This is an observational study to assess the the burden of neuropathic involvement in wild-type transthyretin amyloidosis
wtATTR-CIAP Burden Study
Dissecting the neuropathic burden in wtATTR: its role in staging and burden of disease, and in differentiating from chronic idiopathic axonal polyneuropathy
Transthyretin cardiac amyloidosis
All genders
18+
Recruiting now
Overview
Principal Investigator: Dr. Oscar Soto and Dr. Maria Bartkus
Contact Us
Neuro Research
Study details
Inclusion Criteria
- At least 18 years of age
- Ability to provide informed consent
- Adult diagnosed with of ATTR by immunohistochemistry and TTR genetic testing without pathogenic variant. Tafamidis (+) and tafamidis (-) or Chronic idiopathic axonal polyneuropathy (CIAP)
Exclusion Criteria
- Evidence of polyneuropahty of any cause or disorder commonly associated with polyneuropathy such as: diabetes mellitus, renal insufficiency, hypothyroidism, vitamin B12 deficiency, and paraproteinemia
Study Requirements
Day 1 Screening
- Review of your medical record
- Obtain informed consent
- Phone interview with Dr. Bartkus Day 1 Baseline assessments- in Neurology Dept. at TMC
- Questionnaire Administration • Nerve conduction studies
- Quantitative sensory testing • Heart rate deep breathing
- Quantitative Sweat Measurement System (Q-Sweat)
- Cutaneous and Mixed Nerve Silent Period (CSP, MSP) Week 52 (1-year) Follow-up
- Longitudinal assessment phone call (optional)