Polycystic Kidney Disease

Polycystic kidney disease is a kidney disorder passed down through families in which many cysts form in the kidneys, causing them to become enlarged.

Programs + Services


Center for Polycystic Kidney Disease

Tufts Medical Center in Boston offers specialized, lifelong treatment for PKD and other forms of chronic kidney disease, including access to the latest clinical trials.
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Kidney and Blood Pressure Center

The Tufts MC Kidney and Blood Pressure Center provides both one-time consultations and ongoing care for chronic or acute kidney disease and high blood pressure.
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Doctors + Care Team

Ronald D. Perrone, MD

Ronald D. Perrone, MD

Accepting New Patients

Title(s): Scientific Director, Clinical and Translational Research Center; Professor, Tufts University School of Medicine
Department(s): Medicine, Nephrology, Clinical and Translational Research Center (CTRC)
Appt. Phone: 617-636-5866
Fax #: 617-636-2369

Polycystic kidney disease (PKD)

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Mark J. Sarnak, MD, MS

Mark J. Sarnak, MD, MS

Accepting New Patients

Title(s): Chief, Division of Nephrology; Director, Research Training Program; Professor, Tufts University School of Medicine
Department(s): Medicine, Nephrology
Appt. Phone: 617-636-5866
Fax #: 617-636-2369

Dialysis, general nephrology, chronic kidney disease (CKD), diabetic kidney disease, glomerular disease, vasculitis, hypertension, cardiovascular disease in patients with kidney disease, acute kidney disease, acute kidney injury and kidney stones

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Amy Kuhlik, MD

Amy Kuhlik, MD

Accepting New Patients

Title(s): Nephrologist; Dean for Student Affairs and Assistant Professor, Tufts University School of Medicine
Department(s): Medicine, Nephrology
Appt. Phone: 617-636-5866
Fax #: 617-636-2369

Pregnancy, general nephrology, chronic kidney disease (CKD), diabetic kidney disease, glomerular disease, vasculitis, hypertension, cardiovascular disease in patients with kidney disease, acute kidney disease, acute kidney injury and kidney stones

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Andrew S. Levey, MD

Andrew S. Levey, MD

Accepting New Patients

Title(s): Chief Emeritus, Division of Nephrology; Professor of Medicine, Tufts University School of Medicine; Dr. Gerald J and Dorothy R. Friedman Professor Emeritus, Tufts University School of Medicine
Department(s): Medicine, Nephrology
Appt. Phone: 617-636-5866
Fax #: 617-636-2369

Kidney function evaluation (GFR), chronic kidney disease (CKD), diabetic kidney disease, glomerular disease, systemic lupus erythematosus, vasculitis, hypertension, cardiovascular disease in patients with kidney disease, acute kidney disease, acute kidney injury and kidney stones

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Craig E. Gordon, MD, MS

Craig E. Gordon, MD, MS

Accepting New Patients

Title(s): Nephrologist; Associate Professor of Medicine, TUSM
Department(s): Medicine, Nephrology
Appt. Phone: 617-636-5866
Fax #:

Polycystic kidney disease (PKD), hepatitis C virus in chronic kidney disease, Thrombotic microangiopathy, glomerular disease, kidney transplantation, chronic kidney disease

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Dana C. Miskulin, MD, MS

Dana C. Miskulin, MD, MS

Accepting New Patients

Title(s): Nephrologist; Associate Professor, Tufts University School of Medicine
Department(s): Medicine, Nephrology
Appt. Phone: 617-636-5866
Fax #: 617-636-2369

Polycystic kidney disease (PKD), dialysis, home dialysis, general nephrology, chronic kidney disease (CKD), diabetic kidney disease, glomerular disease, vasculitis, hypertension, cardiovascular disease in patients with kidney disease, acute kidney disease, acute kidney injury and kidney stones

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Klemens B. Meyer, MD

Klemens B. Meyer, MD

Accepting New Patients

Title(s): Medical Director, Dialysis Clinic, Inc., Boston and Walden Pond, Concord, MA; Director Dialysis Services, Tufts Medical Center; Medical Director for Home Dialysis, Dialysis Clinics, Inc, Somerville, MA; Professor, Tufts University School of Medicine
Department(s): Medicine, Nephrology
Appt. Phone: 617-636-5866
Fax #: 617-636-5539

Dialysis, home dialysis, medical treatment for kidney failure without dialysis, general nephrology, chronic kidney disease (CKD), diabetic kidney disease, glomerular disease, vasculitis, hypertension, cardiovascular disease in patients with kidney disease, acute kidney disease, acute kidney injury and kidney stones

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Lesley A.  Inker, MD, MS

Lesley A. Inker, MD, MS

Accepting New Patients

Title(s): Director, Kidney and Blood Pressure Center; Director, Kidney Function and Evaluation Center; Director, Quality Improvement; Associate Professor, Tufts University School of Medicine
Department(s): Medicine, Nephrology
Appt. Phone: 617-636-5866
Fax #: 617-636-2369

Geriatric nephrology, pregnancy, HIV-associated kidney disease, kidney transplantation, kidney donor evaluation, medical treatment for kidney failure without dialysis, kidney function evaluation (GFR), general nephrology, chronic kidney disease (CKD), diabetic kidney disease, glomerular disease, vasculitis, hypertension, cardiovascular disease in patients with kidney disease, acute kidney disease, acute kidney injury and kidney stones

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Scott J. Gilbert, MD

Scott J. Gilbert, MD

Accepting New Patients

Title(s): Director, Fellowship Training Program; Professor, Tufts University School of Medicine
Department(s): Medicine, Nephrology
Appt. Phone: 617-636-5866
Fax #: 617-636-2369

Kidney transplantation, systemic lupus erythematosus, dialysis, general nephrology, chronic kidney disease (CKD), diabetic kidney disease, glomerular disease, vasculitis, hypertension, cardiovascular disease in patients with kidney disease, acute kidney disease, acute kidney injury and kidney stones

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Research + Clinical Trials


Multicenter, randomized, double-blind, placebo-controlled two stage study to characterize the efficacy, safety, tolerability and pharmacokinetics of GZ/SAR402671 in patients at risk of rapidly progressive Autosomal Dominant Polycystic Kidney Disease (ADPKD)

This is an international, multicenter, randomized, double-blind, placebo-controlled two stage study in adult patients at risk of rapidly progressive Autosomal Dominant Polycystic Kidney Disease (ADPKD) aged 18 to 50 years.

 

The study is divided into two stages. The main purpose of Stage 1 is to determine the effect of GZ/SAR402671 on the rate of total kidney volume (TKV) growth in patients with ADPKD and determine the dose that will be used in Stage 2. The main purpose of Stage 2 is to evaluate the impact of GZ/SAR402671 on the rate of renal function decline. Both Stage 1 and Stage 2 will also evaluate safety and tolerability of GZ/SAR402671 in patients with ADPKD.
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A Double-blind Randomized Parallel Group Study of the Efficacy and Safety of Tesevatinib in Subjects with Autosomal Dominant Polycystic Kidney Disease

The purpose of this study is to find out if the experimental study drug, tesevatinib, works as a treatment for ADPKD and if it is safe. Tesevatinib is made by Kadmon, who provides funding to this facility for the conduct of this study.

About 100 subjects will participate in this study across the U.S. Half the subjects (50 subjects) will receive tesevatinib, and the other half (50 subjects) will receive placebo. The study will last approximately 2 years, and will require frequent visits to Tufts Medical Center


More information about research and clinical trials

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