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Cardiac Surgery Research

Research within the Division of Cardiac Surgery at Tufts Medical Center has had a long and productive history. Currently we have ongoing projects that include basic scientific investigation, as well as clinical research and participation in large scale clinical trials.

Current research projects include:

  1. Hemodynamic Evaluation of Heartware MVAD in Bi-Ventricular support in swine. Heartware, Inc.
  2. Hemodynamic Evaluation of Tandem Heart Ventricular Assist in multi-cannulation in swine. Cardiac Assist Inc.
  3. PROCEED: A Prospective, Multi-Centered, Randomnized Clinical Investigation of Transmedic Organ Care System for Cardiac Use (Protocol Number CAR 05-2008).
  4. ENDURANCE: A Prospective, Randomnized, Controlled, Un-blinded, Multi-Center Clinical Trial of Advanced Heart Failure. Funded by HeartWare Inc. (Protocol Number HW-004)
  5. ADVANCE: Evaluation of the HeartWare LVAD System for the treatment of advanced heart failure. Funded by HeartWare Inc. (Protocol Number HW-003).
  6. Impact of reduced arterial pulsatility on vascular tone and function following placement of continuous left ventricular assist devices. (Tufts IRB protocol Number 9963)

Gruner C, Chan RH, Crean A, Rakowski H, Rowin EJ, Care M, Deva D, Williams L, Appelbaum E, Gibson CM, Lesser TR, Haas TS, Udelson JE, Manning WJ, Siminovitch K, Ralph-Edwards AC, Rastegar H, Maron BJ, Maron MS. Significance of left ventricular apical-basal muscle bundle indentified by cardiovascular magnetic resonance imaging in patients with hypertrophic cardiomyopathy. Eur Heart J. 2014 May 8. 

Hassani L, Fazeli Z, Safaei E, Rastegar H, Akbari M. A spectroscopic investigation of the interaction between c-MYC DNA and tetrapyridinoporphyrazinatozinc(II). J Biol Phys. 2014 May 15. 

Kapur NK, Upshaw J, Kiernan MS, Pham DT. Left ventricular assist device thrombosis presenting as an acute coronary syndrome. J Thorac Cardiovas Surg. 2014 Feb 14. 

Malik R, Maron MS, Rastegar H, Pandian NG. Hypertrophic Cardiomyopathy with Right Ventricular Outflow Tract and Left Ventricular Intracavitary Obstruction. Echocardiogr J Card. 2014;31(5):682-685.

Maltias S, Keebler ME, Schlendorf KH, Boyce SW, Najjar SS, Pagani FD, Aranson Kd, Jeevanandam V, Milano CA, Rogers J, Love R, Mahr C, Pham DT, Kiernan MS, Teuteberg JJ, Silvestry SC, Ewald G, McGee EC, Gordon R, Malidi HR, Frazier OH. First report of the PAS INTERMACs registry of the HVAD in commercial 
use. J Heart Lung Transpl. 2014 April;33(4) supplement:S36-37. 

Naseem T, Seong M, Ianchul VS, Rastegar H, Cobey FC. The echocardiographic evaluation of a bicuspid aortic valve: the effect of jet eccentricity and left ventricular outflow tract geometry on the effective orifice area. J Cardiothorac Vasc Anesth. 2014 28(2): 423-7. 

Kapur NK, Paruchcuri V, Jagannathan A, Steinberg D, Chakrabarti AK, Pinto D, Aghili N, Najjar S, Finley J, Orr NM, Tempelhof M, Mudd JO, Kiernan MS, Pham DT, DeNofrio D. Mechanical circulatory support for right ventricular failure. JACC Heart Fail. 2013 Apr;1(2):127-34. 

Kapur NK, Paruchuri V, Esposito M, Schraufnagel DP, McSparren D, Civiello D, Todd-Elliot V, Tamez D, Nunez NJ, Voskoboynikov N, Graham J, Pham DT. A novel algorithm to promote native aortic valve function using the next generation Heartware MVAD. J Heart Lung Transpl. 2013 April;32(4);s179-180.

