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The mission of the Cardiac Biology Research Center (CBRC) is to advance our understanding of fundamental mechanisms that regulate cardiac structure and function across multiple disease conditions, including heart failure, acute myocardial infarction, pulmonary and systemic hypertension, hypertrophic cardiomyopathy, autonomic dysfunction and arrhythmias. With advanced expertise in molecular cardiology, integrative physiology, molecular imaging, nanotechnology, biomedical engineering, and translational research, the CBRC studies novel signaling mechanisms that govern cardiomyocyte and non-myocyte cell populations.

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Tufts Physical Medicine and Rehabilitation Residency program is a three-year Advanced, ACGME-accredited residency.

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The Chen lab develops novel imaging methods to understand mechanisms of cardiovascular disease, to image disease as it progresses and to improve cardiovascular outcomes by targeting or monitoring therapies using molecular imaging. He is applying these novel technologies to heart failure and cardio-oncology.

We are committed to providing exceptional care and injury prevention for children. Our mission goes beyond treating injuries so we develop innovative injury prevention programs for children. Through our community safety programs, we have already reached out to over 33,000 children and their families in New England alone.

Fellows will spend six months at Tufts Medical Center, the tertiary care facility for the Tufts University-Affiliated Hospitals in New England.

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The Kapur Lab focuses on molecular mechanisms of cardiac remodeling and myocardial recovery. The laboratory has generated novel insight into signaling via the transforming growth factor beta (TGFb) family with a particular focus on the TGFb co-receptor endoglin (CD105) and Bone Morphogenetic Protein 9 (BMP9). The lab’s translational research focuses on preclinical models of acute and chronic heart failure, invasive hemodynamics, circulatory support device development, and cardioprotective mechanisms in the setting of acute myocardial infarction.

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Learn, practice and teach in Boston’s thriving medical community

The MCRI Mouse Physiology Core Laboratory is dedicated to the application of whole-animal models to pursue questions related to the pathophysiology of cardiovascular disease. The MCRI has established a series of cardiovascular models in rodents that are in active use in both the MCRI and in laboratories around the U.S. and the world. Models developed at the MCRI include a mouse model of carotid injury; chronic myocardial infarction, transverse aortic constriction and others. Phenotyping methods developed at the MCRI Mouse Core include a closed chest electrophysiology catheter-based procedure and dual ventricular pressure volume loop recording among others. The Mouse Core also routinely performs standard disease models and phenotyping assays relevant to cardiac and vascular physiology, including models of ventricular pressure overload, left and right ventricular pressure-volume loop analysis, cardiac echocardiography, telemetry implantation for blood pressure and ECG monitoring and many others.