus throughout
pregnancy: a prospective study. PLoS One. 2013;8e66368. doi:
10.1371/journal.pone.0066368.

Mulla MJ, Myrtolli K, Tadesse S, Stanwood NL, Gariepy A, Guller S, Norwitz ER,
Abrahams VM. Cutting-edge report: TLR10 plays a role in mediating bacterial
peptidoglycan-induced trophoblast apoptosis. Am J Reprod Immunol. 2013

Perez-Sepulveda A, España-Perrot PP, Norwitz ER, Illanes SE. Metabolic
pathways involved in 2-methoxyestradiol synthesis and their role in preeclampsia.
Reprod Sci. 2013:1020-1029.

Reaves AC, Bianchi DW. The role of social networking sites in medical
genetics research. Am J Med Genet A. 2013;161A:951-7.

Rosen H, Chiou GJ, Stoler JM, Mulliken JB, Tarui T, Meara JG, Estroff JA. Magnetic resonance imaging for detection of brain abnormalities in fetuses with cleft lip and/or cleft palate. Cleft Palate Craniofac J 2011;48:619-622.

Sen S, Iyer C, Klebenov D, Histed A, Aviles JA, Meydani SN. Obesity impairs cell-mediated immunity during the second trimester of pregnancy. Am J Obstet Gynecol. 2013;208:139.e1-8. doi: 10.1016/j.ajog.2012.11.004

Sen S, Iyer C, Meydani SN.  Obesity during pregnancy alters maternal oxidant balance and micronutrient status. Journal of Perinatology 2013. Epub ahead of print; doi: 10.1038/jp.2013.153

Srinivasan A, Bianchi DW, Huang H, Sehnert AJ, Rava RP. Noninvasive detection
of fetal subchromosome abnormalities via deep sequencing of maternal plasma. Am J
Hum Genet. 2013;92:167-176.

Tarui T, Limperopoulos C, Sullivan NR, Robertson RL, du Plessis AJ. Long-term developmental outcome of children with a fetal diagnosis of isolated inferior vermian hypoplasia.
Arch Dis Child Fetal Neonatal Ed. 2013 Aug 20. doi: 10.1136/archdischild-2013-304054. [Epub ahead of print]

Tarui T, Khwaja OS, Estroff JA, Robinson JN, Gregas MC, Grant PE. Altered fetal cerebral and cerebellar development in twin-twin transfusion syndrome. AJNR Am J Neuroradiol 2012 ;33:1121-1126.

Tarui T, Khwaja OS, Estroff JA, Robinson JN, Grant PE. Fetal MR imaging evidence of prolonged apparent diffusion coefficient decrease in fetal death. AJNR Am J Neuroradiol 2011;32:E126-128. PMID:20671062

2012 Publications

Bianchi DW. From prenatal genomic diagnosis to fetal personalized medicine: progress and challenges. Nature Medicine 2012;18:1041-1051.

Bianchi DW. Fetal genes in mother's blood. Nature 2012;487:304-305.

Bianchi DW, Platt LD, Goldberg JD, Abuhamad AZ, Sehnert AJ, Rava RP.

Genome-wide fetal aneuploidy detection by maternal plasma DNA sequencing. Obstet Gynecol 2012;119:890-901.

Dao MC, Sen S, Iyer C, Klebenov D, Meydani SN. Obesity during pregnancy and fetal iron status: is Hepcidin the link? J Perinatol 2012;doi:10.1038/jp.2012.81 [Epub ahead of print].

Dietz JA, Johnson KL, Wick HC, Bianchi DW, Maron JL. Optimal techniques for mRNA extraction from neonatal salivary supernatant. Neonatology 2012;101:55-60.

Edlow AG, Bianchi DW. Tracking fetal development through molecular analysis of maternal biofluids. Biochim Biophys Acta 2012;1822:1970-80.

Edlow AG, Chen M, Smith NA, Lu CA, McElrath T. Fetal Bisphenol A Exposure: Concentration of Conjugated and Unconjugated Bisphenol A in Amniotic Fluid in the Second and Third Trimesters. Reprod Toxicol. 34(1): 1-7, 2012. 

