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Colon and Rectal Surgery Research

The members of the Division of Colon and Rectal Surgery have a wide number of research interests including complications of ostomies, inflammatory bowel disease, pathogenesis of colorectal and anal cancer and treatment of early rectal cancer.

Current research projects include:
  1. The role of myofibroblasts in colitis-associated cancer.
  2. Development of a novel in vivo mouse model to study stromal-epithelial cell interactions.
  3. The role of PKD signaling on COX-2 in myofibroblasts.
  4. The use of platelet angiogenesis regulator proteins to predict colorectal cancer stage.

O’Leary E, Larson E, Lin AY, Reardon S, Lee P, Russell M, Melnitchouk N, Hart S, Ghassemi K, Hecht JR, Wainberg Z, Yoo J. A Multi-Disciplinary Cancer Program Enhances Hereditary Colorectal Cancer Detection.  Am J Dig Dis 2014; 1(1):62-66.

Larson ES, Khalil HA, Lin AY, Russell M, Ardehali A, Ross D, Yoo J.  Diverticulitis Occurs Early After Lung Transplantation, J Surg Res 2014; 190(2): 667-71.

Lee MK, Chen F, Esrailian E, Russell MM, Sack J, Lin AY, Yoo J.  Combined Endoscopic and Laparoscopic Surgery (CELS) May Be an Alternative to Bowel Resection for the Management of Colon Polyps Not Removable by Standard Colonoscopy”.  Surgical Endoscopy, 27(6): 2082-6, 2013.

Yoo J, Rodriguez Perez CE, Nie W, Sinnett-Smith J, Rozengurt E. TNF- and LPA Promote Synergistic Expression of COX-2 in Human Colonic Myofibroblasts: Role of LPA-mediated Transactivation of Upregulated EGFR. BMC Gastroenterology, 20: 13(1): 90, 2013.

Yoo J, Rodriguez Perez CE, Nie W, Edwards RA, Sinnett-Smith J, Rozengurt E. TNF- Induces Up-Regulation of EGFR Expression and Signaling in Human Colonic Myofibroblasts.  Am J Physiol Gastrointest Liver Physiol. 302(8): G805-14, 2012.

Rodriguez Perez CE, Nie W, Sinnett-Smith J, Rozengurt E, Yoo J.  TNF- Potentiates Lysophosphatidic acid-induced COX-2 Expression via PKD in Human Colonic Myofibroblasts.  Am J Physiol Gastrointest Liver Physiol.  300(4): G637-46, 2011. 

Yoo J, Rodriguez Perez CE, Nie W, Sinnett-Smith J, Rozengurt E.  Protein Kinase D1 Mediates Synergistic MMP-3 Expression induced by TNF- and Bradykinin in Human Colonic Myofibroblasts.  Biochemical and Biophysical Research Communications. 413(1):30-5, 2011.

Cabot JC, Lee SA, Yoo J, Nasar A, Whelan RL, Feingold DL.  Long-Term Consequences of Not Closing the Mesenteric Defect After Laparoscopic Right Colectomy.  Dis Colon Rectum. 53: 289-292, 2010.

Yoo J, Chung C, Slice L, Sinnett-Smith J, Rozengurt E.  Protein kinase D mediates synergistic expression of COX-2 induced by TNF-α and bradykinin in human colonic myofibroblasts.  Am J Physiol Cell Physiol. 297(6): C1576-87, 2009.

Offodile AC, Lee SW, Yoo J, Whelan RL, Moradi D, Baxter R, Arnell TD, Nasar A, Sonoda T, Milsom JW, Feingold DL.  Does Prior Abdominal Surgery Influence Conversion Rates and Outcomes of Laparoscopic Right Colectomy in Patients with Neoplasia?  Dis Colon Rectum.  51(11):1669-74, 2008.

Lee SW, Yoo J, Dujovny N, Sonoda T, Milsom JW. Laparoscopic vs. Hand-Assisted Laparoscopic Sigmoidectomy for Diverticulitis. Dis Colon Rectum. 49: 1-6, 2006.

