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DEFENDO Long-Term Follow-Up Study

A long-term extension study to evaluate the safety and efficacy of OXERVATE 0.002% (20 mcg/mL) cenegermin-bkbj ophthalmic solution in patients with Stage 1 Neurotrophic Keratitis who enrolled in the DEFENDO Study

Neurotrophic keratitis

All genders

18+

Recruiting now

Department of Ophthalmology

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Allogenic Hepatocyte Transplantation into Periduodenal Lymph Nodes

A Phase 2a, Open Label, Dose Escalation Study for Safety, Tolerability, and Efficacy of Hepatocyte Transplantation Into Periduodenal Lymph Nodes Among Subjects With End-Stage Liver Disease

Liver diseases

All genders

18-70

Recruiting now

Department of Medicine, Division of Gastroenterology + Hepatology

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SEER-2

A Phase 3, Multi-Center, Randomized, Parallel, Double Masked, Placebo-Controlled Clinical Study to Assess the Safety and Efficacy of 0.1% RGN-259 Ophthalmic Solution for the Treatment of Neurotrophic Keratopathy (SEER-2)

Neurotrophic keratitis

All genders

18+

Recruiting now

Department of Ophthalmology

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POETYK SjS-1

A Phase 3, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Deucravacitinib in Adults with Active Sjögren’s Syndrome (POETYK SjS-1)

Sjogren's syndrome

All genders

18+

Recruiting now

Department of Ophthalmology

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BALATON

A Phase III, Multicenter, Randomized, Double-Masked, Active Comparator-Controlled Study to Evaluate the Efficacy and Safety of Faricimab in Patients with Macular Edema Secondary to Branch Retinal Vein Occlusion

Macular degeneration

All genders

18+

Recruiting now

Department of Ophthalmology

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Belvedere

A Phase IV, Multicenter, Open-label, Single-Arm study of the response to treatment after transition to the port delivery system with Ranibizumab (Susvimotom [Ranibizumab injection]) in patients with neovascular age-related macular degeneration previously treated with intravitreal agents other than Ranibizumab.

Macular degeneration

All genders

50+

Recruiting now

Department of Ophthalmology

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KPI-012-C-001

A Study to Evaluate the Safety and Efficacy of KPI-012 Ophthalmic Solution in Participants with Persistent Corneal Epithelial Defect (PCED)

Corneal disorders

All genders

18+

Recruiting now

Department of Ophthalmology

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Clinical Outcomes Of Primary Sclerosing Cholangitis In North America

Sclerosing cholangitis

All genders

No minimum age

Recruiting now

Department of Medicine, Division of Gastroenterology + Hepatology

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Discovery

Discovery Approach to Ocular Hypertension

Glaucoma

All genders

No minimum age

Recruiting now

Department of Ophthalmology

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NRAD

Effects of Orally Administered Nicotinamide Riboside on Bioenergetic Metabolism, Oxidative Stress, and Cognition in Mild Cognitive Impairment and Mild Alzheimer's Disease.

Alzheimer's disease, Mild cognitive impairment

All genders

55-89

Recruiting now

Department of Psychiatry

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