Granulomatosis with polyangiitis (GPA)

In vasculitis, the immune system causes severe inflammation of blood vessels that can cause many problems, including in the kidneys  Other names for vasculitis in the kidney include microscopic polyangiitis or granulomatosis with polyangiitis.

People with vasculitis in the kidney may have symptoms like fevers, weight loss, fatigue, cough, and joint pain. Urine and blood tests show if the kidney is affected. These tests may blood in the urine (hematuria), protein in the urine (proteinuria), and kidney injury (decreased estimated GFR or increased blood creatinine).  A blood anti-neutrophil cytoplasmic autoantibody (ANCA) test may be positive.  A kidney biopsy is often needed to prove that the kidneys are affected.

Vasculitis does not only affect the kidneys. Other problems can include ear, nose and throat symptoms, lung involvement, skin rashes, joint problems and neurologic symptoms. At Tufts Medical Center, we work with our specialist colleagues in Rheumatology, ENT, Pulmonary, Dermatology, and Neurology. Treatment for vasculitis often consists of medicines which calm down the immune system. We make treatment plans for individual patients only after talking to other specialists. 

At Tufts Medical Center, our goal is to give each patient a lifetime of individualized care. We help patients understand what is known and what is not known about their disease and treatments to make the best decision for them.  We understand what it's like to live with kidney disease. Dr. Inker and her team are experienced and dedicated kidney doctors who can help you and your family live your life with kidney disease.

Our services include: 

  • Treatment of active kidney vasculitis
  • Comprehensive, multidisciplinary care for all stages of chronic kidney disease
  • Second opinion regarding existing kidney vasculitis
  • Nutritional and other lifestyle counseling
  • Dialysis services, including access surgery
  • Kidney transplantation and donor-matching services
  • Access to any new clinical trials  

Programs + Services


Rheumatology

The Division of Rheumatology at Tufts Medical Center in Boston offers comprehensive evaluation, consultation and management of arthritis and rheumatic disease.
More information about programs and services

Doctors + Care Team

Timothy E. McAlindon, MD, MPH

Timothy E. McAlindon, MD, MPH

Accepting New Patients

Virtual Appointments Available

Title(s): Chief, Division of Rheumatology; Professor, Tufts University School of Medicine
Department(s): Medicine, Rheumatology, Allergy and Immunology
Appt. Phone: 617-636-5990
Fax #: 617-636-2388

Osteoarthritis, general rheumatology, lupus

View Full Profile for Timothy E. McAlindon, MD, MPH

Craig E. Gordon, MD, MS

Craig E. Gordon, MD, MS

Accepting New Patients

Virtual Appointments Available

Title(s): Nephrologist; Associate Professor of Medicine, Tufts University School of Medicine
Department(s): Medicine, Nephrology
Appt. Phone: 617-636-5866
Fax #:

Polycystic kidney disease (PKD), hepatitis C virus in chronic kidney disease, Thrombotic microangiopathy, glomerular disease, kidney transplantation, chronic kidney disease

View Full Profile for Craig E. Gordon, MD, MS

David Drew, MD, MS

David Drew, MD, MS

Accepting New Patients

Title(s): Nephrologist; Assistant Professor of Medicine, Tufts University School of Medicine
Department(s): Medicine, Nephrology
Appt. Phone: 617-636-5866
Fax #: 617-636-2369

General nephrology, chronic kidney disease (CKD), diabetic kidney disease, glomerular disease, vasculitis, hypertension, cardiovascular disease in patients with kidney disease, acute kidney disease, acute kidney injury, kidney stones and monoclonal gammopathy of renal significance

View Full Profile for David Drew, MD, MS

Lesley A.  Inker, MD, MS

Lesley A. Inker, MD, MS

Accepting New Patients

Virtual Appointments Available

Title(s): Director, Kidney and Blood Pressure Center; Director, Kidney Function and Evaluation Center; Director, Quality Improvement; Associate Professor, Tufts University School of Medicine
Department(s): Medicine, Nephrology
Appt. Phone: 617-636-5866
Fax #: 617-636-2369

Geriatric nephrology, pregnancy, HIV-associated kidney disease, kidney transplantation, kidney donor evaluation, medical treatment for kidney failure without dialysis, kidney function evaluation (GFR), general nephrology, chronic kidney disease (CKD), diabetic kidney disease, glomerular disease, vasculitis, hypertension, cardiovascular disease in patients with kidney disease, acute kidney disease, acute kidney injury and kidney stones

View Full Profile for Lesley A. Inker, MD, MS

Robert A. Kalish, MD

Robert A. Kalish, MD

Accepting New Patients

Virtual Appointments Available

Title(s): Director, Rheumatology Education; Associate Professor, Tufts University School of Medicine
Department(s): Medicine, Rheumatology, Allergy and Immunology
Appt. Phone: 617-636-5990
Fax #: 617-636-2388

General rheumatology, Lyme disease

View Full Profile for Robert A. Kalish, MD

Steven C. Vlad, MD, PhD

Steven C. Vlad, MD, PhD

Accepting New Patients

Virtual Appointments Available

Title(s): Rheumatologist; Assistant Professor, Tufts University School of Medicine
Department(s): Medicine, Rheumatology, Allergy and Immunology
Appt. Phone: 617-636-5990
Fax #: 617-636-2388

General rheumatology, spondyloarthropathies, psoriatic arthritis and anklylosing spondylitis

View Full Profile for Steven C. Vlad, MD, PhD

William F. Harvey, MD, MSc, FACR

William F. Harvey, MD, MSc, FACR

Accepting New Patients

Virtual Appointments Available

Title(s): Clinical Director, Rheumatology; Rheumatologist; Assistant Professor, Tufts University School of Medicine
Department(s): Medicine, Rheumatology, Allergy and Immunology
Appt. Phone: 617-636-5990
Fax #: 617-636-2388

Osteoarthritis, general rheumatology, musculoskeletal ultrasound

View Full Profile for William F. Harvey, MD, MSc, FACR