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Jennifer DuPont, PhD
Principal Investigator, Molecular Cardiology Research Institute; Director, Vascular Function Core; Assistant Professor, Tufts School of Medicine
Department + Services
Molecular Cardiology Research Institute (MCRI)
Clinical Focus Areas
Sex differences in vascular ageing, Vascular dysfunction in postmenopausal women
June 2016, Natalie V. Zucker Research Center for Women Scholars Award, Tufts Medical Center
March 2016, Young Investigator Award Finalist, International Aldosterone Conference
April 2015, Cardiovascular Section Research Recognition Award, American Physiological Society
April 2015, Caroline tum Suden Professional Opportunity Award, American Physiological Society
2014-2016, American Heart Association Postdoctoral Fellowship, American Heart Association
April 2013, Caroline tum Suden Professional Opportunity Award, American Physiological Society
DuPont JJ, Jaffe IZ. 30 years of the mineralocorticoid receptor: The role of the mineralocorticoid receptor in the vasculature. Journal of Endocrinology. 2017, 234(1):T67-T82.
DuPont JJ, McCurley A, Davel AP, McCarthy J, Bender SB, Hong K, Yang Y, Yoo J, Aronovitz MA, Baur WE, Christou DD, Hill MA, Jaffe IZ. Smooth muscle cell mineralocorticoid receptor regulation of vascular microRNA-155 contributes to vascular dysfunction and rising blood pressure with aging. Journal of Clinical Investigation Insight. 2016, 1(14):e88942.
Burke SD, Zsengeller ZK, Khankin EV, Agnes S. Lo AS, Rajakumar A, DuPont JJ, McCurley A, Moss ME, Zhang D, Clark CD, Wang A, Seely EW, Kang PM, Stillman IE, Jaffe IZ, Karumanchi SA. Soluble fms-like tyrosine kinase 1 promotes angiotensin II sensitivity during preeclampsia by impairing endothelial nitric oxide function. Journal of Clinical Investigation. 2016, 126(7):2561-74.
DuPont JJ, Ramick MG, Farquhar WB, Townsend RR, Edwards DG. NADPH oxidase-derived reactive oxygen species contribute to impaired cutaneous microvascular function in chronic kidney disease. Am J Physiol Renal Physiol. 2014, 306(12):F1499-506.
DuPont JJ, Hill MA, Bender SB, Jaisser F, Jaffe IZ. Aldosterone and mineralocorticoid receptors: Regulators of ion channels beyond the kidney. Hypertension. 2014, 63(4):632-7.
DuPont JJ, Greaney JL, Wenner MM, Lennon-Edwards SL, Sanders PW, Farquhar WB, and Edwards DG. High dietary sodium intake impairs endothelium-dependent dilation in healthy salt-resistant humans. J Hypertens. 2013, 31(3):530-6.
Greaney JL, DuPont JJ, Lennon-Edwards SL, Sanders PW, Farquhar WB, Edwards DG. Dietary sodium loading impairs microvascular function independent of blood pressure in humans: role of oxidative stress. J Physiol. 2012, 590(21): 5519-28.
DuPont JJ, Farquhar WB, Townsend RR, Edwards DG. Ascorbic acid or L-arginine improves cutaneous microvascular function in chronic kidney disease. J Appl Physiol. 2011, 111(6):1561-7.
DuPont JJ, Farquhar WB, Edwards DG. Intradermal microdialysis of hypertonic saline attenuates cutaneous vasodilation in response to local heating. Exp Physiol. 2011, 96(7):674-80.
Kuczmarski JM, Darocki MD, DuPont JJ, Sikes RA, Cooper CR, Farquhar WB, Edwards DG. The effect of moderate-to-severe chronic kidney disease on flow mediated dilation and progenitor cells. Exp. Biol. Med. 2011, 236(9):1085-92
Dr. DuPont received her Ph.D. in Applied Physiology from the University of Delaware in 2013. Her graduate research was focused on mechanisms of microvascular dysfunction in chronic kidney disease patients as well as the vascular effects of dietary sodium. Upon the completion of her Ph.D, Dr. DuPont joined the MCRI as a postdoctoral fellow in Dr. Iris Jaffe’s Laboratory. As a postdoctoral fellow, Dr. DuPont’s work focused on the role of smooth muscle cell-mineralocorticoid receptor in the development of aging-associated hypertension and vascular dysfunction. Dr. DuPont was recruited to the MCRI as a faculty member in 2017. Her laboratory’s research focus is on sex differences in vascular aging and mechanisms of vascular dysfunction in postmenopausal women.
American Physiological Society
American Heart Association