Polycystic Kidney Disease

Polycystic kidney disease is a kidney disorder passed down through families in which many cysts form in the kidneys, causing them to become enlarged.

Programs + Services


Center for Polycystic Kidney Disease

Tufts Medical Center in Boston offers specialized, lifelong treatment for PKD and other forms of kidney disease, including access to the latest clinical trials.
More information about programs and services


Kidney and Blood Pressure Center

The Tufts MC Kidney and Blood Pressure Center provides both one-time consultations and ongoing care for chronic or acute kidney disease and high blood pressure.
More information about programs and services

Doctors + Care Team

Ronald D. Perrone, MD

Ronald D. Perrone, MD

Accepting New Patients

Virtual Appointments Available

Title(s): Scientific Director, Clinical and Translational Research Center; Professor, Tufts University School of Medicine
Department(s): Medicine, Nephrology, Clinical and Translational Research Center (CTRC)
Appt. Phone: 617-636-5866
Fax #: 617-636-2369

Polycystic kidney disease (PKD)

View Full Profile for Ronald D. Perrone, MD

Mark J. Sarnak, MD, MS

Mark J. Sarnak, MD, MS

Accepting New Patients

Virtual Appointments Available

Title(s): Chief, Division of Nephrology; Director, Research Training Program; Professor, Tufts University School of Medicine
Department(s): Medicine, Nephrology
Appt. Phone: 617-636-5866
Fax #: 617-636-2369

Dialysis, general nephrology, chronic kidney disease (CKD), diabetic kidney disease, glomerular disease, vasculitis, hypertension, cardiovascular disease in patients with kidney disease, acute kidney disease, acute kidney injury and kidney stones

View Full Profile for Mark J. Sarnak, MD, MS

Wendy I. McCallum, MD, MS

Wendy I. McCallum, MD, MS

Accepting New Patients

Title(s): Nephrologist
Department(s): Medicine, Nephrology
Appt. Phone: 617-636-5866
Fax #: 617-636-5866

Chronic kidney disease, hypertension, cardiovascular disease in chronic kidney disease, acute kidney injury, autosomal dominant polycystic kidney disease

View Full Profile for Wendy I. McCallum, MD, MS

Amy Kuhlik, MD

Amy Kuhlik, MD

Accepting New Patients

Title(s): Nephrologist; Dean for Student Affairs and Assistant Professor, Tufts University School of Medicine
Department(s): Medicine, Nephrology
Appt. Phone: 617-636-5866
Fax #: 617-636-2369

Pregnancy, general nephrology, chronic kidney disease (CKD), diabetic kidney disease, glomerular disease, vasculitis, hypertension, cardiovascular disease in patients with kidney disease, acute kidney disease, acute kidney injury and kidney stones

View Full Profile for Amy Kuhlik, MD

Andrew S. Levey, MD

Andrew S. Levey, MD

Virtual Appointments Available

Title(s): Chief Emeritus, Division of Nephrology; Professor of Medicine, Tufts University School of Medicine; Dr. Gerald J and Dorothy R. Friedman Professor Emeritus, Tufts University School of Medicine
Department(s): Medicine, Nephrology
Appt. Phone: 617-636-5866
Fax #: 617-636-2369

Kidney function evaluation (GFR), chronic kidney disease (CKD), diabetic kidney disease, glomerular disease, systemic lupus erythematosus, vasculitis, hypertension, cardiovascular disease in patients with kidney disease, acute kidney disease, acute kidney injury and kidney stones

View Full Profile for Andrew S. Levey, MD

Craig E. Gordon, MD, MS

Craig E. Gordon, MD, MS

Accepting New Patients

Virtual Appointments Available

Title(s): Nephrologist; Associate Professor of Medicine, Tufts University School of Medicine
Department(s): Medicine, Nephrology
Appt. Phone: 617-636-5866
Fax #:

Polycystic kidney disease (PKD), hepatitis C virus in chronic kidney disease, Thrombotic microangiopathy, glomerular disease, kidney transplantation, chronic kidney disease

