Endocrinology, Diabetes and Metabolism

Neuroendocrine and Pituitary Program


Specialized care for pituitary disorders

The Neuroendocrine and Pituitary Program at Tufts Medical Center delivers world-class diagnostic and treatment options for patients with hypothalamic, suprasellar and pituitary disorders, including pituitary adenomas.

Patients will be seen by our specialists within two weeks of calling to schedule an appointment.  Patients can be seen by both the endocrinologist and the surgeon on the same day (Monday).  Being able to see both of our specialists on one day means that treatment plans can be made immediately.  It also saves our patients from making multiple trips to our Boston campus.

What we treat

Our team specializes in diagnosing and treating a wide range of neuroendocrine disorders, including:

  • Prolactinomas
  • Cushing’s disease
  • Acromegaly
  • Thyrotoph adenomas
  • Nonfunctioning pituitary tumors
  • Recurrent pituitary adenomas
  • Pituitary apoplexy
  • Suprasellar tumors
  • Craniopharyngioma
  • Rathke’s cleft cysts
  • Hypopituitarism
  • Diabetes insipidus
  • Hypophysitis
  • Neurosarcoidosis
  • Langerhans cell histiocytosis
  • Lymphoma and metastatic disease involving the hypothalamus
  • Germinoma

A Full Range of Treatment Options

Because we are a strong multidisciplinary team, we are able to work together to create comprehensive and individualized treatment plans for each of our patients.

When a patient is referred to our clinic, we usually begin with a diagnostic evaluation that includes a detailed history and physical examination, laboratory tests to identify the chemical abnormalities and often a MRI.  We use the facilities and state-of-the-art equipment in the recently renovated Neely Neuroscience Center at Tufts Medical Center for much of our diagnostic evaluations.

Occasionally, pituitary disorders may not require intensive medical or surgical treatments but instead, can be monitored through careful observation to ensure that they do not become larger problems.

At other times, these disorders may respond to medical therapy through hormone replacement or other medications, avoiding radiation or invasive surgery.

When surgery is required, Tufts Medical Center’s Neuroendocrine and Pituitary Program offers minimally invasive pituitary surgery, which is accomplished through endoscopic approaches and requires no facial incisions or nasal packing.

When pituitary tumors are surgically inaccessible or recurrent, conventional radiation therapy or Gamma Knife (stereotactic) radiosurgery can be used. Gamma Knife treatment uses radiation in a precise way that spares normal, healthy tissue while pinpointing targets with high doses of radiation.  The Gamma Knife is an effective, non-invasive alternative to traditional brain surgery. Other radiation oncology services are also available through our Radiation Oncology Department.

Most patients with diseases affecting the pituitary gland require careful ophthalmic follow-up because of the proximity of the visual apparatus. The result of pituitary disease may be loss of peripheral vision, which may not always be apparent to the patient. Also, pituitary diseases (especially tumors in this area) can affect the ocular motor nerves causing double vision.

Doctors + Care Team

Carl B. Heilman, MD

Carl B. Heilman, MD

Title(s): Neurosurgeon-in-Chief; Chairman of Neurosurgery; Professor, Tufts University School of Medicine
Department(s): Neurosurgery
Appt. Phone: 617-636-5860
Fax #: 617-636-7587

Meningiomas, acoustic neuromas, skull base surgery, pituitary surgery, Chiari surgery

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Ronald M. Lechan, MD, PhD
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Ronald M. Lechan, MD, PhD

Title(s): Chief, Division of Endocrinology, Diabetes and Metabolism; Director, Hypothalamic and Pituitary Disease Center; Professor, Tufts University School of Medicine
Department(s): Medicine, Endocrinology, Diabetes and Metabolism
Appt. Phone: 617-636-5689
Fax #: 617-636-4719

Hypothalamic disease, pituitary disease, disorders of the thyroid, adrenal disease, islet cell tumors

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Thomas R. Hedges III, MD

Thomas R. Hedges III, MD

Title(s): Director, Neuro-Ophthalmology Service; Co-Director, Electrophysiology Service; Director, Neuro-Ophthalmology Fellowship Program; Professor, Tufts University School of Medicine
Department(s): Ophthalmology
Appt. Phone: 617-636-5488
Fax #: 617-636-7029


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James Kryzanski, MD

James Kryzanski, MD

Title(s): Chief, Division of Epilepsy Surgery; Co-Chief, Division of Spinal Surgery; Assistant Professor, Tufts University School of Medicine
Department(s): Neurosurgery
Appt. Phone: 617-636-8585
Fax #: 617-636-7587

Epilepsy neurosurgery, skull base surgery, pituitary surgery, neurovascular surgery, minimally invasive spine surgery, neurosurgical disorders in patients with achondroplasia, neurosurgical disorders in patients with Down syndrome

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John E. Mignano, MD, PhD

John E. Mignano, MD, PhD

Title(s): Radiation Oncologist; Clinic Director; Associate Professor, Tufts University School of Medicine
Department(s): Radiation Oncology, Pediatric Radiation Oncology
Appt. Phone: 617-636-6161
Fax #: 617-636-4513

Oncologic consultation for general radiotherapy and Gamma Knife, pediatric radiation oncology

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Julian K. Wu, MD

Julian K. Wu, MD

Title(s): Associate Chairman, Department of Neurosurgery; Chief, Division of Neurosurgical Oncology; Neurosurgery Residency Program Director; Professor, Tufts University School of Medicine
Department(s): Neurosurgery
Appt. Phone: 617-636-4500
Fax #: 617-636-7587

Neuro-oncology, Gamma Knife radiosurgery, meningiomas, pituitary tumors, gliomas, brain metastasis, trigeminal neuralgia

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Contact Us

Our team welcomes new patients for evaluations, consultations and treatment.

To make an appointment for your patient or yourself, please call 617-636-5860.

Our clinic is located within Tufts Medical Center:

Tufts Medical Center
800 Washington St.
Boston, MA 02111

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