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Icli Lab focuses on the role of microRNAs, a class of non-coding RNAs, in ischemic vascular disease states such as myocardial infarction, diabetic wound healing and obesity-induced chronic inflammation. Our group studies these complex disease states using diverse model systems including human plasma and tissue samples, human organoids, transgenic mouse models as well as primary cells. We take a multifaceted approach to delineate the disease mechanisms by utilizing state-of-the-art molecular biology techniques, bioinformatic approaches, bulk and single-cell RNA-seq, immunohistochemistry, and live animal imaging.