View Full Profile for Craig E. Gordon, MD, MS

Dana C. Miskulin, MD, MS

Dana C. Miskulin, MD, MS

Accepting New Patients

Virtual Appointments Available

Title(s): Nephrologist; Associate Professor, Tufts University School of Medicine
Department(s): Medicine, Nephrology
Appt. Phone: 617-636-5866
Fax #: 617-636-2369

Polycystic kidney disease (PKD), dialysis, home dialysis, general nephrology, chronic kidney disease (CKD), diabetic kidney disease, glomerular disease, vasculitis, hypertension, cardiovascular disease in patients with kidney disease, acute kidney disease, acute kidney injury and kidney stones

View Full Profile for Dana C. Miskulin, MD, MS

Klemens B. Meyer, MD

Klemens B. Meyer, MD

Accepting New Patients

Virtual Appointments Available

Title(s): Medical Director, Dialysis Clinic, Inc., Boston and Walden Pond, Concord, MA; Director Dialysis Services, Tufts Medical Center; Medical Director for Home Dialysis, Dialysis Clinics, Inc, Somerville, MA; Professor, Tufts University School of Medicine
Department(s): Medicine, Nephrology
Appt. Phone: 617-636-5866
Fax #: 617-636-5539

Dialysis, home dialysis, medical treatment for kidney failure without dialysis, general nephrology, chronic kidney disease (CKD), diabetic kidney disease, glomerular disease, vasculitis, hypertension, cardiovascular disease in patients with kidney disease, acute kidney disease, acute kidney injury and kidney stones

View Full Profile for Klemens B. Meyer, MD

Lesley A.  Inker, MD, MS

Lesley A. Inker, MD, MS

Accepting New Patients

Virtual Appointments Available

Title(s): Director, Kidney and Blood Pressure Center; Director, Kidney Function and Evaluation Center; Director, Quality Improvement; Associate Professor, Tufts University School of Medicine
Department(s): Medicine, Nephrology
Appt. Phone: 617-636-5866
Fax #: 617-636-2369

Geriatric nephrology, pregnancy, HIV-associated kidney disease, kidney transplantation, kidney donor evaluation, medical treatment for kidney failure without dialysis, kidney function evaluation (GFR), general nephrology, chronic kidney disease (CKD), diabetic kidney disease, glomerular disease, vasculitis, hypertension, cardiovascular disease in patients with kidney disease, acute kidney disease, acute kidney injury and kidney stones

View Full Profile for Lesley A. Inker, MD, MS

Scott J. Gilbert, MD

Scott J. Gilbert, MD

Accepting New Patients

Virtual Appointments Available

Title(s): Director, Fellowship Training Program; Professor, Tufts University School of Medicine
Department(s): Medicine, Nephrology
Appt. Phone: 617-636-5866
Fax #: 617-636-2369

Kidney transplantation, systemic lupus erythematosus, dialysis, general nephrology, chronic kidney disease (CKD), diabetic kidney disease, glomerular disease, vasculitis, hypertension, cardiovascular disease in patients with kidney disease, acute kidney disease, acute kidney injury and kidney stones

View Full Profile for Scott J. Gilbert, MD

Research + Clinical Trials


A Phase 3 Trial Of The Efficacy And Safety Of Bardoxolone Methyl In Patients With Autosomal Dominant Polycystic Kidney Disease

This international, multi-center, randomized, double-blind, placebo-controlled Phase 3 trial will study the safety, tolerability, and efficacy of bardoxolone methyl in qualified patients with ADPKD.

The primary objectives of this study is assess the off-treatment change from baseline in estimated glomerular filtration rate (eGFR) at Week 52 or following a 4-week drug treatment withdrawal period in the first year of treatment and to assess safety and tolerability.


More information about research and clinical trials


PKD Biomaterials

The project is focused on understanding the underlying biology in kidney cells, with the goal of developing drug to treat kidney diseases, in particular Autosomal Dominant Polycystic Kidney Disease 
(ADPKD). Following the elective removal of a polycystic kidney, otherwise normally discarded kidneys will be sent to Vertex Pharmaceuticals, Inc. to be analyzed. 
More information about research and clinical trials