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Venous Ulcers

Venous ulcer or stasis dermatitis is a change in the skin that occur when blood collects (pools) in the veins of the lower leg. Venous insufficiency is a chronic condition in which the veins have problems sending blood from the legs back to the heart. Some people with venous insufficiency develop venous ulcers, where fluid and blood cells leak out of the veins into the skin and other tissues. 

Doctors + Care Team

Mark D. Iafrati, MD

Mark D. Iafrati, MD

Title(s): Chief, Vascular Surgery; Director, Vascular Center; Director, Center for Vascular, Wound Healing and Hyperbaric Medicine; Vascular Surgeon; Associate Professor, Tufts University School of Medicine
Department(s): Surgery, CardioVascular Center, Vascular Surgery
Appt. Phone: 617-636-5019
Fax #: 617-636-8003

Complex vascular surgery, vascular biology, endovascular surgery, venous surgery, complex wound care

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William C. Mackey, MD

William C. Mackey, MD

Title(s): Surgeon-in-Chief; Andrews Professor and Chairman, Tufts University School of Medicine
Department(s): Surgery, CardioVascular Center, General Surgery, Vascular Surgery
Appt. Phone: 617-636-5927
Fax #: 617-636-8003

Carotid artery surgery, stroke prevention, aortic aneurysms, claudication and other circulatory problems, re-operative vascular surgery, treatment of vascular surgery complications, venous diseases

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Research + Clinical Trials

A Multi-Center, Prospective, Randomized Trial Comparing the Effectiveness of Aurix Therapy to Usual and Customary Care in Venous Leg Ulcers

Aurix is a platelet-rich plasma (PRP) gel used in the treatment of non-healing chronic wounds. The aim of this trial is to demonstrate the effectiveness of complete wound healing in a prospective, open-label, randomized trial in which venous leg ulcers (VLUs) will be treated using Aurix in approximately 100 sites in the US. A physician can enroll a patient in the study for Aurix treatment provided inclusion/exclusion criteria are met. Patients will receive Aurix + Usual and Customary Care (UCC) or UCC alone twice a week for the first two weeks and, then, once a week thereafter. The primary endpoint of the trial is to determine the time to heal at 12 weeks VLUs treated with Aurix + UCC versus UCC alone.
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