The cornea is the very outer layer of the eye. Corneal disorders might include refractive errors, allergies, injuries, and more.
Programs + Services
Ophthalmology (New England Eye Center) at Tufts Medical Center in Boston specializes in the testing and treatment of all types of eye diseases and visual problems.
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Research + Clinical Trials
The study is designed to demonstrate the safety and efficacy of two dose concentrations of SAF312 eye drops (dose 1 [5 mg/ml] and dose 2 [15 mg/ml]) in subjects with chronic induced corneal pain (CICP) persisting at least for 4 months after refractive surgery and chronicity confirmed during the observational period. The study will also determine the optimal dose to carry forward for further development.
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This study will enroll subjects with stage 2 or 3 neurotrophic keratitis. Subjects will be randomized in a 1:1 ratio to the CSB-001 investigational treatment arm or vehicle control arm. All subjects will dose with the randomized treatment four times daily for 8 weeks (controlled treatment phase). During the controlled treatment phase, subjects will return to the clinic weekly from Day 0 to Week 8, and again at Week 10. Subjects randomized to the vehicle arm who are not healed will have the opportunity to participate in an open-label uncontrolled treatment phase.
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The primary objective is to determine the efficacy of ST266 eye drops in healing persistent epithelial defects (PED). After 8 weeks of randomized, double-blind treatment, non-healers will enter into an additional 8-week open-label ST266 treatment period. All patients will be followed for 3-months post-treatment for monitoring of safety and maintenance of re-epithelialization.
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The cornea (window in the front of your eye) is made up of many nerves with important regions that allow you to feel sensations like, heat, cold, pressure and vibration. It is well known that many ocular surface disorders, such as dry eye disease (DED), neurotrophic keratitis and post-herpetic neuralgia, affect corneal nerve structure, which can be detected by a special type of eye imaging called ‘In-vivo Confocal Microscopy (IVCM)’. However, the relationship between eye symptoms, signs and abnormal corneal nerve functions are not yet well understood. The quantitative sensory motor test (QST) is a non-invasive method which evaluates nerve function with different stimuli such as cold, heat and vibration. Therefore, people with different corneal conditions who undergo QST may show varying pain responses to each sensation, and may characterize their pain in unique ways. This goal of this study is to find out which types of stimuli have the most impact on ocular discomfort among those with different types of corneal conditions, and compare QST results between ocular surface patients and those without any ocular surface conditions. Most procedures are standard of care which means they are typically performed during a routine eye exam and therefore during your routine clinical visit.
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We will investigate the efficacy of Oxervate treatment in patients with neuropathic corneal pain (NCP). NCP subjects could benefit from its trophic effect on corneal nerves function and its capacity to restore the ocular surface environment. The aim is to investigate the efficacy and tolerability of topical rhNGF cenegermin 0.002% (20mcg/mL) in patients with NCP.
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Persistent corneal epithelial defect (PCED) is a persistent non-healing corneal defect or wound. KPI-012 is a novel, human bone-marrow derived human mesenchymal stem cell (hMSC) secretome composed of biologically active components, which have been shown in preclinical studies and early clinical trials to facilitate corneal healing. This study will investigate the efficacy and safety of KPI-012 eye drops 4 times daily for 8-weeks for healing of PCED.
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Patients that suffered from neuropathic pain or photoallodynia, reported immediate relief of pain after use of TrueTear® intranasal neurostimulator (ITN). We propose a pilot study for treatment of neuropathic corneal pain (NCP) with ITN with the following specific aims:
- To elucidate the efficacy of ITN in ameliorating pain among neuropathic corneal patients.
- To elucidate the safety, efficacy, longevity of ITN in ameliorating pain among neuropathic corneal patients during a 90-day period with daily use.
- o assess quality of life changes by treating neuropathic corneal pain with ITN during a 90-day period with daily use.
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