Nagy CD, Jumean MF, Pham DT, Kiernan MS, DeNofrio D, Kapur NK. Percutaneous circulatory support for biventricular failure. Circ Cardiovasc Interv. 2013 Apr;6(2):e12-4. 

Maron BJ, Rastegar H, Udelson JE, Dearani JA, Maron MS. Contemporary surgical management of hypertrophic cardiomyopathy, the need for more myectomy surgeons and disease-specific centers, and the Tufts initiative. Am J Cardiol. 2013 Nov;1:112(9). 

Pham DT, Paruchuri V, Esposito M, Schraufnagel DP, McSparren D, Civiello D, Todd-Elliot V, Vassallo C, Murphy B, Reyelt L, Beal CN, Rincon K, Nunez NG, Voskoboynikov N, Tamez D, Warner KG, Kapur NK. Hemodynamic evaluation of Heartware MVAD in normal and infarct swine models. J Heart Lung Transpl. 2013 April;32(4):s184-5.

Rowin EJ, Maron BJ, Lesser JR, Rastegar H, Maron MS. Papillary muscle insertion directly into the anterior mitral leaflet in hypertrophic cardiomyopathy, its identification and cause of outflow obstruction by cardiac magnetic imaging, and its surgical management. Am J Cardiol. 2013 Jun 1;111(11):1677-9. 

Al-Quthami A, Jumean M, Kociol R, Pham DT, Kiernan MK, DeNofrio D, Kapur NK. Eptifibatide for the treatment of HeartMate II left ventricular assist device thrombosis. Circ Heart Fail. 2012 Jul;5(4):e68-70.

Pham DT, Al-Quthami A, Kapur NK. Percutaneous left ventricular support in cardiogenic shock and severe aortic regurgitation. Catheter Cardiovasc Interv. 2012 Feb;81(2):399-401.

Thibodeau E, Boucher H, DeNofrio D, Pham DT, Syndman D. First report of left ventricular assist device infection cause by Staphylococcus schleiferi subspecies coagulans: a coagulase positive organism. Diagn Microbiol Infect Dis. 2012 Sep;74(1):68-69.

Kapur NK. Paruchuri V, Korabathina R, Al-Mohammadi R, Muud JO, Prutkin J, Esposito M, Shah A, Kiernan MS, Such C, Pham DT, Konstam MA, DeNofrio D. Effects of a percutaneous mechanical circulatory support device for medically refractory right ventricular failure. J Heart Lung Transplant. 2011 Dec;30(12):1360-1367.

Korabathina R, Pham DT, Kapur NK. Subactue left ventricular rupture supported with a percutaneous left ventricular assist device. J Inv Card. 2011 Jun;23(6):1-3.

Starling RC, Naka Y, Boyle AJ, Gonzalez-Stawinski G, John R, Ulrich J, Russell SD, Conte JV, Aaronsen KD, McGee EC, Cotts WG, DeNofrio D, Pham DT, Farrar DJ, Pagani FD. Results of the post-FDA approval study with a continuous flow left ventricular assist device as a bridge to heart transplantation: a prospective studyusing the INTERMACS registry. JACC. 2011 May 10;57(19):1890-1898.

Kiernan MS, Pham DT, DeNofrio D, Kapur NK. Management of HeartWare left ventricular assist device thrombosis using intra-cavitary thromolytics. J Thorac Cardiovasc Surg. 2011 Sep;142(3):712-714.

Jumean M, Quintero P, Patel AR, DeNofrio D, Warner KG, Pham DT, Kiernan MS. Effect of continuous-flow LVADs on pulmonary arterial pressures: comparisonbetween axial and continuous flow devices. International Society of Heart and Lung Transplantation Annual Meeting, San Diego, CA. April 2014

Jumean M, Phan D, Patel A, Kiernan MS, Kapur NK, DeNofrio D, Warner KG, Pham DT, Kiernan MS. Natural history of mitral regurgitation in left-ventricular assist device patients. International Society of Heart and Lung Transplantation Annual Meeting, San Diego, CA. April 2014.

