Cushing's Disease

Cushing's disease is a hormonal disorder caused by excessive exposure to cortisol (a hormone produced by the adrenal gland).

Some symptoms include:

- Excessive weight gain, especially in the face and abdominal region
- “Buffalo hump” of fat at the back of the neck
- Easy bruising 
- Poor wound healing
- Red cheeks
- Type 2 Diabetes
- Unusual hair growth on the face, neck, abdomen, and thighs
- Purplish abdominal stretch marks
- Fatigue and/or overall weakness
- Depressed sex drive or fertility
- Menstrual problems 
- Hypertension—particularly if it’s difficult to treat

A pituitary tumor causing Cushing’s disease ultimately elevates the stress hormone, cortisol, which leads to a variety of symptoms that include excessive weight gain, easy bruising, fatigue, diabetes, elevated blood pressure, osteoporosis and decreased fertility.

Programs + Services


Neuroendocrine and Endocrine Neoplasia Clinic

The Neuroendocrine and Endocrine Neoplasia Clinic at Tufts Medical Center in Boston provides care for patients with hypothalamic, suprasellar and pituitary disorders.
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Neuroendocrine and Pituitary Program

Learn more about our Neuroendocrine and Pituitary Program located in downtown Boston, we specialize in the diagnosis and treatment of various neuroendocrine disorders.
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Doctors + Care Team

Ronald M. Lechan, MD, PhD

Ronald M. Lechan, MD, PhD

Accepting New Patients

Virtual Appointments Available

Title(s): Chief, Division of Endocrinology, Diabetes and Metabolism; Co-Director, Hypothalamic and Pituitary Disease Center; Professor, Tufts University School of Medicine
Department(s): Medicine, Endocrinology, Diabetes and Metabolism
Appt. Phone: 617-636-5689
Fax #: 617-636-4719

Hypothalamic disease, pituitary disease, disorders of the thyroid, adrenal disease, islet cell tumors

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Adel M. Malek, MD, PhD

Adel M. Malek, MD, PhD

Accepting New Patients

Virtual Appointments Available

Title(s): Chief, Neurovascular Surgery; Director, Cerebrovascular & Endovascular Division Professor, Tufts University School of Medicine
Department(s): Neurosurgery
Appt. Phone: 617-636-8200
Fax #: 617-636-7587

Aneurysms, arteriovenous malformations, dural fistulas, subarachnoid hemorrhage, intracranial atherosclerosis, arterial dissection

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Carl B. Heilman, MD

Carl B. Heilman, MD

Accepting New Patients

Virtual Appointments Available

Title(s): Neurosurgeon-in-Chief; Chairman of Neurosurgery; Professor, Tufts University School of Medicine
Department(s): Neurosurgery
Appt. Phone: 617-636-5860
Fax #: 617-636-7587

Meningiomas, acoustic neuromas, skull base surgery, pituitary surgery, Chiari surgery

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James Kryzanski, MD

James Kryzanski, MD

Accepting New Patients

Virtual Appointments Available

Title(s): Chief, Division of Epilepsy Surgery; Co-Chief, Division of Spine Surgery; Assistant Professor, Tufts University School of Medicine
Department(s): Neurosurgery
Appt. Phone: 617-636-8585
Fax #: 617-636-7587

Epilepsy neurosurgery, skull base surgery, pituitary surgery, neurovascular surgery, minimally invasive spine surgery, neurosurgical disorders in patients with achondroplasia, neurosurgical disorders in patients with Down syndrome

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John E. Mignano, MD, PhD

John E. Mignano, MD, PhD

Virtual Appointments Available

Title(s): Radiation Oncologist; Clinic Director; Associate Professor, Tufts University School of Medicine
Department(s): Radiation Oncology, Pediatric Radiation Oncology
Appt. Phone: 617-636-6161
Fax #: 617-636-4513

Oncologic consultation for general radiotherapy and Gamma Knife, pediatric radiation oncology

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Julian K. Wu, MD

Julian K. Wu, MD

Accepting New Patients

Virtual Appointments Available

Title(s): Associate Chairman, Neurosurgery; Chief, Neurosurgical Oncology; Neurosurgery Residency Program Director; Professor, Tufts University School of Medicine
Department(s): Neurosurgery
Appt. Phone: 617-636-4500
Fax #: 617-636-7587

Neuro-oncology, Gamma Knife radiosurgery, meningiomas, pituitary tumors, gliomas, brain metastasis, trigeminal neuralgia

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Thomas R. Hedges III, MD

Thomas R. Hedges III, MD

Accepting New Patients

Virtual Appointments Available

Title(s): Director, Neuro-Ophthalmology Service; Co-Director, Electrophysiology Service; Director, Neuro-Ophthalmology Fellowship Program; Professor, Tufts University School of Medicine
Department(s): Ophthalmology
Appt. Phone: 617-636-5488
Fax #: 617-636-7029

Neuro-ophthalmology

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