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Fellows will spend six months at Tufts Medical Center, the tertiary care facility for the Tufts University-Affiliated Hospitals in New England.

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The Kapur Lab focuses on molecular mechanisms of cardiac remodeling and myocardial recovery. The laboratory has generated novel insight into signaling via the transforming growth factor beta (TGFb) family with a particular focus on the TGFb co-receptor endoglin (CD105) and Bone Morphogenetic Protein 9 (BMP9). The lab’s translational research focuses on preclinical models of acute and chronic heart failure, invasive hemodynamics, circulatory support device development, and cardioprotective mechanisms in the setting of acute myocardial infarction.

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The MCRI Mouse Physiology Core Laboratory is dedicated to the application of whole-animal models to pursue questions related to the pathophysiology of cardiovascular disease. The MCRI has established a series of cardiovascular models in rodents that are in active use in both the MCRI and in laboratories around the U.S. and the world. Models developed at the MCRI include a mouse model of carotid injury; chronic myocardial infarction, transverse aortic constriction and others. Phenotyping methods developed at the MCRI Mouse Core include a closed chest electrophysiology catheter-based procedure and dual ventricular pressure volume loop recording among others. The Mouse Core also routinely performs standard disease models and phenotyping assays relevant to cardiac and vascular physiology, including models of ventricular pressure overload, left and right ventricular pressure-volume loop analysis, cardiac echocardiography, telemetry implantation for blood pressure and ECG monitoring and many others.

The Jaffe laboratory is focused on understanding the molecular mechanisms by which blood vessels become dysfunctional to lead to common cardiovascular conditions, including heart attack, stroke, high blood pressure, in-stent restenosis, vein graft failure and heart failure. We are interested in understanding how traditional risk factors like aging, obesity, high blood pressure or high cholesterol, or new risk factors like novel cancer treatments, cause blood vessels to become diseased. We are also focused on understanding sex differences in how these cardiovascular diseases develop, in order to identify sex-specific precision medicine strategies.

According to the Consumer Product Safety Commission, in both 2020 and 2021, approximately 200,000 children were seen in emergency departments across the country for toy-related injuries. We sat down with pediatrician Charles Hannum, MD to talk about the most dangerous toys of the year. By recognizing the dangers and hazards associated with toys, injuries are preventable.

The Center for Health Solutions of the Institute for Clinical Research and Health Policy Studies at Tufts Medical Center provides the following validated questionnaires.

As the warm weather arrives and we begin to emerge from our winter cocoons, many of us are finding the urge to resume the warm-weather activities we’ve all been missing. Golfers, in particular, have been longing to find their way to the fairways and greens this spring.