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Giant Cell Arteritis

Giant cell arteritis is a condition that causes inflammation in the scalp, neck, and arms. This inflammation prevents blood from flowing well in the arteries.

Doctors + Care Team

Mark D. Iafrati, MD

Mark D. Iafrati, MD

Title(s): Chief, Vascular Surgery; Director, Vascular Center; Director, Center for Vascular, Wound Healing and Hyperbaric Medicine; Vascular Surgeon; Associate Professor, Tufts University School of Medicine
Department(s): Surgery, CardioVascular Center, Vascular Surgery
Appt. Phone: 617-636-5019
Fax #: 617-636-8003

Complex vascular surgery, vascular biology, endovascular surgery, venous surgery, complex wound care

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William C. Mackey, MD

William C. Mackey, MD

Title(s): Surgeon-in-Chief; Andrews Professor and Chairman, Tufts University School of Medicine
Department(s): Surgery, CardioVascular Center, General Surgery, Vascular Surgery
Appt. Phone: 617-636-5927
Fax #: 617-636-8003

Carotid artery surgery, stroke prevention, aortic aneurysms, claudication and other circulatory problems, re-operative vascular surgery, treatment of vascular surgery complications, venous diseases

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Research + Clinical Trials


A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study to Evaluate the Efficacy and Safety of Sirukumab in the Treatment of Patients with Giant Cell Arteritis

GlaxoSmithKline is evaluating a study drug called sirukumab for patients with Giant Cell Arteritis. Sirukumab may help block the activity of interleukin-6 (IL-6), which is involved in changes in the immune system related to GCA. The purpose of this study is to test how well sirukumab keeps GCA from returning once prednisone has been stopped. Sirukumab is given with a tapered prednisone regimen. Participants may also enroll in secondary studies evaluating the genetics and biomarkers associated with GCA.
More information about research and clinical trials

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