Hall LM, Hannon DJ, Leisk GG, Wolfberg AJ, House MD. Measurement of fetal heart rate variability on an electronic monitor using a prototype electronic ruler. Am J Perinatol 2012;29:409-413.

House M, Daniel J, Elstad K, Socrate S, Kaplan DL. Oxygen tension and formation of cervical-like tissue in two-dimensional and three-dimensional culture. Tissue Eng Part A 2012;18:499-507.

Hui L, Slonim DK, Wick HC, Johnson KL, Bianchi DW. The amniotic fluid transcriptome: a source of novel information about human fetal development. Obstet Gynecol 2012;119:111-118.

Johnson KL, Stroh H, Tadesse S, Norwitz ER, Richey L, Kallenbach LR, Bianchi DW. Fetal cells in the murine maternal lung have well-defined characteristics and are preferentially located in alveolar septum. Stem Cells Dev 2012;21:158-165.

Kim SM, Park JS, Norwitz ER, Lee SM, Kim BJ, Park CW, Jun JK, Kim CW, Syn HC. Identification of proteomic biomarkers in maternal plasma in the early second trimester that predict the subsequent development of gestational diabetes. Reprod Sci 2012;19:202-209.

Panda B, Panda A, Ueda I, Abrahams VM, Norwitz ER, Stanic AK, Young BC, Ecker JL, Altfeld M, Shaw AC, Rueda BR. Dendritic cells in the circulation of women with preeclampsia demonstrate a pro-inflammatory bias secondary to dysregulation of TLR receptors. J Reprod Immunol 2012 [Epub ahead of print].

Pritchard S, Bianchi DW. Fetal cell microchimerism in the maternal heart: baby gives back. Circ Res 2012;110:3-5.

Snegovskikh VV, Bhandari V, Wright JR, Tadesse S, Morgan T, Macneill C, Foyouzi N, Park JS, Wang Y, Norwitz ER. Surfactant protein-A (SP-A) selectively inhibits prostaglandin F2alpha (PGF2alpha) production in term decidua: implications for the onset of labor. J Clin Endocrinol Metab 2011;96:E624-32.

Sen S, Carpenter AH, Hochstadt J, Huddleston JY, Kustanovich V, Reynolds AA, Roberts S.  Nutrition, weight gain and eating behavior in pregnancy: a review of experimental evidence for long-term effects on the risk of obesity in offspring. Physiol Behav 2012;107:138-145.

2011 Publications

Bianchi, DW. Gene expression analysis of amniotic fluid: new biomarkers and novel antenatal treatments. Clin Biochem 2011;44:448-450.

Cardenas I, Mulla MJ, Myrtolli K, Sfakianaki AK, Norwitz ER, Tadesse S, Guller S, Abrahams VM. Nod1 activation by bacterial iE-DAP induces maternal-fetal inflammation and preterm labor.  J Immunol 2011;187:980-986.

Devaney SA, Palomaki GE, Scott JA, Bianchi DW. Noninvasive fetal sex determination using cell-free fetal DNA: a systematic review and meta-analysis. JAMA 2011 10;306:627-636.

Edlow AG, Hou MY, Maurer R, Benson C, Delli-Bovi, L, Goldberg, AB. Uterine  evacuation for second-trimester fetal death and maternal morbidity. Obstet Gynecol 117 (2 Pt 1): 307-16, 2011.

Hui L, Bianchi DW. Cell-free fetal nucleic acids in amniotic fluid. Hum
Reprod Update
2011;3:362-371.

Hui L, Bianchi DW. Prenatal pharmacotherapy for fetal anomalies: a 2011
update. Prenat Diagn 2011;31:735-743.

Kallenbach LR, Johnson KL, Bianchi DW. Fetal cell microchimerism and cancer: a nexus of reproduction, immunology, and tumor biology. Cancer Res 2011;71:8-12.

Kluge JA, Leisk GG, Cardwell RD, Fernandes AP, House M, Ward A, Dorfmann AL, Kaplan DL. Bioreactor system using noninvasive imaging and mechanical stretch for biomaterial screening. Ann Biomed Eng 2011; 39:1390-1402.

