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Depression

Depression is a serious medical illness and disorder of the brain. It's more than just a feeling of being "down in the dumps" or "blue" for a few days. Feelings persist and interfere with everyday life. Symptoms include: sadness, loss of interest or pleasure in activities, change in weight, difficulty sleeping or oversleeping, energy loss, feelings of worthlessness, and thoughts of death or suicide.

Doctors + Care Team

David A. Adler, MD

David A. Adler, MD

Title(s): Senior Psychiatrist; Director, Mental Health Services Research Group; Senior Scientist, The Center for Health Solutions; Professor, Tufts University School of Medicine
Department(s): Psychiatry
Appt. Phone: 617-636-5731
Fax #: 617-636-4852

Individual and couples psychotherapy, mental health services research, education, treatment of mood and personality disorders, business executive evaluation, consultation and treatment, primary care psychiatry

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Nassir Ghaemi, MD, MPH

Nassir Ghaemi, MD, MPH

Title(s): Director, Mood Disorder Clinic; Director, Psychopharmacology Consultation Clinic; Professor, Tufts University School of Medicine
Department(s): Psychiatry
Appt. Phone: 617-636-5766
Fax #: 617-636-4852

Adult psychiatry

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Peggy Szeto, MSW, LICSW

Peggy Szeto, MSW, LICSW

Title(s): Clinical Social Worker
Department(s): Psychiatry
Appt. Phone: 617-636-5731
Fax #: 617-636-4852

Psychotherapy depression, anxiety, bipolar, schizophrenia, autism spectrum disorder, developmental delay

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Research + Clinical Trials


Omega-3 Fatty Acids for MDD with High Inflammation: A Personalized Approach

The purpose of this research study is to compare the effects of three different doses of an investigational omega-3 fatty acid dietary supplement, eicosapentaenoic acid (EPA), versus placebo on immune system markers in the blood and on treating the symptoms of major depression. Placebo is a pill that looks like the study drug, but contains no active substance. Eicosapentaenoic acid (EPA) is a common omega-3 fatty acid. EPA is available in low dosages in some types of dietary supplements found in health food stores.

In order to qualify for this study you cannot be taking any antidepressants, and you must have a BMI of >25.

If you qualify, you will be randomly assigned (like the flip of a coin) to the EPA or placebo treatment group. You will have a 25% (1 in 4) chance of being assigned to one of the following groups:

  • Group 1 will receive capsules containing an EPA enriched omega-3 fatty acid preparation for a total dose of 1 g/day.
  • Group 2 will receive capsules containing an EPA enriched omega-3 fatty acid preparation for a total dose of 2 g/day.
  • Group 3 will receive capsules containing an EPA enriched omega-3 fatty acid preparation for a total dose of 4 g/day.
  • Group 4 will receive capsules containing placebo (an inactive substance).

Neither you nor the investigator will know to what group you are assigned. This is to make sure that the research study results are not affected by what you or the investigator may expect to happen.

We will ask you to make 9 visits over the course of 12 weeks to our clinic at MGH. At each visit you will meet with a clinician to fill out a number of questionnaires to monitor your progress and you will also receive study medication for the duration of the study. Blood samples will also be collected six times during this study, twice to determine your eligibility to participate in the study, and 4 times to measure changes in immune markers.

You can receive up to $280 total, if you complete all study visits. If you have to drive to come to MGH, you will also be provided with parking vouchers at all visits for the MGH garages. At the conclusion of the study, you will be offered 3 months of free follow up care with one of the study physicians.


More information about research and clinical trials

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