Paruchuri V, Shah N, Dow S, Salehi H, Aghili N, Pandian N, Pham DT, Karas R, Kapur N. Left ventricular mechanics during acute circulatory support in a preclinical model of left heart injury. ISHLT Annual Meeting April 2014.

Pham DT, Narsule C, Julien M, Warner KG. Biventricular assist device replacement using the Heartware Ventricular Assist System: Report of first occurrenceISHLT Annual Meeting April 2014.

Pham DT. Mechanical Circulatory Support: The past, present, and future. Candadian Society of Clinical Perfusionists Annual Meeting. Ottawa, Canada. April 2014

Pham DT, Narsule C, Dermody M, Kapur NK, Halin N. Balloon angioplasty and stenting of outflow graft stenosis following implantation of left ventricular assist device for cardiomyopathy: a case report. Poster presentation. International Society of Heart and Lung Transplantation Annual Meeting. San Diego, CA.
April 2014.

Warner KG. Surgical management of Tetralogy of Fallot. Surgical Interest Group, Tufts Medical School. Boston, MA April 2014.

Warner KG. Resuscitation of cold water drowning victims. Medical Grand Rounds MetroWest Medical Center Natick Campus. Natick, MA 2014.

Milano C, Pagani FD, Slaughter MS, Pham DT, Hathaway DR, Jacoski MS, Najarian KB, Aranson KD, ADVANCE Trial Clinical Investigators. Clinical outcomes following implantation of a centrifugal-flow left ventricular assist device and concurrent cardiac valve procedures. American Heart Association Meeting. 
Dallas, TX. November 2013.

Pham DT. Cardiac Surgery: From Bedside to Bench and Back. Department of Surgery Grand Rounds. Tufts Medical Center, Boston MA. February 2014.

Sylvia L, Ordway L, Kapur NK, Pham DT, DeNofrio D, Kiernan MS. Treatment of LVAD Thrombus: experience with a bivalrudin dosing protocol. Heart Failure Society of America Annual Meeting. Orlando, FL. September 2013.

Pham DT. Right ventricular failure and tricuspid regurgitation in left ventricular assist device implantation.Thoratec Fellows Advisory Council Annual Meeting. Chicago, IL October 2013.

Pham DT. Mechanical Circulatory Support: Past, present, and future. Sixth Annual New England Heart Failure and Transplant Network Conference. Boston MA. November 2013.

Warner KG: Recent advances in cardiac surgery at Tufts Medical Center Lowell General Hospital Cardiology Grand Rounds. Lowell, MA. June 2013.

Frederick  Y. Chen, MD, PhD

Frederick Y. Chen, MD, PhD

Title(s): Chief, Cardiac Surgery; Professor of Surgery, Tufts University School of Medicine
Department(s): Surgery, CardioVascular Center, Cardiac Surgery
Appt. Phone: 617-636-5590
Fax #: 617-636-6410

Surgical treatment of acquired heart disease, surgical repair of valvular heart disease, minimally invasive surgery, arrhythmia surgery, heart transplantation, circulatory assist devices, hypertrophic cardiomyopathy (HCM)

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Hassan Rastegar, MD

Hassan Rastegar, MD

Title(s): Senior Cardiothoracic Surgeon; Professor, Tufts University School of Medicine
Department(s): Surgery, CardioVascular Center, Cardiac Surgery
Appt. Phone: 617-636-5590
Fax #: 617-636-6410

Surgical treatment of acquired heart disease, surgical repair of valvular heart disease, surgical repair of hypertrophic cardiomyopathy, minimally invasive surgery, arrhythmia surgery, heart transplantation, circulatory assist devices

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Kenneth G. Warner, MD

Kenneth G. Warner, MD

Title(s): Senior Cardiothoracic Surgeon; Program Director for the Thoracic Surgery Residency; Associate Professor, Tufts University School of Medicine
Department(s): Surgery, CardioVascular Center, Cardiac Surgery
Appt. Phone: 617-636-5590
Fax #: 617-636-6410

Surgical management of adult and pediatric heart disease, heart transplantation

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