Tufts MC Research in the News


Lesley Inker, MD, MS (Nephrology) -- JAMA 2022

A multi-disciplinary team, including Dr. Inker, was instrumental to the development of the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) who assessed glomerular function estimating equations that are the standard for care world-wide. The newest CKD-EPI equation replaced previous equations that had included race as a variable.




Alysse Wurcel, MD (Infectious Disease) -- Ann Thorac Surgery 2022

This multi-site study sought to gather the perspectives of cardiothoracic surgeons on initial and repeat valve surgery for people with DUA-infective endocarditis through purposeful sampling of surgeons at seven hospitals.  Cardiothoracic surgeons are emotionally and professionally impacted by making decisions about whether to perform valve operations for people with DUA-IE. The use of efficient, agenda-based multidisciplinary care teams is an actionable solution to improve cross-disciplinary partnerships and outcomes for people with DUA-IE




Navin Kapur, MD (Cardiology) -- J Am Coll Cardiol 2022

Risk-stratifying patients with cardiogenic shock (CS) is a major unmet need. Researchers selected parameters of hypotension, hypoperfusion, and treatment intensity and confirmed their association with mortality. Of 3,455 patients, CS was caused by heart failure (52%) or myocardial infarction (32%). Mortality was 35% for the total cohort. Systolic blood pressure, lactate level, alanine transaminase level, and systemic pH were significantly associated with mortality and used to define each stage. Using these criteria, baseline and maximum stages were significantly associated with mortality (n = 1,890).  This is a novel approach to define SCAI stages and identify a significant association between baseline, maximum stage, and mortality. This approach may improve clinical application of the staging system and provides new insight into the trajectory of hospitalized CS patients.




Tamara Vesel, MD (Palliative Care) -- Am J Hosp Pall Med

Findings highlight evolving and increased utilization of palliative care during the pandemic, suggesting a need for greater investment in palliative care programs and for palliative care involvement in public health emergency preparedness and response.



Jeffery Driban, MD (Rheumatology) -- ACR

Novel Framework for Measuring Whole Knee Osteoarthritis Progression Using Magnetic Resonance Imaging

Researchers developed and validated a set of composite scores that combine quantitative magnetic resonance imaging (MRI)-based measurements of hyaline cartilage damage, bone marrow lesions (BMLs), and effusion-synovitis into composite scores. Two composite scores emerged, reflecting discrete domains of knee osteoarthritis progression. First, cumulative damage, which is measured by a whole-knee cartilage damage score, reflects the damage accrued over time. Second, dynamic disease activity, which is measured by a BML plus effusion-synovitis score, relates to changes in a patient's state of disease and symptoms.



John Wong, MD (General Internal Medicine) -- JAMA

The US Preventive Services Task Force lowered the recommended age of eligibility for lung cancer screening from 55 to 50 and reduced the smoking exposure criteria from 30 to 20 pack-years, expanding the opportunity to undergo screening for lung cancer so that nearly twice as many people could benefit from getting the care they need when treatment might be most effective.