A joint is the connection between two or more bones. Joints can be damaged by many types of injuries or diseases, including arthritis, bursitis, and dislocations. The treatment of joint problems depends on the cause. Doctors at Tufts Medical Center work with patients to determine which treatment best suits the injury.
Programs + Services
The Division of Rheumatology at Tufts Medical Center in Boston offers comprehensive evaluation, consultation and management of arthritis and rheumatic disease.
The Total Joint Replacement Program at Tufts Medical Center provides hip and knee replacement surgery and other reconstructive surgeries to relieve pain.
Research + Clinical Trials
This is a phase 3 trial for the treatment of knee osteoarthritis associated with bone marrow lesions. The purpose of the study is to determine whether a study medication, AXS02 (disodium zoledronate tetrahydrate) can reduce bone marrow lesions, and therefore alleviate pain associated with osteoarthritis of the knee. AXS02 is an investigational drug and subjects are monitored to see if it causes any adverse event. Maximum participation is 21 weeks and may include up to 14 visits to Tufts Medical Center. A total of approximately 346 subjects are planned for enrollment. Subjects who are eligible for the study will receive AXS02 or placebo during visits 4-8 (1 tablet per week for 6 weeks). The following 6 visits consist of a number of tests and procedures to gather data.