Koide K, Slonim, DK, Johnson KL, Tantravahi U, Cowan JM, Bianchi DW. Transcriptomic analysis of cell-free fetal RNA suggests a specific molecular phenotype in trisomy 18. Hum Genet 2011;129:295-305.

Lee SM, Park JS, Norwitz ER, Kim SM, Kim BJ, Park CW, Jun JK, Syn HC.
Characterization of discriminatory urinary proteomic biomarkers for severe preeclampsia using SELDI-TOF mass spectrometry. J Perinat Med; 2011;39:391-396.
Maron JL. Exploring the neonatal salivary transcriptome: technical optimization and clinical applications. Clin Biochem 2011;44:467-468.

Massingham LJ, Johnson KL, Bianchi DW, Pei S, Peter I, Cowan JM,Tantravahi U, Morrison TB. Proof of concept study to assess fetal gene expression in amniotic fluid by nanoarray PCR. J Mol Diagn 2011;13:565-570.

Mesiano S, Wang Y, Norwitz ER. Progesterone receptors in the human pregnancy uterus: do they hold the key to birth timing? Reprod Sci 2011;18:6-19.

Mulla MJ, Myrtolli K, Potter J, Boeras C, Kavathas PB, Sfakianaki AK, Tadesse S, Norwitz ER, Guller S, Abrahams VM. Uric acid induces trophoblast IL-1β production via the inflammasome: implications for the pathogenesis of preeclampsia. Am J Reprod Immunol 2011;65:542-548.

Norwitz, ER, Caughey AB. Progesterone supplementation and the prevention of preterm birth. Rev Obstet Gynecol 2011;4:60-72.

Norwitz ER, Greenberg J. FDA approval for use of medications in pregnancy: an uphill battle. Rev Obstet Gynecol 2011;4:439-41.

Parikh R, Patel A, Stack T, Socrate S, House M. How the cervix shortens: an anatomic study using 3-dimensional transperineal sonography and image registration in singletons and twins. J Ultrasound Med 2011;30:1197-1204.

Pritchard S, Hoffman AM, Johnson KL, Bianchi DW. Pregnancy-associated progenitor cells: an under-recognized potential source of stem cells in maternal lung. Placenta 2011;S298-303.

Sasaki K, Norwitz ER. Gonadotropin-releasing hormone/gonadotropin-releasing hormone receptor signaling in the placenta. Curr Opin Endocrinol Diabetes Obes 2011;18:401-408.

Sen S, Simmons RA. Maternal antioxidant supplementation prevents adiposity in the offspring of Western diet-fed rats. Diabetes 2010;59:3058-3065.

Snegovskikh VV, Bhandari V, Wright JR, Tadesse S, Morgan T, Macneill C, Foyouzi N, Park JS, Wang Y, Norwitz ER. Surfactant protein-A (SP-A) selectively inhibits prostaglandin F2alpha (PGF2alpha) production in term decidua: implications for the onset of labor. J Clin Endocrinol Metab 2011;96:E624-632.

Tadesse S, Luo G, Park JS, Kim BJ, Snegovskikh VV, Zheng T, Hodgson EJ, Arcuri F, Toti P, Parikh CR, Guller S, Norwitz ER. Intra-amniotic infection upregulates neutrophil gelatinase-associated lipocalin (NGAL) expression at the maternal-fetal interface at term: implications for infection-related preterm birth. Reprod Sci 2011;18:713-722.

Turcan S, Vetter DE, Maron JL, Wei X, Slonim DK. Mining functionally relevant gene sets for analyzing physiologically novel clinical expression data. Pac Symp Biocomput 2011:50-61.

Urato AC, Norwitz ER. A guide towards pre-pregnancy management of defective implantation and placentation. Best Pract Res Clin Obstet Gynaecol 2011;25:367-387.

Walt DR, Kuhlik A, Epstein SK, Demmer LA, Knight M, Chelmow D, Rosenblatt M, Bianchi DW. Lessons learned from the introduction of personalized genotyping into a medical school curriculum. Genet Med 2011;13:63-66.

