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Heart Failure

Heart failure happens when the heart cannot pump enough blood for the body.

Programs + Services


Clinical Nutrition

The Division of Clinical Nutrition at Tufts Medical Center provides inpatient and outpatient nutritional services.
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Heart Failure + Cardiac Transplant Center

Tufts Medical Center's Heart Failure and Cardiac Transplant Center is a leader when it comes to heart transplantation. Learn more about the care provided.
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Women's Heart Center

Discover The Women’s Heart Clinic at Tufts Medical Center and learn more about the cardiologists dedicated to providing women with the best heart care.
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Doctors + Care Team

Marvin A. Konstam, MD

Marvin A. Konstam, MD

Title(s): Chief Physician Executive, The CardioVascular Center; Professor, Tufts University School of Medicine
Department(s): Medicine, CardioVascular Center, Cardiology
Appt. Phone: 617-636-6293
Fax #: 617-636-7667

Heart failure, cardiac transplant

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James E. Udelson, MD

James E. Udelson, MD

Title(s): Chief, Division of Cardiology; Director, Nuclear Cardiology Laboratory; Professor, Tufts University School of Medicine
Department(s): Medicine, CardioVascular Center, Cardiology
Appt. Phone: 617-636-8066
Fax #: 617-636-7175

Cardiac imaging, heart failure

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Adel Ghuloom, MD

Adel Ghuloom, MD

Title(s): Director, Cardiovascular Critical Care Service
Department(s): Medicine, Cardiology, CardioVascular Center
Appt. Phone: 617-636-2273
Fax #:

Cardiovascular critical care

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Alan T. Kono, MD

Alan T. Kono, MD

Title(s): Cardiologist; Assistant Professor, Tufts University School of Medicine
Department(s): Medicine, CardioVascular Center, Cardiology
Appt. Phone: 617-636-8068
Fax #: 617-636-6030

Heart failure

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Amanda Vest, MBBS, MPH

Amanda Vest, MBBS, MPH

Title(s): Associate Medical Director, Cardiac Transplantation Program; Assistant Professor, Tufts University School of Medicine
Department(s): Medicine, CardioVascular Center, Cardiology
Appt. Phone: 617-636-8068
Fax #: 617-636-6030

Cardiology, heart failure, heart transplantation, mechanical circulatory support

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Ayan R. Patel, MD

Ayan R. Patel, MD

Title(s): Director, Cardiovascular Imaging and Hemodynamic Laboratory; Director, Women's Heart Center; Professor, Tufts University School of Medicine
Department(s): Medicine, CardioVascular Center, Cardiology
Appt. Phone: 617-636-2273
Fax #: 617-636-8070

Echocardiography, heart failure, women's heart disease

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Daniel Levine, MD

Daniel Levine, MD

Title(s): Cardiologist
Department(s): Medicine, CardioVascular Center, Cardiology
Appt. Phone: 617-636-8068
Fax #: 617-636-6030

Heart failure, coronary artery disease

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David DeNofrio, MD

David DeNofrio, MD

Title(s): Director, Heart Failure and Cardiac Transplantation Center; Associate Professor, Tufts University School of Medicine
Department(s): Medicine, CardioVascular Center, Cardiology
Appt. Phone: 617-636-8068
Fax #: 617-636-6030

Heart failure, cardiac transplantation

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David M. Venesy, MD

David M. Venesy, MD

Title(s): Cardiologist; Assistant Professor, Tufts University School of Medicine
Department(s): Medicine, CardioVascular Center, Cardiology
Appt. Phone: 617-636-8068
Fax #: 617-636-7175

Heart failure

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Frederick  Y. Chen, MD, PhD

Frederick Y. Chen, MD, PhD

Title(s): Chief, Cardiac Surgery; Professor of Surgery, Tufts University School of Medicine
Department(s): Surgery, CardioVascular Center, Cardiac Surgery
Appt. Phone: 617-636-5590
Fax #: 617-636-6410

Surgical treatment of acquired heart disease, surgical repair of valvular heart disease, minimally invasive surgery, arrhythmia surgery, heart transplantation, circulatory assist devices

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Hassan Rastegar, MD

Hassan Rastegar, MD

Title(s): Senior Cardiothoracic Surgeon; Professor, Tufts University School of Medicine
Department(s): Surgery, CardioVascular Center, Cardiac Surgery
Appt. Phone: 617-636-5590
Fax #: 617-636-6410

Surgical treatment of acquired heart disease, surgical repair of valvular heart disease, surgical repair of hypertrophic cardiomyopathy, minimally invasive surgery, arrhythmia surgery, heart transplantation, circulatory assist devices

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Kenneth G. Warner, MD

Kenneth G. Warner, MD

Title(s): Senior Cardiothoracic Surgeon; Associate Professor, Tufts University School of Medicine
Department(s): Surgery, CardioVascular Center, Cardiac Surgery
Appt. Phone: 617-636-5590
Fax #: 617-636-6410

Surgical management of adult and pediatric heart disease, heart transplantation

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Michael S. Kiernan, MD, MSc

Michael S. Kiernan, MD, MSc

Title(s): Director, Ventricular Assist Device Program; Assistant Professor, Tufts University School of Medicine
Department(s): Medicine, CardioVascular Center, Cardiology
Appt. Phone: 617-636-8068
Fax #: 617-636-6030

Heart failure, cardiac transplantation, ventricular assist devices

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Navin K. Kapur, MD

Navin K. Kapur, MD

Title(s): Executive Director, The CardioVascular Center for Research and Innovation (CVCRI); Director, Acute Mechanical Circulatory Support Program; Director, Interventional Research Laboratories; Investigator, Molecular Cardiology Research Institute (MCRI); Associate Professor, Tufts University School of Medicine
Department(s): Medicine, CardioVascular Center, Cardiology
Appt. Phone: 617-636-8252
Fax #: 617-636-5913

