Pulmonary Hypertension

Pulmonary hypertension is abnormally high blood pressure in the arteries of the lungs. It makes the right side of the heart work harder than normal.

Doctors + Care Team

Nicholas S. Hill, MD

Nicholas S. Hill, MD

Accepting New Patients

Title(s): Chief, Pulmonary, Critical Care and Sleep Division; Professor, Tufts University School of Medicine
Department(s): Medicine, Pulmonary, Critical Care and Sleep Medicine
Appt. Phone: 617-636-6377
Fax #: 617-636-1649

Pulmonary hypertension, mechanical ventilation, noninvasive ventilation, general pulmonology

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Ambalavanan Arunachalam, MD

Ambalavanan Arunachalam, MD

Accepting New Patients

Title(s): Pulmonary and Critical Care Attending Physician
Department(s): Medicine, Pulmonary, Critical Care and Sleep Medicine
Appt. Phone: 617-636-6377
Fax #: 866-612-2514

Pulmonary and critical care, pulmonary hypertension

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Harrison W. Farber, MD

Harrison W. Farber, MD

Accepting New Patients

Title(s): Pulmonologist
Department(s): Medicine, Pulmonary, Critical Care and Sleep Medicine
Appt. Phone: 617-636-6377
Fax #: 617-636-5953

Pulmonary hypertension

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Ioana R. Preston, MD

Ioana R. Preston, MD

Accepting New Patients

Title(s): Pulmonary Function Lab Director; Director, Pulmonary Hypertension Center; Associate Professor, Tufts University School of Medicine
Department(s): Medicine, Pulmonary, Critical Care and Sleep Medicine
Appt. Phone: 617-636-6377
Fax #: 617-636-1649

Pulmonary hypertension, critical care medicine, general pulmonology

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Kari E. Roberts, MD

Kari E. Roberts, MD

Accepting New Patients

Title(s): Director, Bronchoscopy Service; Associate Chief Medical Officer, Graduate Medical Education; Designated Institutional Official, Graduate Medical Education; Associate Program Director, Internal Medicine Residency; Associate Professor, Tufts University School of Medicine
Department(s): Medicine, Pulmonary, Critical Care and Sleep Medicine
Appt. Phone: 617-636-6377
Fax #: 617-636-1649

General pulmonology, pulmonary hypertension, critical care medicine

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Sucharita R. Kher, MD

Sucharita R. Kher, MD

Accepting New Patients

Title(s): Director, Outpatient Pulmonary Clinic; Pulmonary Attending Physician; Instructor, Tufts University School of Medicine
Department(s): Medicine, Pulmonary, Critical Care and Sleep Medicine
Appt. Phone: 617-636-6377
Fax #: 617-636-1649

Pulmonary diseases, critical care medicine

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Research + Clinical Trials


A study to evaluate the Corvia Medical, Inc. IASD® System II to REDUCE Elevated Left Atrial Pressure in Patients with Heart Failure

This is a research study to investigate the effectiveness and safety of a device for patients with heart failure with preserved ejection fraction (HFpEF). Patients with a left ventricular ejection fraction greater than or equal to 40%, symptoms of heart failure and elevated filling pressures on a test called a right heart catheterization may be eligible to enroll. Participation in this multicenter study involves being randomly assigned either to implantation of an Inter Atrial Shunt Device (IASD) System II, or a sham procedure. Participants will be followed by the Tufts Heart Failure Research Team at regular intervals, for a total of 5 years; however they will remain under the care of their usual Cardiologist. The IASD System II consists of a self-expanding metal structure that is placed into the wall between the upper chambers of the heart (right and left atria) to enable blood to move between these chambers. For HFpEF patients with high pressures in the left atrium, it is thought that enabling blood to move from the left atrium into the right atrium could improve symptoms such as shortness of breath. This device is not yet approved in the United States. Please look at the study website for more information (www.treatmyheartfailure.com).
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206246 : An Open-label, Dose-escalation Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single Doses of GSK2586881 in Participants with Pulmonary Arterial Hypertension

The purpose of this study is to test the safety of different doses of the study drug (GSK2586881) to find out if it causes any changes to the pressures inside the heart and lungs of patients who have Pulmonary Arterial Hypertension (PAH).
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TDE-HF-301: A Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety and Efficacy of Oral Treprostinil in Subjects with Pulmonary Hypertension (PH) in Heart Failure with Preserved Ejection Fraction (HFpEF) 

A multicenter, randomized, double-blind, placebo-controlled, 24-week, parallel-group study. Approximately 310 subjects will be enrolled and randomly allocated (1:1) to receive oral treprostinil or placebo, stratified by Baseline 6MWD. The primary objective of this study is to assess the effect of oral treprostinil compared with placebo on change in exercise capacity as measured by change in 6-Minute Walk Distance (6MWD) from Baseline to Week 24 in subjects with PH associated with HFpEF. The secondary objective of this study is to assess the effect of oral treprostinil compared with placebo on the following: Change in N-terminal pro-brain natriuretic peptide (NT-proBNP) levels from Baseline to Week 24 Time to clinical worsening where clinical worsening is defined by at least 1 
of the following: oospitalization due to a cardiopulmonary indication, Outpatient administration of 1 intravenous (IV) diuretics, Decrease in 6MWD > 15% from Baseline (or too ill to walk) directly related 
to disease under study, at 2 consecutive visits on different days, or Death (all causes) Change in World Health Organization (WHO) Functional Class from Baseline to Week 24.
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An Open-label Extension Study of Oral Treprostinil in Subjects with Pulmonary Hypertension (PH) Associated with Heart Failure with Preserved Ejection Fraction (HFpEF) - A Long-term Follow-up to Study TDE-HF-301

Multi-center, open-label study for eligible patients who completed Study TDE-HF-301. The primary objective of this study is to evaluate the long-term safety of oral treprostinil in subjects with PH associated with HFpEF for subjects who completed Study TDE-HF-301. The secondary objective of this study is to assess the effect of continued long-term therapy with oral treprostinil on the following:

  • 6-Minute Walk Distance (6MWD)
  • Borg dyspnea score
  • World Health Organization (WHO) Functional Class
  • N-Terminal pro-brain natriuretic peptide (NT-proBNP) at Weeks 24 and 48.

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