Cancer Center

Cancer Biology Program


Understanding Cancer Treatment Starts with Cell Biology

The mission of the Cancer Biology (CB) Program is to integrate the activities of basic scientists in the fields of signal transduction, gene regulation, cell motility, cell-cell interaction, tissue engineering and inflammation/immunology, in order to foster novel and exciting collaborations that provide fundamental insights into the basic biology of cancer cells.  Our focus will be on three thematic areas:  

  1. Signal transduction and gene regulation
  2. Inflammation, immunology and the tumor microenvironment
  3. The role of the cancer stem cell niche in tumorigenesis

Adequately addressing these research focus areas requires an integrated and collaborative effort. Our long-term goal is to leverage this information into a functional database of potential validated targets for the development of new cancer treatments and treatment approaches.

The CB Program consists of investigators from diverse backgrounds (Tufts Medical Center, Tufts University School of Medicine/Sackler School of Graduate Biomedical Sciences, Tufts University School of Dental Medicine and Tufts University School of Engineering [Medford Campus]), all of whom share an interest in the regulation of cellular and molecular processes relevant to cancer.  We believe that a diverse membership permits a broad-minded flow of ideas and collaborations that offers fresh insights into the molecular aspects of cancer.

Principal Investigator + Research Team

John Kyriakis, PhD, Leader
Pamela Yelick, PhD, Co-Leader