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The Jaffe laboratory is focused on understanding the molecular mechanisms by which blood vessels become dysfunctional to lead to common cardiovascular conditions, including heart attack, stroke, high blood pressure, in-stent restenosis, vein graft failure and heart failure. We are interested in understanding how traditional risk factors like aging, obesity, high blood pressure or high cholesterol, or new risk factors like novel cancer treatments, cause blood vessels to become diseased. We are also focused on understanding sex differences in how these cardiovascular diseases develop, in order to identify sex-specific precision medicine strategies.

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When Lowell General Hospital was founded in 1891, we opened our doors to the community as a welcoming place where patients always come first. That mission is at the heart of how we provide healthcare to all who come through our doors today.

Did you know Tufts Medical Center is the oldest hospital in Boston? Tufts Medical Center was established as the Boston Dispensary and was the first operating medical center in New England- and the third in the United States. It was commissioned by Paul Revere

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The Vascular Biology Research Center (VBRC) investigators work to understand the molecular underpinnings of healthy blood vessel function and how dysfunction develops, which can lead to cardiovascular diseases including high blood pressure, heart attack and stroke.

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The Clinical Decision Making Fellowship at Tufts Medical Center provides trainees the tools they need to pursue a career in academic medicine. View a list of the alumni from this program.

Tufts Medical Center is located in downtown Boston within walking distance of the Boston Common, the Financial District — the city's center for banking and commerce — the waterfront and the historic Faneuil Hall marketplace.

Tufts Medical Center is located in downtown Boston within walking distance of the Boston Common, the Business district, the center for banking and commerce for the area, and of the Waterfront and Quincy Market areas.

The Tufts Medical Center Hospice and Palliative Medicine (HPM) Fellowship accepts applicants who have completed any of the accredited primary residencies.

In the Department of Pathology, there is a real bond that is formed between all classes of residents, fellows and attendings that extends into our social lives.

Heart failure remains the leading cause of hospital admission in the United States. The Blanton laboratory investigates the basic molecular signaling mechanisms regulating the process of cardiac remodeling: the myocardial structural and functional abnormalities that ultimately cause the heart failure syndrome. Our overarching goal is to discover novel anti-remodeling signaling molecules in the heart which will enable us to design more effective and better-tolerated therapies for heart failure patients.

The overarching goal of the lab is to identify genes associated with human heart disease. We believe firmly in the benefit of making primary discoveries advancing understanding of human disease whenever possible, in humans. Within the past two decades, the human genome sequence has been completed and a map of genetic markers suitable for studying disease associations has been established. Both candidate gene and genome-wide association studies are performed in the Huggins laboratory with a focus on valve disease and genetic cardiomyopathy.