General Surgery and Surgical Oncology Research

Current research projects include:

1. Cancer stem cells and the risk of recurrence.
2. A Phase I Trial of Continuous Low-Irradiance Photodynamic Therapy (CLIPT) for Patients Failing Radiation Therapy.
3. The Stroma as a Gatekeeper of Malignant Transformation.
4. Cyclophosphamide and Docetaxel Every Three Weeks as Neoadjuvant Therapy in Locally Advanced Breast Cancer – A Collaborative Trial
5. Outcomes and change of practice in patients with peritoneal and pleural based malignancies utilizing a clinical database.
6. Working with medical oncology and collaborative groups on pancreatic cancer trials.
7. Near-Infrared Spectral Imaging of the Breast for Cancer Detection and Monitoring.
8. A Novel Therapy for the Treatment of Chest Wall Progression of Breast Cancer.
9. Benign Ultrasound-Guided Core Biopsy with Discordant Ultrasound Features.  Is Excision Necessary?
10. Microwave Thermography (Oncoscan) as an Adjunct to Standard Breast Imaging.
11. A Randomized Study to Prevent Lymphedema in Women Treated for Breast Cancer.
12. Thermal Characterization of Breast Tumors by Oncoscan.
13. Sentinel Node Biopsy in the Management of Breast Cancer.
14. Evaluation of Models for Teaching Residents in Minimally Invasive Surgery.
15. Acute pancreatitis – A Re-evaluation of Current Classification and Prognostic Criteria.

Publications:      

Morrision S, Hill S, Rogers G, Graham R.  Efficacy and safety of continuous low-irradiance photodynamic therapy in the treatment of chest wall progression of breast cancer. J Surg Res. 2014 Jun 24. pii: S0022-4804 (14) 00579-4 (Epub ahead of print).

Goodman MD, Saif MW.  Adjuvant therapy for pancreatic cancer.  J Pancreas. 2014 March 10;15(2):87-90.

McPartland SJ, Goodman MD. The effect of elevated body mass index on outcomes following cytoreductive surgery with hyperthermic intraperitoneal chemotherapy. Ann Surg Oncol. 2014 May;21(5):1463-7.

McPartland SJ, Goodman MD. Mucinous cystadenoma of the mesorectum. Am Surg. 2014 Mar;80(3):E86-7.

Morrison S, Graham R, Hill S, Price L, Holcroft C, Rogers G. Efficacy and safety of continuous low irradiance photodynamic therapy (CLIPT) in the treatment of cutaneous recurrence of breast and dermal malignancies. J Surg Res. 2014:186(2)672-672.

Chaulagain C, Rothschild J, Saif M. Is S-1 a Potential Game Changer in Adjuvant Therapy of Pancreatic Cancer? J Pancreas. 2013;14(4):329-333.

Chaulagain CP, Ng J, Goodman MD, Saif MW.  Adjuvant therapy of pancreatic cancer.  J Pancreas. 2013 Mar 10;14(2):119-22.

Goodman MD, McPartland S, Huber k, Saif MW.  New developments in the management of borderline resectable pancreatic cancer.  J Pancreas. 2013 July 10;14(4):334-6.

McPartland SJ, Goodman MD. The effects of advanced age on post-operative morbidity and mortality following cytoreductive surgery with hyperthermic intraperitoneal chemotherapy. Gastroenterology. 2013;144(5):s1097.

McPartland SJ, Goodman MD. Cytoreductive surgery with heated intraperitoneal chemotherapy improves overall survival in patients with mucinous signet ring peritoneal malignancies. Ann Surg Onc. 2013;20:S83.

Sharma J, Ng J, Goodman MD, Saif MW. New developments in the management of borderline resectable pancreatic cancer. J Pancreas. 2013 Mar 10;14(2):123-5.

Wai CJ, Al-Mubarak G, Homer M, Samenfeld-Specht M, Logvinenko T, Rothschild J, Graham RA.  A modified triple test for palpable breast masses – the value of ultrasound and core needle biopsy.  Ann Surg Oncol. 20: 850-855, 2013.

Magoon P, Graham R, Rothschild J, Lee Y.  Occurrence of lymphedema following sentinel node biopsy (SNB) for lower extremity melanoma. J Curr Surg. 2012;(2): 40-45.

Schumann R, Wilson G, Hariskov S, Buck D, Goodman M, Balonov K, Bonney M, Wurm WH. Impact of intraoperative anesthetic and fluid management on 30-day postoperative outcomes in a surgical peritoneal surface malignancy program. J Anesth Clinic Res. 2012 Sept;3(244).

Kaafarani H, D’Achille J, Graham RA.  Non-trocar related major retroperitoneal bleeding during laparoscopic appendectomy.  World Journal of Emergency Surgery 2011;6: 9.