2010 Publications

Bianchi DW. From Michael to microarrays: 30 years of studying fetal cells and nucleic acids in maternal blood. Prenatal Diagn 2010;30:622-623.

Bianchi DW, Maron JL, Johnson KL. Insights into fetal and neonatal development through analysis of cell-free RNA in bodily fluids. Early Hum Dev 2010;86:747-752.

Gundogan F, Bianchi DW, Scherjon SA, Roberts DJ. Placental pathology in egg donor pregnancies. Fertil Steril 2010;93:397-404.

House M, Sanchez CC, Rice WL, Socrate S, Kaplan DL. Cervical tissue engineering using silk scaffolds and human cervical cells. Tissue Eng Part A 2010;16:2101-2012.

Johnson KL, Tao K, Stroh H, Kallenbach L, Peter I, Richey L, Rust D, Bianchi DW. Increased fetal cell trafficking in murine lung following complete pregnancy loss from exposure to lipopolysaccharide. Fertil
Steril
2010;93:1718-1721e2.

Lang CT, Iams JD, Tangchitnob E, Socrate S, House M. A method to visualize 3-dimensional anatomic changes in the cervix during pregnancy: a preliminary observational study. J Ultrasound Med 2010;29:255-260.

Lee J, Park JS, Norwitz ER, Kim BJ, Park CW, Jun JK, Syn HC. Identification and characterization of proteins in amniotic fluid that are differentially expressed before and after antenatal corticosteroid administration. Am J Obstet Gynecol 2010;202:388.e1-388.e10

Lee HJ, Snegovskikh VV, Park JS, Foyouzi N, Han KT, Hodgson EJ, Guller S, Norwitz ER. Role of GnRH-GnRH receptor signaling at the maternal-fetal interface. Fertil Steril 2010;94:2680-2687.

Luo G, Abrahams VM, Tadasse S, Funai EF, Hodgson EJ, Gai J, Norwitz ER.  Progesterone inhibits basal and TNF-alpha-inducted apoptosis in fetal membranes: a novel mechanism to explain progesterone-mediated prevention of preterm birth. Reprod Sci 2010;17:532-539.

Maron JL, Johnson KL, Rocke DM, Cohen MG, Liley AJ, Bianchi DW. Neonatal salivary analysis reveals global development gene expression changes in the premature infant. Clin Chem 2010;56:409-416.

Maron JL, Johnson KL, Parkin C, Iyer L, Davis JM, Bianchi DW. Cord blood genomic analysis highlights the role of redox balance. Free Radic Biol Med 2010;49:992-996.

Mirza FG, House M, Craigo SD. Urato AC. The patient with asymptomatic shortened cervix at 23 to 28 weeks: is delivery imminent? Am J Perinatol 2010;27:37-40.

Myers KM, Socrate S, Paskaleva A, House M. A study of the anisotropy and tension/compression behavior of human cervical tissue. J Biomech Eng 2010;132:021003.

Peterson E, Craigo S, House M. Risk factors for postpartum antihypertensive medication requirement in severe preeclampsia. Hypertens Pregnancy 2010;29:350-356.

Sen S, Simmons RA. Maternal antioxidant supplementation prevents adiposity in the offspring of Western diet-fed rats. Diabetes 2010;59: 3058-3065.

van der Hoorn ML, Lashley EE, Bianchi DW, Claas FH, Schonkeren CM, Scherjon SA. Clinical and immunologic aspects of egg donation pregnancies: a systematic review. Hum Reprod Update 2010; 16:704-712.

Vora NL, Johnson KL, Lambert-Messerlian G, Tighiouart H, Peter I, Urato AC,Bianchi DW. Relationships between cell-free DNA and serum analytes in the first and second trimesters of pregnancy. Obstet Gynecol 2010; 116:673-678.

Vora NL, Johnson KL, Peter I, Tighiouart H, Ralston SJ, Craigo SD, Bianchi DW.Vora NL, Johnson KL, Peter I, Tighiouart H, Ralston SJ, Craigo SD, Bianchi DW. Circulating cell-free DNA levels increase variably following chorionic villus sampling. Prenat Diagn 2010;30: 25-328.