Cryoglobulinemic vasculitis syndrome (CVS)

Cryoglobulinemic vasculitis (CV) is a syndrome of decreased kidney function, skin rash, abdominal pain, and can involve multiple other organs and is potentially life-threatening.  Membranoproliferative glomerulonephritis (MPGN) is a form of this syndrome that mainly affects the kidneys.  A wide range of acquired and inherited conditions can be predispose to this syndrome.  The most common of these is hepatitis C virus (HCV) but it can also be seen in certain auto-immune conditions as well as rare forms of cancer.  

 The syndrome can damage tiny blood vessels in your kidneys and other organs and can lead to kidney disease and kidney failure.  This an exciting time in CV syndrome, MPGN and particularly in HCV.  We now understand several of the processes that can lead to these syndromes and can offer directed therapies including treatment of HCV (direct acting antivirals (DAA)), immunosuppressive treatments that decrease the organ damage of CV and MPGN, and plasma exchange therapies.

Differentiating between the different forms of CV and MPGN and deciding upon the right course of treatment is challenging and requires a multidisciplinary team approach.  At Tufts Medical Center, our multidisciplinary team will perform a careful assessment of the potential causes of CV and MPGN in each patient and come to consensus about the correct treatment strategy.  Team members include Nephrologists, Rheumatologists, Hepatologists, Hematologists, Blood Bank specialists, Pharmacologists and several other medical specialities who work together to provide you the individualized care to manage your symptoms and take control of your health.

It is an exciting time in CV, MPGN and in HCV-related kidney disease. There are multiple ongoing studies testing new treatments. Dr. Gordon has extensive experience in CV, MPGN and HCV-related kidney disease and was involved the formation of the KDIGO clinical practice guidelines on HCV and kidney disease (2008 and 2018) and has lectured extensively around the world and published articles focused on HCV and kidney disease.  As new treatments become available, each patient will have more options for what is best for their own health and life goal.

At Tufts Medical Center, our goal is to give each patients a lifetime of individualized care.  We help patients understand what is known and what is not known about their disease and treatments to make the best decision for them.   We understand what it is like to live with kidney disease.  Drs. Gordon, Inker, Drew and Miskulin and other members of the team are dedicated kidney doctors who can help you and your family live your life with kidney disease.

Services: 

  • Multidisciplinary team approach to CV, MPGN and HCV-related kidney disease
  • Kidney biopsy and interpretation
  • Use of latest diagnostic algorithms to determine cause of CV or MPGN
  • Access to personalized direct-acting antiviral agents (DAA) regimen for HCV based on patient and viral characteristics
  • Access to immunosuppressive agent therapies for CV and MPGN
  • Urgent access to plasmapheresis therapies
  • Dialysis services, including access surgery
  • Kidney transplantation and donor-matching services
  • Genetic testing in cases of inherited MPGN, counseling and family planning

Programs + Services


Nephrology

The Division of Nephrology at Tufts Medical Center in Boston specializes in the study, diagnosis and treatment of kidney disease and high blood pressure and more.
More information about programs and services

Doctors + Care Team

Craig E. Gordon, MD, MS

Craig E. Gordon, MD, MS

Accepting New Patients

Virtual Appointments Available

Title(s): Nephrologist; Associate Professor of Medicine, Tufts University School of Medicine
Department(s): Medicine, Nephrology
Appt. Phone: 617-636-5866
Fax #:

Polycystic kidney disease (PKD), hepatitis C virus in chronic kidney disease, Thrombotic microangiopathy, glomerular disease, kidney transplantation, chronic kidney disease

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Dana C. Miskulin, MD, MS

Dana C. Miskulin, MD, MS

Accepting New Patients

Virtual Appointments Available

Title(s): Nephrologist; Associate Professor, Tufts University School of Medicine
Department(s): Medicine, Nephrology
Appt. Phone: 617-636-5866
Fax #: 617-636-2369

Polycystic kidney disease (PKD), dialysis, home dialysis, general nephrology, chronic kidney disease (CKD), diabetic kidney disease, glomerular disease, vasculitis, hypertension, cardiovascular disease in patients with kidney disease, acute kidney disease, acute kidney injury and kidney stones

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David Drew, MD, MS

David Drew, MD, MS

Accepting New Patients

Title(s): Nephrologist; Assistant Professor of Medicine, Tufts University School of Medicine
Department(s): Medicine, Nephrology
Appt. Phone: 617-636-5866
Fax #: 617-636-2369

General nephrology, chronic kidney disease (CKD), diabetic kidney disease, glomerular disease, vasculitis, hypertension, cardiovascular disease in patients with kidney disease, acute kidney disease, acute kidney injury, kidney stones and monoclonal gammopathy of renal significance

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Lesley A.  Inker, MD, MS

Lesley A. Inker, MD, MS

Accepting New Patients

Virtual Appointments Available

Title(s): Director, Kidney and Blood Pressure Center; Director, Kidney Function and Evaluation Center; Director, Quality Improvement; Associate Professor, Tufts University School of Medicine
Department(s): Medicine, Nephrology
Appt. Phone: 617-636-5866
Fax #: 617-636-2369

Geriatric nephrology, pregnancy, HIV-associated kidney disease, kidney transplantation, kidney donor evaluation, medical treatment for kidney failure without dialysis, kidney function evaluation (GFR), general nephrology, chronic kidney disease (CKD), diabetic kidney disease, glomerular disease, vasculitis, hypertension, cardiovascular disease in patients with kidney disease, acute kidney disease, acute kidney injury and kidney stones

View Full Profile for Lesley A. Inker, MD, MS