Book Edits:

Goodman MD. Regional Therapeutics for Advanced Malignancies. Jaypee Brothers Pub 2012

Goodman MD, Saif MW. Tumors of the Pancreas.  Jaypee Brothers Work in Progress. 2014

Book Chapters:

McPartland S, Goodman MD. Pathophysiology of Peritoneal Malignancies and Modalities of Treatment. In: Goodman MD eds. Regional Therapeutics for Advanced Malignancies.  Jaypee Brothers Pub 2012

Graham R. Thyroid Cancer – Current Controversies in 2014.  Southcoast Health Physician Program. New Bedford, MA: Sept 18, 2014. 

Anderson P, Kainerstorfer J, Krishnamurthy N, Homer M, Sassaroli A, Graham R, Fantini S.  Broadband Optical Mammography: Hemoglobin Saturation Maps for Cancerous Human Breasts.  Optical Society of America. Miami, FL: April 2014.

DeVito N, Goodman MD, Caplain J, Rajagopal S, Popowich D, Orkin BA, Grimm E, Tsichlis PN, Martell RE, Saif WM.  A pilot study evaluating the safety and impact of pretreatment with metformin on colorectal cancer stem cells (CCSC) in patients undergoing resection. 2014 ASCO Annual Meeting.

Goodman MD, Young M, McPartland S.  Cytoreductive surgery with HIPEC for signet ring peritoneal malignancies.  Ninth International Symposium on Regional Cancer Therapies: Steamboat Springs Colorado February 15 -17, 2014.

Young M, McPartland S. Goodman MD.  Cardiac toxicity associated with intraperitoneal administration of mitomycin C.  Ninth International Symposium on Regional Cancer Therapies: Steamboat Springs Colorado February 15 -17, 2014.

Graham R. Breast Cancer – A Surgeon’s Perspective. MetroWest Medical Center, Framingham, MA: Nov 19, 2013.

Graham R. Thyroid Cancer. MetroWest Medical Center, Natick, MA: Oct 16, 2013.

Graham R. Updates in Melanoma – 2013.Winchester Hospital, Winchester, MA:  May 31, 2013.

Anderson P, Kainerstorfer J, Sassaroli A, Graham R, et al.  Broadband optical mammography:  oxygenation mapping, edge-effect corrections, and depth discrimination.  SPIE Photonics West Conference: Feb 2013.

McPartland SJ, Goodman MD. The effect of elevated body mass index on outcomes following cytoreductive surgery with hyperthermic intraperitoneal chemotherapy.  Presented at the 8^th International Symposium on Regional Cancer Therapies: Palm Springs, CA, 2013.

McPartland SJ, Goodman MD. Mechanical bowel preparation prior to cytoreductive surgery with hyperthermic intraperitoneal chemotherapy.  Presented at the 8th International Symposium on Regional Cancer Therapies: Palm Springs CA, 2013.

McPartland SJ, Goodman MD. The effects of advanced age on post-operative morbidity and mortality following cytoreductive surgery with hyperthermic intraperitoneal chemotherapy. Presented at the Society for Surgery of the Alimentary Tract Annual Meeting: Orlando, FL, 2013.

McPartland SJ, Goodman MD. Cytoreductive surgery with heated intraperitoneal chemotherapy improves overall survival in patients with mucinous signet ring peritoneal malignancies. Presented at the Society of Surgical Oncology Annual Meeting: Washington DC, 2013.

McPartland SJ, Goodman MD. Mucinous adenocarcinoma originating from an appendiceal stump. Presented at the 8th International Symposium on Regional Cancer Therapies: Palm Springs, CA, 2013.

Morrison S, Graham R, Rogers G, Hill S, Price LL, Breeze J, and Holcroft C.  Efficacy and safety of continuous low irradiance photodynamic therapy in the treatment of cutaneous recurrence of breast and dermal malignancies.  American Society for Laser Medicine and Surgery - Annual Conference: April 2013.

Anderson P, Cantor-Balan R, Wellwitigoda G, Yu Y, Sassaroli A, Larusson F, Miller E, Kilmer M, Homer M, Graham R, Fantini S.  Broadband optical mammography: Clinical measurements, quantitative oximetry and phantom data. Biomedical Engineering Society Conference. Atlanta, GA: Oct 2012.

Persico J, Wazer D, Melanson AM, Rogers G, Graham R.  Continuous low-irradiance photodynamic therapy (CLIPT):  A novel treatment for cutaneous recurrences of breast cancer.  American Society of Clinical Oncology: June 2012.

Ryan J, Graham, RA, Burow L, Rothschild J, Carr K.  Passive microwave thermography (Oncoscan) as an adjunct to standard breast imaging.  The American Society of Breast Surgeons. Phoenix, AZ: May 2012.

Wai C, Al-Mubarak G, Homer M, Rothschild J, Graham RA.  The modified triple test in predicting cancer in a palpable breast mass.  Society of Surgical Oncology. San Antonio, TX: March 2011.

Weliwitigoda G, Anderson P, Cantor-Balan R, Yu Y, Sassaroli A, Larusson F, Miller E, Kilmer M, Homer M, Graham R, Fantini S.  Broadband optical mammography: quantitative oximetry, depth sensitivity, and spectral image reconstruction.  NIH Conference. Bethesda, MD: Sept 2011.