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The researchers in Tufts Medical Center’s Department of Medicine Divisions and Institutes are pioneers in groundbreaking bench research, clinical trials and developments in health policy. Research is funded by the National Institutes of Health, AHRQ, private foundations, industry, and private individuals. Our three-part mission of providing superb patient care, advancing knowledge, and training the next generation of investigators drives forward with one goal in mind: quickly translating innovative research into pioneering care.  Tufts Medical Center and Floating Hospital rank among the top 10 percent of all institutions that receive research funds from the National Institutes of Health.

Clinical research occurs in every division of the Department.  We are home to ground-breaking investigator-initiated Phase I trials for the sickest cancer patients where Tufts Medical Center is the only hospital in Boston offering such cutting-edge therapy.  We also engage in multi-site industry-sponsored trials from testing new drug therapies for knee osteoarthritis to evaluating the latest ventricular assist device for patients awaiting heart transplant.  Many major pharmaceutical companies conduct research at Tufts Medical Center as we offer a diverse patient population served by physicians determined to provide the best care possible.

Tufts Medical Center’s basic research program applies state-of-the-art molecular methods to understanding mechanisms important in human biology and disease. The ultimate goal of our researchers’ work is to translate basic findings into new clinical strategies for diagnosis and therapy.  The program is synergistic with our clinical strengths including cardiology, infectious disease, pulmonology, endocrinology, oncology and nephrology.  Our renal program is nationally recognized for their contributions in the fight against chronic kidney disease.  Our cardiac researchers investigate ischemic cardiovascular diseases as well as hypertension and congestive heart failure.

Comparative Effectiveness Research

Tufts Medical Center is internationally recognized for its work in the field of Comparative Effectiveness Research (CER).  Comparative Effectiveness Research is designed to inform health-care decisions by providing evidence on the effectiveness, benefits, and harms of different treatment options. The evidence is generated from research studies that compare drugs, medical devices, tests, surgeries, or ways to deliver health care.  Our CER programs investigate the genetic, social, behavioral, and biologic factors that can influence patient outcomes and healthcare decisions.  Results from our studies influence and create national health policy and drive better and more cost-effective clinical care.  CER represents a major growth opportunity for Tufts Medical Center, and because of our established presence in the field, continue to be well-positioned to take advantage of the significant funding being allocated at the national level for this line of work.

The Tufts Clinical and Translational Science Institute

The Tufts Clinical and Translational Science Institute (CTSI), a collaboration of 39 organizations, founded by Tufts Medical Center and Tufts University, is a 5-yr $20M Clinical and Translational Science Award (CTSA) from the National Center for the Advancement of Translational Sciences at NIH.  The goal of the CTSA network of grants is to create a national consortium intended to transform how clinical and translational research is conducted throughout the country. Tufts-CTSI reflects a unique emphasis on community in biomedical research and includes multiple hospitals, health plans, industry leaders, community organizations and universities with the ultimate goal of translating research into better health.