Heart failure is a harmful disease that is associated with high avoidable moribidity that can be treated with a cardiac resynchronization therapy device (CRT-D). Previous studies have shown links between CRT-D implants and reduced rates of morbidity in patients with heart failure with left bundle branch blockages (LBBB). However, there is limited amounts of evidence for the success of heart failure patients with non-LBBB. This prospective, multi-center study is looking at heart failure patients with non-LBBB that are implanted with CRT-D.
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The primary goal of this study is to use the WHOOP fitness band as a way to measure heart rate variability (HRV) in patients with coronary artery disease (CAD) and to establish a change in HRV before coronary artery bypass graft (CABG) surgery and during post-operative stay. The secondary aim of this study would be to associate this change in HRV with the patient’s clinical course. The validation component will test WHOOP’s HRV capabilities compared to the gold-standard Holter monitor.
This is a Prospective, multi‐center, international, randomized controlled, post‐market trial.
Obesity is a chronic, debilitating, multi-factorial disease that has reached worldwide pandemic proportions. The prevalence of obesity has tripled since the 1980s in many countries of the World Health Organization (WHO) European region. The WHO estimates that by 2015, 2.3 billion people will be overweight and over 700 million will be obese.
This is a Phase 3, randomized, double-blind, placebo-controlled study to evaluate sotatercept when added to background PAH therapy in newly diagnosed intermediate- and high-risk PAH patients.
The purpose of this randomized study is to evaluate the safety and effectiveness of EVAHEART 2 Implantable Left Ventricular Assist System (EVA2 LVAS) by demonstrating non-inferiority to HeartMate 3 when used for the treatment of advanced, refractory, New York Heart Association Class IV heart failure.
This is a Phase 2 study investigating safety and tolerability of Inhaled Treprostinil in participants with Pulmonary Hypertension associated with Interstitial Lung Disease.
Collecting and storing heart tissue and blood samples from consented Tufts Medical Center patients for the purpose of cardiovascular research.
This study explores changes in heart function before and after activation of Impella or ECMO devices used to support subjects in cardiogenic shock.
This research is being done to study a potential method of improving blood flow and oxygen delivery to the organs of patients on VA-ECMO. This study involves positioning the return cannula in the aorta, which is the main artery that carries blood away from the heart. We aim to prove that returning oxygenated blood to the aorta is safe and feasible. We also aim to better understand the effects that this method may have on the forces that affect blood flow and heart function.
Aortic stenosis (AS) affects over 12.6 million adults and causes an estimated 102,700 deaths annually. There is interest in novel approaches to identify valve disease earlier the disease course before symptoms occur. We previously used machine learning (ML) to develop a system for fully automated AS screening. Here we are validating the performance of this new method for identifying AS.