Del Castillo IC, Fedor-Chaiken M, Song JC, Starlinger V, Yoo J, Matlin KS, Matthews JB. Dynamic Regulation of NKCC1 Surface Expression by Protein Kinase C-epsilon in Chloride Secretory Epithelia.  Am J Physiol Cell Physiol 289(5):C1332-42, 2005.

Yoo J: Changing Paradigms in the Treatment of Colorectal Cancer. Leonard Morse Hospital Specialty Grand Rounds: June 18, 2014.

Yoo J: Endoscopic Model of Hirschprung’s Disease in Mouse. Pacific Association of Pediatric Surgeons, 2014

Yoo J: Primary Myofibroblasts Maintain Short-Term Viability Following Submucosal Injection in Syngeneic, Immune-Competent Mice Utilizing Murine Colonoscopy. Academic Surgical Congress, 2014.

Yoo J: Diverticulitis Occurs Early After Lung Transplantation. Academic Surgical Congress, 2014.

Yoo J: Colonic Myofibroblasts Support the Expansion of Ex-Vivo Primary Mouse and Human Colonic Stem Cells. Academic Surgical Congress, 2014.

Yoo J: A Multi-Disciplinary Cancer Program Enhances Hereditary Colorectal Cancer Detection. Academic Surgical Congress, 2014.

Yoo J: Combined Endoscopic and Laparoscopic Surgery (CELS) May Be An Alternative to Bowel Resection for the Management of Colon Polyps Not Removable by Standard Colonoscopy. Academic Surgical Congress, 2013.

Yoo J: Diverticular Disease. Department of Surgery Grand Rounds– Ronald Reagan UCLA Medical Center, Los Angeles, CA: January 16, 2013.

Yoo J: Evidence-Based Treatment of Colorectal Diseases: Perforated Diverticulitis (Operative and Non-Operative Management). Society for Surgery of the Alimentary Tract Maintenance of Certification Course: May 18, 2013.

Yoo J: Synergistic COX-2 Expression Induced by LPA and TNF- Involves Transactivation of the EGF Receptor in Human Colonic Myofibroblasts. Academic Surgical Congress, 2012.

Yoo J: TNF- and Bradykinin Mediate Synergistic MMP-1 and MMP-3 Expression via PKC/PKD and p42/44 MAPK in Human Colonic Myofibroblasts. American Society of Colon and Rectal Surgeons, 2011.

Yoo J: Colonic Myofibroblasts, COX-2, and PKD: Novel Partners in an Intriguing Pathway. CURE: Digestive Diseases Research Center Annual Meeting, 2011.

Yoo J: American College of Surgeons Laparoscopic Colectomy Skills Course “Laparoscopic Sigmoid Colectomy”. 2011.

Lilian  Chen, MD

Lilian Chen, MD

Accepting New Patients

Title(s): Colon and Rectal Surgeon; Associate Program Director of the General Surgery Residency Program; Associate Director of Surgical Education; Assistant Professor, Tufts University School of Medicine
Department(s): Surgery, Colon and Rectal Surgery
Appt. Phone: 617-636-6190
Fax #: 617-636-6110

Minimally invasive and robotic colorectal surgery, colon and rectal cancer, inflammatory bowel disease including Crohn's disease and ulcerative colitis, anorectal disease, rectal prolapse and sacral nerve stimulator for fecal incontinence

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James Yoo, MD

James Yoo, MD

Accepting New Patients

Title(s): Chief, Division of Colon and Rectal Surgery; Assistant Professor, Tufts University School of Medicine
Department(s): Surgery, Colon and Rectal Surgery
Appt. Phone: 617-636-6190
Fax #: 617-636-6110

Minimally invasive colorectal surgery, colon and rectal cancer, inflammatory bowel disease including Crohn's disease and ulcerative colitis

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