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The Vascular Neurology Fellowship at Tufts Medical Center in Boston is a one year, ACGME-accredited fellowship in preparation for sub-specialization in the care and management of patients with stroke and other cerebrovascular diseases as well as clinical research, education and quality improvement practices.
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The Department of Neurology at Tufts Medical Center in Boston is dedicated to pursuing new knowledge aimed at better treatments for patients with neurological disease.
Neurology Research
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Molecular mechanisms of neurovascular dysfunction:

The Good Laboratory is focused on understanding the mechanisms that regulate blood vessel function and inflammation and their contribution to the development of neurological diseases. Alzheimer’s Disease (AD) and ischemic stroke are both in the top 10 leading causes of mortality in the US, however, therapeutics are severely lacking to improve outcomes in these patients. CBF dysregulation, blood-brain barrier (BBB) dysfunction and neuroinflammation are key features observed chronically in Alzheimer’s Disease patients and acutely in ischemic stroke patients. A gap in our knowledge, and an area with high potential for pharmacological intervention, is understanding vascular-mediated mechanisms that influence ischemic stroke outcome, such as recovery of cerebral blood flow (CBF) and inflammatory responses, and progression of Alzheimer’s disease.
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The Vascular Biology Research Center (VBRC) investigators work to understand the molecular underpinnings of healthy blood vessel function and how dysfunction develops, which can lead to cardiovascular diseases including high blood pressure, heart attack and stroke.
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The Jaffe laboratory is focused on understanding the molecular mechanisms by which blood vessels become dysfunctional to lead to common cardiovascular conditions, including heart attack, stroke, high blood pressure, in-stent restenosis, vein graft failure and heart failure. We are interested in understanding how traditional risk factors like aging, obesity, high blood pressure or high cholesterol, or new risk factors like novel cancer treatments, cause blood vessels to become diseased. We are also focused on understanding sex differences in how these cardiovascular diseases develop, in order to identify sex-specific precision medicine strategies.
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The MCRI is comprised of 12 scientists dedicated to investigating the molecular mechanisms of common cardiovascular diseases and translating those discoveries into new clinical strategies for diagnosis and therapy to prevent and treat heart diseases including heart attack, high blood pressure and heart failure.
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The Molecular Cardiology Research Institute (MCRI) at Tufts Medical Center studies the molecular mechanisms of common cardiovascular diseases, including heart attack, stroke, heart failure and high blood pressure, and then translates these discoveries into new clinical strategies for diagnosis and therapy.
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The Molecular Cardiology Research Institute (MCRI) at Tufts Medical Center is dedicated to investigating the molecular mechanisms of common cardiovascular diseases and translating those discoveries into new clinical strategies for diagnosis and therapy to prevent and treat various forms of heart disease including heart attack, high blood pressure and heart failure.
Molecular Cardiology Research Institute (MCRI)
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As a medical professional, you play a pivotal role at Tufts Medicine. Whether you are looking to refer a patient into our care, seeking medical education and training opportunities, or would like to learn more about our academic departments, we are here to collaborate with you. Together we can discover breakthroughs, improve patient outcomes and revolutionize healthcare.

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Real innovation starts with real people. Our doctors and researchers never stop working to advance medicine that improves healthcare for all. One way we do so is through clinical studies that explore new drugs, therapies, medical devices and clinical and surgical methods. Be part of medicine's evolution by participating in a clinical trial at Tufts Medicine.
Clinical Trials
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The Neuro-Critical Care Fellowship at Tufts Medical Center in Boston is a two year, UCNS-accredited fellowship in preparation for sub-specialization in the care and management of patients in neurointensive care as well as clinical research, education and quality improvement practices.
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With the explosion in novel cancer therapies, cancer outcomes have improved dramatically resulting in a growing population of cancer survivors. Simultaneously, there has been a rise in cardiovascular side effects of these cancer therapies that is limiting quality of life and life expectancy of cancer survivors.
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The Interventional Cardiology Fellowship Program at Tufts Medical Center in Boston is a 1-year advanced fellowship for cardiovascular specialists seeking interventional expertise.
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The faculty and team of the Institute for Clinical Research and Health Policy Studies (ICRHPS) at Tufts Medical Center regularly present their research in articles published in the world’s most prestigious, peer-reviewed journals and by the Agency for Healthcare Research and Quality.
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