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clinical trial
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Multi-center, observational post-approval registry to compare patient and graft survival of adult primary heart transplant recipients receiving DBD donor hearts perfused and assessed on the OCS Heart System compared to adult recipients of DBD donor hearts preserved using ischemic cold storage hearts (Control) at the same Registry centers over the same time period. The objective of this post-approval registry is to provide additional real-world evidence of the performance of the OCS Heart System to preserve DBD donor hearts.
clinical trial
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This is a pilot/feasibility study on the accuracy of HRV measured by the Apple Watch on the clinical status of patients admitted for acute heart failure decompnsation. We hypothesize that there will be a statistically significant improvement in the HRV that correlates clinically over the course of hospitalization. Meaningful findings from this study will strengthen the potential for a telemonitoring system where HRV measured remotely from home using wearable devices like Apple Watch can help physicians monitoring their health and intervene accordingly.
clinical trial
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The primary goal of this study is to improve our understanding of changes in skeletal muscle mass in the arms and the legs during a hospitalization for advanced HF. We plan to measure muscle thickness with an ultrasound machine in two locations on the body (the outer thigh and the upper arm muscle, of the dominant side) from the time a patient is first admitted to the ICU with HF as well as before and after any surgical HF therapies.
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MCRI is comprised of 12 scientists dedicated to investigating the molecular mechanisms of common cardiovascular diseases and translating those discoveries into new clinical strategies for diagnosis and therapy to prevent and treat heart diseases including heart attack, high blood pressure and heart failure.
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The Molecular Cardiology Research Institute (MCRI) at Tufts Medical Center is dedicated to investigating the molecular mechanisms of common cardiovascular diseases and translating those discoveries into new clinical strategies for diagnosis and therapy to prevent and treat various forms of heart disease including heart attack, high blood pressure and heart failure.
Molecular Cardiology Research Institute (MCRI)
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The mission of the Cardiac Biology Research Center (CBRC) is to advance our understanding of fundamental mechanisms that regulate cardiac structure and function across multiple disease conditions, including heart failure, acute myocardial infarction, pulmonary and systemic hypertension, hypertrophic cardiomyopathy, autonomic dysfunction and arrhythmias. With advanced expertise in molecular cardiology, integrative physiology, molecular imaging, nanotechnology, biomedical engineering, and translational research, the CBRC studies novel signaling mechanisms that govern cardiomyocyte and non-myocyte cell populations.
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The Galper Lab has a long-standing interest in autonomic control of the heart and more recently in the pathogenesis of lethal ventricular arrhythmias following myocardial infarction in mouse models for type II diabetes and metabolic syndrome. We also have an interest in the mechanism of atrial fibrillation in these mouse models for metabolic heart disease.
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The Kapur Lab focuses on molecular mechanisms of cardiac remodeling and myocardial recovery. The laboratory has generated novel insight into signaling via the transforming growth factor beta (TGFb) family with a particular focus on the TGFb co-receptor endoglin (CD105) and Bone Morphogenetic Protein 9 (BMP9). The lab’s translational research focuses on preclinical models of acute and chronic heart failure, invasive hemodynamics, circulatory support device development, and cardioprotective mechanisms in the setting of acute myocardial infarction.
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The core focus of the Pulakat lab is the elucidation and manipulation of various biological pathways that contribute to the development and pathogenesis of cardio-metabolic diseases and aging and uncovering markers of sex differences in heart disease.
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The Interventional Cardiology Fellowship Program at Tufts Medical Center in Boston is a 1-year advanced fellowship for cardiovascular specialists seeking interventional expertise.
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At Tufts Medical Center, we treat the whole family. Whether you’re welcoming a newborn into the world or preparing for surgery, we’re here to help you navigate all phases of the health and wellness journey.
About Tufts Medical Center
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The Women’s CV Health Research Group brings together basic scientists from the Molecular Cardiology Research Institute (MCRI) with scientists, clinician investigators and population researchers from diverse Departments at Tufts Medical Center including Internal Medicine, the Mother Infant Research Institute (MIRI), Obstetrics and Gynecology, and Pediatrics with the Tufts Freidman School of Nutrition Science and Policy, Tufts University School of Medicine and School of Public Health, and the Human Nutrition Research Center on Aging (HNRCA) with common interests in studying the unique aspects of Women’s Cardiovascular Health.
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Your gift to Lowell General Hospital supports the same programs that provide your friends, family and neighbors with the healthcare they rely on and deserve.
Give to Lowell General Hospital
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The Division of Geographic Medicine and Infectious Diseases faculty at Tufts Medical Center in downtown Boston is deeply committed to helping all of our fellows reach their career goals.