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Asthma is a chronic disease that affects the airways, the tubes that carry air in and out of the lungs. With asthma, the inside walls of the airways become sore and swollen. 

Doctors + Care Team

John L. Ohman, Jr., MD

John L. Ohman, Jr., MD

Title(s): Chief, Division of Allergy; Professor, Tufts University School of Medicine
Department(s): Medicine, Rheumatology, Allergy and Immunology
Appt. Phone: 617-636-5333
Fax #: 617-636-4843

Asthma, hay fever, chronic sinusitis, food allergy, adverse drug reactions, insect sting allergy, occupational allergy/ respiratory disease, atopic eczema, hives/urticaria, adult immunodeficiency, skin testing, pulmonary function testing, allergen challenge

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John Leung, MD
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John Leung, MD

Title(s): Director, Center for Food Related Diseases at Tufts Medical Center; Co-Director, Food Allergy Center at Floating Hospital for Children; Allergist; Assistant Professor, Tufts University School of Medicine
Department(s): Medicine, Pediatric Allergy, Gastroenterology, Pediatric Gastroenterology
Appt. Phone: 617-636-5883 (Gastroenterology)
Fax #: 617-636-9292

Allergic rhinitis (seasonal allergy), anaphylaxis, angioedema, asthma, celiac disease, chronic urticarial (hives), drug allergies, eczema, eosinophilic esophagitis/eosinophilic gastrointestinal disorders, food allergy (e.g. peanuts, cow milk, soy, etc.), food intolerance (lactose, fructose, fructan), food protein-induced enterocolitis syndrome (FPIES), immunodeficiency, oral allergy syndrome, pruritus, sinusitis, stinging insect allergy, wheat hypersensitivity

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Research + Clinical Trials

Effectiveness of the Aeroneb compared to a jet nubulizer for the delivery of bronchodilator therapy of acute severe asthma

Background: The bronchodilator therapy is an essential component of the management of asthma exacertbation. The delivery of the bronchodilator to the lungs in asthma exacerbations is usually achieved through nebulizing the bronchodilator medications. The commonly used nebulizer device is a small volume jet nebulizer which has not been persistently reliable in delivering the bronchodilator therapy. Aeroneb nebulize device is a FDA approved device which produced consistently respirable sized particles which could potentially result in better bronchodilator effect.

Aim: To study whether Aeroneb nebulizer is more effective than small volume jet nebulizer in delivering bronchodilators in severe asthma exacerbation.

Experiment Design: Patients will be randomized (lie a flip of a coin) to receive the bronchodilator therapy as per the emergency room protocol either via small volume jet nebulizer or Aeroneb nebulizer.

Subjects: Adults patients between the age of 18 and 66 years who present to the emergency room with severe asthma exacerbation with peak respiratory flow rate <50% of predicted.

Study Procedure: When enrolled int he study and after randomization, we will then collect data that is standard for the hospital like heart rate, blood pressure and breathing indices and also some non-routine things like some scoring scales for shortness of breath and serial measurements of the peak expiratory flow rate.

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