IgA

IgA is an immunoglobulin (protein which the body produces to fight infections) which is usually produced in the respiratory and gastrointestinal tract to help fight off infections in these areas. People with IgA nephropathy, for an unclear reason produce abnormal IgA molecules which enter the bloodstream and deposit in the kidney. Here, these molecules aggregate and cause inflammation. This can manifest as blood or protein in the urine, high blood pressure and decline in kidney function, sometimes severe enough to require long term dialysis or kidney transplantation.  

At Tufts, we see a high volume of IgA nephropathy. We use the most recent evidence to create an individualized plan of care for our patients with this disease. We explore both non immune therapies (including blood pressure control, dietary modification, glucose control in diabetics) as well as evidence based immune therapy as part of our approach. In addition, Tufts is a center for an ongoing clinical trial, the Omeros trial which is investigating the effect of a drug which acts on a specific part of the immune system (called the complement) on the progression of IgA nephropathy. Eligible patients can be enrolled in this trial.

At Tufts Medical Center, our goal is to give each patients a lifetime of individualized care. We help patients understand what is known and what is not known about their disease and treatments to make the best decision for them. We understand what it's like to live with kidney disease. The glomerular disease team are dedicated kidney doctors who can help you and your family life your life with kidney disease.

 

Programs + Services


Nephrology

The Division of Nephrology at Tufts Medical Center in Boston specializes in the study, diagnosis and treatment of kidney disease and high blood pressure and more.
More information about programs and services

Doctors + Care Team

Craig E. Gordon, MD, MS

Craig E. Gordon, MD, MS

Accepting New Patients

Virtual Appointments Available

Title(s): Nephrologist; Associate Professor of Medicine, Tufts University School of Medicine
Department(s): Medicine, Nephrology
Appt. Phone: 617-636-5866
Fax #:

Polycystic kidney disease (PKD), hepatitis C virus in chronic kidney disease, Thrombotic microangiopathy, glomerular disease, kidney transplantation, chronic kidney disease

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David Drew, MD, MS

David Drew, MD, MS

Accepting New Patients

Title(s): Nephrologist; Assistant Professor of Medicine, Tufts University School of Medicine
Department(s): Medicine, Nephrology
Appt. Phone: 617-636-5866
Fax #: 617-636-2369

General nephrology, chronic kidney disease (CKD), diabetic kidney disease, glomerular disease, vasculitis, hypertension, cardiovascular disease in patients with kidney disease, acute kidney disease, acute kidney injury, kidney stones and monoclonal gammopathy of renal significance

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Lesley A.  Inker, MD, MS

Lesley A. Inker, MD, MS

Accepting New Patients

Virtual Appointments Available

Title(s): Director, Kidney and Blood Pressure Center; Director, Kidney Function and Evaluation Center; Director, Quality Improvement; Associate Professor, Tufts University School of Medicine
Department(s): Medicine, Nephrology
Appt. Phone: 617-636-5866
Fax #: 617-636-2369

Geriatric nephrology, pregnancy, HIV-associated kidney disease, kidney transplantation, kidney donor evaluation, medical treatment for kidney failure without dialysis, kidney function evaluation (GFR), general nephrology, chronic kidney disease (CKD), diabetic kidney disease, glomerular disease, vasculitis, hypertension, cardiovascular disease in patients with kidney disease, acute kidney disease, acute kidney injury and kidney stones

View Full Profile for Lesley A. Inker, MD, MS