Ankylosing Spondylitis

Ankylosing spondylitis is a type of spinal arthritis that causes swelling between the discs that make up the spine.

Programs + Services


Rheumatology

The Division of Rheumatology at Tufts Medical Center in Boston offers comprehensive evaluation, consultation and management of arthritis and rheumatic disease.
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Doctors + Care Team

Timothy E. McAlindon, MD, MPH

Timothy E. McAlindon, MD, MPH

Accepting New Patients

Title(s): Chief, Division of Rheumatology; Professor, Tufts University School of Medicine
Department(s): Medicine, Rheumatology, Allergy and Immunology
Appt. Phone: 617-636-5990
Fax #: 617-636-2388

Osteoarthritis, general rheumatology, lupus

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Robert A. Kalish, MD

Robert A. Kalish, MD

Accepting New Patients

Title(s): Director, Rheumatology Education; Associate Professor, Tufts University School of Medicine
Department(s): Medicine, Rheumatology, Allergy and Immunology
Appt. Phone: 617-636-5990
Fax #: 617-636-2388

General rheumatology, Lyme disease

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Senada Arabelovic, DO

Senada Arabelovic, DO

Accepting New Patients

Title(s): Rheumatologist; Chair Elect, Women in Medicine Committee (WiMS), Assistant Professor of Medicine, Tufts University School of Medicine
Department(s): Medicine, Rheumatology, Allergy and Immunology
Appt. Phone: 617-636-5990
Fax #: 617-636-2388

General rheumatology, transitioning young adults with autoimmune diseases to the adult rheumatology clinic, pregnancy in rheumatologic disease

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Steven C. Vlad, MD, PhD

Steven C. Vlad, MD, PhD

Accepting New Patients

Title(s): Rheumatologist; Assistant Professor, Tufts University School of Medicine
Department(s): Medicine, Rheumatology, Allergy and Immunology
Appt. Phone: 617-636-5990
Fax #: 617-636-2388

General rheumatology, spondyloarthropathies, psoriatic arthritis and anklylosing spondylitis

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William F. Harvey, MD, MSc, FACR

William F. Harvey, MD, MSc, FACR

Accepting New Patients

Title(s): Clinical Director, Rheumatology; Rheumatologist; Assistant Professor, Tufts University School of Medicine
Department(s): Medicine, Rheumatology, Allergy and Immunology
Appt. Phone: 617-636-5990
Fax #: 617-636-2388

Osteoarthritis, general rheumatology, musculoskeletal ultrasound

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Research + Clinical Trials


 A randomized, double-blind, parallel-group, multicenter study of secukinumab to compare 300 mg and 150 mg at Week 52 in patients with Ankylosing Spondylitis who are randomized to dose escalation after not achieving inactive disease during an initial 16 weeks of open-label treatment with secukinumab 150 mg (ASLeap)   

The purpose of this study is to estimate the difference in clinical response between 300 mg and 150 mg of secukinumab at Week 52 in patients with Ankylosing Spondylitis (AS). Patients will be on an open-label secukinumab 150 mg until Week 16, followed by a randomization phase to receive either secukinumab 150 mg or secukinumab 300 mg. This study will also investigate the link between secukinumab and sleep disturbances, and daytime activity patterns.
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Tufts Spondyloarthritis Registry

This is an observational study of people who have spondyloarthritis. This includes diseases such as ankylosing spondylitis, psoriatic arthritis, reactive arthritis, inflammatory bowel disease associated arthritis. Those in the registry must be patients of providers in the Tufts rheumatology clinic. 
More information about research and clinical trials