Interventional cardiology, advanced heart failure, mechanical circulatory support

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Nicole M Orr, MD, FACC

Nicole M Orr, MD, FACC

Title(s): Cardiologist; Assistant Professor, Tufts University School of Medicine
Department(s): Medicine, CardioVascular Center, Cardiology
Appt. Phone: 781-762-0009
Fax #: 781-255-8880

Geriatric cardiology, echocardiography

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Robb Kociol, MD

Robb Kociol, MD

Title(s): Cardiologist
Department(s): Medicine, CardioVascular Center, Cardiology
Appt. Phone: 617-636-8068
Fax #: 617-636-6030

Advanced heart failure, cardiac transplant, mechanical circulation support

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Research + Clinical Trials


A Study of a Technology-enabled Disease Management Program to Reduce Hospitalizations for Heart Failure (SpanCHFIII)

This study will randomize participants with a diagnosis of congestive heart failure and at least one risk factor for hospitalization to either a tablet computer and web based disease management program or a telephone based disease management program. Both interventions are home based with heart failure education and symptom monitoring provided by nurse managers. The nurse managers are in close communication with both the participants and the participants' physicians . The components of the disease management program have been developed at Tufts Medical Center and the New England Quality Care Alliance with studies showing improved clinical outcomes, including reduced hospitalizations. The goal of this study is to transition this successful home monitoring and disease management program to a table computer and web-based implementation to both improve clinical outcomes (reducing hospitalizations and improving self-perceived health status) and improve provider-patient satisfaction. We hypothesize that the tablet computer based disease management will decrease heart failure hospitalizations.
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Mechanical Circulatory Support: Measures of Adjustment and Quality of Life

The purpose of this study is to develop a measurement system to assess adjustment to mechanical circulatory support (MCS) (also referred to as a ventricular assist device [VAD]) and health-related quality of life (HRQOL) in patients with advanced heart failure who receive a VAD. The investigators refer to this measurement system as Mechanical Circulatory Support: Adjustment and Quality of Life (MCS A-QOL).
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A Randomized Parallel-Group, Placebo-Controlled, Double-Blind, Event-Driven, Multi-Center Pivotal Phase III Clinical Outcome Trial of Efficacy and Safety of the Oral sGC Stimulator Vericiguat in Subjects With Heart Failure With Reduced Ejection Fraction (HFrEF) - VerICiguaT Global Study in Subjects With Heart Failure With Reduced Ejection Fraction (VICTORIA)

This is a randomized, placebo-controlled, parallel-group, multi-center, double-blind, event driven study of vericiguat (MK-1242) in participants with heart failure reduced ejection fraction (HFrEF). The primary hypothesis is vericiguat (MK-1242) is superior to placebo in increasing the time to first occurrence of the composite of cardiovascular (CV) death or heart failure (HF) hospitalization in participants with HFrEF.
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Transcatheter Aortic Valve Replacement to UNload the Left ventricle in patients with ADvanced heart failure: a randomized trial  (TAVR UNLOAD)

The TAVR UNLOAD trial is an international, multi-center, randomized, open-label, clinical trial comparing the safety and efficacy of Transcatheter Aortic Valve Replacement (TAVR) with the SAPIEN 3 Valve and optimized heart failure therapy ( OHFT ) versus OHFT in heart failure (HF) patients, with moderate aortic stenosis ( AS). OHFT is defined as guideline-directed medical therapy. It can be medication only or a combination of medical therapy and approved HF devices.

Clinical efficacy of TAVR is assessed after 1 year of follow-up in all 600 patients. All patients are followed for 2 years to evaluate the value of the study device in to treat patients with Heart Failure (HF) who have moderate aortic stenosis (AS). The Edwards SAPIEN 3 Valve has already been approved by the FDA for use in patients who require an aortic valve replacement due to severe aortic stenosis


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The Global cVAD Registry Protocol

The global cVAD registry collects clinical and procedural data retrospectively from hospital medical records for patients who received one or multiple Impella devices during routine clinical care. Patients who qualify for this registry include patients who received the Impella 2.5, Impella CP, or Impella 5.0 for left ventricular support as well as the Impella RP for right ventricular support during their inpatient stay. The registry is an observational, multicenter, retrospective records review. In order to best represent real-world practice, patients receiving Impella devices will be included in the registry without pre-selection. The purpose of the registry is to capture data that reflects "real world"? use of the Implella devices in clinical practice and provide insight into patients characteristics, comorbid conditions, patterns of care, quality of care and performance measurements.
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A study to evaluate the Corvia Medical, Inc. IASD® System II to REDUCE Elevated Left Atrial Pressure in Patients with Heart Failure

This is a research study to investigate the effectiveness and safety of a device for patients with heart failure with preserved ejection fraction (HFpEF). Patients with a left ventricular ejection fraction greater than or equal to 40%, symptoms of heart failure and elevated filling pressures on a test called a right heart catheterization may be eligible to enroll. Participation in this multicenter study involves being randomly assigned either to implantation of an Inter Atrial Shunt Device (IASD) System II, or a sham procedure. Participants will be followed by the Tufts Heart Failure Research Team at regular intervals, for a total of 5 years; however they will remain under the care of their usual Cardiologist. The IASD System II consists of a self-expanding metal structure that is placed into the wall between the upper chambers of the heart (right and left atria) to enable blood to move between these chambers. For HFpEF patients with high pressures in the left atrium, it is thought that enabling blood to move from the left atrium into the right atrium could improve symptoms such as shortness of breath. This device is not yet approved in the United States. Please look at the study website for more information (www.treatmyheartfailure.com).
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